Barts & The London Nhs Trust

This study tests a personalized approach to catheter ablation for people with persistent atrial fibrillation (AFib), a common heart rhythm problem. Researchers will identify specific areas in the heart that drive AFib and target them during the procedure. The goal is to improve s…

This study compares two treatments for persistent atrial fibrillation (AF), a heart rhythm problem. One group gets catheter ablation (a procedure to destroy tiny areas causing the irregular rhythm), the other gets a controlled electric shock (cardioversion) to reset the heart. Re…

This study tests a new method for placing spinal cord stimulator leads using electrical recordings (ECAP) to ensure the device targets the right nerves. Twenty adults with chronic lower back pain will receive the procedure, and researchers will measure pain relief using a standar…

This study tests whether stem cells taken from your own bone marrow and injected into heart arteries can reduce chest pain and improve daily life for people with refractory angina. About 110 adults with severe, ongoing chest pain despite standard treatments will be randomly assig…

This study looks at whether certain gene changes make some people more likely to develop a weakened heart muscle (cardiomyopathy) from atrial fibrillation (AF). Researchers will compare DNA from 299 adults with AF and heart failure to those with AF alone or other heart conditions…

This study looks at whether using continuous EEG (a brain wave monitor) in the intensive care unit helps people with a severe, hard-to-stop seizure condition called refractory status epilepticus. Researchers will compare standard care to standard care plus continuous EEG, measuri…

This study follows 141 adults with atrial fibrillation and moderate-to-severe functional mitral or tricuspid valve regurgitation (leaky heart valves). Researchers will use echocardiograms, exercise tests, and blood work to identify patterns and risk factors that predict disease p…

This study looks at how well a heart procedure called catheter ablation improves quality of life for people with a fast heart rhythm (ventricular tachycardia) who also have an implantable defibrillator. Researchers will ask 70 adults to fill out questionnaires about their health …

This study aims to find new genes that cause pituitary tumors, especially in families where the condition runs in the family. Researchers will collect blood and tumor samples from up to 10,000 people with certain types of pituitary tumors, including those with acromegaly or prola…

This study looks at whether CT and heart echo scans taken before and after a TAVI procedure can help predict how the new heart valve will perform over time. Researchers will collect scan data from 40 adults with severe aortic stenosis and use it to train a computer program. The g…

This study compares two types of dental implant surfaces to see which one helps keep the bone around the implant more stable and gives better aesthetic results. About 39 adults who need a front tooth extracted will receive one of the two implant types. Researchers will measure bo…

This study is for people with cardiogenic shock, a serious condition where the heart suddenly can't pump enough blood. Researchers want to understand why some people respond differently to treatment by looking at their genes and immune system. They will collect blood samples and …

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…

This study follows 100 adults who needed a machine called ECMO to support their heart and lungs after a severe failure. Researchers want to understand how muscle wasting and weakness affect patients' recovery and quality of life. The goal is to find better ways to help people reg…

This study looks at why some people with persistent atrial fibrillation (AFib) continue to have heart rhythm problems even after a standard ablation procedure. Researchers will create detailed 3D maps of the heart's electrical activity and scar tissue in 160 adults having their f…

This study looks at how muscle wasting in the mouth and throat affects swallowing in critically ill adults in the ICU. Researchers will measure muscle size and strength, and test swallowing safety in 160 patients. The goal is to find better ways to diagnose and treat swallowing p…