Assistance Publique - Hôpitaux De Paris

This study tests whether regular email check-ins can help people with gout reach and maintain safe urate levels, which can dissolve crystals and cure the disease. About 204 adults with gout will either get usual care or email-guided dose adjustments of urate-lowering medication. …

This study was designed to see if a web-based fracture liaison service (e-FLS) helps more people over 60 start osteoporosis treatment within a year after a low-trauma fracture, compared to standard fracture liaison services. The study was withdrawn before enrolling any participan…

This study tests whether transferring healthy stool bacteria (fecal transplant) can help people with ulcerative colitis, a chronic gut disease. About 150 adults with active symptoms will receive either a real transplant or a sham procedure. The goal is to see if the treatment can…

This study tests a drug called ivabradine to see if it can safely lower heart rate in adults with septic shock, a life-threatening infection that causes very fast heartbeats. Unlike standard drugs, ivabradine lowers heart rate without weakening the heart's pumping or dropping blo…

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can increase the chance of having a baby after a fertility treatment called ICSI. The trial involves 366 couples where the woman is under 37 years old. Researchers will compare liv…

This study was designed to test a combination of two experimental drugs, monalizumab and MEDI5752, in people with metastatic cancers that have a specific genetic feature called MSI or dMMR. The goal was to see if the combination could shrink tumors. However, the trial was withdra…

This study tests whether electronic cigarettes containing nicotine help people quit smoking better than a standard stop-smoking medication (varenicline) or e-cigarettes without nicotine. About 650 adult smokers who want to quit will use one of these options for 12 weeks. The main…

This study tests whether giving a short course (48 hours) of tocolysis—medication that stops contractions—can reduce death or serious health problems in babies born after preterm premature rupture of membranes (PPROM) between 22 and 33 weeks of pregnancy. About 857 pregnant peopl…

This study follows 50 adults with tophaceous gout to see how urate-lowering therapy reduces crystal deposits in hands and feet over 6 months. Using a special CT scan, researchers measure changes in crystal volume and check if bone erosions heal. The goal is to understand why some…

This study tests whether telling smokers their 'pulmonary age' (how old their lungs act compared to their real age) helps them quit. About 100 adult smokers will visit their doctor, get a lung age test or standard care, and be followed for 12 months. The main goal is to see if mo…

This study tests a machine that keeps donor hearts alive outside the body for a longer time before transplant. The goal is to see if these hearts work well within 15 days after surgery. About 20 adults with severe heart failure who cannot get a standard transplant will take part.

This study tests whether giving two immunotherapy drugs (durvalumab and tremelimumab) before and after a standard liver cancer ablation procedure can help keep the cancer from coming back. About 30 adults with early-stage liver cancer will receive one infusion of the drug combina…

This study aimed to see if adding hydroxychloroquine to standard treatment (aspirin and blood thinners) could help more women with antiphospholipid syndrome have a healthy full-term pregnancy. The trial was withdrawn before any participants were enrolled, so no results are availa…

This study planned to test the drug eculizumab in kidney transplant patients who had signs of rejection not yet causing symptoms. The goal was to see if blocking part of the immune system could prevent long-term kidney damage. However, the trial was withdrawn before enrolling any…

This study looks at whether routine blood tests that screen for fetal genetic conditions can also detect signs of cancer in pregnant women. Researchers will analyze DNA from 300 pregnant women with known or suspected cancer to identify specific chromosomal patterns linked to mali…

This study looks at whether people with early Alzheimer's disease can follow a ketogenic diet (high fat, low carb) for a full year. The diet may provide an alternative fuel for the brain and reduce inflammation. Researchers will measure brain changes with PET scans and track thin…

This study was designed to see if an educational game called Yapouni could help children aged 3 to 16 and their parents feel more comfortable with CPAP or NIV machines used for sleep breathing problems. The study planned to compare standard teaching versus teaching plus the game,…

This study aimed to find out if a patient's body language and behavior during a pre-surgery chat with a nurse could reveal how anxious they feel. Researchers planned to video record interviews and compare behaviors to anxiety questionnaires. However, the study was withdrawn befor…

This study was designed to watch how doctors treat cataracts in children, looking at different surgery methods and implant types. It planned to include children aged 0 to 17 having cataract surgery at one hospital in France. However, the study was withdrawn before any participant…

This study was designed to look at how a type of birth control pill (macro-progestins) affects bone health in young women aged 16 to 25. Researchers planned to review medical records and run blood and urine tests to measure bone density and related markers. However, the study was…

This study aimed to see if a small thermal camera that attaches to a smartphone could help doctors tell how deep a child's burn is. Deep burns often need skin grafts, but it can be hard to tell right away. The researchers planned to measure temperature differences between burned …

This study was designed to learn how the protein calprotectin changes blood stem cells in people with severe COVID-19 or certain blood cancers. Researchers planned to compare cells from patients and healthy adults in lab tests. However, the study was withdrawn before any particip…

This study looks at whether a fast, painless eye test (automated pupillometry) can predict delirium—a state of sudden confusion—in intensive care patients who need a breathing machine. Delirium is common and serious, but current screening methods take time and training. The resea…

This study aimed to translate and validate a French version of a questionnaire that measures quality of life in children with chronic otitis media (long-term ear infections). Researchers planned to compare responses from children with and without the condition to see if the quest…

This study was designed to investigate whether new skin lesions on fingers or toes were linked to COVID-19. It planned to test adults with these symptoms for the virus using PCR and antibody tests. However, the study was withdrawn before enrolling any participants, so no results …

This study aimed to understand how remote therapeutic education via videoconferencing works for people with chronic diseases and their caregivers. Researchers planned to interview patients, parents, and healthcare providers to learn about their experiences. However, the study was…

This study follows 362 children with severe asthma to identify different types of the disease and what makes it worse. Researchers will track their health from childhood into adulthood to find factors that lead to severe asthma. The goal is to better understand the disease, not t…

This study looks at whether using a connected scale that tracks body composition (not just weight) can improve the physical and mental quality of life for people with chronic diseases. About 90 adults will take part in a 6-week physical activity rehab program. Half will use the s…

This study explores freezing ovarian tissue in girls with Turner syndrome, a condition that often leads to early ovarian failure and infertility. Researchers aim to find which patients are most likely to have healthy eggs in their tissue, using genetic, hormonal, and clinical clu…

This study looks at how well vaginal self-sampling works for detecting high-risk HPV in women aged 30-65 who have immune-mediated inflammatory diseases like lupus or Sjögren's syndrome. Researchers will track HPV infection rates, types, and clearance over one year. The goal is to…

This study follows 98 new mothers who received a blood patch to treat a severe headache caused by an accidental spinal fluid leak during labor. Researchers want to find out if certain factors during the blood patch procedure are linked to headaches that last for months. Participa…

This study aimed to track heart muscle changes over time in people with Duchenne muscular dystrophy using MRI scans and blood tests. It was designed for children aged 6 and older with a confirmed genetic diagnosis. However, the study was withdrawn before enrolling any participant…

This study follows 25 people with limb-girdle muscular dystrophy 2A (LGMD2A) to measure how their muscle strength and quality of life change over time. Participants must have a confirmed genetic diagnosis and be able to perform muscle tests. The goal is to better understand the n…

This study follows 69 adults infected with HTLV-1, a virus that can cause a rare type of blood cancer (adult T-cell leukemia/lymphoma). Researchers are tracking how long people live and how the virus behaves in the body. The goal is to better understand the disease and its long-t…

This study was designed to see if a test measuring how well the lung's blood vessels relax could predict whether a person would develop high blood pressure in the lungs one year after having a heart shunt closed. It planned to include both children and adults with congenital hear…

This study is testing a new, non-invasive 3D imaging technique to measure how much air the lungs can hold in people with suspected diaphragm weakness. Researchers will compare results from a trained technician and a lung doctor to see if the method is reliable. The goal is to mak…

This study aimed to look back at the safety and effectiveness of hydroxychloroquine in children with Lipin-1 deficiency, a rare genetic condition causing severe muscle breakdown and pain. Researchers planned to review medical records of patients who had already received the drug …

This study was designed to see if MRI can measure blood flow in the placenta during pregnancy, especially in cases where the baby is not growing well (called IUGR). The researchers planned to compare MRI scans from pregnant women with and without growth problems. However, the stu…

This study looks at whether a new way of analyzing CT scans (called radiomics) can help doctors tell early on if chemotherapy is working for people with advanced pancreatic cancer. Researchers will study 400 adults with metastatic pancreatic cancer who are starting their first ro…

This study planned to follow nursing mothers who had a breast abscess treated with ultrasound-guided puncture. Researchers wanted to learn what factors help women continue breastfeeding and whether the treatment followed best practices. However, the study was withdrawn before enr…