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Nerve zap could unclog heart failure lungs

NCT ID NCT06733012

Symptom relief Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether blocking signals from the splanchnic nerve can reduce congestion and improve exercise ability in people with heart failure. About 54 adults with heart failure and reduced pumping function will receive either a nerve-blocking procedure or a sham procedure. The goal is to see if this approach safely eases symptoms and improves daily function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
catheter-based ablation of the right greater splanchnic nerve
What this could lead to
If it works, this could offer a new way to reduce heart failure symptoms like shortness of breath and fatigue, improving daily life.
What could go wrong
This is an early, small study (54 people) testing safety and effectiveness. The procedure carries risks like bleeding, infection, or nerve damage, and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

May 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years * Established diagnosis of HFrEF with left ventricular ejection fraction \<50% * NYHA II-III symptoms * Stable HF drug regimen for the preceding 1 month * Wedge pressure \>/=15 mmHg at rest or \>/=20 mmHg with peak stress on the initial invasive exercise testing * Glomerular filtration rate ≥ 15 mL/min per 1.73 m2 * Heart rate with activity such as the 6 min walk increases by at least 10 beats Exclusion Criteria: * Type I myocardial infarction within 3 months * Infiltrative (i.e., amyloid) or hypertrophic cardiomyopathy * Uncontrolled atrial (heart rate \>100bpm) or ventricular arrhythmia * Chronic oxygen use \>2L * Hypersensitivity to albumin and pregnancy * History or scoliosis * Orthostatic hypotension (including a drop of pulse pressure with standing of more than 10)

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Conditions

The condition(s) this trial relates to.

heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Duke

    RECRUITING

    Durham, North Carolina, 27278, United States

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