Assistance Publique - Hôpitaux De Paris

This study tested a special device called Vigi'Fall® that detects when an elderly person falls at home. Researchers wanted to see if using the device could help seniors get to the hospital faster and reduce deaths after a fall. The study planned to include 200 people over 75 livi…

This study tested a way to improve stem cell transplants for children with combined immunodeficiency (CID), a condition where the immune system doesn't work properly. The approach removed certain naive cells from the donor stem cells to try to prevent graft-versus-host disease (a…

This study tested whether doing an early endoscopic ultrasound and removing any gallstones from the bile duct could help people with severe pancreatitis caused by gallstones. The trial planned to enroll many patients but was stopped early after only 27 participants. The main goal…

This study looked at whether a daily inhaled medicine (fluticasone and salmeterol) could improve lung function in children aged 6–17 who had a stem cell transplant and showed early signs of lung decline. The goal was to prevent a serious lung condition called bronchiolitis oblite…

This study aimed to create and validate a screening tool for auditory processing disorder (APD) in children aged 7 to 13. The tool combined a parent/teacher questionnaire with a short set of hearing tests. The goal was to see if it could accurately identify children who need a fu…

This study tested whether giving two drugs—oxytocin and misoprostol—together could prevent postpartum hemorrhage (heavy bleeding) after vaginal birth better than oxytocin alone. The trial planned to include over 1,700 women giving birth at 36 to 42 weeks, but it was terminated ea…

This study looked at whether a breathing machine (non-invasive ventilation) could prevent acute chest syndrome, a severe lung problem, in children with sickle cell disease who are in the hospital for a pain crisis. The usual prevention method is spirometry, which requires the chi…

This pilot study looked at whether an interactive storyteller called LUNII could lower anxiety in children aged 4 to 6 with cleft lip and palate before their bone graft surgery. The goal was to see if using the device before the operation would also reduce pain and shorten hospit…

This study looked at whether adding clorazepate to standard treatment can ease migraine attacks in adults visiting the emergency room. It included 323 people with moderate to severe migraine. The trial was terminated before completion, so results are limited.

This study aimed to see if CT colonography (a virtual scan) is more acceptable than standard colonoscopy for detecting advanced polyps in people at high risk for colorectal cancer. It enrolled 39 adults with a personal or family history of advanced polyps or cancer. The trial was…

This study looked at whether a variation in the PDE4 gene influences how well children with persistent asthma respond to the common inhaler drug salbutamol. Researchers measured lung function before and after giving salbutamol to 99 children aged 6 to 18. The goal was to see if t…

This study aimed to find out whether performing surgery within 48 hours of a severe burn (early excision) or later leads to better outcomes. Researchers planned to follow 470 severely burned adults, but the study was terminated early. Because of this, we cannot draw reliable conc…

This study tested whether raising the blood pressure target from 65 mmHg to 85 mmHg in patients with septic shock could help prevent kidney injury. Researchers used a drug called norepinephrine to adjust blood pressure and monitored kidney function. The trial was stopped early an…

This study aimed to measure how well the COVID-19 vaccine triggers an immune response in people with autoimmune or inflammatory diseases who take immunosuppressants or biologics. Researchers planned to enroll 78 adults, but the study was stopped early. The goal was to understand …

This study aimed to understand how growth hormone treatment affects growth and metabolism in children who were born small for gestational age and remained short. Researchers planned to compare two different ways of giving the hormone and look at genetic factors. Only 10 children …

This study looked at whether an online video simulator helps surgeons learn a specific type of prostate cancer surgery (laparoscopic radical prostatectomy). It involved 29 surgeons who were new to the procedure. The main goal was to see if the simulator reduced surgery time and i…

This study aimed to see if certain immune cells in the blood could predict which patients with advanced liver cancer would benefit from a combination of immunotherapy drugs (Atezolizumab and Bevacizumab). Researchers planned to measure these cells before and after starting treatm…

This study aimed to understand how age influences serious health issues like infections, cancer, heart disease, and bone fractures in people with rheumatoid arthritis. Researchers compared patients over 65 with younger adults (18-50) who had the same disease. The study was stoppe…

This study aimed to track four markers of bone turnover in the blood and urine of multiple myeloma patients receiving intravenous bisphosphonates, a standard bone-strengthening treatment. Only 3 patients were enrolled before the study was terminated, so results are very limited. …

This study looked at whether immunosuppressive medications used for rheumatoid arthritis or spondyloarthritis change how the body fights a COVID-19 infection. Researchers compared 150 patients on these drugs with infected family members not on the same treatments. The goal was to…

This study aimed to understand what happens in the mind during sleep by using sound cues in people who sleepwalk. Researchers wanted to see if they could trigger and measure mental processes in real time. The study was terminated early, so results are limited.

This study aimed to check if women with thrombophilia (a condition that makes blood clot easily) have differences in how their blood vessels work, which might raise their risk for heart problems. Researchers planned to compare blood vessel function in healthy women and those with…

This study looked at whether people with both rheumatoid arthritis and type 2 diabetes have a more severe diabetes course than those with osteoarthritis and diabetes. Researchers tracked 176 adults to see how quickly diabetes treatments were added. The study was stopped early, so…

This study looked at why a common numbing shot for knee surgery works so well. Doctors used ultrasound to see if the medicine spreads to nerves behind the knee. The goal was to measure how often this spread happens in 30 adults having knee surgery. The study was stopped early, bu…

This study aimed to find the best level of a drug called mycophenolate mofetil (MMF) in the blood to improve skin tightness and lung function in people with systemic sclerosis. Only 2 people joined before the study was stopped early. The research was designed to see if measuring …