HEART FAILURE

This study tested a new drug called XXB750 in 136 people with heart failure and reduced heart function. The goal was to see if the drug could lower a marker of heart strain (NT-proBNP) and was safe. The trial was stopped early, so results are limited.

This study tested a single dose of an experimental drug called REGN5381 in 89 people with chronic heart failure whose hearts pump less blood than normal. The goal was to check safety, side effects, and how the drug affects a key heart stress marker (NT-proBNP). The trial was term…

This study tested a small heart pump (HeartWare MVAD) in 11 people with severe heart failure. The goal was to see if the device could help them live longer and feel better. The trial was stopped early, so results are limited, but the pump is designed to support the heart long-ter…

This study tested whether adding a new drug called AZD5462 to the standard medicine dapagliflozin could help people with both heart failure and moderate kidney disease. The trial was stopped early and only included 8 participants. The main goal was to see how the drug combination…

This study tested a new drug called LY3540378 in 332 adults with worsening chronic heart failure where the heart pumps normally but doesn't fill properly. The goal was to see if the drug could improve heart function and safety compared to a placebo. The trial was terminated early…

This study looked at whether letting patients manage their own sternal precautions after heart surgery leads to better quality of life without increasing pain or complications. Ten adults who had heart surgery were followed for up to a year. The goal was to see if a self-managed …

This study tested whether a medicine called Ponsegromab could improve symptoms and quality of life in adults with heart failure. Participants received either the drug or a placebo as a shot every four weeks for about 9 months. The trial was stopped early, so results are limited. …

This study aimed to see if a special wearable shirt could predict heart failure hospitalizations by collecting data from sensors. It planned to enroll up to 500 people with heart failure, but was stopped early with only 13 participants. The goal was to develop an algorithm to war…

This study looked at how different pacing modes affect blood pressure in people with heart failure who have a special pacemaker (CRT). Researchers measured the highest systolic blood pressure achieved with each mode. The goal was to find which setting works best acutely, but the …

This study looked at whether a wearable defibrillator (WCD) can accurately record heart sounds in people with heart failure. About 60 adults with heart failure and weak heart pumping (ejection fraction 40% or less) took part. The goal was to compare the WCD's recordings to a stan…