HEART FAILURE

This study is testing a device called the OPTIMIZER Smart, which is implanted in the chest to help the heart pump better. It is for people with moderate to severe heart failure who still have symptoms despite taking standard medications. The study will follow 620 participants for…

This study tested whether stimulating the vagus nerve in the neck could help people with advanced heart failure. 118 participants received an implanted device that sends mild electrical pulses to the nerve. The goal was to see if this therapy could improve heart size and function…

This study tests a new procedure called pulmonary artery denervation for people with heart failure and a type of high blood pressure in the lungs (Group 2 PH). The procedure uses a special device to calm overactive nerves in the lung arteries, which may improve blood flow and qua…

This study is testing a new implantable heart device called the CorSky ICD, which helps control dangerous heart rhythms and heart failure. About 50 people who need a defibrillator will get the device and be followed for 12 months to see if it works safely. The main goal is to che…

This study tests whether adding a traditional Japanese herbal medicine called Goreisan to standard heart failure treatment helps reduce swelling (edema) and improve outcomes. About 1,179 adults with worsening heart failure and fluid buildup are participating. The main goals are t…

This study tests a new type of lead for implantable heart devices (ICD or CRT-D) that helps pace the heart's natural conduction system. It includes up to 414 adults with heart failure or dangerous heart rhythms who need a new device. The goal is to see if the lead is safe and wor…

This early study tests a small sensor placed in a vein near the heart that sends daily readings to doctors. The goal is to catch fluid buildup early and help manage heart failure. 25 adults with advanced heart failure are taking part to see if the device is safe and works as inte…

This study tests a new device called the Edwards EVOQUE system to replace the tricuspid valve in people whose valve leaks severely. The goal is to see if the device can safely reduce the leak and improve symptoms like shortness of breath and fatigue. About 864 adults with severe …

This study tests the safety and performance of a new pacemaker and lead system for people who need a pacemaker to help their heart beat properly. About 152 participants will be followed for up to a year after implantation. The goal is to see if the system works well and has few s…

This study tests whether empagliflozin, a drug usually used for diabetes, can improve exercise ability and quality of life in people with hypertrophic cardiomyopathy (a condition where the heart muscle is abnormally thick). About 250 adults without diabetes will take either empag…

This study looks at whether treating gum disease (periodontitis) can improve heart failure in 80 adults. Participants with heart failure and gum disease get deep dental cleaning, while a control group waits 6 months for treatment. Researchers check blood and saliva for heart fail…

This study tests whether an anti-inflammatory drug called anakinra can prevent heart failure in people who have had a heart attack. About 84 adults who recently had a severe heart attack will receive the drug to reduce inflammation and protect their heart. The main goal is to see…

This early-stage trial tests whether injecting lab-grown heart muscle cells (made from stem cells) into the hearts of 10 people with severe heart failure is safe and can improve heart function. Participants have heart failure caused by blocked arteries and are monitored for 26 we…

This study tests a new machine that keeps donor hearts healthy outside the body longer before transplant. It includes 141 adults with heart failure who need a new heart. The goal is to see if this method is safe and effective, potentially allowing more hearts from older or less i…

This study tests a program called De-HF that helps heart failure patients and their family caregivers work as a team to manage the condition at home. The program includes face-to-face and online support to improve self-care, quality of life, and reduce hospital readmissions. Abou…

This study tests whether a small pressure sensor placed in the lung artery can help doctors better manage heart failure. About 550 people with advanced heart failure will either get standard care or standard care plus the sensor. The sensor sends daily pressure readings to the ca…

This study tests a device called the Supira System, which temporarily helps the heart pump blood during high-risk procedures for blocked arteries. About 71 adults with heart disease will receive this support to see if it safely prevents dangerously low blood pressure. The goal is…

This study aimed to compare a newer, more natural pacing method (left bundle branch area pacing) with the standard method (right ventricular pacing) in people who developed heart block after TAVR valve replacement. It planned to enroll 60 patients across six centers and follow th…

This study looks at 300 people having a procedure for atrial fibrillation (an irregular heartbeat). During the procedure, doctors measure the blood pressure inside the heart's left upper chamber. If it is high, it may mean the heart is struggling with unrecognized heart failure. …

This early-phase study tests whether empagliflozin, a drug already approved for diabetes, heart failure, and kidney disease, is safe for people on dialysis. Researchers will give 24 dialysis patients the drug for 3 months and monitor their health, blood, urine, and heart function…

This study tests whether dapagliflozin, a drug used for diabetes and heart failure, can help adults born with a single ventricle who had Fontan surgery. The goal is to see if it lowers pressure in the veins and improves exercise ability. About 29 adults will take the drug daily f…

This study tests a small device called the Corvia Atrial Shunt, which creates a tiny passage in the heart to relieve pressure. It is for 750 people with heart failure who still have symptoms despite medication. Participants are randomly assigned to get the device or a sham proced…

This study tests whether injecting lab-grown heart muscle cells into the heart during bypass surgery can help people with severe chronic heart failure. About 36 adults with damaged heart tissue will receive the cells directly into the heart muscle. The main goal is to check safet…

This study tracks over 1,000 people with heart failure who received a special heart device lead. The goal is to see how well the lead works and how safe it is over 5 years. Researchers are checking for any problems related to the lead. This is a follow-up study required by the FD…

This study was designed to test an experimental drug called OPC-131461 in people hospitalized for worsening heart failure who still had signs of fluid buildup after initial treatment. The goal was to see if the drug could improve a key heart stress marker (NT-proBNP) over 30 days…

This study looks at a device called the InterAtrial Shunt (IASD System II) that is already approved in Europe. It creates a small passage between the upper chambers of the heart to lower pressure and improve symptoms. About 500 people with heart failure are being followed in Germ…

This study tests whether a newer type of blood thinner (direct oral anticoagulant) works better than the standard one (vitamin K antagonist) for dissolving blood clots inside the heart. About 340 adults with such clots will be randomly assigned to one of the two treatments. The g…

This study looks at whether a dietary supplement called ketone ester can improve heart function in people with heart failure. About 50 participants will receive either the supplement or a placebo for 12 weeks, and their hearts will be scanned with MRI before and after. The goal i…

This study tests a new way to care for heart failure patients in Uganda using a smartphone app and a standard treatment bundle. About 576 adults with moderate heart failure will use the app to report symptoms and get guidance, while doctors monitor them remotely. The goal is to i…

This study compares two diabetes medications, oral semaglutide and sitagliptin, in over 25,000 adults with type 2 diabetes and a specific type of heart failure (preserved ejection fraction). The goal is to see which drug better prevents serious heart events like hospitalizations …

This study tests a new way to replace a failing mitral heart valve without open-heart surgery. It involves 53 people whose surgically implanted mitral valve is no longer working well. Doctors use a catheter to place a new valve (SAPIEN 3) inside the old one. The main goal is to s…

This study looks at two diabetes medications, tirzepatide and semaglutide, in 26,000 adults with type 2 diabetes and a type of heart failure called HFpEF. The goal is to see which drug better prevents hospitalizations for heart failure and death. Participants are already taking o…

This study is testing a new device that creates a small opening inside the heart to lower pressure and ease symptoms in people with heart failure. About 71 participants who have severe symptoms despite standard medications will receive the implant. The goal is to see if the devic…

This study tests a device called the Edwards APTURE Transcatheter Shunt System in 100 people with heart failure. The device is placed in the heart to help reduce pressure and improve symptoms like shortness of breath. Half of the participants get the real device, and the other ha…

This study looks at whether treating people with conditions like heart failure, infections, or diabetes at home (instead of in the hospital) can lead to better health and happier patients. About 9,600 adults will take part, receiving hospital-level care in their own homes. Resear…

This study tests a device called Barostim that stimulates nerves to help control heart failure. It involves 2500 adults with moderate heart failure who still have symptoms despite standard medications. The goal is to see if the device reduces deaths and heart-related emergencies …

This study tests whether a daily pill called finerenone can reduce fat and scarring in the heart muscle of people with diabetic kidney disease and heart failure. About 40 adults will take the drug for 6 months and get advanced heart scans to measure changes. The goal is to see if…

This study compares a new, step-by-step plan for giving water pills (diuretics) based on urine salt levels to the usual care for people with acute heart failure in the emergency room. About 474 adults will take part to see if the new plan helps them feel better faster and reduces…

This early study tests a small heart pump called Impella BTR in 10 adults with severe heart failure. The pump is placed inside the body to help the heart pump blood for up to 28 days. The goal is to see if it is safe and can support patients until their heart recovers or they rec…

This study compares two initial treatments for people with non-ischemic heart failure and a specific heart block. One group gets standard medications, the other gets medications plus a special heart pacing technique. The goal is to see if the pacing approach improves heart functi…

This study tests a new device that creates a small channel in the heart to help reduce pressure, without leaving a permanent implant. It is for people with heart failure and a weak heart pump. The study will compare the device to a sham procedure to see if it improves survival an…

This study looks at 82 people with heart failure and a type of irregular heartbeat called atrial fibrillation. All participants will have a procedure to control their heart rate and then get a pacemaker. The study compares a newer pacing method (conduction system pacing) with the…

This study tests a device that scans your feet and lower legs to spot early signs of fluid buildup, a common sign of worsening heart failure. The goal is to catch problems before they lead to a hospital stay. About 186 adults with heart failure who already take water pills will u…

This study tests whether a newer type of diabetes drug (called dual incretin therapy) can improve heart function and blood sugar in 120 adults with both chronic heart failure and type 2 diabetes. Participants receive the drug and are monitored for 40 weeks with heart tests, blood…

This study tests whether dapagliflozin, a drug originally for diabetes, can reduce the risk of death, kidney failure, or heart failure hospitalization in people with severe chronic kidney disease, including those on dialysis or with a kidney transplant. About 1,750 adults with ad…

This study tests whether placing the left ventricle lead of a cardiac resynchronization therapy (CRT) device at the area of latest electrical activation improves outcomes for people with heart failure. About 1000 participants with heart failure and a widened QRS on ECG are being …

This study tests a new mechanical heart pump (EVAHEART®2) in 399 adults with severe heart failure. The pump helps the heart pump blood while patients wait for a heart transplant or recover. The study compares this pump to an existing one to see if it works as well or better at ke…

This study looks at whether opening a completely blocked heart artery with a procedure called PCI, on top of taking standard heart medications, helps people live longer or feel better. About 2000 adults with stable heart disease and symptoms like chest pain or shortness of breath…

This study is a registry that follows 5,000 people with heart failure who have already received a Barostim implant. The goal is to see how safe and helpful the device is in everyday medical practice. Researchers will track symptoms, quality of life, and physical function over tim…

This study compares different catheter ablation strategies in 300 adults aged 18-80 who have both persistent atrial fibrillation (an irregular heartbeat) and heart failure. The goal is to see which approach best reduces the risk of death, hospitalization, or urgent care due to wo…

This study tests a method to preserve hearts from donors after circulatory death using a machine that keeps them cool and oxygenated. The goal is to increase the number of hearts available for transplant. About 20 adults with heart failure who are already on the transplant list w…

This study looks at how vericiguat, a new heart failure drug, improves heart function during rest and exercise. Thirty adults with heart failure will take either vericiguat or a placebo for about three months. Researchers will measure blood flow, blood pressure, and quality of li…

This study looks at whether heart failure patients can get the same benefits from doing spot-jogging at home as they would from going to a clinic for rehab. About 40 adults with heart failure will be assigned to either a home program with adjustable jogging intensity or a standar…

This study tests a new device that creates a small passage between the upper chambers of the heart to help relieve pressure in people with chronic heart failure. The device is inserted through a blood vessel and does not leave a permanent implant. About 700 participants with hear…

This study tests whether early use of a special pacemaker (left bundle branch pacing) can improve heart function better than standard medications in people with heart failure whose heart pumps slightly less than normal. The trial involves 36 adults with symptoms despite medicatio…

This study tests a small device called the APTURE shunt, which is placed in the heart to help reduce fluid buildup and ease symptoms of heart failure. About 45 people with moderate to severe heart failure and reduced pumping function will take part. The main goal is to see if the…

This study is testing a new driving system for the Berlin Heart EXCOR, a heart pump used in children with severe heart failure who are waiting for a heart transplant. The goal is to see if the new system works safely and effectively. About 40 children will take part, and the stud…

This study looks at whether a special clinic with a team of experts can improve quality of life and reduce hospital visits for people with a mechanical heart pump (VAD). About 110 patients and their caregivers will take part. The goal is to see if this team approach helps patient…

This study tests a targeted screening approach to detect undiagnosed heart failure in 706 adults aged 40+ with type 1 or type 2 diabetes who also have additional heart risk factors. Participants are randomly assigned to receive the screening or usual care, and researchers track h…

This study looks at better ways to detect heart failure in people with pacemakers. About 1 in 3 pacemaker patients may have undiagnosed heart failure, but current tests are expensive and time-consuming. Researchers will test if a handheld ultrasound guided by artificial intellige…

This study looks at whether existing biomarkers (substances in the blood) can accurately determine the underlying cause of heart failure in 511 patients. Participants were recently diagnosed with heart failure. The goal is to improve diagnosis and potentially save costs by reduci…

This study looks at whether a quick blood test (NT-proBNP) can help doctors find heart failure earlier in adults who take water pills but haven't been diagnosed. About 400 people from GP practices in Jersey will take part. Some practices will offer the test, while others will con…

This study tests a small, wearable sensor that reads pulse patterns to help detect heart failure. Heart failure is often missed in early stages because its symptoms are similar to other conditions. The sensor uses principles from Traditional Chinese Medicine and artificial intell…

This study looks at whether a supervised exercise program can improve heart function, exercise capacity, and quality of life in people with heart failure and pulmonary hypertension. About 40 adults with stable heart failure will take part. The goal is to see if exercise can lower…

This study looks at whether people with heart failure can safely receive a special pacemaker (CRT-P) and be discharged on the same day. Researchers are tracking serious side effects for six months and checking if same-day discharge reduces hospital time. The goal is to make the p…

This study aimed to see if an extended-release version of the water pill torsemide helps heart failure patients get rid of salt better than the standard version, especially after a salty lunch. It planned to enroll stable heart failure patients and compare urine salt levels over …

This study tests whether using game-like rewards and personal coaching can help older adults (50+) become more active after leaving the hospital. About 350 participants with conditions like high blood pressure or heart failure will wear a Fitbit to track steps. The goal is to see…

This study looks at whether teaching cancer survivors with mild to moderate heart failure about exercise and diet can help them change their lifestyle. About 85 participants will take part in the program. The goal is to see if this approach is practical and helpful for managing h…

This study tests whether adding video-call education (via WhatsApp) to standard teaching helps heart failure patients improve self-care. 100 adults with moderate-to-severe heart failure will be split into two groups: both get usual in-person training, but one group also gets a vi…

This study looks at whether gradually stopping beta-blockers can improve symptoms and quality of life in older adults (age 60+) with heart failure with preserved ejection fraction (HFpEF). About 240 participants will either stop their beta-blocker or continue it for 4 months. Res…

This study tests whether a 9-month walking program can improve how far people with heart failure can walk in 6 minutes, compared to standard care. About 200 adults with stable heart failure will take part. The goal is to see if increasing daily steps and walking speed helps with …

This pilot study looks at whether the DASH diet, a heart-healthy eating plan, can help people with heart failure. Researchers will track the diets, blood pressure, and heart failure markers of 26 participants who receive nutrition counseling. The goal is to see if this diet can i…

This study looks at whether a 12-week yoga program can improve brain function and thinking skills in older adults with heart failure and mild memory loss. Researchers will use brain scans, memory tests, and blood samples to measure changes. The goal is to see if yoga is a helpful…

This study tests whether a combination of virtual reality exercises and computer-based brain training can improve memory and thinking in 172 older adults with heart failure who have mild cognitive impairment. Participants will use these tools at home or in clinic, and researchers…

This study tests whether providing specially prepared meals to heart failure patients after they leave the hospital can help their recovery. Researchers will check if the meal delivery is practical and if patients find it helpful. The study involves 85 adults on Medicare or Medic…

This study looks at how the diabetes drug sitagliptin affects people who naturally have lower levels of a protein called DPP4 due to their genes. Researchers will compare blood sugar and other markers in 20 adults with and without this gene change. The goal is to understand why s…

This study tests a new digital platform that helps hospitals share patient information more reliably when a patient is transferred from one hospital to another. About 1,000 adults being moved to Brigham and Women's Hospital from three other hospitals will take part. The goal is t…

This study uses a small device implanted under the skin to collect information from people with heart failure. The goal is to learn more about how heart failure changes over time. About 525 adults with moderate heart failure will take part. The data gathered may help doctors bett…

This study aimed to see if using wearable devices and game-like features could encourage hospital patients with heart conditions to walk more. It was designed for adults aged 50 and older admitted to medicine or cardiology floors. However, the study was withdrawn before any parti…

This study looks at 10,000 people with both sleep apnea and high blood pressure to see how well their treatments work together to prevent major heart problems or death. Researchers will track whether using a breathing machine at night (PAP) and taking blood pressure medicine lowe…

This study looks at 180 adults newly diagnosed with heart failure and a weak heart pump. Researchers will use multiple heart scans and tests to see if they can predict whose heart function will improve over 3-12 months. A smaller part of the study tests a higher dose of a drug us…

This study looks at 65 adults with heart failure who are getting a special pacemaker called CRT. During the procedure, doctors take a blood sample from a vein near the heart to measure oxygen and other gases. The goal is to see if these blood gas levels can help predict which pat…

This study looks at whether a heart ultrasound can better identify which heart failure patients truly benefit from a special pacemaker (CRT). Currently, 30-40% of patients who get the device don't improve. The trial will compare standard selection methods with an ultrasound-based…

This study looks at real-world data from 6,000 heart failure patients to compare two types of heart pacing: a newer method called conduction system pacing (CSP) and the standard biventricular pacing (BVP). The goal is to see if CSP is as safe and effective as BVP in reducing comp…

This study looks at why many people with heart failure also lose muscle mass and strength, a condition called sarcopenia. Researchers will measure muscle mass, walking speed, and grip strength, and analyze blood samples from 80 participants aged 50 and older. The goal is to find …

This study collects tissue and blood samples from 200 people with advanced heart failure who are getting a heart pump or a heart transplant. Researchers will store these samples along with medical information to learn more about heart failure over time. No experimental treatments…

This study watches over 800 heart failure patients in Germany who are starting dapagliflozin, a drug recently approved for heart failure. Researchers will track how long patients stay on the drug, any side effects, and changes in symptoms and quality of life. The goal is to see h…

This study looks at 2000 people who had a heart attack to see if checking the stiffness of their blood vessels one month later can help predict who will develop heart failure, have another heart attack, or experience bleeding. Participants undergo extra tests like blood vessel st…

This study uses advanced heart MRI scans to better understand early-stage heart failure in 3000 people with diabetes, high blood pressure, or obesity. Participants will get detailed imaging and check-ups, then be followed over time to see who develops serious heart problems. The …

This study will test arm strength and endurance in 72 adults with heart failure who have an implanted defibrillator or pacemaker. Researchers want to see if arm function can help predict hospital stays, complications, and survival. Participants will perform simple arm exercises a…

This study aimed to compare a long-acting version of the water pill torsemide to the standard version in people with stable heart failure. Researchers planned to measure how much salt the body got rid of after a single dose and a salty meal. The study was withdrawn before enrolli…

This study tests a training program that teaches family doctors how to use focused heart ultrasound. About 500 patients with suspected heart issues will have both a family doctor's ultrasound and a cardiologist's full exam. The goal is to see how well the doctors' results match t…

This study aims to collect blood, urine, and stool samples from 2000 adults with heart failure. Researchers will analyze these samples to find proteins and other factors linked to worsening heart function. Participants have one study visit and are followed via medical records for…

This study looks at how well a feature called TriageHF works in everyday medical practice to predict when heart failure might get worse. About 2200 people with heart failure who have a special implanted device (ICD or CRT) and use remote monitoring are included. The main goal is …

This study looks at whether a small device placed under the skin (an implantable cardiac monitor) can find hidden atrial fibrillation in people with heart failure who are at high risk for stroke. About 477 participants will either get the monitor or standard care. The goal is to …

This study tests whether a simple, non-invasive eye scan can help assess heart failure severity. Researchers will compare retinal images from 250 adults with and without heart failure to see if blood vessel changes in the eye relate to heart function and exercise ability. The goa…

This study tests a new computer tool that gives doctors personalized reminders to prescribe the best medications for heart failure. The tool is designed to show only the information each doctor needs, avoiding irrelevant alerts. About 764 doctors in outpatient clinics are taking …

This study looks at ways to help pharmacists better manage heart failure medications for veterans. It compares giving pharmacists education alone versus education plus regular feedback on their performance. The goal is to see which approach leads to more medication adjustments an…

This study looks at whether standard blood tests for heart failure show different results in African American patients compared to Caucasian patients. Researchers will review medical records of 400 adults newly diagnosed with heart failure. The goal is to see if current tests mis…

This study follows about 3,000 adults in Port-au-Prince, Haiti, for up to 7 years to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other problems. Participants give blood, stool, a…

This study tests a personalized approach called N-of-1 trials to help older adults (65+) with a type of heart failure (HFpEF) decide whether to continue or stop taking beta-blockers. Each participant serves as their own experiment, alternating between taking the drug and a placeb…

This study looks at how often and when doctors talk with seriously ill patients about their care wishes. It includes up to 5,000 adults with cancer, heart failure, COPD, or dementia. The goal is to find ways to make these important conversations happen earlier and more often.

This study tests a smartphone app that analyzes daily voice recordings to detect early signs of heart failure worsening. 123 adults hospitalized for heart failure will record their voice and answer symptom questions for 6 months. The app's predictions are compared to actual healt…

This study tests whether an AI voice assistant can accurately capture health information reported by heart failure patients. About 100 adults with heart failure at Stanford University will use the tool to share their symptoms and well-being. The goal is to see if this technology …

This early-stage study is testing a new drug called SHR-6934, given as an injection under the skin, to see if it is safe and how the body processes it. The study involves 88 healthy adults aged 18 to 60. Researchers are monitoring for side effects and measuring drug levels in the…

This study tests a web-based platform called 'My Voice' that helps heart failure patients and their caregivers learn about the disease, decide on end-of-life care goals, and share those wishes with doctors. About 244 patients and their caregivers in Singapore will use the tool an…

This study looks at whether a breathing device called adaptive servo-ventilation (ASV), used for 6 months, can improve how the heart uses energy and how well the heart's nerves work in people with heart failure and sleep apnea. About 60 adults will have heart scans and heart rate…

This study aimed to see if a computer program could predict how long patients would stay in a home hospital program. Researchers used data from past patients to train the program. The study was withdrawn before enrolling any participants, so no results are available.

This study looks at 4,500 people with pacemakers or similar heart devices to find out who is most likely to develop a condition where the heart weakens over time. Researchers will use routine medical and device data to create a risk score that helps doctors choose the best pacing…

This study looks at whether early blood tests for heart failure can improve care for patients with rapid breathing (tachypnea). About 574 adults will be randomly assigned to either receive early biomarker testing with feedback to doctors or standard care. The goal is to see if th…

This study tests whether a phone app called StudyU can help people with heart failure reach the right dose of their beta blocker medicine. Five adults aged 65 and older with heart failure will use the app to track their progress. The goal is to see if the app is practical and acc…

This study tests a new computer tool that helps doctors prescribe the right heart failure medications during phone or video visits. Researchers will compare the new tool to an existing one in 20 cardiology clinics. The goal is to see if the tool works well and can be used fairly …

This long-term study followed over 6,400 adults from different racial and ethnic backgrounds to learn how early signs of heart disease develop and lead to serious events like heart attacks or strokes. Participants were healthy at the start and were monitored for years through exa…

This study tests if a wearable sensor can accurately estimate the heart's pumping ability (LVEF) in 50 adults who are already scheduled for an echocardiogram. The goal is to see if the sensor matches the standard ultrasound test. If successful, this could lead to easier, more fre…

This study looks at heart failure patients with a severe leaky tricuspid valve who received a new valve through a tube in a blood vessel (transcatheter replacement). It focuses on those who had unstable blood pressure right after the procedure. Researchers want to understand how …

This study looks at new ways to help heart patients attend cardiac rehab, a program that only 30% of eligible people currently use. Researchers will test if offering $50, case management, text messages, and coaching helps more patients go. They will also compare four different wa…

This study aimed to see if a computer program could predict potassium levels in the blood using a simple heart monitor. Researchers planned to use data from patients treated at home. The study was withdrawn before any participants were enrolled, so no results are available.

This study looks at balance and thinking skills in middle-aged and older adults with heart failure who are in a post-acute care program. Researchers will compare them to healthy people of the same age and track changes one and three months after leaving the hospital. The goal is …

This study is a registry that collects health information from 700 adults with heart failure whose heart pumping ability has either improved or is naturally high. Researchers will track their health over time to understand how these patients do. No new treatments or procedures ar…

This study uses a special MRI technique called T1 mapping to measure changes in heart muscle tissue. Researchers will follow 8,000 adults who are already having a heart MRI to see if these measurements can help predict future health problems like heart failure or death. The goal …

This study follows 1,599 people who had their first heart attack to see how the heart's shape and function change over time. Researchers want to understand which patterns of remodeling lead to heart failure. Participants are from several Minnesota counties and are not receiving a…

This study follows over 3,000 heart failure patients who get a special heart device (CRT) to see how they do over time. The goal is to track hospital visits, deaths, and device problems to find better ways to use the device. Participants must be getting the device for the first t…

This study reviews medical records of 85 adults with chronic heart failure to see if SGLT2 inhibitors (a type of diabetes drug) improve red blood cell production and heart/kidney function over 12 months. Researchers compare those who started the drug to a similar group who did no…

This study watches 40 adults with heart failure to see how SGLT2 inhibitors affect their body's energy use and blood markers. Participants do a walking test, a leg MRI, and give blood samples before and after starting the drug. The goal is to understand the early metabolic change…