New study aims to uncover why some heart valves leak in AFib patients
NCT ID NCT05920824
First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 2 times
Summary
This study follows 141 adults with atrial fibrillation and moderate-to-severe functional mitral or tricuspid valve regurgitation (leaky valves). Researchers will use echocardiograms, exercise tests, and blood work to identify patterns and predict how the disease progresses over one year. The goal is to better understand risk factors and outcomes, not to test a new treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Aug 2023
- Expected to finish
-
Aug 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Recruitment will take place from the out-patient clinics \& echocardiography laboratory at St Bartholomew's Hospital
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Informed consent * Age of 18 years or older * Atrial fibrillation * Moderate or severe atrial valve disease * Adequate 2D echocardiography views including parasternal long axis, short axis, apical two chamber, apical three chamber and four chamber. Exclusion Criteria: * Unwilling or unable to give consent * Left ventricular impairment (ejection fraction \< 50%). * Primary/organic valve disease
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Atrial fibrillation are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
1 site. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
St Bartholomew's Hospital
RECRUITINGLondon, United Kingdom
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Heart hole or stroke trigger? global registry tracks who gets closure and what happens next
- Two ways to quiet a racing heart: trial pits hybrid ablation against standard catheter treatment
- Stroke's hidden heart rhythm clue under investigation
- Suture device may get heart patients walking sooner after leg vein procedures
- Two ways to catch a hidden heart rhythm after stroke
- Can an implanted heart monitor catch hidden irregular heartbeats after stroke?