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Heart surgery tweak could slash stroke risk in millions

NCT ID NCT03724318

Prevention Sponsor: Helena DOMINGUEZ Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether closing the left atrial appendage—a small sac in the heart where blood clots often form—during planned heart surgery can prevent strokes in people with atrial fibrillation. About 1500 patients having coronary bypass or valve surgery are included. The goal is to provide clear evidence for or against routinely closing this sac to reduce stroke risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
closure of the left atrium appendage (a surgical procedure)
What this could lead to
If successful, this could establish a standard surgical step to prevent strokes in patients with atrial fibrillation undergoing heart surgery.
What could go wrong
This is a follow-up study, but results are not yet final. The procedure may not reduce strokes significantly, and there are always surgical risks like bleeding or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,500 people

The number who actually took part.

Started

Mar 2019

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients referred for planned first-time heart surgery: * Coronary artery by-pass surgery (CABG) * Valve surgery * Combined CABG and valve surgery Exclusion Criteria: * Endocarditis * No possible follow-up * Planned closure of the left atrium appendage as part of surgery

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Conditions

The condition(s) this trial relates to.

atrial fibrillation stroke disorder ischemic stroke prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial fibrillation Stroke, ischemic

Contacts and locations

Locations

  • Aarhus University Hospital Skejby

    Aarhus, Denmark

  • Hospital Universitario Vall d'Hebron

    Barcelona, Spain

  • Rigshospitalet

    Copenhagen, Denmark

  • Sahlgrenska University Hospital

    Gothenburg, Sweden

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