STROKE ISCHEMIC

This large study is testing whether adding two daily medications to standard care can better protect people who have recently had a minor stroke or warning sign. It will compare a low-dose anti-inflammatory drug (colchicine) and a stronger blood thinner (ticagrelor) against stand…

This study is testing if adding a weekly injection called dulaglutide to standard stroke-prevention medicine can improve blood flow in the brain and reduce the risk of another stroke. It will involve 130 adults who recently had a minor stroke or warning sign and have a severe nar…

This study is testing whether a procedure to physically remove blood clots from medium-sized brain arteries works better than standard medication alone for certain stroke patients. It will enroll 568 adults who have had an ischemic stroke within the last 24 hours, where imaging s…

This study is testing if a clot-busting drug called tenecteplase can help people recover better from a specific type of stroke caused by a blockage in a medium-sized brain artery. It will compare the drug against standard medical care in about 600 adults who had a stroke within t…

This study is testing if giving a blood-thinning drug called tirofiban before a standard clot-removal surgery helps people recover better from a major stroke. It will involve 870 adults who have had a stroke caused by a blocked artery in the brain. The goal is to see if this extr…

This study is testing whether a surgically implanted brain device can help people regain arm and hand movement after a stroke. The device delivers mild electrical stimulation to the brain while participants do physical therapy, aiming to 'rewire' neural connections. It is a small…

This study tests whether performing skull removal surgery very early after a severe stroke can prevent dangerous brain swelling and improve survival. It compares early surgery against standard care in 380 patients who have had a major stroke and are at high risk for brain swellin…

This study aims to find the best timing for surgery to prevent major strokes in people who recently had a minor stroke or warning sign (TIA). Researchers will compare performing surgery within 3 days versus waiting 4-15 days to see which timing better prevents death, stroke, or h…

This study is testing whether a procedure to remove a blood clot from the brain is safe and effective for people whose mild stroke symptoms suddenly get worse more than a day after the stroke began. About 272 participants will be randomly assigned to receive either standard medic…

This study aims to find out if a clot-removal procedure is safe and effective for stroke patients who already had moderate-to-severe disabilities before their stroke. It will compare the procedure plus standard medical care against standard medical care alone. The goal is to dete…

This large Phase 3 trial is testing which of two clot-busting drugs works better for people having a major stroke caused by a large blocked artery. About 850 patients will be randomly assigned to receive either the standard drug (alteplase) or a newer alternative (tenecteplase) w…

This study is testing whether a catheter-based heart procedure that closes off a small pouch in the heart (left atrial appendage) can prevent strokes in people with atrial fibrillation. Participants have a high stroke risk despite already taking blood-thinning medications. The tr…

This study is testing a surgical procedure called a 'nerve transfer' to improve arm and hand function in people who have long-term weakness after a stroke. The surgery connects a healthy nerve from the non-paralyzed side of the body to the nerves controlling the weak arm. Researc…

This study is testing whether a simple, widely available CT scan works as well as more complex imaging for selecting stroke patients who need a procedure to remove a blood clot. Researchers will compare outcomes for patients selected using each method to see if the simpler approa…

This study is testing a simple scoring system called TriAGE+ to help emergency doctors better identify patients whose dizziness might actually be a sign of a stroke. Researchers will use the tool on about 841 patients coming to the emergency room with dizziness to see how well it…

This study is testing a new type of MRI scan to see if it can better predict who is most at risk of having a stroke due to narrowed brain arteries. It will follow 400 patients in China for one year while they receive standard stroke-prevention medications. The goal is to see if t…

This study is testing new computer software designed to find a hidden, irregular heartbeat called atrial fibrillation (AF) using data from common wrist-worn devices like smartwatches. Researchers are enrolling 500 people who recently had a stroke to see if the software is as reli…

This study tests a virtual coaching program designed to help prevent future strokes and cognitive decline. It works with people who have had a stroke and their adult biological family members, who are also at higher risk. The program teaches strategies for managing health risks a…

This study aims to help stroke survivors who are losing muscle mass, a condition called sarcopenia. Researchers will compare two different exercise programs—short bursts of high-intensity training versus longer sessions of moderate, steady exercise—to see which is better at rebui…

This study is testing two simple, self-guided rehabilitation programs to help stroke survivors in Nigeria improve their movement and quality of life. Researchers will compare a video-based program to a printed manual to see which is more effective for people who have limited acce…

This study is testing whether a non-invasive brain stimulation technique can help people who have lost some speech ability after a stroke. Researchers will use magnetic pulses on the brain, combined with standard speech therapy, to see if it improves word-finding and communicatio…

This study is testing whether special prism glasses, combined with a gentle form of brain stimulation, can help stroke patients who have 'neglect'—a condition where they have trouble noticing things on one side of their body or environment. It will compare the glasses plus real b…

This study is testing if adding a special type of physical therapy called Vojta therapy to standard rehab helps people recover movement after a recent stroke. Vojta therapy involves gently pressing specific points on the body to trigger automatic movement patterns. Researchers wi…

This study is testing whether a gentle, non-invasive form of electrical brain stimulation can help people who have had a stroke. The goal is to see if stimulating the front part of the brain can reduce the severe tiredness (fatigue) that often follows a stroke and also improve la…

This study is testing whether a brain training technique called EEG neurofeedback can help people regain arm and hand movement after a recent stroke. It will compare patients who receive real brain training plus standard rehab to those who receive fake brain training plus standar…

This study aims to understand how the brain changes when people with vision loss from a stroke do visual training exercises. Researchers will use MRI brain scans to see which areas are damaged and how the remaining healthy parts of the brain respond before and after training. The…

This study aims to understand the precise timing of brain injury after a stroke by measuring a specific protein (BD-tau) in the blood. Researchers will take blood samples every hour for 48 hours from 100 patients who have just had a stroke. The goal is to learn exactly when brain…

This study is creating a collection of blood, tissue, and fluid samples from stroke patients and their families. The goal is to store these samples for future research to discover the genetic factors that cause stroke. By understanding these genetics, scientists hope to find bett…

This study aims to understand what factors lead to brain diseases like stroke and dementia by following 5,000 adults over many years. Participants, including those with a diagnosis, at high risk, or who are healthy, will regularly complete health questionnaires and interviews. Th…

This study aims to understand how well a proven emergency stroke treatment works in everyday hospital practice across the Asia-Pacific region. Researchers will observe 350 adult patients who have a severe stroke caused by a major blocked brain artery. The goal is to identify fact…

This study aims to understand if COVID-19 vaccines affect brain health, specifically looking for signs of stroke or dementia. Researchers in Hong Kong will follow 500 healthy adults, comparing brain scans and memory tests from before and after vaccination to those from unvaccinat…

This is a large, observational registry designed to monitor the long-term safety and performance of already-approved medical devices used to treat brain aneurysms and strokes. It will follow 4,000 adult patients who receive these devices in real-world hospital settings. The main …

This study aims to better understand how narrowed arteries in the neck affect blood flow and energy use in the brain. Researchers will use combined PET and MRI scans on 200 patients with this condition to look for patterns and connections with their symptoms. The goal is to find …

This study aims to understand how vision loss caused by a stroke affects a person's ability to drive and navigate. Researchers will use a virtual reality driving simulator to compare the steering behavior of 40 people with stroke-related vision loss to people with normal vision. …

This study aims to predict how well people recover their quality of life more than four years after having a minor stroke. Researchers will analyze data from 1,000 patients in France, looking at their early stroke characteristics, health questionnaires, and optional MRI scans and…

This study aims to validate tests that can predict how well a person's arm will recover after a stroke. Researchers will use brain scans and a safe, non-invasive brain stimulation technique on about 657 recent stroke patients. The goal is to create reliable tools to identify whic…