Assistance Publique - Hôpitaux De Paris

This study tests a new gene therapy for children with a severe immune disorder called Artemis-SCID, where the body cannot fight infections. Doctors take the child's own blood stem cells, fix the faulty gene in a lab, and put the corrected cells back. The goal is to rebuild a work…

This study involves 792 people aged 60-80 who had a stroke linked to a patent foramen ovale (PFO), a small hole in the heart. It compares three approaches: closing the hole with a device plus antiplatelet drugs, taking newer blood thinners (apixaban, dabigatran, or rivaroxaban), …

This study looks at whether people with active cancer who have a blood clot in their lungs (pulmonary embolism) can be safely treated at home instead of in the hospital. About 824 participants will be randomly assigned to either go home within 24 hours or stay in the hospital for…

This Phase 3 trial tests whether a drug called obinutuzumab, combined with mycophenolate mofetil (MMF), can control lupus nephritis without the need for oral steroids. About 196 people with active lupus kidney disease will be randomly assigned to either the obinutuzumab/MMF regim…

This phase 2 trial tests whether giving a short course of radiation before pancreatic surgery can prevent a common and serious complication called pancreatic fistula. About 50 patients with a high risk of this complication will receive two doses of radiation before their surgery.…

This Phase 3 trial tests whether colchicine, an anti-inflammatory drug, can reduce heart scarring and prevent serious complications in people with acute myocarditis (heart inflammation). 300 participants will receive either colchicine or a placebo for six months, alongside standa…

This Phase 3 trial tests whether fampridine can improve movement and vision in people with spinocerebellar ataxia SCA27B, a rare genetic condition that affects balance and coordination. About 70 adults will take either fampridine or a placebo twice daily for 12 weeks. The main go…

This Phase 3 trial tests baricitinib, a JAK inhibitor pill, in 62 adults with dermatomyositis, a rare disease causing muscle weakness and skin rashes. The goal is to see if baricitinib can improve symptoms and allow patients to stop steroids. Participants receive baricitinib or p…

This study compares two oxygen therapy strategies for adults in the ICU with severe breathing failure. One group gets high-flow oxygen alone, the other gets high-flow oxygen plus CPAP sessions. The goal is to see if adding CPAP reduces the need for a breathing tube and lowers the…

This early-stage trial tests whether an implanted ultrasound device called SonoCloud-9 can safely open the blood-brain barrier in children with recurrent malignant brain tumors. The idea is to let chemotherapy (carboplatin) reach the tumor more effectively. The study involves 24 …

This study compares two sedatives, dexmedetomidine and midazolam, in very premature babies who need a breathing tube. The goal is to see if dexmedetomidine helps them come off the ventilator sooner, which could reduce lung injury. About 380 babies born before 32 weeks will take p…

This study looks at 600 ICU patients with hospital-acquired sepsis to see if giving antibiotics continuously or adding a second antibiotic improves survival. Patients will be randomly assigned to receive a beta-lactam antibiotic either continuously or intermittently, and some wil…

This study compares a single IV iron dose to daily oral iron pills for women with moderate anemia after a C-section. The goal is to see if IV iron reduces postpartum depression symptoms at 8 weeks. About 2,860 women will take part across multiple hospitals.

This study tests a drug called baricitinib (a JAK1 inhibitor) to see if it can shrink large inflammatory liver adenomas (a rare, non-cancerous tumor) in 25 people. The goal is to reduce tumor size enough to avoid surgery. Participants will take the drug for a short time, and doct…

This study tests whether the drug dapagliflozin can reduce deaths and serious heart or kidney problems in people leaving the intensive care unit (ICU). About 600 adults who needed a breathing machine or blood pressure support will take either the drug or a placebo for up to 12 mo…

This study tests whether using chemotherapy alone before surgery works as well as chemotherapy followed by radiation for people with locally advanced rectal cancer. About 540 adults with stage T3 or node-positive rectal cancer will take part. The goal is to see if avoiding radiat…

This Phase 3 trial tests whether giving the lungs a near-complete rest (apneic ventilation) early after starting ECMO helps people with the most severe form of acute respiratory distress syndrome (ARDS). About 280 participants will be randomly assigned to either near-apneic venti…

This study looks at whether keeping patients with severe lung failure (ARDS) on their stomachs for 40 hours at a time, instead of the usual 16 hours, can lower the chance of death. About 800 adults on breathing machines will be randomly assigned to one of the two positions. The g…

This study looks at whether heart failure patients aged 70 and older can do just as well with medication alone as with medication plus an implanted defibrillator (ICD) to prevent sudden cardiac death. About 730 participants with weak hearts will be randomly assigned to one of two…

This study is for people who have had a stroke caused by a blood clot and are at high risk for another one. Researchers want to see if adding colchicine (an anti-inflammatory drug) and ticagrelor (a blood thinner) to standard care can reduce the chance of another stroke, heart at…

This study tests whether a drug called glycerol phenylbutyrate (RAVICTI®) can reduce fatigue and improve daily life for people with pyruvate dehydrogenase (PDH) deficiency, a rare genetic condition that affects energy production. About 15 children and young adults (ages 2 to 25) …

This study tests whether the drug letermovir can stop cytomegalovirus (CMV) in unborn babies better than the current treatment valaciclovir. Pregnant women with a CMV-infected fetus will take one of the two drugs daily until delivery. The goal is to see if letermovir leads to a n…

This trial tests a new gene therapy called DREAM01 for people with severe sickle cell disease who cannot find a matching bone marrow donor. The therapy uses the patient's own blood stem cells, modified to produce healthy hemoglobin and block the sickle cell gene. Up to 15 partici…

This study tests whether people with heart failure whose heart function has returned to normal can safely stop taking beta-blockers. About 1,300 participants will either taper off their beta-blocker or continue it, and researchers will monitor for signs of heart failure relapse, …

This study tests whether adding a protein called albumin to standard IV fluids during a major cancer surgery (cytoreduction with heated chemotherapy) can reduce complications. The surgery causes large fluid shifts, and the trial aims to see if albumin helps patients recover bette…

This phase 2 trial is testing whether a combination of two drugs, atezolizumab and bevacizumab, can safely treat liver cancer that has come back after a liver transplant. The study includes 50 patients who will receive the drug combo every three weeks along with a strict immunosu…

This study tests a drug called ruxolitinib as the first treatment for children with a rare, life-threatening immune condition called primary HLH. The goal is to calm the overactive immune system and help more children survive long enough to receive a stem cell transplant. The tri…

This study looks at whether giving FOLFIRINOX chemotherapy before surgery helps people with mid or lower rectal cancer that has spread to the liver. The goal is to see if both the rectal tumor and liver spots can be completely removed. 550 adults will take part, and the main resu…

This study tests whether wrapping the arteries near the pancreas with a piece of the patient's own fatty tissue (omentoplasty) during surgery can reduce the risk of severe bleeding afterward. The trial includes 150 adults who are at high risk for a pancreatic leak after their ope…

This study tests whether adding a balloon pump early to reduce pressure on the heart improves survival and recovery in 298 adults on ECMO for severe cardiogenic shock. Participants are randomly assigned to early preventive unloading or standard care with rescue unloading only if …

This study follows 20 adults with severe, drug-resistant Tourette syndrome who receive deep brain stimulation (DBS) targeting a specific brain region. Researchers will check tic severity, mental health, and quality of life every year for five years after surgery. The goal is to u…

This study tests whether metformin, a common diabetes medicine, can improve muscle function in people with myotonic dystrophy type 1 (Steinert's disease). About 142 non-diabetic adults aged 18-70 who can still walk will receive either metformin or a placebo for 6 months. The main…

This study tests whether adding blood thinners (anticoagulants) to standard steroid treatment is better than steroids alone for deep vein clots in people with Behçet's syndrome. About 134 adults with a first or repeat clot will be randomly assigned to one of two groups. The goal …

This study looks at 386 adults with both COPD and sleep apnea who recently had a life-threatening breathing crisis. Researchers want to see if using a non-invasive ventilator (NIV) at home works better than a CPAP machine to prevent future severe COPD flare-ups or death over one …

This study tests whether adding letermovir to the standard drug valganciclovir works better than valganciclovir alone for treating CMV infections in kidney transplant recipients. About 80 adults who have a kidney transplant and a CMV infection will take part. The goal is to see i…

This study compares two treatments for people with long blockages (15-25 cm) in the main leg artery that cause pain when walking. One treatment is bypass surgery, and the other is a less invasive procedure using a catheter. The goal is to see which approach keeps the artery open …

This study tests whether giving antibiotics before burn surgery lowers the chance of infections after the operation. About 506 adults with burns covering 5% to 40% of their body will take part. Half will get antibiotics before surgery, and half will get a placebo. The goal is to …

This study tests whether early, intensive treatment in a day hospital for teenagers with recent-onset anorexia nervosa can improve their health and reduce the need for emergency care or full hospitalization. About 164 teens aged 12-18 and their families will be assigned to either…

This study tests whether tadalafil, a drug that relaxes blood vessels, can improve exercise ability in people with severe high blood pressure in the lungs caused by COPD. About 200 adults will receive either tadalafil or a placebo for 16 weeks. The main goal is to see if they can…

This study tests a stem cell transplant method for adults aged 40 to 60 with severe aplastic anemia that has not improved or has returned after standard drug therapy. The approach uses a special drug after transplant to lower the risk of graft-versus-host disease, a common and se…

This study compares two weight-loss surgeries for people with severe obesity: the standard Roux-en-Y gastric bypass and a newer omega gastric bypass with a shorter intestinal loop. The goal is to see if the newer surgery works just as well for weight loss and causes fewer nutriti…

This study looks at whether children aged 8-13 with early onset anorexia nervosa can be treated with a shorter hospital stay followed by day treatment (going home at night) instead of staying in the hospital full-time. The goal is to see if this approach works just as well for we…

This study tests whether a drug called interferon gamma can help intensive care patients whose immune systems have shut down after a severe injury or infection. The main goal is to see if it helps them spend more days alive and off a breathing machine. About 170 adults on ventila…

This study is for adults with granulomatosis with polyangiitis (GPA), a rare disease that inflames blood vessels, who haven't improved with usual treatments. Researchers will compare three different drug strategies—adding a standard arthritis drug to rituximab, or using tocilizum…

This study tests whether ruxolitinib, a drug that blocks a specific immune signal (interferon-γ), can help people with inclusion body myositis, a rare muscle disease that causes progressive weakness. About 80 adults aged 45 and older will receive either the drug or a placebo. The…

This study tests a high-precision radiation treatment called SBRT for people with liver cancer who are waiting for a liver transplant but cannot have standard bridging treatments like radiofrequency ablation or chemoembolization. The goal is to see if SBRT can keep the cancer und…

This study compares a 3-day course of intravenous (IV) antibiotics to a 10-day course (3 days IV plus 7 days oral) for treating acute kidney infection in children aged 1 month to 3 years. The goal is to see if the shorter treatment works just as well, while reducing antibiotic re…

This study explores whether using connected inhalers that track medication use, combined with video doctor visits when problems arise, can manage childhood asthma as well as standard in-person care. Fifty children aged 4 to 12 with asthma will take part for 8 months. Half will us…

This study tests whether a dietary supplement made from omega-3 fatty acids (called SPM) can reduce blood vessel damage caused by inflammation in people with obesity and high blood pressure. Researchers will give 60 participants either the supplement or a placebo for 12 weeks and…

This study looks at people with colorectal cancer that spread to the liver. After successful liver surgery and initial chemotherapy, half the participants will restart chemotherapy (FOLFIRI) and half will receive no further treatment. The goal is to see if restarting chemo helps …

This study tests whether a drug called levosimendan, usually used for heart failure, can help prevent dangerous brain spasms and delayed damage after a type of bleeding stroke (aneurysmal subarachnoid hemorrhage). About 30 adults in intensive care will receive either the drug or …

This early-phase study tests whether injecting specially grown immune cells (HTLP) after a cord blood transplant can help rebuild the immune system more quickly in adults with blood cancers. Ten participants will receive the injection and be monitored for side effects like graft-…

This study tests whether adding newer antibody-based drugs to standard chemotherapy can improve survival and reduce the need for stem cell transplants in adults with acute lymphoblastic leukemia (ALL). About 1,200 patients aged 18–65 with newly diagnosed ALL will be assigned to o…

This study is testing whether a combination of two steroids (hydrocortisone and fludrocortisone) can reduce death or long-term organ failure in adults with sepsis in the ICU. About 1,800 participants will receive either the steroid combo or a placebo, and researchers will track t…

This study tests whether a liver transplant after a special type of radiation (SIRT) and chemotherapy can help people with advanced bile duct cancer that cannot be removed by surgery but hasn't spread. About 36 adults aged 18 to 65 in France will receive the treatment and be foll…

This study tests whether dapagliflozin, a drug already used for diabetes and heart failure, can help the heart heal better after a heart attack. About 450 adults who have had a heart attack and have weak heart pumping will receive either the drug or a placebo for 6 months. The go…

This study looks at 240 adults with septic shock who develop a new, fast heart rhythm problem. It compares three treatment approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors wi…

This study tests which of two anti-thymocyte globulin drugs (ATG-thymoglobulin vs. ATLG-grafalon) better prevents graft-versus-host disease (GVHD) in adults aged 50-70 with acute myeloid leukemia or myelodysplastic syndrome. Participants receive a stem cell transplant from a matc…

This study tests a new vaccine designed to help the immune system recognize and attack glioblastoma, an aggressive brain cancer. About 35 people who have already had standard surgery and radiation will receive the vaccine. The goal is to see if it is safe and whether it triggers …

This study tests whether giving a low dose of the hormone vasopressin during liver transplant surgery can prevent acute kidney injury, a common and serious complication. About 304 adults scheduled for a liver transplant will receive either vasopressin or the standard drug norepin…

This study compares a new device called Endorotor to standard endoscopic techniques for removing dead tissue from the pancreas in people with severe pancreatitis. About 64 adults who need this procedure will be randomly assigned to one of the two methods. The goal is to see if th…

This study tests whether an oral drug called dimethyl fumarate (Tecfidera) can safely slow the growth of geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 90 adults aged 55–85 with geographic atrophy will take the drug for 12 m…

This study tests whether a single dose of rituximab, a drug that calms the immune system, can improve heart function six months after a severe type of heart attack called anterior STEMI. About 372 adults who have had this heart attack will receive either rituximab or a placebo. T…

This study looks at how long it takes for urate crystals to dissolve in the joints of people with gout when uric acid levels are kept very low. Researchers will use ultrasound to monitor crystal disappearance in 250 adults over time. The goal is to find out what factors affect ho…

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard medication helps children with unstable Crohn's disease have fewer flare-ups over a year. About 120 kids aged 6-17 will be randomly assigned to either diet plus medication or medication al…

This study tests a drug called obinutuzumab in 33 adults with a relapsing form of granulomatosis with polyangiitis (GPA, formerly Wegener's). The goal is to see if the drug can stop disease activity and turn off the related antibody. Participants will be followed for 6 months to …

This study tests whether itacitinib is safe and effective for adults with systemic sclerosis, a disease that causes skin thickening and organ damage. About 74 participants with early or active disease will receive the drug or a placebo for one year. The main goal is to see if it …

This study tests whether using a quick genetic test to choose a milder blood thinner (clopidogrel or aspirin) instead of a stronger one (ticagrelor or prasugrel) can reduce bleeding in people at high risk after a heart attack. About 2,468 participants will be randomly assigned to…

This study compares starting with two oral medications (tadalafil and ambrisentan) versus one medication alone in people newly diagnosed with pulmonary arterial hypertension (PAH) who also have at least two heart-related conditions. The goal is to see if the two-drug approach lea…

This study tests whether lowering blood pressure can slow the growth of white matter lesions (small brain changes linked to thinking problems) in older adults aged 60-88 who have memory concerns and high blood pressure. Researchers will compare brain scans from 820 participants o…

This pilot study tests a new blood test that looks at markers on white blood cells to tell if a feverish baby under 3 months has a serious bacterial infection. Researchers will collect an extra small blood sample from 180 infants in the emergency department. The goal is to see if…

This study is testing whether low-dose CT scans can help find lung cancer early in people at high risk. About 20,000 adults aged 50-74 who are current or former heavy smokers will get a CT scan at the start, then again after 1 and 3 years. The goal is to see how many lung cancers…

This study is testing whether a simple 8-item screening tool called the Autism Mental Status Exam (AMSE) can help non-specialist doctors and psychologists identify autism in adults. Currently, getting a diagnosis can take nearly two years in France, and many people referred to ex…

This study looks at whether automated software can consistently measure the amount of lung damage from interstitial lung disease on chest CT scans. Researchers will scan 150 adults twice in a row and compare results. The goal is to see if these tools are accurate enough for routi…

This study is testing a new blood test that can diagnose single-gene disorders in unborn babies using a sample from the mother. The test looks at fetal DNA found in the mother's blood, which is safer than traditional invasive methods that carry a small risk of miscarriage. Resear…

This study tests a new MRI technique called eASL that may better measure blood flow in the brains of children with arterial diseases like Moyamoya or sickle cell disease. The standard MRI method often misses changes in blood flow timing. Researchers will compare the new 4-minute …

This study tests a decision-support tool called MyCMV that helps doctors interpret blood test results for cytomegalovirus (CMV) infection during pregnancy. CMV is a common virus that can cause hearing loss and developmental problems in babies if the mother catches it for the firs…

This study is testing whether a small, portable ultrasound probe (echOpen) can help doctors diagnose patients faster. About 100 adults who need a quick diagnosis will be included. Researchers will compare how long it takes to get a diagnosis when doctors use the probe versus when…

This study looks at a new way to quickly figure out why someone is struggling to breathe in the emergency room. By measuring the difference between two types of carbon dioxide levels, doctors hope to tell if the cause is fluid buildup in the lungs (congestive) or something else. …

This study tests a new technology (HD-sEMG) that monitors muscle signals to better diagnose sarcopenia—a condition where older adults lose muscle mass and strength. Researchers will enroll 846 people aged 75 and older who are hospitalized and at risk for sarcopenia. The goal is t…

This study tests whether a short, 10-minute MRI (Fast-MRI) is better than standard ultrasound for catching liver cancer early in people with cirrhosis who are at high risk. About 944 participants will be randomly assigned to get either ultrasound alone or both ultrasound and Fast…

This study looks at whether a single trained radiologist can accurately read low-dose CT scans to screen for lung cancer in women, compared to the current standard of two experts reading the same scan. It will enroll about 2,635 women aged 50-74 who are at risk due to heavy smoki…

This study aims to develop an artificial intelligence tool that can analyze images and videos from capsule endoscopy—a procedure where you swallow a tiny camera. The goal is to help doctors detect bowel diseases like Crohn's, celiac disease, and tumors more accurately and quickly…

This study aims to see if a special MRI scan called CEST can accurately tell apart radiation damage from tumor growth in people with lung cancer that has spread to the brain. About 60 adults who have had radiation therapy for brain metastases and show new changes on follow-up MRI…

This study looks at whether a simple nose swab or mouth rinse can accurately diagnose pneumocystis pneumonia, a serious lung infection, in 240 adults with weakened immune systems. Currently, diagnosis often requires a more invasive procedure called a bronchoscopy. If successful, …

This study is testing a new, fast thinking test using building blocks to find a condition called minimal hepatic encephalopathy (MHE) in people with liver problems. MHE can cause subtle memory and attention issues that are hard to diagnose. The study will compare this new test wi…

This study tests a new medical device called PrediMAP to see if it can accurately predict whether a pregnant woman in preterm labor will give birth within 7 days. Researchers will enroll 3,600 women visiting the emergency room with signs of preterm labor. If successful, the devic…

This study is testing whether a simple screening test in early pregnancy (around 11-14 weeks) can predict and help prevent preeclampsia, a dangerous condition involving high blood pressure. The trial will involve 14,500 pregnant women and aims to reduce severe complications like …

This phase 3 trial is testing three different ways to give the meningococcal B vaccine to adults who have had their spleen removed. People without a spleen are at higher risk for serious infections. The study will compare how well each vaccine schedule triggers an immune response…

This study looks at whether smokers aged 50-74 are more likely to get a low-dose CT scan for lung cancer when their family doctor recommends it. Researchers will track how many people complete the scan within one year. The goal is to catch lung cancer early in high-risk smokers.

This study compares yoga therapy to standard physiotherapy for people with moderate axial spondyloarthritis, a type of inflammatory arthritis affecting the spine and pelvis. Seventy-two participants will attend group sessions twice a week for ten weeks. The goal is to see if yoga…

This study tests whether using a connected exercise bike at home, along with usual care, can improve daily activities for people with lumbar spinal stenosis—a condition that causes leg and back pain when walking. About 302 adults aged 50 and older with confirmed spinal narrowing …

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce tobacco cravings and help people smoke less. About 100 adult smokers will receive either real or fake tDCS sessions alongside counseling. The goal is to see if this gentle, low-side-effect …

This study tests a special dressing made with cinnamon to reduce bad smells from chronic or infected wounds. About 98 adults with smelly wounds will try the dressing for 14 days. The goal is to see if it improves their quality of life by cutting down on odor discomfort.

This study tests whether a connected scale can help monitor people with lymphoma or multiple myeloma who are receiving chemotherapy. Thirty patients will weigh themselves daily for about 7 weeks, and their medical team will get alerts if weight or heart rate changes worryingly. T…

This study tests whether automatic hearing aid settings help children with hearing loss understand speech better in noisy environments. Twenty children aged 6 to 16 who use a Sky hearing processor will compare three different settings. The goal is to find which setting gives the …

This study compares two common surgical techniques (Billroth II and Roux-en-Y) used to reconnect the stomach after partial removal for gastric cancer. The goal is to see which method leads to better quality of life, especially regarding eating, reflux, and pain. About 250 adults …

This study tests whether immersive virtual reality (IVR) can reduce persistent shortness of breath in people with ALS who already use a breathing machine (non-invasive ventilation). 35 participants will try both a VR session based on medical hypnosis and a music therapy session. …

This study tests whether balance rehabilitation that changes how patients see (closing eyes, using a mask, or projecting moving dots) can improve walking stability better than standard rehab with eyes open. It includes 40 adults with chronic nerve damage who have trouble with bal…

This study tests a program that trains emergency doctors and gives patients simple educational materials to manage acute low back pain. The goal is to reduce pain and disability within a week and prevent long-term problems. About 782 adults with new or worsening back pain will ta…

This study tests whether using a smartphone app for follow-up after a gynecological emergency is as good as or better than coming back to the hospital. About 200 women aged 18-60 with conditions like infections, early pregnancy issues, or severe vomiting will either use the app o…

This study compares two approaches for treating newly diagnosed Alzheimer's disease: the drug donepezil versus a non-drug approach using cognitive stimulation or remediation. Researchers will measure changes in thinking and memory over 6 months in 240 participants aged 50 and old…

This study tests whether adding a single dose of ketamine to the antidepressant venlafaxine can relieve severe depression faster than venlafaxine alone. It involves 60 hospitalized adults with major depression. The goal is to reduce suffering, lower suicide risk, and shorten hosp…

This study tests whether a nasal spray of fentanyl or ketamine can relieve moderate to severe pain from limb injuries in children (ages 2-17) faster than oral morphine. About 300 children in the emergency room will be randomly assigned to one of the three medicines. The goal is t…

This study compares different visual keyboard layouts to see which helps people with complex sensorimotor disabilities type faster and with less fatigue. Twelve adults who already use a virtual scanning keyboard will test each layout. The goal is to find the best design to improv…

This study tests whether regular yoga practice can improve quality of life and well-being in adults with stable chronic heart failure. Researchers will measure changes in physical and mental health using standard questionnaires. The goal is to see if adding yoga to standard care …

This study tests whether adding cannabidiol (CBD) to standard alcohol detox treatment helps people with severe alcohol use disorder stay sober longer. About 210 adults will receive either CBD or a placebo for 11 days during a hospital stay. Researchers will check if participants …

This study compares two different materials used in multifocal lenses for cataract surgery. 40 people will receive one type of lens in each eye. The goal is to see which lens provides better contrast sensitivity (ability to see differences in light and dark) 3 months after surger…

This study looks at whether using walking sticks can help people with a forward-leaning spine walk longer distances. Thirty-five adults aged 50 and older who have trouble walking will try using walking sticks for three months. Researchers will measure how far they can walk in six…

This study looks at whether a cochlear implant can improve hearing in children aged 4 to 6 who have severe hearing loss in one ear or uneven hearing between ears. The implant sends sound signals directly to the hearing nerve, potentially helping kids understand speech better in n…

This study compares two types of catheter ablation for people with paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if a newer method called pulse field ablation preserves heart muscle function better than the standard cryoablation. Eighty adults…

This study tests whether workshops and exchange groups can improve quality of life for people who had their larynx removed due to cancer. About 50 participants who had surgery in the last four years will join group sessions. Researchers will compare their well-being before and af…

This study tests whether one or two Botox injections into the thumb joint, combined with a custom splint, can reduce pain from base-of-thumb osteoarthritis for up to 6 months. About 120 adults with moderate to severe thumb pain will be randomly assigned to receive Botox, a mix of…

This study tests a new 3D calendar tool designed to help people with mild to moderate Alzheimer's disease better understand what day, month, or season it is. Twenty participants will use the tool during their hospital stay to see if it improves their time orientation. The goal is…

This study looks at whether shiatsu, a type of Japanese bodywork, can improve symptoms and quality of life in people with cardiac amyloidosis, a serious heart condition. Researchers will compare targeted shiatsu to comfort-focused shiatsu and no shiatsu in 108 adults. They will m…

This study is collecting blood samples from 100 pregnant women with and without preeclampsia to measure key proteins involved in the condition. The goal is to better understand the angiogenic imbalance that causes symptoms and to develop a device that filters out harmful proteins…

This study looks at how removing a life-support machine (ECMO) affects blood flow in the brains of children. Researchers will use MRI scans and computer models to compare two ways of repairing the neck artery after ECMO. The goal is to understand which method better protects brai…

This study looks at whether measuring kidney-specific DNA in the blood can help monitor kidney transplant health. Researchers will measure these DNA levels in 30 patients before and after transplant surgery. The goal is to tell the difference between DNA from the patient's own fa…

This study follows 600 people with birdshot chorioretinopathy, a rare inflammatory eye disease, to track how the condition changes over time. Researchers will use eye exams, imaging, and genetic tests to identify patterns and possible risk factors. The goal is to better understan…

This study looks at how bladder sensations during filling are linked to overactive bladder severity in people with multiple sclerosis. Researchers will perform repeated cystometries, including a test with a distracting task, to assess sensation reliability. The goal is to better …

This study looks at how the immune system and inflammation affect recovery in 540 adults admitted to intensive care. Researchers will take extra blood samples to measure immune cells and inflammatory markers. The goal is to build models that predict survival and infections over o…

This study tests a standardized health program for children under 5 who are in child protective services. It compares their mental and physical health over 2 years to children receiving usual care. The goal is to see if the program improves emotional development and overall well-…

This study looks at hearing and balance in 44 people aged 12 to 20 with osteogenesis imperfecta (brittle bone disease). Participants will have hearing tests and special balance tests to see if the condition affects their inner ear. The goal is to better understand how OI impacts …

This study looks at how different types of lung cancer surgery affect a person's breathing and posture. Researchers will measure changes in spine shape, rib cage size, and balance before and after surgery in 50 patients. The goal is to understand why less invasive surgeries, like…

This study looks at how the brain and lungs communicate in patients with severe breathing failure who are getting high-flow oxygen. Researchers will use brain wave monitors (EEG), oxygen sensors (NIRS), and muscle activity sensors (EMG) before and after starting oxygen therapy. T…

This study looks at different types of neutrophils (a kind of immune cell) in the blood of people with lung cancer. Researchers want to see if certain neutrophil types are linked to tumor growth and resistance to immunotherapy. They will compare blood samples from 100 lung cancer…

Acute alcoholic hepatitis is a serious liver condition with a high risk of death, but current prediction tools are limited. This study will analyze data from 1,400 patients to find more accurate markers of prognosis. By integrating clinical, lab, and tissue information, researche…

This study is investigating whether a chronic infection with a common gut virus might cause liver and digestive problems in people with primary or secondary immune deficiencies. Researchers will collect blood, stool, urine, and tissue samples from 120 participants to look for the…

This study will survey 2,000 medical residents in Paris hospitals about their physical and mental health, including anxiety, depression, burnout, and sexual health. Researchers aim to find how many have health issues and improve workplace support. Participants fill out a question…

This study follows 250 atrial fibrillation patients who received a left atrial appendage closure device to prevent strokes. The procedure blocks a small pouch in the heart where clots often form, allowing patients to avoid long-term blood thinners. Researchers will track how many…

This study looks at how multifamily therapy works for teenagers with anorexia nervosa. In this approach, several families meet together for group sessions to support each other. Researchers want to understand what happens during these sessions and how they affect the teens, their…

This study looks at whether serotonin, a chemical in the body, plays a role in oculocutaneous albinism. Researchers will measure serotonin and related substances in the blood of 160 children with and without albinism. The goal is to understand how serotonin might affect symptoms …

This study is looking at how anti-infective drugs work in critically ill children. The goal is to find the right doses for each child to improve treatment and reduce risks. Researchers will collect blood samples and health data from 3000 children in intensive care or immuno-hemat…

This study aims to understand how to better coordinate care for people with multiple sclerosis (MS). Researchers will hold focus groups with patients, carers, and healthcare professionals to identify what works and what doesn't in current care pathways. The goal is to propose imp…

This study is looking at 327 adults with severe burns to understand why some develop invasive fungal infections while others do not. Researchers will collect blood and skin samples over several weeks to study the immune response. The goal is to uncover immune factors that could l…

This observational study will follow 800 adults with IgA nephropathy, a common kidney disease, to see how well current treatments control protein in the urine and preserve kidney function over 12 months. Researchers want to understand why some patients do not respond to standard …

This study follows 80 obese patients who are planning to have bariatric surgery (gastric sleeve or bypass). Researchers want to see how major weight loss changes back pain, spine alignment, and fat around the spine. Participants will get X-rays and MRIs before and after surgery, …

This study is creating a large collection of leftover blood, urine, and other samples from 800 hospitalized patients. The samples will be stored with medical data to help researchers develop and evaluate rapid diagnostic tests for emerging infectious diseases and biological threa…

This study tests whether a small recording device called LENA can help speech therapists guide parents to improve their deaf child's language development after early cochlear implantation. Thirty children implanted before 18 months old will wear the recorder at home for two 10-ho…

This study aims to establish normal scores for four paper-and-pencil tests that detect spatial neglect, a common attention problem after stroke. Researchers will test 210 healthy French-speaking adults aged 20 to 89, divided by age and sex. The results will help doctors know what…

This study follows 5,300 women aged 18-42 with endometriosis or adenomyosis to see if these conditions get worse over time. Researchers track pain, bleeding, fertility, and use imaging to monitor changes. They also explore immune system and gut bacteria links. No new treatment is…

This study is testing whether simple, noninvasive tests (like urine, blood, or mouth swabs) can track disease activity in children with eosinophilic esophagitis, a chronic allergic condition that inflames the esophagus. Currently, kids need repeated endoscopies under anesthesia t…

This study looks at 400 women aged 29–37 who are freezing their eggs for non-medical reasons. Researchers will use vaginal ultrasound to check for endometriosis and adenomyosis, and compare the results with symptoms, anxiety, depression, and quality of life. The goal is to unders…

This study looks at whether severe hearing loss in middle-aged adults (45-64 years) is linked to mild memory and thinking problems. Researchers will compare 180 people with severe hearing loss to those with normal hearing using memory and thinking tests. The goal is to understand…

This study aims to understand brain differences in people with autism by using MRI scans and eye-tracking tests. Researchers will compare brain structure and blood flow in 160 participants, including those with autism and healthy volunteers. The goal is to link these brain featur…

This study looks at why some kidney transplant patients reject their new kidney despite treatment. Researchers will collect and study B cells (a type of immune cell) from 45 adult patients who need a kidney biopsy or have their transplant removed. They hope to find new clues abou…

This study looks at children born with a lung spot (congenital lung malformation) and compares those who had surgery to those who didn't. The main goal is to see how the decision affects parents' anxiety levels when the child is 6 to 9 years old. Researchers will also track how m…

This study follows 900 couples whose preimplantation genetic diagnosis (PGD) did not lead to a live birth. Researchers want to learn how many later had a healthy child, why some stopped treatment, and how they moved forward. The goal is to better support couples facing this diffi…

This study looks at infections that happen after surgery to remove esophageal cancer. Researchers will review medical records of 350 patients who had this surgery in France between 2017 and 2024. The goal is to find out what factors increase infection risk and how infections affe…

This study tests whether healthcare workers with minimal training can use an AI-guided tool to measure blood flow (stroke volume) in critically ill patients as accurately as expert doctors. The goal is to see if AI can make this important measurement more accessible in busy inten…

This study aims to improve how doctors assess movement in infants with spinal muscular atrophy (SMA), a severe muscle-weakening disease. Researchers will use sensors to measure babies' movements in a special bathtub, where water helps reduce gravity's effects. The goal is to crea…

This study follows 130 adults with hypophosphatasia, a rare bone condition, to learn how they are diagnosed and what symptoms they have. Researchers hope to find ways to shorten the long delay between first symptoms and diagnosis. Participants will have their medical history and …

This study monitors the immune system of 20 adults with serious mold infections (like Aspergillus) to see how their T cells respond. The goal is to find out which patients might benefit from adding immunotherapy to standard antifungal drugs. Researchers will measure immune checkp…

This study looks at how different types of speech therapy affect language development in children with severe hearing loss who receive cochlear implants before age 2. Researchers will compare two therapy methods and also examine how often therapy is needed and how parents can be …

This study aims to bring new molecular markers (biomarkers) into routine care for patients with rare adrenal cancers. Researchers will check if these markers can be delivered within 3 months after surgery and if they provide useful information. The goal is to see if these markers…

This study looks at whether treating severe gum disease can reduce inflammation in the arteries of people who recently had a heart attack. About 210 participants will either receive specialized gum treatment or standard dental care. Researchers will use PET scans to measure arter…

This study looks at whether people with disorders of consciousness (like coma or minimally conscious state) can form and recall memories. Researchers will use brain wave (EEG) and skin sensors to detect memory activity that can't be seen through behavior alone. The goal is to bet…

This study looks at why some people with severe nearsightedness develop a bulge at the back of the eye called posterior staphyloma. Researchers will collect blood samples and eye images from 200 adults in France, the Netherlands, and Spain to find genetic and protein differences.…

This study looks at whether playing a recording of a familiar voice saying the patient's own name can trigger stronger brain responses than an unfamiliar voice. Researchers will test 114 ICU patients with disorders of consciousness after cardiac arrest, stroke, or head injury. Th…

This study is testing whether a special physiotherapy assessment, called the EPIC Assessment, can predict which patients in the intensive care unit will have trouble after their breathing tube is removed. About 330 adults on ventilators for more than 48 hours will be evaluated. T…

This study is looking at a test called EndoPredict that helps doctors figure out the risk of breast cancer coming back in the next 10 years for people with a certain type of early breast cancer (HR-positive, HER2-negative). The goal is to see if the test can accurately identify p…

This study looks at young adults with chronic inflammatory rheumatic diseases who are moving from pediatric to adult healthcare. Researchers want to see if a structured program that includes education workshops and joint doctor visits helps patients manage their own care better. …

This study looks at how early menopause (premature ovarian insufficiency) affects the heart's electrical signals, which can raise the risk of dangerous heart rhythms. Researchers will compare 120 women with and without this condition, and also check how hormone replacement therap…

This study is for 244 people with early-stage Alzheimer's disease. Researchers want to find new blood markers that show why some people's brains are more resilient to the disease. Participants will give blood samples and take memory tests over time. No new treatment is being test…

This study looks at blood samples from 80 children (ages 2-17) recently diagnosed with type 1 diabetes and compares them to healthy children. Researchers want to understand how certain immune cells (called T cells) stop working properly, leading to the disease. The goal is to gat…

This study aims to create a tool to assess how well people understand tone of voice (prosody) after a right-sided stroke. Over half of right-stroke patients have trouble with prosody, which can affect social interactions and quality of life. Researchers will test 150 participants…

This study looks at how T cells—a type of immune cell—respond after hepatitis B vaccination in healthy adults. Researchers want to understand why some people maintain protection longer and how these cells might help control the virus. About 115 participants will provide blood sam…

This study examines how the community of bacteria in the lungs (the microbiome) affects how well pneumonia patients respond to antibiotics. Researchers will follow 300 adults with pneumonia, taking samples from the mouth, rectum, and lungs over 90 days. The goal is to see if the …

This study looks at whether the position a person is in during a urodynamic exam (a test that measures bladder function) affects the diagnosis of an overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from tests done while…

This study looks at whether people with a staph bloodstream infection and a low VIRSTA score (under 3) can safely avoid routine heart ultrasound (echocardiography). The VIRSTA score helps predict the risk of a serious heart infection called infective endocarditis. 700 adults will…

This study looks at whether CAR-T cell therapy, a new immune treatment for blood cancers, can cause early heart problems. Researchers will check heart function with ultrasound in 60 patients before and a few days after treatment. The goal is to find out how often heart issues hap…

This study is collecting detailed information from 180 people with Susac syndrome, a rare condition that affects the brain, hearing, and vision. Researchers want to learn more about the symptoms, possible causes, and how the disease progresses over time. The goal is to improve di…

This study follows 180 people who had a benign thyroid nodule treated with radiofrequency heat ablation three years ago. Researchers will use ultrasound and a fine-needle biopsy to see how the nodule looks and whether any cells have changed. The goal is to create a new guide for …

This study follows 700 patients with infective endocarditis, a serious heart infection, to gather real-world data on complications and outcomes. Researchers aim to improve treatment guidelines, which currently rely on expert opinion due to limited evidence. No new drug or treatme…

This study is looking at people with a rare type of tumor called GEP-NET that has spread and is growing. Participants will get special PET-MRI scans before, during, and after a standard treatment called targeted radiation therapy (PRRT). The goal is to find imaging markers that c…

This study aims to find new biomarkers in blood, urine, and stool to better screen and monitor Activated PI3K Delta Syndrome (APDS), a rare immune disorder. Researchers will collect samples from 14 patients over two years, including those starting a PI3K inhibitor treatment. The …

This study aims to validate French versions of two quick screening questionnaires: the PHQ-4 for anxiety and depression, and the PC-PTSD-5 for post-traumatic stress disorder. Researchers will enroll 90 adults who speak French and are either outpatients or hospitalized for any rea…

This study looks at how immune cells called macrophages behave in people with rare brain diseases like adrenoleukodystrophy and metachromatic leukodystrophy. Researchers will collect blood samples from 100 participants to analyze immune cell activity and metabolism. The goal is t…

This study looks at 1,200 children and young adults (ages 1-20) with suspected sleep-disordered breathing to see if their sleep test results match up with problems in thinking, mood, and behavior. Participants will complete sleep studies, questionnaires, and thinking tests. The g…

This study is testing whether a simple blood test (called a liquid biopsy) can better predict relapse in children and young adults with classical Hodgkin lymphoma. Researchers will track 400 participants under age 25, comparing the test's accuracy to standard PET/CT scans. The go…

This study at Necker Hospital in Paris is checking how well patients with inherited metabolic diseases follow their daily oral medication routines. About 200 patients (children aged 7 and up, teens, and adults) will fill out a questionnaire during a regular visit. The goal is to …

This study in France tests whether having the national health insurance pay for vaccines during outpatient visits increases how many people get vaccinated. Researchers will compare vaccination rates for pneumococcal infections and whooping cough (pertussis) before and after the f…

This study is testing whether adding fetal MRI to standard ultrasound can help doctors better see and diagnose congenital anomalies in unborn babies. Researchers will enroll 1500 pregnant women with single or twin pregnancies between 16 and 36 weeks. The goal is to see if MRI can…

This study is following 200 children and teens (ages 7-20) who have experienced psychosis to see if they fall into distinct subgroups. Researchers will use interviews, brain scans, and genetic tests to classify participants. The goal is to see if these subgroups predict how well …

This study aims to understand how adolescents with post-traumatic stress disorder (PTSD) experience psychotherapy. Researchers will interview 65 teens aged 12-18, along with their parents and therapists, to explore what helps them feel better. The goal is to learn more about the …

This study follows 1,600 advanced practice nurses (APNs) in France to see how their role grows and works in real healthcare settings. Researchers will use surveys and interviews over several years. The goal is to learn what helps or hinders APNs from being fully used in patient c…

This study looks at whether adding humidified airflow through the nose can improve brain activity and lung function in sedated patients who are breathing through a tube in their mouth. Researchers will measure brain waves and oxygen levels in 22 adults with severe respiratory fai…

This study aims to learn more about how the spleen works, especially how it filters abnormal blood cells in diseases like malaria. Researchers will use spleens removed during planned surgeries from 100 adult patients. By studying these spleens in the lab, they hope to understand …

This study watches 600 adults on a heart-lung machine (ECMO) for severe shock to see how often they develop heart rhythm problems like atrial fibrillation. It tracks complications and recovery times. The goal is to learn more, not to test a new treatment.

This study uses a special PET-MRI scan to measure brain inflammation in people with multiple sclerosis (MS). Researchers will scan 41 adults with active MS and compare the results to healthy volunteers. The goal is to better understand inflammation patterns and improve how we pre…

This study follows 140 people who were first hospitalized for early-onset anorexia nervosa between 2016 and 2021. Researchers want to see how they are doing 4 to 9 years later by checking their quality of life, eating habits, and overall health. The goal is to better understand l…

This study looks at how drugs travel from a mother to her baby through the placenta. Researchers will test placentas after delivery from 2,000 pregnant women. The goal is to learn which medicines reach the baby and in what amounts, helping doctors prescribe safer drugs during pre…

This study aims to create and test a better way to measure breathing difficulty (dyspnea) in children aged 6 to 17. Researchers will use special questionnaires to see if they can accurately describe the symptom, which could lead to improved treatment and follow-up for kids with l…

This study aims to better understand how children aged 8 to 16 with neurodevelopmental disorders (like autism or ADHD) process social information. Researchers will use a new set of tests to measure skills like recognizing emotions and understanding others' thoughts. The goal is t…

This study follows 150 adults with cirrhosis who are waiting for a liver transplant. Researchers will measure sexual function before and one year after transplant using questionnaires, hormone tests, and brain scans. The goal is to understand how transplant and anti-rejection dru…

This study looks at how the brain handles negative beliefs in people with treatment-resistant depression. Researchers will use brain scans to see how these beliefs change after a single dose of ketamine. The goal is to understand why some depressed patients hold onto negative tho…

This study follows about 643 children who were born very early (before 32 weeks) to see if giving their mothers half the usual dose of a steroid called betamethasone is as safe for the children's brain development as the full dose. The children are now 5 years old and will take t…

This study follows 425 adults with recent psoriatic arthritis (PsA) for up to 10 years to see how many develop joint damage and what factors predict it. Researchers will use X-rays and other data to identify early signs of aggressive disease. The goal is to help doctors decide wh…

This study follows 700 women aged 18–50 who have had three or more early miscarriages or failed embryo implants. Researchers will collect medical history, test results, and track future pregnancy outcomes to better understand what causes these losses. No new treatment is given; t…

This study aims to better understand unclear genetic changes (called variants of unknown significance) in people with autoinflammatory diseases or AA amyloidosis, a complication that can cause kidney failure. Researchers will study blood samples from 200 participants to determine…

This study looks at whether special brain scans (MRI and PET) can predict how multiple sclerosis (MS) will affect a person's disability over many years. Researchers will follow 80 adults with MS who were in earlier studies to see if certain brain changes can forecast worsening sy…

This study looks at whether certain substances in urine can help predict which pregnant women with high blood pressure will go on to develop pre-eclampsia, a more serious condition. Researchers will measure these markers in 110 women between 26 and 34 weeks of pregnancy. The goal…

This study looks at how antibiotic-resistant bacteria move between people and their pet dogs. Researchers will follow 525 dog owners and their dogs for three months, collecting samples to track bacterial changes. The goal is to create better strategies to prevent the spread of th…

This study looks at whether removing surgical dressings the day after abdominal surgery is as safe as keeping them on for about a week. About 1,288 adults having planned abdominal surgery will be randomly assigned to stop dressings on day 1 or day 6. The main goal is to see if ea…

This study looks at slow brain waves during sleep and wakefulness to understand how they relate to memory and attention problems in aging and early Alzheimer's disease. Researchers will study 90 people: young adults, healthy seniors, and those with early Alzheimer's. They will al…

This study looks at 50 children (over 1 year old) in intensive care who are on breathing machines due to acute respiratory distress syndrome (ARDS). Researchers want to see if two methods can reliably measure airway opening pressure, which could help doctors personalize ventilati…

This study monitors immune function in 200 intensive care patients after severe trauma, high-risk surgery, or respiratory distress. Researchers use a simple, automated blood test to measure interferon-gamma levels, which indicate immune strength. The goal is to identify when pati…

This study looks back at the medical records of 150 patients who died in intensive care between 2018 and 2022 after being treated for a joint prosthesis infection. The goal is to understand what went wrong and identify patterns that could help doctors better manage similar cases …

This study tests whether using a special tube to measure pressure inside the chest can help doctors set breathing machines better for severely obese patients with acute lung injury. About 40 adults with a BMI over 40 and moderate to severe ARDS will take part. The goal is to see …

This study follows 200 children aged 3 to 17 with growth hormone deficiency who are starting treatment with either daily or long-acting growth hormone. Researchers will measure body mass index, muscle mass, and fat mass over three years to understand how these treatments affect b…

This study looks at people with a rare condition called cerebral folate deficiency, where the brain lacks enough folate. Researchers think the problem may be in the choroid plexus, a part of the brain that helps control what goes in and out of brain fluid. They will use MRI scans…

This study aims to find markers in the skin and blood that can predict how well a person with a chronic inflammatory skin disease (like psoriasis, eczema, or lupus) will respond to treatment. Researchers will follow 830 adults over one year to see which markers are linked to bett…

This study follows 1,000 children and teens with rare epilepsies (like West and Dravet syndromes) to see how different treatments affect their seizures and thinking skills. Researchers will compare care across hospitals to find what works best. The goal is to give families cleare…

This study looks at how hard children with muscle, lung, or heart conditions have to work to breathe. Researchers use a small tube placed in the food pipe to measure the strength of the diaphragm and other breathing muscles. The goal is to better understand breathing problems in …

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a pill-sized camera) to screen for pre-cancerous growths or cancer in the small intestine. The goal is to see how well this camera test finds these lesions compared …

This study follows 800 people who carry a PRSS1 gene mutation, which can cause hereditary pancreatitis. Researchers want to learn how often pancreatic cancer develops in this group and how the disease progresses over time. Participants are identified through genetic testing and f…

This study looks at whether a sleep breathing test done at home can help doctors check how well a nighttime breathing machine is working for people with neuromuscular diseases. The goal is to see if the test is practical and gives useful information to adjust the machine settings…

This study tests whether a blood test that measures donor DNA can help doctors decide when a kidney biopsy is truly needed after a transplant. About 500 kidney transplant recipients will be randomly assigned to standard care or to have their doctors receive this blood test result…

This study follows 3,000 adults with cirrhosis or who have had a liver transplant at a French hospital. Researchers will track survival and complications like bleeding or infections to learn how to improve patient care. The goal is to collect data and samples to better understand…

This study involves 50 adults with lung cancer whose disease has worsened while on immunotherapy. Researchers will take a new tumor sample (rebiopsy) to study why the treatment stopped working. The goal is to better understand resistance mechanisms, not to provide a direct treatm…

This study follows people who survived a cardiac arrest and received ultra-rapid cooling treatment in a previous study. Researchers will check their health and survival status over 5 years through phone interviews and medical records. The goal is to understand the long-term effec…

This study collects blood, spinal fluid, and brain tissue from 400 people with severe seizures (status epilepticus) or epilepsy linked to brain inflammation (dysimmune encephalitis), plus control patients. Researchers aim to find antibodies and markers of nerve cell death that co…

This study looks at whether a non-invasive digital cuff can accurately measure blood pressure during carotid artery surgery, instead of the usual arterial catheter inserted into an artery. The catheter can cause discomfort and complications like infection or blocked blood flow. R…

This study aims to map gene activity in the placenta at two key points in pregnancy: the first trimester and at childbirth. Researchers will analyze small tissue samples from 100 pregnant women to understand how placental cells change over time. The goal is to learn more about no…

This study aims to find immune system markers that can predict how well a cancer patient responds to radiotherapy. Researchers will analyze blood samples from 40 adults who have already completed radiotherapy without major side effects. The goal is to personalize future cancer tr…

This study looks at sleep problems in people with Parkinson's disease and those with a sleep disorder called REM sleep behavior disorder (iRBD). Researchers will compare sleep quality among these groups and healthy volunteers using overnight sleep tests. The goal is to better und…

This study is building a registry of 450 adults with tic disorders to understand how tic severity affects quality of life differently in men versus women. Researchers will track changes in tics over time using standard questionnaires. The goal is to gather information, not to tes…

This study aims to find the best doses of anti-infective medicines for hospitalized patients, especially those with sepsis. Researchers will use mathematical models to understand how the body processes these drugs and how to personalize dosing. The study involves 60 adults at Coc…

This study looks at whether a new 3D ultrasound method can measure heart muscle stiffness in people with a leaky mitral valve (mitral regurgitation). The goal is to see if these measurements match findings from MRI scans that show scarring in the heart. About 40 adults with diffe…

This study is testing a special camera (Mueller polarimetric colposcopy) to see if it can measure changes in the cervix during pregnancy. The goal is to find patterns that could help predict if a baby will be born early (preterm). Researchers will study 683 pregnant women, both w…

This study is for people aged 70 and older with early-stage lung cancer who are scheduled for surgery. Researchers want to see if markers of aging (like changes in DNA and cell health) can help predict who will have complications or need unplanned hospital stays. The goal is to u…

This study looks at how limiting eating to an 8-hour window each day (time-restricted feeding) affects the immune system of women with severe obesity. Researchers will compare two groups of women with obesity—one following the 8-hour eating schedule and one eating normally—and al…

This study looks at how gut bacteria influence the energy use of immune cells in healthy adults and people with inflammatory bowel disease (IBD). Healthy volunteers will take a short course of antibiotics to change their gut bacteria, while IBD patients will be tested once. Resea…

This study looks at how often young children (ages 1 to 6) with inherited metabolic diseases develop eating disorders when they are on special diets. Researchers will use a feeding scale to measure eating problems in 200 children. The goal is to understand the link between these …

This study follows 840 adults who had a heart attack outside the hospital and received ECMO, a machine that pumps blood for the heart and lungs. The goal is to see how many survive for one year and how well their brains recover. Researchers want to learn if this emergency treatme…

This study looks at how well people with frontotemporal dementia or Alzheimer's disease can recognize emotions in others and how aware they are of their own performance. Researchers will ask 34 participants (ages 50-80) to complete computer tasks and confidence ratings. The goal …

This study explores whether a specific gut bacterium, Akkermansia muciniphila, can serve as a marker to predict how well men with advanced prostate cancer respond to a common hormone therapy (abiraterone acetate). Researchers will measure the levels of this bacterium in stool sam…

This study aims to find better ways to detect acute mesenteric ischemia, a condition where blood flow to the intestine is blocked, causing severe pain and damage. Researchers will analyze blood samples and CT scans from 556 adults with sudden abdominal pain to identify early biom…

This study aims to better understand why some patients with ARDS (a severe lung condition) get very sick while others recover. Researchers will collect blood and lung fluid from 50 ICU patients to study their immune cells and inflammation patterns. The goal is to identify differe…

This study reviews medical records from over 1,200 people with immune thrombotic thrombocytopenic purpura (iTTP), a rare and life-threatening blood disorder. The goal is to understand long-term health problems, such as heart disease and thinking issues, that survivors face. By an…

This study looks at how vasoplegic syndrome (a condition causing dangerously low blood pressure after heart surgery) affects the adrenal glands. Researchers will measure steroid levels in 200 adults undergoing scheduled heart surgery. The goal is to better understand adrenal func…

This study tests a virtual reality (VR) game to measure hand-eye coordination in children aged 7 to 17 with and without chronic balance (vestibular) disorders. Researchers want to see if the VR tasks are reliable and fun for kids, and how balance problems affect coordination. The…

This study aims to see if newer lab techniques can better detect the germs causing serious eye infections like endophthalmitis and corneal abscesses. Researchers will compare standard culture methods with advanced genetic tests (metagenomics and multiplex PCR) on samples from 153…

This study looks at how small fiber neuropathy (nerve damage causing pain, burning, and numbness) impacts the quality of life and medical costs for people with Sjögren's syndrome. Researchers will follow 100 adults with Sjögren's to measure their symptoms, daily functioning, and …

This study tests a new questionnaire that measures how well patients stick to a bowel management technique called transanal irrigation. The method helps people with bowel movement or leakage problems, but many stop using it over time. Researchers will enroll 100 adults who have u…

This study looks at whether cancer patients do better when they go to an emergency room at their own cancer hospital versus a regular hospital. Researchers will track 2,000 adults with active cancer or recent remission to see how many days they spend alive and out of the hospital…

This study tests a new tool called PRECOM that uses brain wave signals to predict whether coma patients after cardiac arrest will wake up within three months. Researchers will enroll 100 adults in French ICUs and compare the tool's predictions to actual outcomes. The goal is to i…

This study looks for substances in the blood that might be linked to fatigue in people with low platelet counts (thrombocytopenia). Researchers think a protein called BDNF, which is stored in platelets, could play a role. They will measure BDNF levels in 280 patients and healthy …

This study looks at whether low oxygen levels during sleep after hip fracture surgery are linked to delirium (sudden confusion) in patients over 70. Researchers will monitor 70 participants in the hospital to see if nighttime hypoxia increases the risk of complications like infec…

This study is following 670 adults with vasculitis, a rare blood vessel disease, to learn more about how the disease shows up, how it is treated, and what health problems may arise over time. Researchers will collect medical data during regular doctor visits but will not test any…

This study looks at why some people with liver cirrhosis develop blood clots in the portal vein (a major liver blood vessel). Researchers will compare blood samples taken from a neck vein and the portal vein during a routine procedure (TIPS) in 45 adults. The goal is to understan…

This study compares 3D models of children's pelvic and retroperitoneal tumors to standard 2D scans to see if they help surgeons plan better. About 60 children and their surgeons will answer questions about the images. The goal is to improve surgical precision, not to test a new t…

This study uses advanced MRI scans to measure how well the brains of children with multiple sclerosis (MS) can repair myelin, the protective coating around nerve cells. Researchers will compare these repair levels with thinking and memory test scores. The goal is to understand if…

This study is testing a new cell therapy in the lab for people with Merkel cell carcinoma, a rare skin cancer linked to a virus. Researchers will take immune cells from 15 patients and try to train them to attack the cancer in a test tube. The goal is to see if this approach work…

This study looks at whether a rapid test that checks for three common respiratory viruses (COVID-19, flu, and RSV) can help doctors prescribe fewer antibiotics for infections that are likely viral. About 2,000 people with fever or cold symptoms will take part. The goal is to see …

This study aims to find genetic differences that make some cancer patients more likely to develop a rare but life-threatening heart inflammation (myocarditis) from immune checkpoint inhibitors. Researchers will compare the DNA of 100 patients who had this side effect with 400 who…

This study looks at people with a mechanical heart valve who hear a clicking noise from it. Researchers want to know if remembering information given before surgery about this noise affects their quality of life afterward. About 180 participants will answer questionnaires over th…

This study is looking at how well robotic surgery works in both children and adults. Researchers want to see if it is safe, efficient, and worth the cost compared to other methods. The study will track complications, pain, and quality of life in 16,000 people who need surgery.

This study looks at DNA methylation patterns (chemical marks on DNA) in tissue from fetuses and children with rare genetic diseases. Researchers aim to create a reference map of these patterns using samples from amniotic fluid, lung tissue, and blood. The goal is to improve diagn…

This study aims to validate a new serious game test called REALSoCog that detects social thinking and behavior problems in people with Alzheimer's, Lewy body dementia, or frontotemporal degeneration. Researchers will enroll 120 patients and their caregivers to see how well the te…

This study talks to siblings aged 9 to 18 whose brother or sister is in the pediatric intensive care unit (PICU). Researchers want to learn about the siblings' needs and how this experience affects their daily life. They will interview each sibling twice: once during the hospital…

This study aims to understand why blood vessels become leaky during severe inflammation (SIRS), a condition common in sepsis and shock. Researchers will measure certain proteins in the blood and lung fluid of 180 ICU patients and see how they relate to fluid balance and organ fun…

This study looks at how standard ICU treatments, like giving fluids or drugs to support blood pressure, affect blood flow in the small vessels near the skin. Researchers will monitor 180 patients with acute circulatory failure to see how quickly these treatments improve blood flo…

This study aims to identify biological markers in blood and joint fluid that can predict how knee osteoarthritis will progress over time. Researchers will follow 300 participants with knee pain for up to 10 years, collecting samples during routine joint fluid removal or injection…

This study looks at how children with Angelman syndrome (a rare genetic disorder causing severe developmental delays) pay attention to social cues. Researchers will use eye-tracking technology to measure where children look when watching social scenes. The goal is to find a relia…

This study looks at whether measuring a natural ear reflex (the stapedial reflex) can help doctors set the right loudness levels in cochlear implants for children aged 8-17. Currently, children must describe how loud sounds feel, which can be hard. The reflex test may offer a fas…

This study looks at how blood pressure changes affect blood flow to the brain in adults in the intensive care unit (ICU). Researchers will use non-invasive tools like ultrasound and brain wave monitors to measure brain activity and oxygen levels. The goal is to find safe blood pr…

This study follows 50 children and young adults (ages 6 months to 21 years) with Dravet syndrome caused by an SCN1A gene mutation. Researchers will measure changes in thinking, movement, and daily skills over 4 years using standard tests. The goal is to better understand how the …

This study takes small skin samples from people with ALS, healthy carriers of ALS-related gene changes, and volunteers without the disease. The skin cells are grown in the lab to see how they behave under stress. The goal is to better understand what goes wrong in ALS at the cell…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This study looks at how women with a severe form of congenital adrenal hyperplasia (classic 21-hydroxylase deficiency) become pregnant and what happens during their pregnancies. Researchers will collect information from medical records and phone interviews with 200 adult women. T…

This study is for adults with advanced liver cancer who are starting a common immunotherapy combination (Atezolizumab and Bevacizumab). Researchers want to see if levels of a protein called Glypican-3 in the blood can help predict how well the treatment works. About 240 participa…

This study follows 1,200 people from two memory clinics in Paris to see if sleep patterns and other personal factors are linked to different types and stages of dementia. Researchers will track participants for up to 15 years using routine clinic visits. The goal is to find simpl…

This study looks at how losing all your teeth and getting dentures affects your sense of taste, touch in the mouth, and food likes. Researchers will compare 40 people who have worn dentures for at least a year with 40 people who still have their natural teeth. The goal is to unde…

This study examines whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5-7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using standard …

This study follows 500 adults who received a stem cell transplant at least 10 years ago to see if iron buildup in the body raises the risk of liver problems. Researchers will use blood tests and a special liver scan (FibroScan) to check for damage. The goal is to understand wheth…

This study aims to observe a specific behavior called behavioral sensitization in people addicted to crack-cocaine. Researchers will track the movement and sleep patterns of 20 participants over 3 weeks using a wearable device called an actimeter. The goal is to see how crack use…

This study looks at how viruses change the environment around tumors in people with lymphoma, lung cancer, or anal cancer. Researchers will analyze blood and tumor samples from 254 patients to understand why some cancers resist treatment. The goal is to find new ways to make anti…

This study looks at why a numbing injection in the thigh (adductor canal block) works so well for knee surgery pain. Researchers think the medicine may spread to the sciatic nerve, but they want to measure how often this happens. About 70 adults having knee surgery will be tested…

This study looks at whether private medical practices can safely perform direct oral challenges to check for mild, delayed allergic reactions to beta-lactam antibiotics (like amoxicillin) in children. About 200 kids aged 0-17 will be tested, and researchers will track how many ha…

This study looks at fetal cells that remain in a mother's blood after pregnancy to see if they help heal skin ulcers. Researchers will compare women with and without ulcers to find which receptors on these cells are active. The goal is to gather basic knowledge that could lead to…

This study looks at children aged 9 to 15 who were hospitalized after a serious suicide attempt. Researchers want to understand what psychiatric or developmental conditions these children may have, using detailed interviews and questionnaires. The goal is to better identify and h…

This study aims to find out why some people lose more weight than others after a minimally invasive stomach-shrinking procedure called endoscopic sleeve gastroplasty. Researchers will follow 205 obese adults for 12 months, measuring weight, blood markers, and gut bacteria changes…

This study looks at whether a device called Mostcare® can help doctors know when critically ill children need more fluids. It involves 100 children aged 0-10 who are in the intensive care unit after surgery or severe injury. The device uses blood pressure readings to estimate flu…

This study looks at whether using a standardized checklist (AnesList) when anesthesiologists hand over patient care in the operating room can reduce serious problems like death, major complications, or return to the hospital within a month after major surgery. About 1,120 adults …

This study looks at whether an enzyme called glucocerebrosidase is less active in people with Lewy body dementia. If so, it might mean that treatments already used for a related disease (Gaucher disease) could help. The study will compare enzyme activity in 236 people with and wi…

This study surveys 200 adult women with primary immune deficiency diseases to see if using IUDs, tampons, or menstrual cups leads to infections. Doctors often advise against these products due to infection risk, but there is little data. The goal is to gather real-world informati…

This study looks at 40 intensive care patients on breathing machines who need chest physiotherapy to clear mucus and improve lung function. Researchers will compare two common ventilator settings to see which one helps the lungs expand more during the therapy. The goal is to find…

This study aims to understand how the immune system causes bone destruction in gum disease (periodontitis) and implant-related gum disease (peri-implantitis). Researchers will collect samples like plaque, saliva, and gum fluid from 219 adults with severe gum disease and compare t…

This study looks at 200 severely burned adults in intensive care to see if giving albumin (a protein in blood) during the first day affects their risk of death, kidney failure, or lung injury. Researchers will observe patients and collect data, but won't assign treatments. The go…

This study follows 480 children up to age 6 to see if taking nifedipine (a blood pressure drug) during pregnancy affects their brain development. The children's mothers had early rupture of membranes and were part of an earlier trial. Researchers will check for conditions like ce…

This study looks at how medical care affects the quality of life of 100 pregnant women living with HIV. Researchers will ask women to fill out questionnaires about their feelings and experiences during pregnancy and one year after giving birth. The goal is to improve care and sup…

This study tests whether a bedside bone biopsy done by a diabetes doctor works as well as the usual surgical or radiology-guided biopsy for people with diabetic foot infections. About 320 adults with diabetes and a foot ulcer suspected of bone infection will take part. The goal i…

This study aims to find out if certain proteins in the blood can predict how severe juvenile idiopathic arthritis (JIA) will become in children and teens. Researchers will measure these markers in 300 participants aged 16 and older and track their joint damage and treatments over…

This study interviews 90 participants—teens with anorexia nervosa, their parents, and healthcare professionals—to understand their personal experiences with psychotropic medications. The goal is to gather insights through open-ended conversations, not to test a treatment. Finding…

This study looks at how certain immune cells (monocytes and macrophages) behave in sarcoidosis and tuberculosis. Researchers will compare blood and tissue samples from 100 adults to find patterns that explain why these cells stay overactive in sarcoidosis. The goal is to better u…

This study looks at the link between gut bacteria and mental health symptoms like anxiety and depression in people with anorexia nervosa. Researchers will compare 120 participants (patients with severe anorexia and healthy volunteers) to see if changes in gut bacteria, intestinal…

This study uses a one-time survey to learn about the eye and body symptoms of people with congenital aniridia, a rare genetic condition that affects the iris. Researchers want to see how much patients understand about their own disease. About 100 patients of all ages will take pa…