Assistance Publique - Hôpitaux De Paris

This study tracks 250 adults with gout to see how quickly urate crystals in the joints dissolve when uric acid levels are kept very low. Participants will have regular ultrasound scans of their feet and knees. The goal is to find out what affects the time to crystal clearance and…

This trial tests a stem cell transplant method for adults aged 40 to 60 with severe aplastic anemia that has not improved or has returned after standard drug therapy. The new approach uses a drug called cyclophosphamide after the transplant to lower the risk of graft-versus-host …

This study tests whether colchicine, an anti-inflammatory drug, can reduce heart scarring and prevent serious complications in people with acute myocarditis (heart inflammation, often from a virus). About 300 participants will receive either colchicine or a placebo for six months…

This study tests whether chemotherapy alone works as well as chemotherapy followed by radiation for people with advanced rectal cancer that can be surgically removed. About 540 adults with stage 2 or 3 rectal cancer will be randomly assigned to one of two treatment groups. The go…

This study tests if the drug letermovir can better control CMV virus in unborn babies compared to the current drug valaciclovir. Pregnant women with a first-trimester CMV infection and an infected fetus (confirmed by amniotic fluid test) may join. The goal is to see if letermovir…

This study tests whether using a connected scale at home can help people who had bariatric surgery avoid regaining too much weight. 182 adults who had surgery one year ago will either get standard follow-up or also weigh themselves weekly with a smart scale. If they regain more t…

This study tests whether taking a daily oral medication (dimethyl fumarate) for 12 months can slow the growth of geographic atrophy, a form of advanced age-related macular degeneration that causes blind spots. About 90 adults aged 55–85 with geographic atrophy will participate. T…

This study looks at whether adding letermovir to the standard valganciclovir treatment works better than valganciclovir alone for clearing CMV infections in kidney transplant recipients. About 80 adults who have a CMV infection after their transplant will take part. The goal is t…

This study tests whether adding continuous positive airway pressure (CPAP) to high-flow nasal cannula (HFNC) oxygen therapy reduces deaths in patients with severe, sudden breathing failure. About 1,084 adults in intensive care will be randomly assigned to receive either HFNC alon…

This study looks at whether adding blood thinners (anticoagulants) to standard steroid therapy is better than steroids alone for treating deep vein thrombosis (DVT) in people with Behçet's syndrome. About 134 adults with Behçet's and a first or repeat DVT will be randomly assigne…

This early-stage study tests whether a special ultrasound device can safely open the blood-brain barrier in children with hard-to-treat brain tumors. The goal is to let chemotherapy reach the tumor more effectively. About 24 children aged 5 to 17 will receive ultrasound before th…

This study tests a drug called ruxolitinib in 80 adults with inclusion body myositis, a rare disease that causes progressive muscle weakness. The goal is to see if blocking a specific immune signal can help patients walk farther in 6 minutes. Researchers will also check for side …

This study tests whether a combination of two drugs (atezolizumab and bevacizumab) is safe for liver transplant patients whose liver cancer has come back and cannot be treated with surgery or local therapies. About 50 participants will receive the drug combo along with a standard…

This study compares a 3-day course of intravenous (IV) antibiotics against the standard 10-day treatment (3 days IV plus 7 days oral) for acute kidney infection in children aged 1 month to 3 years. The goal is to see if the shorter treatment is just as effective at preventing the…

This study tests whether a combination of two steroids (hydrocortisone and fludrocortisone) can reduce death or long-term organ damage in adults with sepsis in the ICU. About 1,800 participants will receive either the steroids or a placebo, and researchers will track survival and…

This study is testing whether giving antibiotics before burn surgery can lower the chance of infections afterward. It involves 506 adults with burns covering 5% to 40% of their body. Half will get antibiotics and half will get a placebo, and researchers will compare infection rat…

This study looks at whether starting intensive day hospital treatment early for teenagers (ages 12-18) with anorexia nervosa can improve their health and reduce serious events like hospital stays, compared to standard outpatient care. It also examines how this approach affects th…

This study tests a high-precision radiation therapy called SBRT as a temporary treatment for liver cancer patients waiting for a liver transplant. The goal is to stop the cancer from growing so patients can stay on the transplant list and eventually receive a new liver. The study…

This study tests a drug called ruxolitinib as the first treatment for children with primary hemophagocytic lymphohistiocytosis (HLH), a rare and severe immune disorder. The goal is to see if ruxolitinib, given with steroids, helps children survive long enough to receive a stem ce…

This study tests whether adding a special diet called the Crohn's Disease Exclusion Diet (CDED) to standard medication can help children and teens with unstable Crohn's disease avoid flare-ups for a full year. About 120 participants aged 6-17 will be randomly assigned to either c…

This study tests which of two drugs (ATG-thymoglobulin or ATLG-grafalon) works better at preventing graft-versus-host disease (GVHD) in adults aged 50-70 with acute myeloid leukemia or myelodysplastic syndrome. Participants receive a stem cell transplant from a matched unrelated …

This study tests whether giving a low dose of the hormone vasopressin during liver transplant surgery can prevent acute kidney injury, a common complication. About 304 adults scheduled for a liver transplant will receive either vasopressin or standard treatment. The goal is to se…

This study tests whether dapagliflozin, a drug already used for diabetes and heart failure, can reduce death and serious heart or kidney problems in people leaving the intensive care unit (ICU). About 600 adults who needed a breathing machine or blood pressure support in the ICU …

This study tests whether dapagliflozin, a drug already used for diabetes and heart failure, can help prevent further heart damage in people who have had a major heart attack. About 450 adults with weakened heart pumping function will receive either the drug or a placebo for 6 mon…

This study looks at whether people whose heart function has returned to normal after heart failure can safely stop taking beta-blockers. Beta-blockers can cause tiredness and other side effects, and it's unclear if they still help once the heart has recovered. The trial will foll…

This study looks at 792 adults aged 60 to 80 who had a stroke linked to a small hole in the heart (PFO). It compares three approaches: closing the hole with a device plus antiplatelet drugs, taking blood thinners alone, or taking antiplatelet drugs alone. The goal is to see which…

This study looks at 240 adults with septic shock who develop a new irregular heartbeat. It compares three treatment approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors without a…

This study looks at whether heart failure medication alone works as well as medication plus an implantable cardioverter-defibrillator (ICD) for people aged 70 and older. The goal is to see if avoiding the device can still keep patients alive just as long. About 730 participants w…

This study tests a JAK1 inhibitor drug (baricitinib) to shrink large inflammatory hepatocellular adenomas (liver tumors) in 25 people. These tumors are rare, often affect young women on birth control, and usually require surgery when larger than 5 cm. The goal is to see if a shor…

This study tests whether levosimendan, a drug used for heart failure, can reduce dangerous brain spasms and delayed damage after a bleeding stroke (aneurysmal subarachnoid hemorrhage). Thirty adults in intensive care will receive either the drug or a placebo. The goal is to see i…

This study tests a new gene therapy for people with severe sickle cell disease who do not have a matching bone marrow donor. The treatment uses the patient's own blood stem cells, which are modified in a lab to produce healthy red blood cells and reduce sickling. The goal is to d…

This study looks at 600 ICU patients with sepsis caused by hard-to-treat bacteria. It compares giving antibiotics as a continuous drip versus intermittent doses, and also tests adding a second antibiotic versus using just one. The main goal is to see which approach lowers the cha…

This study is for adults aged 18–65 newly diagnosed with acute lymphoblastic leukemia (ALL). It tests whether adding newer immunotherapy drugs (blinatumomab for B-cell ALL, isatuximab for T-cell ALL) to standard treatment can improve survival and reduce the need for a stem cell t…

This study tests a new, quick thinking test using building blocks to find a hidden brain condition called minimal hepatic encephalopathy (MHE) in people with liver disease. About 100 adults with liver problems will take the test, and results will be compared to standard tests and…

This study compares standard ultrasound monitoring to ultrasound plus a short, 10-minute MRI (Fast-MRI) for detecting early-stage liver cancer in people with cirrhosis who are at high risk. About 944 participants will be followed for several years to see which method finds more e…

This study aims to develop an artificial intelligence tool that can analyze images and videos from capsule endoscopy (a camera pill) to help doctors diagnose bowel diseases like Crohn's disease, celiac disease, and tumors. The AI is trained on data from 10,000 patients undergoing…

This study is testing a quick, portable device (qLabs®FIB) that measures a key blood clotting protein (fibrinogen) right at the bedside in women with severe bleeding after childbirth. The goal is to see if this rapid test gives results as accurate as the standard lab test, which …

This study is testing a new medical device called PrediMAP to see if it can accurately predict whether a woman in preterm labor will give birth within the next 7 days. The study will involve 3,600 pregnant women who visit the emergency room with signs of preterm labor. If success…

This study aims to improve how doctors diagnose sarcopenia—age-related muscle loss that can lead to falls and loss of independence. Researchers will test a new, high-definition muscle-reading technology (HD-sEMG) in 846 adults aged 75 and older who are already in the hospital. Th…

This study aims to see if a simple blood test from the mother can accurately diagnose single-gene disorders (like sickle cell disease or cystic fibrosis) in the fetus, starting as early as 9 weeks of pregnancy. The test looks at fetal DNA found in the mother's blood, which avoids…

This study looks at whether a simple measurement called GapCO2 can help emergency doctors quickly tell if a patient's shortness of breath is caused by fluid buildup (congestive) or other reasons. About 45 adults with sudden breathing trouble will have their blood gases measured a…

This study tests a software tool called MyCMV that helps doctors interpret blood test results for cytomegalovirus (CMV) infection during pregnancy. CMV is a common virus that can cause hearing loss and developmental problems in babies if the mother gets infected for the first tim…

This study tests whether screening pregnant women early (at 11-14 weeks) for preeclampsia risk can reduce severe health problems for mothers and babies. About 14,500 first-time or low-risk pregnant women will be randomly assigned to receive either the new screening or standard ca…

This study tests three different schedules of the meningococcal B vaccine in 84 adults aged 18 to 75 who have had their spleen removed. People without a spleen are at higher risk for severe infections. The goal is to find which vaccine strategy produces the strongest immune respo…

This study tests whether injecting Botox into the thumb joint can reduce pain and improve hand function in people with base-of-thumb osteoarthritis. 120 adults with moderate to severe thumb pain will receive either Botox, a mix of Botox and saline, or plain saline injections, plu…

This study looks at whether children aged 8-13 with early onset anorexia nervosa can switch from full-time hospital care to day treatment (going home at night) after a short hospital stay. The goal is to see if day treatment works just as well for weight gain and is better for th…

This study looks at whether using walking sticks can help people with a forward-leaning spine walk longer distances. Thirty-five adults aged 50 and older who have trouble walking will try using walking sticks for three months. Researchers will measure how far they can walk in six…

This study tests if shiatsu, a type of Japanese bodywork, can improve symptoms like fatigue, pain, and anxiety in people with severe cardiac amyloidosis. 108 participants will receive either targeted shiatsu or a gentle "comfort" shiatsu. The goal is to see if shiatsu can improve…

This study tests whether regular yoga practice can improve quality of life and well-being in adults with stable chronic heart failure. Researchers will measure changes in physical and mental health using standard questionnaires. The goal is to see if adding yoga to standard care …

This study tests if joining workshops and exchange groups can improve the quality of life for people who have had their larynx removed (laryngectomy) due to throat cancer. Researchers will compare the well-being of 50 participants who attend the program with those who do not. The…

This study looks at whether cancer patients with a blood clot in the lung (pulmonary embolism) can be safely treated at home instead of in the hospital. About 824 adults with active cancer and a stable clot will be randomly assigned to go home within 24 hours or stay in the hospi…

This study compares different visual keyboard arrangements to see which helps people with complex sensorimotor disabilities type faster and feel less tired. Twelve adults who already use a virtual scanning keyboard will test each layout. The goal is to improve communication and d…

This study tests whether adding a single dose of ketamine to the standard antidepressant venlafaxine can relieve severe depression faster than venlafaxine alone. It involves 60 hospitalized adults with major depression who are not responding quickly to usual care. The goal is to …

This study tests whether using a connected exercise bike at home, along with standard care, can improve daily activities and walking ability in people with lumbar spinal stenosis. About 302 adults aged 50 and older with confirmed spinal narrowing will be randomly assigned to eith…

This study tests whether metformin, a common diabetes medicine, can improve muscle function in adults with myotonic dystrophy type 1 (Steinert's disease). About 142 non-diabetic participants will receive either metformin or a placebo for 6 months. The main goal is to see if metfo…

This pilot study tests whether a personalized home respiratory exercise program is practical for people with systemic sclerosis (scleroderma) who have early lung disease. Fifteen participants will do one supervised session then follow a 3-month home program. The goal is to see if…

This study tests whether automatic settings on hearing aids help children with hearing loss understand speech better in noisy environments. Twenty children aged 6 to 16 who use a cochlear implant and hearing aid (or two implants) will compare three different hearing aid programs.…

This study compares two approaches for people newly diagnosed with early Alzheimer's disease: taking the drug donepezil versus using non-drug methods like cognitive stimulation or remediation. Researchers want to see which approach better helps with memory and thinking symptoms a…

This study compares yoga therapy to standard physiotherapy for people with moderate axial spondyloarthritis, a type of arthritis that causes back pain and stiffness. Researchers will measure changes in disease activity, pain, and fatigue over 6 months. The goal is to see if yoga …

This study looks at how well a life-support machine called ECMO works for people whose hearts stop outside a hospital and don't restart with standard CPR. Researchers will follow 840 patients treated by a special Paris emergency team to see how many survive for one year and how w…

This study looks at different types of immune cells called neutrophils in the blood of 100 people with lung cancer, comparing them to healthy volunteers. Researchers want to find out if certain neutrophil subtypes are linked to tumor growth and resistance to treatment. Participan…

This study looks at whether a rapid test that checks for COVID-19, flu, and RSV using a nose swab can help doctors decide when antibiotics are truly needed. Many respiratory infections are viral and don't need antibiotics, but they are often prescribed anyway, which can lead to a…

This study aims to find better ways to detect acute mesenteric ischemia, a condition where blood flow to the intestine is blocked, causing severe pain and damage. Researchers will analyze blood and tissue samples from 556 adults with sudden abdominal pain to identify early biomar…

This study aims to define normal test results for spatial neglect, a common attention disorder after stroke. Researchers will recruit 210 healthy French-speaking adults aged 20-89 to take simple paper-and-pencil tests. The results will help doctors better diagnose spatial neglect…

This study will track 16,000 children and adults who need robotic surgery to see how safe and effective it is compared to standard approaches. Researchers will measure complications, pain, recovery quality, and costs. The goal is to understand whether the benefits of robotic tool…

This study checks if French versions of two short questionnaires (PHQ-4 for anxiety/depression and PC-PTSD-5 for PTSD) work as well as the original English ones. About 90 adults will fill out the forms during doctor visits. The goal is to give French doctors simple, proven ways t…

This study checks on 5-year-old children who were born very early (before 32 weeks) and whose mothers received either a full or half dose of a steroid called betamethasone before birth. The goal is to see if the lower dose is just as safe for the children's brain development and …

This study is monitoring the immune system of 20 adults with serious mold infections (like aspergillosis) to see how their T cells respond. The goal is to find out which patients might benefit from adding immunotherapy—drugs that boost the immune system—to standard antifungal tre…

This study creates a registry of 450 adults with tic disorders to compare how tic severity impacts quality of life between men and women. Researchers will measure tic severity and quality of life using standard questionnaires. The goal is to better understand gender differences i…

This study aims to better understand why some patients with Acute Respiratory Distress Syndrome (ARDS) get very sick while others recover. Researchers will analyze blood and lung fluid from 50 ICU patients on ventilators to identify different immune system patterns. The goal is t…

This study looks at how special brain scans (MRI and PET) can help predict long-term disability in people with multiple sclerosis (MS). Researchers will follow 80 adults who have been in earlier MS studies for at least 8 years. The goal is to find better ways to track and underst…

This study looks at children who needed a heart-lung machine (ECMO) through a neck artery. After the machine is removed, doctors either repair the artery or tie it off. The study uses brain scans to see how each method affects blood flow in the brain. It aims to find which approa…

This study aims to create a tool to assess how well people understand tone of voice (prosody) after a right-sided stroke. About 150 participants, including stroke patients and healthy controls, will listen to variations of the word "really" to test their perception. The goal is t…

This study tracks 600 adults on a heart-lung machine (VA ECMO) for severe shock to see how often they develop heart rhythm disorders like atrial fibrillation. Researchers will monitor these patients in the ICU to measure the impact on recovery time and survival. The goal is to ga…

This study looks at 200 children and teenagers (ages 7-20) who have had psychotic episodes, such as schizophrenia. Researchers will use interviews, thinking tests, brain scans, and DNA analysis to group participants by their symptoms. The goal is to see if these groups can help p…

This study looks at how losing all your teeth and wearing full dentures affects your sense of taste, touch in the mouth, and food likes. Researchers will compare 40 people: those who have been wearing dentures for at least a year and those with natural teeth. No treatment is give…

This study looks at whether measuring a tiny ear muscle reflex (eSRT) can help doctors set comfortable sound levels for children with cochlear implants. Currently, kids must describe how loud sounds feel, which can be hard. The study will compare the reflex test to the usual meth…

This study looks at 50 children (over 1 year old) in intensive care who are on breathing machines due to acute respiratory distress syndrome (ARDS). Researchers want to see if two methods can reliably measure airway opening pressure, which could help doctors tailor ventilation to…

This study explores whether using advanced automated insulin pumps soon after diagnosis can protect brain growth and thinking skills in children aged 5–7 with type 1 diabetes. Researchers will compare brain scans and cognitive tests over 18 months between children using the new s…

This study aims to understand why blood vessels become leaky during severe inflammation (SIRS), a condition common in sepsis and shock. Researchers will measure certain proteins in the blood and lung fluid of 180 ICU patients and see how they relate to fluid buildup and organ fun…

This study looks at how medicines move from a mother to her baby through the placenta. Researchers will test placentas after delivery to measure drug levels. The goal is to better understand drug safety during pregnancy. The study involves 2,000 pregnant women aged 18 and older.

This study looks at infections that happen after surgery to remove esophageal cancer. Researchers will review records of 350 patients who had this surgery in France between 2017 and 2024. The goal is to find out how often infections occur, what causes them, and how they affect re…

This study aims to understand the overall health of hospital residents (doctors-in-training) at a Paris hospital. Researchers will assess 450 residents' physical health, mental wellbeing, sexual health, and access to medical care. The goal is to identify health issues and unmet n…

This study looks at blood samples from 80 children (ages 2-17) recently diagnosed with type 1 diabetes and healthy children to understand why the immune system attacks the pancreas. Researchers will compare specific immune cells (regulatory and conventional T cells) between the t…

This study follows 700 people hospitalized with infective endocarditis, a severe heart infection. Researchers will track complications like strokes and deaths to learn how to better manage the disease. The goal is to gather real-world data that can lead to improved treatment guid…

This study looks at whether people with a low-risk staph bloodstream infection (based on the VIRSTA score) can safely skip a heart ultrasound. About 700 adults will be randomly assigned to get the ultrasound or not. The goal is to see if skipping the test leads to similar rates o…

This study will follow 80 people with advanced gastroenteropancreatic neuroendocrine tumors (GEP-NETs) who are receiving peptide receptor radionuclide therapy (PRRT). Researchers will use advanced PET-MRI scans and genetic profiling before, during, and after treatment to find pat…

This study looks at whether a special physiotherapy assessment, called the EPIC Assessment, can help doctors know when it's safe to remove a breathing tube from patients in the intensive care unit. About 330 adults who have been on a ventilator for more than 48 hours will be chec…

This study looks at whether remembering information given before surgery about the noise from a mechanical heart valve affects a patient's quality of life after the operation. Researchers will interview 180 people who have a mechanical aortic valve. The goal is to understand if b…

This study looks at why some people with severe burns get dangerous fungal infections while others do not. Researchers will follow 327 adult burn patients to measure their immune responses and track infections. The goal is to better understand the body's defenses against fungi, w…

This study looks at whether severe hearing loss in adults aged 45 to 64 is linked to mild memory or thinking problems. Researchers will compare cognitive test results from 180 participants—half with severe hearing loss and half with normal hearing. The goal is to understand if he…

This study aims to understand the immune and inflammatory processes that lead to bone destruction in gum disease (periodontitis) and infections around dental implants (peri-implantitis). Researchers will collect plaque, saliva, and gum fluid from 219 adults with advanced gum dise…

This study reviews medical records of 150 patients who died in intensive care between 2018 and 2022 with a joint prosthesis infection. Researchers want to understand what these patients had in common and how their care was managed. The goal is to find ways to better treat and pre…

This study looks at people with autoinflammatory diseases or AA amyloidosis who have genetic changes that are hard to interpret. The goal is to figure out whether these changes actually cause the disease. Researchers will study blood samples from up to 200 participants to better …

This study looks at children ages 9 to 15 who were hospitalized after a serious suicide attempt. Researchers want to understand what psychiatric disorders or developmental traits these children may have. By using detailed questionnaires and interviews, they hope to find patterns …

This study looks at how multi-family therapy works for teenagers with anorexia nervosa. Researchers will interview teens, parents, and siblings who took part in group therapy sessions to understand what helps. The goal is to learn more about the therapy process, not to test a new…

This study talks to siblings (ages 9-18) of children in the pediatric intensive care unit to understand their needs and feelings. Researchers interview them twice: once during the ICU stay and again one month after discharge. The goal is to learn how to better support these often…

This study is looking at whether a blood test that detects tumor DNA (called ctDNA) can help predict if Hodgkin lymphoma will come back in children and young adults under 25. Researchers will follow 400 participants over time to see if ctDNA levels at diagnosis and during treatme…

This study is looking at a protein called Glypican-3 (GPC-3) in the blood of people with advanced liver cancer who are receiving a combination of immunotherapy drugs (Atezolizumab and Bevacizumab). The goal is to see if levels of GPC-3, alone or with other markers, can predict ho…

This study observes 50 young adults with chronic inflammatory rheumatic diseases to see which transition program works best when moving from pediatric to adult care. Some participants received a special education workshop plus a joint doctor visit, while others had only the joint…

This study aims to improve how doctors measure movement in infants with spinal muscular atrophy (SMA), a condition that causes severe muscle weakness. Researchers will use a special bathtub and motion sensors to detect subtle movements in water that are hard to see on land. The g…

This study looks at whether delivering humidified air through the nose can improve brain activity and lung function in sedated patients who are on a breathing tube. Researchers will measure brain waves and blood flow in 22 adults with severe respiratory failure. The goal is to un…

This study looks at whether taking off surgical bandages on the first day after abdominal surgery is as safe as keeping them on for about a week. About 1,288 adults having planned abdominal surgery will be randomly assigned to have their dressing removed on day 1 or day 6. The ma…

This study looks at how parents can help their deaf children develop language after early cochlear implant surgery. Researchers will use a special recording device called LENA to measure conversations at home. The goal is to see if speech therapy guidance based on LENA data impro…

This study looks at whether people with disorders of consciousness (like coma or minimally conscious state) can form and recall memories. Researchers will use EEG and skin sensors to detect memory-related brain activity in 175 participants. The goal is to better understand these …

This study looks at 70 adults having knee surgery to see how often the numbing medicine used in a standard adductor canal block spreads to the nearby sciatic nerve. Researchers will test sensation and movement in the foot and leg one and four hours after the block. The goal is to…

This study aims to develop and validate questionnaires that help children describe their breathing difficulties more precisely. Researchers will test these tools in 400 children aged 6 to 17 with acute or chronic breathing problems. The goal is to improve how doctors assess and m…

This study tests a new questionnaire that measures how well patients stick to a bowel management technique called transanal irrigation. About 100 adults who have used the method for at least one month will fill out the questionnaire. The goal is to identify who is having trouble …

This study looks at whether a simple breathing test done at home can tell doctors how well a nighttime breathing machine is working for people with neuromuscular diseases. About 25 adults who just started using a breathing machine at night will take part. The goal is to see if th…

This study collects leftover blood, urine, and other samples from 800 hospitalized adults to create a biobank. The samples are used to develop and test rapid diagnostic tools for emerging infectious diseases and chemical, biological, radiological, and nuclear threats. No extra pr…

This study looks at how medical care affects the quality of life of pregnant women living with HIV. About 100 women will fill out surveys during pregnancy and one year after giving birth. The goal is to learn what helps or hurts their well-being so hospitals can improve care.

This study will follow 3,000 adults with cirrhosis or who have had a liver transplant at a French hospital. Researchers will track survival and complications like bleeding or infections. The goal is to learn how to improve patient care over time. No new treatments are being teste…

This study looks at 2,000 cancer patients who visit an emergency department to see if going to their usual cancer hospital leads to better outcomes than going to another hospital. The goal is to understand whether specialized emergency care improves survival and reduces time spen…

This study looks at how well people with frontotemporal dementia or Alzheimer's disease can recognize emotions in others and how aware they are of their own performance. Researchers will ask 34 participants (ages 50-80) to complete computer tasks and confidence ratings. No treatm…

This study looks at whether the position a person is in during a bladder test (lying down vs sitting) affects the diagnosis of overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from both positions in 160 patients to see …

This study looks at how the hepatitis B vaccine activates T-cells, a key part of the immune system, in healthy adults. Researchers want to understand why some people have a stronger T-cell response and how that relates to long-term protection. The goal is to improve future vaccin…

This study is testing whether adding MRI scans to standard ultrasound can help doctors better see and diagnose birth defects in unborn babies. About 1500 pregnant women will get a fetal MRI to check if it provides clearer details than ultrasound alone. The goal is to improve how …

This study looks at how anti-infective medicines (like antibiotics) behave in critically ill children. The goal is to understand why drug levels vary so much and to find the right dose for each child. Researchers will collect blood samples and health data from 3,000 children in i…

This study is testing whether measuring a protein called EDN in urine, blood, or esophageal brushings can help monitor eosinophilic esophagitis in children without needing repeated endoscopies. Researchers will collect samples from 60 children undergoing upper GI endoscopy for di…

This study looks at whether certain proteins in the blood can help predict how severe juvenile idiopathic arthritis (JIA) will become. Researchers will measure these markers in 300 teenagers and young adults with JIA and track their joint damage and treatments over time. The goal…

This study aims to find out how often young children (ages 1 to 6) with inherited metabolic diseases who follow special diets develop eating disorders. Researchers will use a feeding scale to assess 200 children. The goal is to better understand and identify these eating problems…

This study looks at how well patients with inherited metabolic diseases follow their daily oral medication plans. Researchers will survey 200 patients and their parents at Necker Hospital to measure adherence and assess disease knowledge. The goal is to see if a special education…

This study aims to understand how sleep-disordered breathing (like snoring or pauses in breathing during sleep) affects thinking, mood, and behavior in children and young adults aged 1 to 20. Researchers will compare sleep test results with questionnaires and cognitive tests in 1…

This study follows 600 people with birdshot chorioretinopathy, a rare inflammatory eye disease that affects the retina and choroid. Researchers will use eye exams, imaging, and genetic tests to better understand the disease and find factors that may increase risk. No new treatmen…

This study checks if too much iron in the body causes liver problems in people who had a stem cell transplant more than 10 years ago. About 500 adults will have their medical history reviewed and get a special liver scan. The goal is to learn if treating iron overload can prevent…

This study follows 12 people who survived a cardiac arrest and received ultra-rapid cooling to protect their brain and heart. Researchers will check their health and survival over 5 years by phone and medical records. The goal is to learn about long-term outcomes after this exper…

This study looks at why blood clots form in the portal vein (a major liver vein) in people with liver cirrhosis. Researchers will take blood samples from two different veins during a routine procedure called TIPS to compare clotting activity. The goal is to understand how local a…

This study looks at how immune cells called macrophages work in people with certain rare brain diseases (X-ALD, MLD, and ALSP). Researchers will collect one blood sample from 100 participants during a regular check-up. The goal is to learn if these diseases cause a specific immun…

This study looks at how children with Angelman syndrome (a rare genetic disorder causing severe developmental delays) pay attention to social cues compared to healthy children. Researchers will use eye-tracking technology to measure where kids look when watching social scenes. Th…

This study investigates whether chronic infections with enteric (gut) viruses can cause long-term liver inflammation and damage in people with primary or secondary immune deficiencies. Researchers will collect blood, stool, and urine samples from 120 participants across four grou…

This study follows 130 adults with hypophosphatasia, a rare bone disease, to see how long it takes to get diagnosed and what symptoms appear first. Researchers will also look at non-bone symptoms like joint calcifications. No treatments are tested—only information is collected fr…

This study looks at whether giving albumin (a protein in blood) during the first day after a severe burn can reduce death, kidney failure, or lung injury. Researchers will follow 200 adults with burns over 30% of their body who are admitted to the ICU within 12 hours. The goal is…

This study looks at whether a blood test that measures donor DNA can help doctors decide when a kidney biopsy is truly needed after a transplant. About 500 kidney transplant recipients will be split into two groups: one gets standard care with scheduled biopsies, and the other ge…

This study looks at whether CAR-T cell therapy, a new immune treatment for blood cancers, can cause early heart problems. Researchers will check heart function with ultrasound before and a few days after treatment in 60 patients. The goal is to find out how often heart issues hap…

This study aims to understand how the brain is different in people with autism, especially in areas related to social thinking. Researchers will use MRI scans and eye-tracking tests to compare brain structure and function between 160 people with autism and healthy volunteers. The…

This study looks at whether 3D models of children's tumors are better than regular 2D scans for planning surgery. About 60 children with pelvic or retroperitoneal tumors will take part. Surgeons and parents will answer questions comparing the two types of images to see if 3D help…

This study compares two types of lung cancer surgery—traditional open surgery (thoracotomy) and newer, less invasive methods (video-assisted or robotic surgery). The goal is to understand why patients who have minimally invasive surgery often have fewer complications and a better…

This study follows 1,200 people from two memory clinics in Paris to see if sleep patterns and other personal factors are linked to different types and stages of dementia. Researchers will track participants for up to 15 years using routine clinic visits. The goal is to find simpl…

This study interviews 90 teens with anorexia, their parents, and healthcare professionals to understand their experiences with psychiatric drugs. The goal is to learn about perceptions and feelings, not to test a new treatment. No medication is given as part of this research.

This study aims to better understand amyotrophic lateral sclerosis (ALS) by growing skin cells from patients in the lab. Researchers will collect skin biopsies and blood samples from 110 adults, including people with ALS, healthy carriers of ALS-related gene mutations, and contro…

This study looks at whether children with multiple sclerosis (MS) can repair myelin, the protective coating around nerves, better than adults. Researchers will use special MRI scans to measure myelin repair in the brain's cortex. The study involves 40 children aged 12-18 with MS …

This study follows 425 adults with recent psoriatic arthritis (PsA) for up to 10 years to see who develops joint damage and why. Researchers will use X-rays and other data to find early signs of aggressive disease. The goal is to help doctors identify high-risk patients sooner an…

This study tests whether measuring pressure inside the chest can help doctors set breathing machines better for severely obese patients with acute lung injury. About 40 adults with a BMI over 40 and moderate to severe ARDS will take part. Researchers will use a special tube to me…

This study looks at 40 ICU patients on breathing machines to see if the ventilator mode affects how well chest physiotherapy works. The goal is to find out if one mode helps clear mucus and improve lung function better than the other. Results may help doctors choose the best vent…

This study aims to learn more about how the spleen filters blood cells and fights infections. Researchers will study spleens removed from 100 adult patients during surgery. By pumping blood through the spleens in the lab, they hope to understand the spleen's role in diseases like…

This study looks at whether a non-invasive digital cuff can accurately measure blood pressure continuously during carotid artery surgery, instead of the usual invasive arterial catheter. The catheter, while standard, can cause discomfort and complications like infection or blocke…

This study looks at how vasoplegic syndrome—a serious drop in blood pressure after heart surgery—affects the adrenal glands. Researchers will measure stress hormones in 200 adults using advanced lab tests. The goal is to better understand this complication, not to test a new trea…

This study is looking back at the health records of over 1,200 people who survived a rare, life-threatening blood disorder called immune thrombotic thrombocytopenic purpura (iTTP). The goal is to understand their long-term health, especially heart and brain problems, and how diff…

This study looks at how slow brain waves during sleep and wakefulness are linked to memory and attention problems in normal aging and early Alzheimer's disease. Researchers will study 90 people: young adults, healthy seniors, and those with early-stage Alzheimer's. They aim to un…

This study looks at whether a special health program (PEGASE) helps young children in foster care have better mental and physical health. About 220 children under 3.5 years old will be followed for 2 years. The program provides regular medical and mental health check-ups, and the…

This study tests a new tool called PRECOM that uses brain wave signals to predict whether comatose patients after cardiac arrest will wake up within 3 months. Researchers will enroll 100 adults in French ICUs who remain in a coma 3 days after cardiac arrest. The goal is to see if…

This study follows 900 couples in Paris who tried preimplantation genetic diagnosis (PGD) to avoid passing on severe genetic disorders but did not have a baby from the procedure. Researchers want to learn how many later had a healthy child through other means, and why some couple…

This observational study aims to identify biomarkers in blood and joint fluid that can predict how knee osteoarthritis will progress over time. Researchers will follow 300 participants with knee pain for up to 10 years, collecting samples and tracking symptoms, X-ray changes, and…