Heart failure breakthrough? trial tests stopping Beta-Blockers in recovered patients

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 years-old 2. Established diagnosis of HF for more than 12 months, from an ischemic or a non-ischemic origin 3. With a documented history of reduced left ventricular ejection fraction (LVEF ≤ 45%), followed by a normalisation of LVEF (≥ 50 % for the last 6 months) assessed by cardiac echography. 4. With a left ventricular end diastolic volume indexed to body surface area (LVEDVi) within the normal range (≤74ml/m2 in men and ≤61 ml/m2 in women) 5. No or mild symptoms of HF (defined as NYHA functional class I or II) 6. No heart failure-related hospital admission within the last six months 7. Currently receiving a beta-blocker indicated for chronic heart failure (i.e. bisoprolol or carvedilol or metoprolol or nebivolol) whatever the dose used, for at least 12 months 8. And receiving the guideline-directed optimal medical therapy for at least 12 months (i.e., maximal tolerated dose of SGLT2 inhibitors, and of RAAS blocker (Angiotensin receptor neprilysin inhibitor OR Angiotensin-converting-enzyme-inhibitors OR Angiotensin II receptors blockers), and MRA if tolerated). Loop diuretics use is adjusted to congestive signs according to physicians' decision. No initiation or major adjustment in heart failure therapies should have occurred during the 3 months prior to study inclusion. 9. With or without ICD 10. Ability to provide written informed consent to participate to the study 11. Patient affiliated to Social Security Exclusion Criteria: 1. Atrial, supra-ventricular, or ventricular arrhythmias, in the last 12 months and/or requiring beta-blockers according to investigator. 2. Uncontrolled arterial hypertension according to investigator decision. 3. Symptomatic angina or evidence of infra-clinic myocardial ischemia requiring beta-blockers according to investigator decision. 4. Cardiac resynchronization therapy 5. Extra-cardiac conditions requiring beta-blockers (migraine, essential tremor, prevention of bleeding from esophageal varices in patients with liver cirrhosis, adrenergic symptoms of hyperthyroidism…) according to investigator decision. 6. History of severe outcomes at beta-blockers interruption: HF relapse, occurrence of arrythmias 7. Severe valvulopathy, restrictive, infiltrative or hypertrophic cardiomyopathy, constrictive pericarditis, or acute myocarditis within 3 months prior to inclusion Visit. 8. Planned coronary, carotid, or peripheral artery revascularization known at the day of inclusion 9. Chronic renal failure with eGFR \<20mL/Min per 1.73m² (CKD-Epi) at inclusion 10. Hepatic insufficiency classified as Child-Pugh B or C at the inclusion Visit. 11. Any past solid organ transplantation or planned organ transplantation within 12 months 12. Any condition other than HF that could limit survival to less than one year 13. Pregnancy or breastfeeding women or women of childbearing potential without adequate contraceptive method 14. Current participation in another interventional trial. 15. Patient under legal protection (protection of the court, or in curatorship or guardianship). 16. Any disorder, unwillingness or inability, which in investigator's opinion, might jeopardise the patient's safety or compliance with the protocol