Assistance Publique - Hôpitaux De Paris

This study planned to test whether a direct injection of potassium chloride could help people whose hearts had stopped and were not responding to standard shocks. The trial was withdrawn before any patients were enrolled, so no results are available.

This study tests whether giving nifedipine, a drug that relaxes the uterus, for 48 hours can improve health outcomes for babies when a pregnant person's water breaks too early (between 22 and 34 weeks). About 857 participants will receive either nifedipine or a placebo. The goal …

This study tests whether regular email communication between gout patients and their doctors can help lower uric acid levels more effectively than standard care. 204 adults with confirmed gout will either follow usual care or use a secure messaging system to adjust their medicati…

This study tests whether a drug called mepolizumab can help people with a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA) reach remission better than standard treatments. About 100 adults with active EGPA will receive either mepolizumab or usual care, and…

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis, a chronic bowel disease. About 150 adults with active or steroid-dependent disease will receive either real fecal transplants or a sham procedure. The goal is to see i…

This study tests whether myo-inositol, an oral dietary supplement, can help pregnant women with gestational diabetes control their blood sugar without needing insulin shots. About 1,080 women with newly diagnosed gestational diabetes will receive either myo-inositol or a placebo …

This was a planned Phase 2 trial to test two immunotherapy drugs—monalizumab and MEDI5752—in people with metastatic cancers that have a specific genetic feature called MSI/dMMR. The study was withdrawn before enrolling any participants, so no data or results are available. The go…

This study aimed to test the drug eculizumab (Soliris) in kidney transplant recipients who had signs of early, hidden rejection. The goal was to see if blocking part of the immune system could prevent long-term damage. However, the trial was withdrawn before any participants were…

This phase 3 trial tests whether metformin, a standard diabetes drug, can reduce calcium buildup in leg arteries of people with type 1 diabetes. 230 adults with type 1 diabetes and some complications or risk factors will take either metformin or a placebo for two years. The main …

This study tests whether telling smokers their 'pulmonary age' (how old their lungs act compared to their real age) helps them quit. About 100 adult smokers will either get their lung age measured or just standard advice. The main goal is to see if more people stop smoking after …

This study aimed to see if adding hydroxychloroquine to standard treatment (aspirin and blood thinners) could help more women with antiphospholipid syndrome have healthy, full-term pregnancies. The trial planned to enroll pregnant women before 14 weeks, but it was withdrawn and n…

This study tests whether using a connected scale at home can help people who had bariatric surgery avoid regaining too much weight. About 182 adults who had surgery one year ago will either get standard follow-up or also weigh themselves weekly with a smart scale. If the scale sh…

This study looks at how to best give a chemotherapy drug called pegaspargase to children and teenagers with acute lymphoblastic leukemia (ALL). About 2,000 participants will either get one large dose or two smaller doses of the drug during treatment. The goal is to see which meth…

This study compares nicotine e-cigarettes, nicotine-free e-cigarettes, and the medication varenicline to see which works best for helping people quit smoking. About 650 adult smokers who want to quit will take part. The main goal is to see who can stay away from regular cigarette…

This study tests if adding evolocumab (a powerful cholesterol-lowering injection) to standard care helps heart attack patients reach very low LDL cholesterol goals and reduces the risk of death or unplanned hospital visits. About 2,166 adults who had a recent heart attack and nee…

This study tests a minimally invasive procedure called radiofrequency to treat thyroid cancer that has spread to lymph nodes in the neck. It involves 14 adults who have already had surgery and radioactive iodine therapy. The goal is to see if the heat-based treatment can shrink o…

This study tests a machine that keeps donor hearts alive outside the body for a longer time before transplant. It involves 20 adults with severe heart failure who cannot get a heart through standard methods. The goal is to see if the heart works well within 15 days after the tran…

This study tests whether a blood pressure medication (angiotensin receptor blocker) can reduce the risk of major heart problems and kidney disease in patients who had acute kidney injury while in the intensive care unit (ICU). About 508 adults aged 18-75 who have recovered from a…

This phase 2 trial tests whether giving two immunotherapy drugs (durvalumab and tremelimumab) before and after a standard tumor-burning procedure (ablation) can help prevent liver cancer from coming back. About 30 adults with early-stage liver cancer will receive one infusion of …

This study tests whether adding the drug lenvatinib before and after a standard tumor-burning procedure (ablation) can prevent liver cancer from returning in patients with aggressive tumors. About 32 adults with high-risk features (like high AFP levels or infiltrative tumors) wil…

This study aimed to see if a web-based service (e-FLS) could help more people over 60 start osteoporosis treatment after a low-trauma fracture, compared to standard care. The trial was withdrawn before any participants were enrolled, so no results are available. It was designed t…

This study tests whether an oral medicine called glibenclamide can control high blood sugar in very premature babies (born before 32 weeks and weighing under 1500 grams). The goal is to see if it can be used instead of insulin, which is the current standard treatment. The study i…

This study looks at adults with sarcoidosis who are in remission after taking the drug infliximab. It compares two strategies: stopping the drug versus continuing it, to see which better prevents the disease from coming back. The goal is to find the safest and most effective way …

This study tests a drug called ivabradine in 429 adults with septic shock, a life-threatening condition where infection causes dangerously low blood pressure. Many patients develop a fast heart rate, which can worsen outcomes. Ivabradine slows the heart without weakening its pump…

This study aimed to see if a surgical procedure called scleral buckling could prevent retinal detachment in people with Stickler syndrome, a genetic condition that raises the risk of vision loss. It planned to enroll patients aged 5 to 35 who had already had a retinal detachment …

This study was designed to see if treating a common stomach bacteria (H. pylori) along with using a stomach acid drug could prevent ulcers caused by low-dose aspirin. It planned to enroll adults with heart or artery disease who needed long-term aspirin therapy. However, the study…

This study tests a therapy where parents of children with autism (ages 1.5 to 3) get video feedback to help them better understand and respond to their child's cues. The goal is to improve joint attention and parent-child interaction. Only 27 families are taking part, so results …

This study tests if anakinra is better than prednisone for treating gout flares in people with advanced chronic kidney disease or who have had a kidney transplant. Gout causes sudden, severe joint pain. Standard treatments can be risky for these patients. The study measures pain …

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can increase the number of live births in women under 37 who are having a type of IVF called ICSI. About 366 couples took part. The goal is to see if this simple change can improve…

This study looks at whether a ketogenic diet (high-fat, low-carb) is practical and safe for people with early-stage Alzheimer's disease over one year. The diet may provide an alternative energy source for the brain and reduce inflammation. Researchers will track diet adherence, b…

This study looks at whether analyzing CT scans with a computer technique called radiomics can predict which patients with advanced pancreatic cancer will not respond to chemotherapy. Researchers will study 400 patients and track survival over time. The goal is to find early signs…

This study observes 150 adults in French intensive care units who have an infected hip, knee, or shoulder prosthesis. Researchers will track their care, recovery, and survival for two years. The goal is to describe patient profiles and identify factors linked to better or worse o…

This study aimed to find out if video recordings of pre-surgery interviews could reveal behavioral signs of anxiety in day-surgery patients. Researchers planned to compare these signs with patients' own reports of anxiety. However, the study was withdrawn before enrolling any par…

This study was designed to see if a special MRI technique could measure how well a fetus's lungs work, especially in babies with diaphragmatic hernia or abdominal wall defects. Researchers planned to compare MRI results with how the baby breathed after birth. However, the study w…

This study was designed to translate and validate a questionnaire that measures quality of life in children with chronic otitis media (long-term ear infections). Researchers planned to have children aged 7 to 15 with and without ear infections fill out the French version of the C…

This study follows 73 young women with breast cancer to see if certain genes make them more likely to lose fertility after chemotherapy. Researchers measure ovarian reserve (egg supply) before and up to 5 years after treatment. The goal is to better predict who might face fertili…

This study follows 69 adults infected with HTLV-1, a virus that can cause a rare type of blood cancer (adult T-cell leukemia/lymphoma). Researchers are tracking how long people survive, whether they receive treatment or not, and analyzing their blood and tumor cells. The goal is …

This study aimed to help doctors and nurses spot delirium in children in the pediatric intensive care unit (PICU) using a French version of a standard checklist called the CAPD. The goal was to find out how common delirium is in this setting. However, the study was withdrawn befo…

This study was designed to track heart muscle changes in people with Duchenne muscular dystrophy using two cardiac MRIs taken two years apart, along with blood tests for heart failure markers. It planned to enroll participants aged 6 and older with a confirmed genetic diagnosis. …

This study follows 35 infants with spinal muscular atrophy (SMA) who are receiving innovative therapies like gene therapy. Researchers use wearable motion sensors to measure how well the babies move their arms and legs over two years. The goal is to develop a more accurate way to…

This study planned to test whether a thermal camera attached to a smartphone could help doctors decide how deep a child's burn is, which guides whether surgery is needed. It was designed for children under 18 with second-degree burns covering less than 10% of their body. However,…

This study tests a new care protocol (EXPRIM) for extremely preterm infants born between 22 and 26 weeks. The protocol involves early counseling, standardized steroid use, and team-based decisions. Researchers will compare survival without severe health problems in 2377 babies ac…

This study was designed to observe how well medications like antidepressants and anti-androgens work over time for men with paraphilia who have committed sex offenses, and what side effects occur. It planned to follow participants for three years, but was withdrawn before enrolli…

This study looks at whether the standard blood test given to pregnant women to screen for fetal conditions can also detect signs of cancer in the mother. Researchers will analyze DNA from 300 pregnant women with known or newly diagnosed cancer to identify specific chromosomal pat…

This study looked at nursing mothers who had a breast abscess drained using ultrasound guidance. The goal was to understand why abscesses happen and whether women can safely continue breastfeeding after treatment. However, the study was withdrawn before enrolling any participants…

This study looks at how well vaginal self-sampling works to find high-risk HPV infections in women aged 30-65 who have immune-mediated inflammatory diseases like lupus or Sjögren's syndrome. Researchers will check HPV rates, types, and how the infection changes over a year. The g…

This study planned to create artificial intelligence tools that could diagnose kidney transplant rejection using urine tests instead of invasive biopsies. Researchers wanted to combine urine markers with standard medical data to make diagnosis safer and easier. However, the study…

This study planned to see if faster testing and treatment for hepatitis C could be given to inmates right when they enter prison. The goal was to start medication sooner to reduce the spread of the virus. However, the study was withdrawn and no one took part.

This study collects blood samples from 500 people with rare diseases of the brain's blood vessels. The goal is to find markers that can predict how the disease will progress or point to new treatments. Participants must have a confirmed diagnosis of a rare cerebrovascular conditi…

This study was designed to learn how the protein calprotectin might change blood stem cells in people with severe COVID-19 or certain blood cancers. Researchers planned to compare cells from patients and healthy donors in the lab. However, the study was withdrawn before any parti…

This study aimed to learn how video calls affect education sessions for people with chronic diseases and their caregivers. It planned to interview patients, parents, and healthcare workers about their experiences. However, the study was withdrawn before enrolling any participants…

This study was designed to look back at the safety and effectiveness of hydroxychloroquine given to children with Lipin-1 deficiency, a rare genetic condition that causes severe muscle breakdown and pain. The researchers planned to review medical records of patients who had alrea…

This study was designed to investigate whether new skin lesions on fingers or toes were linked to COVID-19. It planned to test adults with these lesions for the virus using PCR and antibody tests. However, the study was withdrawn before enrolling any participants, so no results a…

This study looks at whether a fast, automatic eye test can predict delirium (sudden confusion) in intensive care patients who need a breathing machine. Delirium is common and serious, but current screening methods take time and training. Researchers will measure pupil reactions i…

This study aimed to develop a new questionnaire to better understand how lumbar spinal stenosis limits daily activities. It planned to include patients aged 50 and older with the condition. However, the study was withdrawn before any participants were enrolled, so no results are …

This study looks at 100 adults hospitalized in intensive care units with severe pneumonia caused by Mycoplasma or Chlamydia bacteria. Researchers will track how patients are treated, how long they stay in the hospital, and how often the bacteria resist common antibiotics. The goa…

This study was designed to compare certain immune cells (called ILC2) in the lungs of children with severe asthma versus children without asthma. The goal was to see if these cells are higher in asthmatic children and if they relate to other markers of airway inflammation. Howeve…

This study planned to observe different surgical approaches for children with cataracts, focusing on implant types and surgery timing. It was withdrawn before enrolling any participants, so no information was collected. The goal was to understand which strategies work best for yo…

This study was designed to follow women with rare autoimmune diseases (like lupus, arthritis, and scleroderma) during pregnancy to learn about complications and improve care. It was withdrawn before any participants were enrolled, so no results are available. The goal was to help…

This study looks at freezing ovarian tissue in girls with Turner syndrome, a condition that often causes early ovary failure and infertility. Researchers want to find out which patients are most likely to have healthy eggs in their tissue by checking their genes, hormones, and me…

This study aimed to see if a simple breathing test (Müller maneuver) could predict which patients on ventilators would develop fluid in their lungs during a weaning trial. The test measures changes in heart output to assess fluid status. The study was withdrawn before enrolling a…

This study looks at whether using a connected scale that measures body composition (not just weight) can improve the physical and mental quality of life for people with chronic diseases. About 90 adults will take part in a 6-week physical activity rehab program. Half will use the…

This study planned to train 400 hospital workers each year using realistic emergency drills for children. Researchers wanted to see if the training boosted staff confidence, teamwork, and reduced stress. However, the study was withdrawn before enrolling any participants, so no re…

This study aims to find genetic and metabolic markers that explain why some people develop diabetes, high blood pressure, or bone loss from glucocorticoids while others do not. Researchers will analyze blood and urine samples from up to 600 participants, including those with exce…

This study was designed to observe brain wave (EEG) changes in adults with chronic neuropathic pain during ketamine treatment. Researchers hoped to find patterns that could predict which patients benefit most. However, the study was withdrawn before enrolling any participants, so…

This study aimed to measure two proteins, ACE2 and TMPRSS2, in tonsils and adenoids of children and adults. These proteins help the COVID-19 virus enter cells. The goal was to understand where the virus might enter the body. However, the study was withdrawn before any participant…

This study planned to find out how often teenagers with juvenile idiopathic arthritis experience chronic pain, especially when their arthritis seems quiet or mild. Researchers wanted to measure pain intensity and how it affects daily life, school, sleep, and social activities. Th…

This study is creating a large group of HIV patients to collect information about their health over time. Researchers will look at heart and brain health, medical history, and how well current HIV medicines work. The goal is to learn more about HIV and improve care, not to test n…

This study was designed to see if a special MRI technique could measure blood flow in the placenta during pregnancy. The goal was to compare placentas in pregnancies where the baby is growing poorly (IUGR) with healthy pregnancies. However, the study was withdrawn before any part…

This study follows 362 children with severe asthma to learn what makes their asthma worse and how it changes as they grow up. Researchers will also compare them to children with milder asthma. The goal is to find better ways to predict and manage severe asthma, not to test a new …

This study aimed to see if an educational game called Yapouni could help children aged 3 to 16 with severe sleep apnea feel better about using CPAP or NIV breathing machines at night. The plan was to compare standard teaching with teaching plus the game, measuring parents' and ch…

This study follows 25 adults with limb-girdle muscular dystrophy 2A (LGMD2A) to measure how their muscle strength and quality of life change over time. Researchers will test arm and leg muscle strength using manual tests and motor scales. The goal is to better understand the natu…

This study looks at how urate-lowering therapy reduces gout crystals in the hands and feet of 50 adults with tophaceous gout. Using a special CT scan, researchers measure crystal shrinkage after 6 months of treatment. The goal is to understand what factors help crystals dissolve …

This study was planned to learn how certain rare genetic mutations disrupt protein production and cause severe diseases affecting the lungs, liver, brain, and digestion. Researchers would have used cells from patients to measure protein levels and stress responses. However, the s…

This study planned to test whether a connected toothbrush (ARA 2) helps children with cleft lip and palate keep their mouths cleaner before a bone graft surgery. It aimed to enroll kids aged 5 to 12 who were about to have the surgery. However, the study was withdrawn before any p…

This study tests a new 3D imaging method to measure how much air the lungs can hold in people with suspected diaphragm weakness. About 100 adults will have two quick 3D scans while holding their breath. The goal is to see if this technique gives reliable results compared to stand…

This study was designed to track hidden symptoms like memory or concentration problems in people recovering from a brain bleed (subarachnoid hemorrhage). Researchers planned to follow patients for one year using questionnaires to see how these symptoms affected daily life and ret…

This study aimed to see if a test measuring how well lung blood vessels widen could predict whether a person with a congenital heart shunt would develop pulmonary hypertension one year after shunt closure. The test involved giving acetylcholine and measuring blood flow. However, …

This study aimed to look at bone health in young women aged 16 to 25 who took a specific type of birth control pill (macro-progestins) for at least six months. Researchers planned to review medical records and run blood and urine tests to see if these pills affected bone density.…

This study is looking at two substances in the blood, called Activin-A and FSTL3, to see if they can help predict how people with pulmonary hypertension will do over time. Researchers will follow 550 adults with different types of this condition to see if these markers are linked…

This study tests a remote monitoring wristband (Bora Care) to see if it can detect early signs of worsening COPD. 64 people with COPD who have had recent flare-ups are being followed. The goal is to see if the device can alert patients and doctors before a serious attack happens.