HEART FAILURE

This study will test several different treatments at once in 1,000 adults with heart failure. The goal is to see which treatments help people live longer and stay out of the hospital. Participants will be randomly assigned to one of the treatment options being studied.

This study tests a device called TricValve for people with severe tricuspid regurgitation, a condition where a heart valve leaks blood backward. About 780 adults will receive either the device plus standard care or standard care alone. The goal is to see if the device reduces blo…

This study tests whether a national hospital accreditation program for heart failure care can improve patient outcomes. About 6,240 adults hospitalized with heart failure will be enrolled across multiple hospitals in China. Hospitals are randomly assigned to either the accreditat…

This study looks at whether making a small opening between the upper chambers of the heart during mitral valve surgery can help prevent heart failure symptoms after the operation. The trial will include 50 adults with severe mitral regurgitation (a leaky heart valve) who are sche…

This early-stage trial tests whether a second infusion of a patient's own modified immune cells (CAR-DC) can safely improve heart function in people with end-stage dilated cardiomyopathy. The cells target a protein called FAP to calm harmful inflammation. Only 5 adults who previo…

This study tests a new system that monitors a large vein in the body to help doctors manage heart failure. The goal is to reduce hospital stays and deaths. About 800 adults with moderate to severe heart failure will either get the device plus standard care, or standard care alone…

This study looks at whether using a real-time continuous glucose monitor (CGM) can help people with type 2 diabetes and worsening heart failure better manage their blood sugar. About 140 adults admitted to the hospital for heart failure will be monitored during their stay and for…

This study tests whether people with acute heart failure can safely go home early and receive a daily shot of furosemide instead of staying in the hospital for IV diuretics. About 250 adults will be randomly assigned to either early discharge with the shot or standard hospital ca…

This early-stage trial tests a new treatment for people with severe heart failure. Doctors will inject heart muscle cells grown from stem cells directly into the heart. The goal is to see if it is safe and can help the heart pump better. The study involves 14 participants and fol…

This large Phase 3 study tests whether a new weekly injection, NNC0487-0111, can reduce death and hospital stays in people with a common type of heart failure who also have obesity. About 5,600 participants will be randomly assigned to receive the drug or a placebo. The goal is t…

This study looks at whether people with heart failure caused by a treatable problem (like a blocked artery or leaky valve) can safely wait 6 months before starting certain heart failure drugs, if their heart function improves after surgery or a procedure. About 80 adults whose he…

This study tests whether providing home-delivered meals and extra dietary advice helps older veterans with heart failure recover better after leaving the hospital. About 1,400 veterans aged 60 and older will be randomly assigned to receive either the meal support plus standard ca…

This study looks at a new generation of implantable heart devices (ICDs) for people with dangerous heart rhythms or heart failure. About 151 participants will get the device to confirm it works safely. The main goal is to see if serious device-related problems are rare within 6 m…

This study tests a device that uses radiofrequency energy to calm overactive nerves in the lung arteries of people with heart failure and a specific type of high blood pressure in the lungs. About 750 adults who are stable on heart failure medications will either get the procedur…

This study will test whether the drug finerenone can slow kidney function decline and lower the risk of heart failure in 120 adults with type 2 diabetes and chronic kidney disease. Participants must already be on standard blood pressure medications. The study will measure changes…

This early-stage study tests a single injection of SHR-4658 in 48 healthy people and those with high blood pressure to see if it is safe and how the body processes it. The goal is to gather initial safety data for a potential heart failure treatment. Participants must be 18-55 an…

This study tests if a newer blood thinner called apixaban works better and causes fewer side effects than the standard drug warfarin in people with advanced heart failure who have a HeartMate 3 heart pump. About 460 adults who have had the pump for at least 3 months will be rando…

This study will test a new clinic that treats both heart failure and methamphetamine use disorder at the same time. About 50 adults with heart failure who use methamphetamine will receive heart medications, counseling, and rewards for staying drug-free over 6 months. The goal is …

This study tests a new approach for people with end-stage heart failure and permanent atrial fibrillation who are waiting for a heart transplant or a heart pump. Participants will receive a special pacemaker and a procedure to calm the heart's electrical signals, along with an im…

This study tests whether checking kidney function less often helps heart failure patients reach higher, more effective doses of their medications safely. About 344 adults with heart failure and reduced pumping ability will be randomly assigned to either standard or reduced kidney…

This study compares two heart pacing methods after a procedure to control heart rate in adults with atrial fibrillation and heart failure. Participants will receive either a new type of pacing (conduction system pacing) or standard cardiac resynchronization therapy. The goal is t…

This study tests whether giving women the full recommended doses of heart failure medications quickly after a hospital stay can reduce the risk of death or readmission within a year. About 360 women from 13 Italian hospitals will be randomly assigned to either intensive medicatio…

This study compares two ways to monitor heart failure patients: using a special algorithm (HeartLogic) that sends alerts from an implanted device versus regular in-person checkups. About 578 adults with heart failure who recently got a compatible defibrillator will take part. The…

This study tests whether a small implanted monitor (CardioMEMS) can help reduce heart-related hospital visits for people with a mechanical heart pump (LVAD). About 40 adults with a HeartMate III LVAD will be randomly assigned to either standard care or standard care plus the moni…

This study tests whether a nurse-led education program can reduce hospital readmissions for patients with conditions like heart failure, COPD, or obesity who are having hip or knee replacement. About 300 participants will either receive the extra nurse support or standard care. T…

This study is testing a device called Valvosoft that uses focused ultrasound pulses from outside the chest to soften hardened heart valves. It is for people with severe aortic stenosis who cannot or choose not to have standard surgery or valve replacement. The registry will follo…

This study tests whether adding relaxin, a natural hormone, to standard care can reduce abnormal heart rhythms in 208 veterans with atrial fibrillation who are scheduled for a heart procedure called catheter ablation. The goal is to see if relaxin lowers the daily burden of atria…

This study tests if a drug called sodium zirconium cyclosilicate (SZC) can help people with heart failure stay on higher, more effective doses of a standard medication (MRA). About 110 adults over 70 with heart failure will take SZC or a placebo for 6 months. The goal is to see i…

This study tests whether the drug finerenone can improve heart structure and function in 156 adults with heart failure and an enlarged left side of the heart. Participants will take finerenone or a placebo daily for 12 months and undergo heart scans to measure changes. The goal i…

This study tests whether adding a saltwater solution (hypertonic saline) to standard water pills can help people with heart failure and chronic kidney disease. About 60 adults will receive either the combination or standard care in an outpatient setting. The goal is to see if thi…

This study tests whether a special pacing method called Bachmann bundle pacing can prevent new atrial fibrillation (a type of irregular heartbeat) in people with heart failure who already need a pacemaker or defibrillator. About 110 participants will be randomly assigned to recei…

This study tests if a digital support package (DEEPER) helps heart patients maintain health after completing cardiac rehab. 306 adults with heart disease or heart failure will either get standard care or standard care plus the digital program. The goal is to see if the digital pr…

This study tests whether adding L-arginine, a natural amino acid, to standard heart failure treatment can improve heart function and symptoms. About 200 adults with reduced heart pumping ability (ejection fraction below 40%) will receive L-arginine or a placebo. The goal is to se…

This study tests a new method for placing a pacing lead in the heart to treat heart failure. The goal is to target a specific area called Bachmann's bundle to improve heart function. About 40 adults with heart failure will be enrolled. The study will check if the new method is sa…

This study tests whether using a home blood pressure monitor and video doctor visits can help people living in rural areas better manage their heart failure. Researchers will enroll 32 adults with heart failure to see if this approach is practical and acceptable. The goal is to i…

This study looks at whether adding the drug finerenone to standard heart failure treatment (an SGLT2 inhibitor) can help patients more than the standard treatment alone. About 60 adults with newly diagnosed heart failure will take either the combination or the standard drug and b…

This study compares a newer pacing method (directly pacing the heart's natural electrical system) to the standard pacing method in 1100 people with heart failure and a specific heart block. The goal is to see if the new method reduces the chance of death or unplanned hospital vis…

This study tests a procedure called renal denervation (RDN) that uses radiofrequency energy to calm certain nerves in the kidneys. The goal is to see if it can lower a key heart failure marker (NT-proBNP) and improve exercise ability in 20 adults with heart failure. Participants …

This study tests whether a heart pump (Impella 5.5) combined with optimized heart failure medications can help people with severe heart failure and shock recover without needing a transplant or permanent heart assist device. About 250 adults aged 18-79 with a weak heart pump (LVE…

This study tests whether adding extra pacing from a heart device can improve heart function in people with heart failure and a specific electrical problem (left bundle branch block). Eighty adults who already qualify for a special pacemaker-defibrillator will try two pacing metho…

This study tests whether a mouthpiece worn during sleep can improve heart health and quality of life in people with both heart failure and obstructive sleep apnea. The device, called a mandibular advancement device (MAD), keeps the airway open. 328 adults in Singapore will use ei…

This study tests whether a newer drug, finerenone, is safer than an older drug, spironolactone, for people with heart failure and diabetic kidney disease who are at high risk for high potassium levels. About 60 participants will receive either finerenone daily or spironolactone e…

This study looks at whether switching heart failure patients in rural Tanzania from their current medication to a newer drug called sacubitril-valsartan can improve their daily health and ability to walk. About 298 adults with reduced heart function will be followed for 10 months…

This study tests whether taking selenium and coenzyme Q10 (CoQ10) supplements can reduce heart failure-related hospital visits and deaths. About 1,100 adults with chronic heart failure will receive either the supplements or a placebo, alongside their usual care. The goal is to se…

This study compares a newer pacing method (left bundle branch area pacing) with the standard approach for cardiac resynchronization therapy in 44 adults who have both permanent atrial fibrillation and heart failure. The goal is to see if the newer method improves the heart's pump…

This study tests a telemedicine program for older adults (ages 65-80) with both atrial fibrillation and heart failure in rural China. Village doctors use a digital platform with remote expert support to guide medication and lifestyle changes, including group exercise and wearable…

This study looks at whether using lower doses of two blood thinners (argatroban and enoxaparin) can reduce bleeding and clotting problems in adults on ECMO, a machine that helps the heart and lungs. About 200 participants with pneumonia or heart failure will be enrolled. The goal…

This study tests if a sensor placed on the skin can accurately measure kidney function in 15 adults with heart failure. Participants receive an injection of a fluorescent dye and a standard dye, then wear a sensor on their chest for up to 24 hours. The goal is to see if the senso…

This study tests if a non-invasive liver stiffness measurement (FibroScan) can accurately detect elevated central venous pressure in people with heart failure. About 149 adults with suspected or diagnosed heart failure will undergo both the scan and a standard right-heart cathete…

This study will test a rapid finger-prick blood test in about 618 people with leg swelling (lymphoedema) to see if it can spot hidden heart failure. Heart failure often goes undetected because leg swelling is mistaken for lymphoedema. The test gives results in 12 minutes during a…

This study tests a new imaging agent called 18F-mFBG to see how well it can show nerve damage in the hearts of people with heart failure and an implantable defibrillator (ICD). About 20 adults with stable heart failure from blocked arteries will get a PET scan using this agent. T…

This study aims to see if a single-lead electrocardiogram (ECG) analyzed by machine learning can screen for heart conditions, diabetes, and chronic kidney disease. Researchers will enroll about 5000 adults who have already had a full medical exam. They will record a 1-minute ECG …

This study tests whether a tool called FIND HF can spot people at high risk for undiagnosed heart failure. About 475 adults aged 40 and older will have a blood test and an ultrasound of their heart. Researchers will compare how often heart problems are found in high-risk versus l…

This study tests if artificial intelligence (AI) can spot a rare heart condition called ATTR-CM in adults with heart failure. Researchers will use AI to analyze electrocardiograms (ECGs) and echocardiograms (Echos) from 150 participants. The AI's findings will be checked against …

This study tests whether a telemedicine program led by village doctors can prevent heart failure in older adults (ages 65-80) in rural China who have atrial fibrillation but not yet heart failure. Participants will either receive standard care or a digital program with wearable h…

This early-stage study tests a single dose of a new drug called LY3971297 in 90 adults with heart failure (either preserved or reduced ejection fraction). The main goal is to check for side effects and see how the body handles the drug. Participants will be in the hospital for ab…

This study tests a new support program called HELP for family members who care for someone with heart failure. About 180 carers and 180 patients will take part across three UK sites. The program includes six weekly online sessions, a booklet, and a website to help carers manage t…

This study looks at whether a type of breathing exercise, called inspiratory muscle training, can improve memory, attention, and thinking in adults with heart failure. 54 participants will be split into three groups: one does standard breathing exercises, one does breathing exerc…

This study tests a 10-session program called ViCCY to help caregivers of heart failure patients who also have memory issues. About 256 caregivers and 60 patients will take part. The goal is to see if the program reduces stress and improves the caregiver's mental health and abilit…

This study tests whether an 8-week video-based exercise and thinking program can improve fitness and reduce frailty in older adults (65+) with stable heart failure. Seventy participants will either do the live online program or a caregiver-guided home workout. The goal is to see …

This study looks at different arm exercise routines to see which one best improves arm strength and overall fitness in people with heart failure who have an implanted heart device like a pacemaker or defibrillator. About 36 adults will be assigned to different exercise groups to …

This study is testing whether a mobile app can help people with heart failure take better care of themselves after leaving the hospital. The app provides educational content, symptom tracking, and reminders, and is used alongside standard medical care. Thirty adults with heart fa…

This study tests if a 7-day course of steroids can reduce dangerous inflammation in 30 adults with heart failure-related cardiogenic shock. Participants must have high inflammation levels and be on temporary heart pumps. The goal is to see if steroids safely help the heart and or…

This study tests a custom exercise and education program for people over 65 with heart failure. The program starts in the hospital and continues at home after discharge. Researchers want to see if it helps improve walking ability, fitness, and quality of life. About 114 participa…

This study compares two exercise programs—neuromuscular training and resistance training—for people with chronic heart failure. Forty adults aged 40-60 will do supervised workouts for 10 weeks. Researchers will measure walking ability, fitness, and leg strength to see which appro…

This study tests whether dapagliflozin, a drug used for diabetes, can improve exercise ability and heart function in people who have had the Fontan procedure for a single-ventricle heart condition. About 30 adolescents and adults will take the drug daily for 3 months. The main go…

This study tests a program designed to help people with heart failure take their medications as prescribed. The program focuses on building confidence and skills, and will be tested with 870 adults in Pakistan who have trouble sticking to their medication routine. The goal is to …

This study tests a personalized system that uses smart wristbands and a mobile app to help heart failure patients increase physical activity and sit less. The system sets custom activity goals based on each person's heart data and provides real-time feedback and motivation. About…

This study tests whether adding sauna therapy to standard cardiac rehabilitation can reduce fluid buildup (congestion) in people with heart failure. About 46 adults with reduced heart function will be randomly assigned to either a standard rehab program or one that includes sauna…

This study will observe about 3,000 Chinese adults with a type of heart failure called HFpEF who are starting the drug Jardiance. Researchers want to see how effective and safe the drug is in everyday medical practice, not in a controlled lab setting. The study will track heart-r…

This study looks at whether a hybrid care model—using digital tools like telemonitoring and online consultations—can help manage type 2 diabetes and chronic heart failure during health emergencies. About 180 patients will be observed and interviewed over a year to see how this ap…

This study will follow 3000 adults with chronic heart failure to see how often they also have kidney disease, diabetes, fatty liver, or other metabolic problems. Researchers want to learn which combinations are most common and how they affect patient outcomes over two years. The …

This study looks at how muscle loss (sarcopenia) affects recovery in people aged 80 and older hospitalized for acute heart failure. Researchers will use ultrasound, strength tests, and blood markers to better predict outcomes like rehospitalization or death. The goal is to improv…

This study tests a new tool that helps doctors and cancer survivors decide together on the best heart-protecting medications and heart scans. About 60 adult cancer survivors who have not yet seen a heart specialist will take part. The goal is to see if the tool is easy to use and…

This study looks at whether reminding doctors about iron deficiency in hospitalized heart failure patients leads to more use of IV iron. About 3,000 adults with heart failure and low iron levels will take part. Doctors in one group get a reminder with test results and treatment g…

This study will check whether three common heart failure risk scores, developed mostly in Western countries, accurately predict outcomes for Egyptian patients. Researchers will follow 140 adults with heart failure for one year to see if the scores correctly predict death or hospi…

This study will use artificial intelligence and 3D ultrasound to measure how well the right side of the heart works together in healthy adults and people with certain heart conditions. Researchers will enroll about 2,640 participants to establish normal values and see if these me…

This early-stage study tests a new medicine called HRS-5765 in 74 healthy adults to see if it is safe and how the body processes it. Participants will take single or multiple doses of the drug or a placebo. The goal is to gather safety and drug-level information, not to treat any…

This study looks at how iron deficiency (with or without anemia) affects heart rhythm problems in 300 adults hospitalized with heart failure. Researchers will check for irregular heartbeats and ECG changes to see if iron levels can help identify high-risk patients. The goal is to…

This study tests a simple idea: showing heart failure patients easy-to-understand pictures of how their medications can help them live longer and feel better. About 100 adults with heart failure will receive these visual guides alongside their usual care. Researchers will use blo…

This study looks at how closely heart failure and atrial fibrillation patients follow their medication plans after being admitted to the coronary care unit. Researchers will interview 250 adults to check if their prescriptions are appropriate and understand their beliefs about ta…

This study looks at whether a remote monitoring system, called RAPHAEL, can work for heart failure patients who may need palliative care. About 90 adults with worsening heart failure will fill out a digital questionnaire for 4 weeks, and their healthcare team will follow up as us…

This study will observe about 1,000 people who receive a BIOTRONIK pacemaker designed to pace the heart's natural conduction system. Researchers will track how well the devices work and any safety issues over time. The goal is to learn how these pacemakers perform in everyday med…

This study will follow 2000 adults hospitalized with heart failure in Brazil to understand how they are treated and what happens to them over the next year. Researchers will look at which medicines patients receive, how quickly treatment is started, and what barriers exist to pro…

This study tests whether a personalized approach called N-of-1 trials can help older adults with heart failure find the beta-blocker dose that works best for them. Fifty participants aged 60 and older will be randomly assigned to either the personalized approach or enhanced usual…

This study looks at how closely people with advanced heart failure follow a four-part treatment plan recommended by doctors. Researchers will track 300 patients aged 18 to 75 to see if they take their medications as prescribed. The goal is to understand current care gaps and impr…

This study looks at how a class of diabetes drugs called SGLT2i affects the balance between the 'fight or flight' and 'rest and digest' nervous systems in people with type 2 diabetes. Researchers will monitor heart rate patterns in 150 adults who also have heart failure, chronic …

This study looks at 130 adults with heart failure who were part of a telemonitoring program but later removed because they no longer met eligibility rules. Researchers will track them for one year to see how many have serious heart events or need urgent care. The goal is to under…

This study follows 200 adults with suspected or confirmed cardiac amyloidosis, a condition where protein buildup stiffens the heart and leads to heart failure. Over two years, participants will have heart MRIs (at rest and during exercise), blood tests, and exercise breathing tes…

This study will test a new computer tool that helps doctors decide when to refer people with heart failure to palliative care. The tool uses a risk model to predict who might benefit from extra support. Researchers will see if the tool is easy to use and if it leads to more timel…

This study looks at whether certain blood markers can predict delirium (sudden confusion) in older adults with heart failure. Researchers will compare markers of inflammation and metabolism in 100 participants. The goal is to find a simple way to identify high-risk patients early…

This study will see if data from an Apple Watch, combined with medical information, can predict when heart failure gets worse. About 360 adults with heart failure will wear an Apple Watch and do exercise tests. The goal is to find better ways to monitor heart health and prevent h…

This observational study looks at how changes in urinary sodium and chloride levels relate to fluid overload in 223 adults hospitalized with acute heart failure. Researchers will track these salt levels during treatment to see if they predict how well excess fluid is removed and …

This study tests whether an AI tool can help doctors improve medication plans for adults with heart failure. The AI reviews patient records and sends suggestions to doctors before appointments. 500 patients will take part, and the study will check if more patients get the right m…

This study aims to better understand heart failure by combining detailed patient information with advanced molecular analysis. Researchers will study blood and tissue samples from 500 adults with heart failure to find molecular patterns, especially non-coding RNAs, linked to the …

This study will check how often heart problems (diastolic dysfunction) occur in 100 adults with kidney failure who are on regular hemodialysis. Researchers will use ultrasound to look at heart function and see how it connects to dialysis factors and other health measures. The goa…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and remote monitoring to see which patients respond best to treatment and which have complications. The goal is to fin…

This study looks at whether using a smartwatch and artificial intelligence (AI) can help doctors better manage patients after a heart attack. About 200 adults who recently had a heart attack and received a stent will wear a smartwatch for 3 months after leaving the hospital. The …

This study looks at 200 adults with a type of heart failure called HFpEF to see if they can be grouped into different categories based on their medical information. Researchers want to know if these groups have different health profiles and respond differently during an exercise …

This study observes 30 adults in Mexico who are already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans, heart CT scans, and body composition tests to see how the drug affects knee cartilage, heart fat, and overall body health over one y…

This study is collecting data from 392 adults with heart failure who are already scheduled for a right heart catheterization. Researchers will use this data to train a machine learning model for a non-invasive device that estimates heart pressures. The goal is to help doctors mon…

This study aims to test new MRI methods that can see tiny changes in heart muscle structure, which may help detect heart disease earlier than current tests. Researchers at the Cleveland Clinic will compare these advanced scans with standard blood tests and imaging in 1000 adults …

This study will review the medical records of 200 adults with heart failure, moderate-to-severe chronic kidney disease, and anemia who took roxadustat for at least a year. Researchers want to see if the drug improved heart function and reduced serious heart events. This is an obs…

This study aims to understand how inflammation and genetic factors influence the health of people hospitalized with heart failure. Researchers will analyze blood samples from 112 participants to find markers that may predict future heart problems. The study is observational, mean…