STROKE, ISCHEMIC

This study looks at whether a rescue procedure (endovascular therapy) can help people who had a mild stroke but then got worse. The procedure is done more than 24 hours after the stroke started. The study will compare people who get the procedure plus standard care to those who g…

This study tests whether early skull surgery (decompressive hemicraniectomy) can prevent dangerous brain swelling in people who had a severe stroke and already had a clot removal procedure. About 380 participants aged 18-75 with large strokes and high risk of swelling will be ran…

This study tests whether a weekly injection of dulaglutide, a drug used for diabetes, can improve blood flow in the brain for people with severely narrowed arteries inside the skull. About 130 adults who recently had a mild stroke or mini-stroke will receive either standard care …

This study tests if repeatedly inflating a blood pressure cuff on the arm (remote ischemic preconditioning) can improve collateral blood flow in the brains of people who have had a stroke due to a blocked large artery. About 300 adults over 40 with stable stroke symptoms will rec…

This study tests whether giving a medicine called tirofiban through a vein before a procedure to remove a blood clot can help people recover better after a stroke caused by a blocked artery in the brain. About 870 adults with a certain type of stroke will take part. The goal is t…

This study tests whether a catheter-based procedure to close a small pouch in the heart (the left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are still at high risk despite taking blood thinners. About 4,000 participants will be ran…

This study tests whether high-dose statins can shrink or stabilize fatty plaques in brain arteries of people who recently had a stroke. About 100 participants will get intensive statin therapy and be monitored with special MRI scans to see changes in plaque size and composition. …

This study tests whether two drugs, colchicine and ticagrelor, can reduce inflammation and lower the risk of another stroke or heart attack in people who have already had a stroke. About 2,800 high-risk participants will take these medications alongside standard care. The goal is…

This study looks at whether a procedure called endovascular thrombectomy (EVT) can help people who have a stroke but already had a moderate-to-severe disability before the stroke. About 1,060 adults with a large blood vessel blockage in the brain will be randomly assigned to get …

This study tests a surgery that moves a nerve from the neck to help people with arm weakness after a stroke. It includes 95 adults whose arm function stopped improving 1-5 years after stroke. The goal is to see if the surgery can improve arm movement and control.

This study tests whether the clot-busting drug tenecteplase can help people with a type of stroke caused by blockages in medium-sized brain arteries. About 600 adults who had a stroke 4.5 to 24 hours earlier will receive either tenecteplase or standard care. The goal is to see if…

This study tests whether a procedure to remove blood clots from medium-sized brain arteries, guided by special brain scans, helps people recover better than standard medical treatment alone. It includes 568 adults who have had a stroke within the last 24 hours. The goal is to see…

This study tests whether a newer clot-busting drug (tenecteplase) works better than the standard drug (alteplase) when given before a mechanical procedure to remove a large blood clot from the brain. About 850 adults who have had a severe stroke within the last 4.5 hours will be …

This study tests whether performing carotid artery surgery within 72 hours of a mini-stroke or minor stroke is better than waiting 4 to 15 days. About 456 adults with a blocked neck artery and recent symptoms will be randomly assigned to one of two timing groups. The goal is to s…

This study checks if a smartwatch can spot an irregular heartbeat (atrial fibrillation) in 500 older adults who had a stroke with an unknown cause. Participants wear a study smartwatch and a standard heart monitor for 30 days. Researchers compare the smartwatch data to the standa…

This study tests a new device called NobleStitch EL against an already approved device (Amplatzer) for closing a small hole in the heart called a PFO. The goal is to see which one works better at preventing another stroke in people aged 18-60 who have already had a stroke from an…

This study tests whether a brain-training technique called EEG neurofeedback can improve arm movement when started soon after a stroke. About 40 adults who had a stroke within the past 3 weeks will either get real or fake neurofeedback alongside standard rehab. The goal is to see…

This study tests whether amantadine, a drug used for other conditions, can improve recovery after a stroke. Sixty adults who had an ischemic or hemorrhagic stroke will receive either amantadine or a placebo for one month. Researchers will check safety and measure recovery using q…

This study tests a task-specific self-rehabilitation program (TASSRET) for stroke survivors living at home with no access to physiotherapy. Fifty Hausa-speaking adults will use either a video or manual guide to improve their movement, balance, and quality of life. The goal is to …

This study looks at whether high-intensity interval training (short, intense exercise bursts) or moderate-intensity continuous training (steady, moderate exercise) better helps stroke survivors who have lost muscle mass. Researchers will measure changes in muscle thickness, stren…

This study looks at whether adding Vojta therapy—a technique that uses gentle pressure on specific body areas to trigger automatic movement—to standard physical therapy can improve posture, trunk control, and arm function in people recovering from a first-time stroke. About 62 ad…

This study tests whether a brain implant called the CorTec Brain Interchange can help people who had a stroke at least 6 months ago regain movement in their arm. The implant delivers electrical stimulation to encourage the brain to rewire itself. Four adults with moderate arm wea…

This study tests whether a safe, non-invasive brain stimulation technique called theta burst stimulation (TBS) can improve language recovery in people who have trouble speaking after a stroke. 45 adults with non-fluent aphasia will receive either real TBS (targeting the left or r…

This study tests whether combining prismatic lenses with a gentle brain stimulation technique (tDCS) can help people who have lost awareness of one side of space after a stroke. Thirty adults who had an ischemic stroke within the last 90 days will receive either the real stimulat…

This study tests if mild electrical stimulation to the front of the brain can reduce fatigue and improve language and attention in people who have had a stroke. Sixty adults who are at least six months post-stroke will receive either real or fake stimulation during 10 sessions of…

This study looks at whether a simple CT scan can be used to decide if stroke patients need a procedure to remove a blood clot, instead of more complex scans. About 1,846 adults who had a stroke within the last 24 hours will take part. The goal is to see if the simple scan leads t…

This study looks at how people with vision loss from a stroke steer and navigate in a virtual driving environment. Researchers will compare 40 participants with and without vision problems to understand how they adapt. No treatment or cure is involved—just observation to learn mo…

This study is a large registry that will follow about 4,000 people who have been treated with Medtronic devices for brain aneurysms or ischemic stroke. The goal is to see how well these devices work in everyday medical practice, including how often aneurysms are fully closed and …

This study tests a virtual program that combines cognitive training and health coaching for stroke survivors and their biological family members. The goal is to see if it's feasible to reduce vascular risk and promote brain health in both groups. Forty participants will be enroll…

This study looks at people who had a minor stroke to see if doctors can predict their quality of life more than 4 years later. Researchers will use information collected soon after the stroke, along with questionnaires and optional saliva samples and MRI scans, to build a predict…

This study is creating a biobank of blood, spinal fluid, and tissue samples from 500 Chinese adults, including stroke patients, their families, and healthy volunteers. The goal is to store high-quality samples and medical data for future research into the genetics and biology of …

This study looks at a blood marker called BD-tau, which may show how much brain injury happens after a stroke. Researchers will take blood samples every hour for 48 hours from 100 adults who had a stroke. The goal is to learn when the marker rises and how long it stays high, whic…

This study is testing a new, noninvasive MRI technique to see if it can better predict stroke risk in people with narrowed arteries in the brain (ICAS). Researchers will measure blood flow pressure using a special MRI scan and follow 400 participants for one year to see who has a…

This study is for people with severely narrowed arteries in the head or neck who have already had a mini-stroke or stroke. Researchers will use a special PET/MR scanner to measure blood flow and sugar use in the brain. The goal is to find better ways to diagnose and treat these p…

This study compares a new MRI-based method (IMPROVE) against the standard approach for deciding which patients with narrowed carotid arteries need surgery or stenting. The standard method mainly looks at how narrow the artery is, while IMPROVE checks for unstable plaque that rais…

This study is tracking 350 stroke patients in the Asia-Pacific region to see how well a procedure called endovascular thrombectomy (clot removal) works outside of clinical trials. Researchers want to understand what helps or hinders recovery in everyday hospital settings. The goa…

This study follows 5,000 adults in Hong Kong who either have or are at high risk for brain diseases like stroke and dementia. Researchers will collect medical records, surveys, and phone interviews over many years to identify what factors lead to these conditions. The goal is to …

This study is testing whether brain scans and a technique called transcranial magnetic stimulation can predict how well someone will recover arm movement after a stroke. Researchers will collect data from 657 adults who recently had a stroke and have arm weakness. The goal is to …

This study looks at how the brain changes after a stroke that causes vision loss. Researchers will use brain scans to see if visual training can help the remaining healthy parts of the brain improve sight. The goal is to better understand vision recovery, not to test a new treatm…

This study examines tiny RNA molecules in the blood of 300 adults who had a stroke and received a procedure to remove the clot. Researchers want to see if certain RNA patterns can help predict how well patients recover. The goal is to find new markers that could guide future stro…

This study aims to understand if COVID-19 vaccines have any impact on brain health. Researchers will use MRI scans to look at the brains of 500 healthy adults in Hong Kong, comparing scans taken before and after vaccination. The goal is to provide clear, evidence-based informatio…