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Brain scans and stimulation may predict stroke recovery

NCT ID NCT05338697

Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This study aims to see if brain scans and a technique called transcranial magnetic stimulation (TMS) can predict how well someone will recover arm movement after a stroke. Researchers will collect data from 657 adults who recently had a stroke and have arm weakness. The goal is to create a large dataset to help design better future stroke recovery trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 657 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2022

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with ischemic stroke consented within 24-96 hours of stroke onset in the acute hospitalization setting

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 years or older 2. Unilateral symptomatic stroke due to ischemia. (Note: Bilateral acute stroke is permitted if the stroke that is contralateral to the index stroke is asymptomatic). 3. Motor deficits in the acutely affected UE, defined as a Shoulder Abduction and Finger Extension (SAFE) score ≤ 8 out of 10 points20,61 (i.e., excluding full or nearly full motor strength in both shoulder abduction and finger extension) within 48 to 96 hours of stroke onset (or time last known well). a. Please note that, if significant imbalance is observed in SAFE score or MEP+ rates, the enrollment threshold for SAFE score may be updated with a formal study memo. 4. Provision of signed and dated informed consent form within 24 to 96 hours of stroke onset, (or time last known well). Note: Participant is considered "enrolled" upon starting TMS (at least one stimulation is delivered) or starting study-specific MRI pulse sequence (at least one MRI beep occurs) 5. Stated willingness to comply with all study procedures and availability for the duration of the study, including Day 90 visit which must occur in-person. 6. Fluent in study approved languages (i.e., English or Spanish) Exclusion Criteria: 1. UE injury or conditions on paretic side that limited use prior to the stroke 2. Legally blind 3. Dense sensory loss on paretic side indicated by a score of 2 on NIHSS sensory item 4. Unable to abduct the shoulder or extend the fingers of the non-paretic UE on verbal command 5. Isolated cerebellar stroke 6. Symptomatic stroke in any location within 30 days prior to index stroke. 7. Co-enrollment in a trial of an intervention targeting the incident stroke (acute treatment or rehabilitation/recovery intervention) after baseline assessments for VERIFY are initiated 8. Known or expected inability to maintain follow-up with study procedures through 90 days 9. Cognitive or communication impairment precluding informed consent by the participant. 10. Major medical, neurological, or psychiatric condition that would substantially affect functional status 11. Non-cerebrovascular diagnosis associated with unlikely survival at 90 days 12. Pregnancy 13. Contraindication to noncontrast MRI (certain metallic implants, metallic foreign bodies or severe claustrophobia) 14. Contraindication to TMS 1. Implanted electronic cardiac devices (e.g., Automatic Implantable Cardioverter-Defibrillator \[AICD\] or pacemaker) 2. Any electronic devices in the body at or above the level of the seventh cervical vertebra (such as cochlear implant, cortical stimulator, deep brain stimulator, vagus nerve stimulator, cervical spine epidural stimulator, or ventriculoperitoneal shunt) 3. Ferromagnetic intracranial metallic implant 4. Skull defect related to current stroke 5. Seizure after onset of current stroke 6. Seizure within the last 12 months while taking anti-epileptic medications 7. Previous serious adverse reaction to TMS 15. Anticipated inability to perform study procedures within 168 hours of symptom onset 1. Unable to perform behavioral assessments within 48-120 hours of symptom onset (or time last known well). 2. Unable to receive TMS within 72-168 hours or get MRI within 48-168 hours of symptom onset (or time last known well).

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Conditions

The condition(s) this trial relates to.

ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke Stroke, acute Stroke, ischemic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    41 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Advocate Lutheran General Hospital

    RECRUITING

    Park Ridge, Illinois, 60068, United States

  • Aurora St. Luke's Medical Center

    RECRUITING

    Milwaukee, Wisconsin, 53215, United States

  • Banner University Medical Center

    RECRUITING

    Tucson, Arizona, 85719, United States

  • Baystate Medical Center

    RECRUITING

    Springfield, Massachusetts, 01199, United States

  • Birmingham VA Medical Center

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • Corewell Heath Butterworth Hospital

    RECRUITING

    Grand Rapids, Michigan, 49503, United States

  • Duke University Hospital

    RECRUITING

    Durham, North Carolina, 27710, United States

  • Emory University Hospital

    RECRUITING

    Atlanta, Georgia, 30322, United States

  • Froedtert & Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Harborview Medical Center

    RECRUITING

    Seattle, Washington, 98104, United States

  • Houston Methodist Hospital

    WITHDRAWN

    Houston, Texas, 77030, United States

  • IU Health Methodist Hospital

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Kaiser Permanente Redwood City Medical Center

    RECRUITING

    Redwood City, California, 94063, United States

  • Keck Medical Center of USC

    RECRUITING

    Los Angeles, California, 90033, United States

  • Lahey Hospital & Medical Center

    RECRUITING

    Burlington, Massachusetts, 01805, United States

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • Mayo Clinic Saint Marys Campus

    RECRUITING

    Rochester, Minnesota, 55902, United States

  • MedStar Washington Hospital Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Medical University of South Carolina (MUSC)

    RECRUITING

    Charleston, South Carolina, 29425, United States

  • Memorial Hermann Texas Medical Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Memorial Hospital of Carbondale

    RECRUITING

    Carbondale, Illinois, 62901, United States

  • Montefiore Medical Center

    RECRUITING

    The Bronx, New York, 10467-0121, United States

  • NYU Langone Hospital - Brooklyn

    SUSPENDED

    Brooklyn, New York, 11220, United States

  • OSU Wexner Medical Center

    RECRUITING

    Columbus, Ohio, 43210, United States

  • Penn State Hershey Medical Center

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

  • Pennsylvania Hospital

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • Prisma Health Richland Hospital

    RECRUITING

    Columbia, South Carolina, 29203, United States

  • Richmond VA Medical Center

    WITHDRAWN

    Richmond, Virginia, 23249, United States

  • Ronald Reagan UCLA Medical Center

    WITHDRAWN

    Los Angeles, California, 90095, United States

  • San Francisco General Hospital

    RECRUITING

    San Francisco, California, 94110, United States

  • Strong Memorial Hospital

    RECRUITING

    Rochester, New York, 14642, United States

  • The Mount Sinai Hospital

    RECRUITING

    New York, New York, 10029, United States

  • UCSF Medical Center

    RECRUITING

    San Francisco, California, 94143, United States

  • UPMC Presbyterian Hospital

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

  • UT Southwestern Medical Center

    RECRUITING

    Dallas, Texas, 75390, United States

  • UVA Medical Center

    RECRUITING

    Charlottesville, Virginia, 22903, United States

  • University of Alabama

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • University of Cincinnati Medical Center

    RECRUITING

    Cincinnati, Ohio, 45219, United States

  • University of Iowa Hospitals & Clinics

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • University of Maryland Medical Center

    ACTIVE_NOT_RECRUITING

    Baltimore, Maryland, 21201, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48108, United States

  • University of Utah Healthcare

    RECRUITING

    Salt Lake City, Utah, 84132, United States

  • University of Wisconsin University Hospital

    RECRUITING

    Madison, Wisconsin, 53792, United States

  • Westchester Medical Center

    RECRUITING

    Valhalla, New York, 10595, United States

  • Yale New Haven Hospital

    RECRUITING

    New Haven, Connecticut, 06511, United States

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