Assistance Publique - Hôpitaux De Paris

This Phase 2 trial tests a new combination of three drugs—mezigdomide, carfilzomib, and dexamethasone—in 70 adults with relapsed or refractory multiple myeloma who have already tried lenalidomide and an anti-CD38 antibody. The goal is to see if this combo can slow or stop the can…

This study tests whether tocilizumab, an anti-inflammatory drug already used for rheumatoid arthritis, can reduce joint pain and improve quality of life in people with chronic inflammatory calcium pyrophosphate deposition disease (CPPD) that hasn't improved with standard treatmen…

This phase 2 trial tests whether secukinumab, a drug that blocks IL-17A, can help people with active severe Takayasu arteritis achieve remission and stop taking steroids. About 52 participants will receive either secukinumab injections or standard care (like TNF inhibitors). The …

This phase 3 trial tests whether giving the clot-busting drug tenecteplase before mechanical clot removal improves outcomes for people with large ischemic strokes. About 486 participants will be randomly assigned to receive either the drug plus clot removal or clot removal alone.…

This study tests whether giving a combination of activated charcoal and polyethylene glycol (a laxative) can reduce the amount of poison absorbed in people who have taken a severe overdose of certain drugs and are in intensive care. The trial will include 200 adults who need a br…

This phase 2 trial tests a low-dose immune drug called interleukin-2 (ILT-101) in 22 children aged 6 to 8 with moderate to severe autism whose mothers had an autoimmune condition during pregnancy. The goal is to see if the drug can increase helpful immune cells (Tregs) and improv…

This early study tests whether repeatedly opening the blood-brain barrier with ultrasound is safe and might slow ALS. Twenty-three adults with ALS will receive 9 ultrasound sessions over 24 weeks. The first part checks safety; the second looks for signs of slowing the disease.

This study tests whether adding the drug sildenafil (Revatio) to standard cooling therapy can help prevent brain damage in full-term newborns who suffered oxygen deprivation at birth. The trial will enroll 24 babies and focus on how the drug moves through their bodies. It is a fi…

This phase 3 trial compares a single intravenous dose of temocillin to the standard ceftriaxone shot for treating gonorrhea. The goal is to see if temocillin works just as well while having less impact on the gut's healthy bacteria, which can help prevent the rise of drug-resista…

This phase 3 trial tests whether a lower dose of the chemotherapy drug cyclophosphamide can reduce side effects after a half-matched stem cell transplant for blood cancers. The standard dose often causes complications, so researchers want to see if a lower dose works just as well…

This study tests whether adding a steroid (prednisone) to standard antibiotics can improve joint function in adults with septic arthritis, a serious joint infection. Two hundred participants will receive either prednisone or a placebo for 7 days. The main goal is to see if steroi…

This study tests whether giving one unit of red blood cells to critically ill patients right before removing their breathing tube can reduce the need for re-intubation or death within 7 days. It involves 800 adults at high risk of reintubation, such as those over 65 or with heart…

This study tests whether the steroid prednisolone can slow the decline in lung function for people with fibrotic hypersensitivity pneumonitis, a lung disease caused by inhaling certain substances. About 120 adults with mild to moderate lung impairment will receive either predniso…

This study tests whether transplanting healthy donor stool into the gut can improve liver function in people with primary sclerosing cholangitis (PSC), a rare liver disease often linked to inflammatory bowel disease. 72 adults with both conditions will receive either fecal transp…

This study tests whether giving sepsis patients drugs tailored to their specific biological traits can improve survival and reduce the need for life support. It will enroll 2000 adults and children across multiple countries, using an adaptive platform to test several treatments a…

This study tests a new 6-month treatment called BPaLM for people with multidrug-resistant tuberculosis (MDR-TB). The goal is to see if it works as well as the current 18+ month regimen. About 55 adults in France will receive the shorter treatment, and their outcomes will be compa…

This study will test whether using two OSIA bone conduction implants (one on each side) helps children with severe ear malformations hear better in noisy places compared to using just one implant. Twelve children aged 7 to 17 who already use a bone conduction device will receive …

This study tests whether frozen stool capsules (fecal transplants) can help children aged 8-17 with ulcerative colitis stay in remission. After a colon cleanse and colonoscopy, children will either swallow capsules or receive enemas containing healthy donor stool. The main goal i…

This phase 2 trial tests obinutuzumab, a drug similar to rituximab but possibly stronger, in 30 adults with active cryoglobulinemic vasculitis who did not improve or could not tolerate rituximab. The goal is to see if obinutuzumab can bring the disease under control and allow pat…

This study tests whether giving a combination of three antibiotics to pregnant women who show signs of very early labour (between 18 and 23 weeks) can help prolong the pregnancy and reduce the risk of death or serious health problems for the baby. About 350 participants will be r…

This study tests whether eating fiber-rich snacks (with inulin and pectin) for 28 days, alongside standard care, can improve alcohol withdrawal in adults aged 19-65 with alcohol use disorder. The goal is to reduce gut permeability and support recovery. Participants will provide b…

This study tests a drug called teclistamab in 24 adults with a severe, rapidly worsening lung disease linked to anti-MDA5 antibodies. The disease has a very poor outlook, with only about 25% of patients surviving 90 days without a lung transplant. Teclistamab aims to improve surv…

This study tests whether a combination of three drugs (prednisone, azithromycin, and hydroxychloroquine) can slow lung function decline in adults with interstitial lung disease caused by certain gene variants. About 30 participants will receive either the triple therapy or standa…

This study compares two strategies for starting the drug etoposide in adults with severe hemophagocytic lymphohistiocytosis (HLH) who are in the intensive care unit. HLH is a life-threatening overreaction of the immune system that can cause organ failure. The goal is to see if gi…

This study tests a new way to use breathing machines for people with severe lung failure (ARDS). The goal is to reduce lung damage by using very gentle breaths and adding a machine that helps remove carbon dioxide from the blood. About 290 adults on breathing machines for less th…

This study tests whether adding visits with a nurse, dietitian, and pharmacist to standard care helps more heart attack patients reach their LDL (bad) cholesterol goals. About 230 adults who had a recent heart attack will be randomly assigned to usual follow-up or extra team-base…

This study tests whether a combination of aspirin and folic acid can help people recover from sudden sensorineural hearing loss, a condition where hearing drops sharply over a few days. The researchers believe that improving blood flow to the inner ear may aid recovery. About 142…

This study looks at whether giving the drug rituximab early, when signs of the disease reappear in the blood, can prevent relapses in people with certain types of vasculitis (GPA and MPA). About 70 adults who have been on maintenance rituximab for at least 18 months will be rando…

This study tests biologic drugs for folliculitis decalvans, a rare scalp disease that causes painful pustules and permanent hair loss. Current antibiotics only work about half the time and the condition often returns. The trial will enroll 120 adults who have already tried at lea…

This early-phase trial tests a new drug called DT-7012 for people with a rare type of skin lymphoma (CTCL) that has not responded to other treatments. The drug is an antibody designed to find and kill cancer cells in the skin and boost the immune system. About 30 adults with adva…

This study tests whether adding extra nursing care—both in the hospital and at home—helps people with tuberculosis complete their full treatment. About 40 adults in Paris will take part. The goal is to see if this support improves treatment completion rates and reduces the number…

This study tests whether changing the order of steps during a Whipple surgery for pancreatic head cancer can help surgeons remove the tumor more completely and lower the chance of cancer coming back. About 150 adults with operable pancreatic cancer will be randomly assigned to ei…

This study tests whether giving the drug brentuximab vedotin after a stem cell transplant can prevent early relapse in people with advanced cutaneous T-cell lymphoma (CTCL). About 84 adults aged 18-70 with CD30-positive mycosis fungoides who have had at least one prior treatment …

This study looks at whether a single, image-guided radiation implant can control advanced cervical cancer as well as the usual multiple implants. About 400 women from six French hospitals who had this single-implant treatment between 2014 and 2024 will have their medical records …

This study tests a liquid material called SQUIDPERI for a procedure that blocks blood flow to the prostate (prostatic artery embolization) in men with an enlarged prostate. The goal is to see if it works better than standard particles at easing urinary symptoms like frequent or w…

This study tests whether anakinra, a drug used for arthritis, can help children with severe heart inflammation (myocarditis) recover heart function faster. About 110 children in intensive care will receive either anakinra or a placebo, in addition to standard care. The main goal …

This study tests a new gene therapy for GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff diseases. Researchers will take blood cells from 6 patients, fix the genetic defect in the lab, and then see if these cells can help brain cells work better. The goal is to show the …

This early study tests whether MRI-guided high-intensity focused ultrasound (HIFU) can safely heat and destroy small brain areas causing seizures in 13 adults with drug-resistant epilepsy. Participants have visible brain lesions that are too risky or deep for traditional surgery.…

This study looks at whether a special day hospital program helps people with inflammatory bowel disease (IBD) manage their condition better. About 240 adults with Crohn's disease or ulcerative colitis will take part. In one visit, they get blood tests, a doctor checkup, education…

This study tests whether adding bosentan to standard steroid treatment helps people with giant cell arteritis (GCA) stay relapse-free longer and use less steroids. About 40 adults with GCA will receive either bosentan plus steroids or steroids alone for 3 months, then be followed…

This trial tests a gene therapy for FHL3, a rare immune disorder caused by a gene mutation. Instead of a donor stem cell transplant, patients receive their own stem cells that have been corrected with a healthy gene. The goal is to restore immune function while avoiding transplan…

This study will collect thousands of photos of mouth lesions from patients seen over 50 years at a French hospital. Experts will review each photo to confirm the diagnosis. Researchers will then use these images and patient data to train an AI system to automatically identify can…

This study will look at women with polycystic ovary syndrome (PCOS) to see if some have a hidden genetic condition that causes severe insulin resistance. Researchers will compare their insulin and blood sugar levels to those of women already diagnosed with a known genetic disorde…

This study evaluates a new rapid test that can detect Candida auris, a drug-resistant fungus, in about 15 minutes. Researchers will compare the test's accuracy to standard lab methods using 554 stored and new samples from patients. No extra samples are taken from patients, and th…

This study will test whether analyzing stool and urine samples using a technique called metagenomics can find infections in people with weakened immune systems (due to HIV, chemotherapy, or immunosuppressive drugs). Currently, doctors often need to take invasive samples like bloo…

This study tests whether a special PET scan using 82-Rb can tell how aggressive kidney cancer is without needing a biopsy or surgery. Researchers will scan 50 adults with suspected or confirmed kidney cancer before they have surgery, then compare the scan results to the actual tu…

This study aims to improve how doctors diagnose and manage hyperandrogenism, a hormone condition causing excess male-pattern hair growth, acne, and infertility in women. Researchers will use machine learning and metabolomics to analyze data from 800 women aged 16-45. The goal is …

This study will test a smartphone app that automatically measures how quickly blood returns to a fingertip after pressing on it. Researchers will compare the app's reading to measurements made by expert doctors. The goal is to see if the app can reliably monitor blood flow in 60 …

This study looks at whether measuring a protein called S100B in the blood can help emergency doctors quickly tell if a person's fainting spell was caused by epilepsy or something else, like a heart problem. About 100 adults who come to the ER after losing consciousness will give …

This study looks at whether a special 4D MRI scan can accurately measure blood flow and pressure in the liver without needing an invasive needle procedure. It will enroll 60 adults with cirrhosis, some with early-stage disease and others needing a shunt (TIPS) for complications. …

This study tests whether a quick, non-invasive liver scan (Fibroscan) can help emergency doctors diagnose acute heart failure in patients with sudden shortness of breath. Researchers will enroll 100 adults in the emergency department to see if liver stiffness measurements can acc…

This study aims to improve how doctors classify colon tumors by using artificial intelligence (AI) to analyze CT scans. The AI will be trained to tell early-stage tumors from advanced ones and to detect lymph node involvement, which is key for deciding on treatments like chemothe…

This study tests whether a personalized prevention plan helps female night shift workers reduce their breast cancer risk. Night shift work is linked to higher cancer risk due to disrupted sleep cycles. One hundred women at a Paris hospital will receive tailored advice on diet, ex…

This study tests whether adding backward walking exercises to standard rehabilitation can reduce falls in people over 75 who are at high risk of falling. About 300 participants in France will either receive usual care or replace part of their rehab with supervised backward walkin…

This study tests a new way to help transgender sex workers and their clients get HIV and STI prevention services using a digital teleconsultation system called E-PrevenT. The goal is to see if offering online doctor visits can make it easier for these often-overlooked groups to g…

This study tests whether a smartphone app, called ICD-Shield, can help doctors adjust Parkinson's medications to prevent impulse control disorders (like compulsive gambling or shopping). About 528 people with early-stage Parkinson's will be randomly assigned to use the app or rec…

This study tests whether using a special breathing device (intrapulmonary percussive ventilation) at home can prevent hospitalizations for children with multiple disabilities. About 146 children aged 1 to 16 will be randomly assigned to either standard chest therapy or the device…

This study compares carbon fiber ankle braces to standard plastic ones in 38 children with cerebral palsy aged 8-15. Each child will try both braces for 4 weeks to see which one improves walking, running, and jumping. The goal is to find out which brace helps kids be more active …

This study tests whether having children aged 1 to 3 shake a maraca with the arm opposite to where a blood draw happens can lower their pain. About 160 children will be randomly assigned to either usual care or usual care plus guided maraca shaking. The goal is to see if this sim…

This study tests whether several sessions of medical hypnosis can improve quality of life for people with COPD who still have severe shortness of breath despite standard treatment. About 154 adults with advanced COPD will be randomly assigned to either five hypnosis sessions or f…

This study tests whether a custom-molded back brace, worn alongside usual care, can reduce low back pain in adults aged 40-75 with degenerative scoliosis (a curved spine that worsens with age). About 130 participants will be randomly assigned to receive the brace or not, and pain…

This study tests whether wearable body sensors can help doctors better adjust medication for people with Parkinson's disease who experience motor fluctuations. 218 participants will wear the sensors for 7 days before each visit, and only the experimental group's data will guide t…

This study tests whether a smartphone app called MAELA® can help people recover better after surgery for digestive cancers. About 555 adults will use the app to report symptoms for 90 days after surgery, while doctors monitor alerts. The goal is to see if the app reduces serious …

This study tests whether adding sound to movement (called movement sonification) can help people with acute stress disorder (ASD) feel more connected to their bodies. ASD often causes feelings of detachment after a traumatic event. The study will include 30 adults who recently ex…

This study tests if methoxyflurane, a painkiller gas that patients breathe in themselves, works as well as morphine for severe chest pain during a heart attack. About 700 adults with a specific type of heart attack (STEMI) will be treated by emergency medical teams. The goal is t…

This study tests whether awake prone positioning (lying on the stomach) can improve breathing in 15 adults with sickle cell disease who are in the ICU for severe acute chest syndrome. The approach aims to improve oxygen levels and reduce breathing effort. The trial will monitor s…

This study tests whether a personalized digital coaching program can reduce daily activity limitations in adults with chronic low back pain. About 330 participants will receive either the coaching or usual care. The goal is to see if automated, tailored advice can help people mov…

This study tests whether cannabidiol (CBD) can reduce severe self-injuries like biting or head-hitting in children aged 5 to 17 with severe neurodevelopmental disorders. Researchers will give CBD to 21 participants and measure if the frequency of self-harm drops by at least 30% o…

This study looks at whether a special education program and a check-in on caregivers' own needs can boost the quality of life for people caring for someone with multiple myeloma. About 27 caregivers will take part. The goal is to see if this extra support helps them feel better a…

This study looks at whether a functional restoration program—a mix of exercise, education, and support—can help people with chronic low back pain who are unable to work. The goal is to see if the program improves quality of life, reduces healthcare use, and helps people return to…

This study tests whether a drug called gamma-hydroxybutyrate (GHB) can improve deep sleep in intensive care patients. Sleep problems are very common in the ICU and cause major discomfort. The trial will involve 24 adults in the ICU who will receive either GHB or a placebo, and th…

This study tests whether adding low-dose ketamine to standard sedatives helps critically ill patients on breathing machines recover faster and spend more days alive at home. About 640 adults who need unplanned ventilation and sedation will receive either ketamine or a placebo for…

This study tests whether bringing airflow back to the nose can reduce shortness of breath in people who breathe through a tracheostomy tube connected to a ventilator. Researchers will compare three simple, non-drug methods: continuous nasal airflow, nasal sprays, and a fan blowin…

This study tests whether personalized text messages sent after in-person rehab sessions can help people with chronic low back pain do more daily activities. One hundred adults with back pain lasting over 3 months will receive either standard rehab or rehab plus automated SMS foll…

This study aims to create and test a self-rehabilitation program that uses everyday activities to help people who have had a stroke more than 6 months ago. About 158 participants will be randomly assigned to either the program or usual care. The goal is to see if this approach ca…

This study tests a special education program focused on improving self-image for 60 adults with chronic inflammatory rheumatic diseases like rheumatoid arthritis. Participants will attend workshops designed to help them feel better about their bodies and themselves. The goal is t…

This study tests a portable device called ActiTENS mini that uses mild electrical pulses to relieve chronic pelvic pain in women with endometriosis. About 208 women will try different stimulation strengths over 9 months to see if it reduces pain and improves quality of life. If i…

This study looks at whether special 'active' sports shoes can help people with severe COPD walk farther during a 6-minute walk test. About 75 adults with advanced COPD will try both the special shoes and their usual shoes, and researchers will compare how far they walk and how br…

This study looks at whether custom-made shoes can improve walking quality in people who have had a stroke and still have trouble walking due to muscle tightness and foot dragging. About 58 adults who had a stroke at least 6 months ago will wear adapted shoes and be tested on how …

This study will review medical records of 300 immunocompromised adults hospitalized with COVID-19 in France between June 2023 and April 2024. Researchers want to see how well antiviral drugs like nirmatrelvir/ritonavir and remdesivir work in these patients. The study is observati…

This study looks at how surgery for a rare brain tumor called craniopharyngioma might change what foods people like, especially fatty and sugary ones. Researchers will compare food preferences of 346 adults who had this surgery with two other groups: people who had a different pi…

This study will test a new markerless motion capture system that uses only four cameras to analyze how children walk. Researchers will enroll 125 healthy children aged 6 to 17. The goal is to see if this simpler setup can provide useful information about walking patterns, which c…

This study aims to find biological markers that predict how well people with major depressive episodes respond to light therapy. Researchers will treat 173 adults with unipolar or bipolar depression using a bright light box for 4 weeks. By measuring sleep, mood, and circadian rhy…

This study will test whether a new 3D ultrasound method, combined with artificial intelligence, can better detect early brain injury in very preterm infants (born before 30 weeks). Researchers will scan 360 babies at several time points and compare the results with brain MRIs and…

This large French study will follow 1,810 adults receiving their first liver transplant to see if the way the donor liver is removed affects outcomes. The main focus is on avoiding artery and bile duct complications for three years after transplant. The goal is to identify the be…

This study looks at whether tumor DNA found in blood or peritoneal fluid can predict the spread of digestive cancers (stomach, colon, pancreas) to the lining of the abdomen. Researchers will follow 300 patients with early-stage tumors to see if those with positive tumor DNA have …

This study will interview 63 people, including patients with prosthetic joint infections, their family members, and healthcare professionals, to understand their experiences. The goal is to use this information to create a therapeutic education program that helps patients manage …

This study looks at why some cancer patients develop neurological problems after receiving immunotherapy drugs called checkpoint inhibitors. Researchers will analyze spinal fluid and blood from 160 participants to find immune cells that may mistakenly attack the nervous system. T…

This study will follow 45,000 university students over three years to understand how financial struggles, housing issues, and loneliness affect their mental health and whether they seek help. Participants will fill out questionnaires about their well-being and life circumstances.…

This study looks at whether a simple blood test can track how well treatment is working in children with acute lymphoblastic leukemia (ALL). Currently, doctors must take bone marrow samples to check for leftover cancer cells, which is invasive and painful. The researchers will co…

This study explores whether testing hospital wastewater can reliably track the spread of multidrug-resistant bacteria, instead of using uncomfortable rectal swabs on patients. Researchers will compare bacteria and resistance genes found in the sewage of a single hospital building…

This observational study will collect pulp tissue from 1,200 adults during routine dental procedures like root canals or extractions. Researchers will analyze the tissue to understand the immune and inflammatory response at the molecular level. The goal is to see if current diagn…

Severe preeclampsia is a dangerous pregnancy complication that can cause high blood pressure, harming both mother and baby. This observational study will follow 350 women to identify factors that make blood pressure control with the drug labetalol fail. By understanding these fac…

This study aims to translate and adapt the COMFORTneo pain assessment scale into French for newborns. Researchers will work with 50 healthcare professionals from French neonatal units to ensure the translated items are accurate and easy to understand. The goal is to provide a rel…

This study aims to better understand a condition called multilocus imprinting disorder (MLID), where multiple genes are affected by abnormal chemical marks. Researchers will test a new technique to detect these marks in 96 people, including those with known imprinting disorders a…

This study tests a mobile app called EPIDAY that uses daily symptom reports and machine learning to predict the risk of an epileptic seizure. Researchers will enroll 50 adults with focal epilepsy to see how accurate the app's daily predictions are in real life. The goal is to giv…

This study will follow 4500 adults with Crohn's disease or ulcerative colitis to identify biological markers, especially gut bacteria, that predict disease progression and complications. Researchers will analyze stool and tissue samples to better understand why IBD behaves differ…

This study will review medical records and brain scans (MRI or CT) from 60 people treated for nocardiosis, a rare brain infection. Researchers want to see how lesions change over time and whether those changes relate to how well patients recover. The goal is to better understand …

This study looks at the bacteria, fungi, and viruses living on the skin, in the gut, and in the mouth of people with Netherton syndrome, a rare condition that damages the skin barrier and often causes allergies. Researchers will compare these microbes to those of healthy voluntee…

This study aims to see if ultrasound measurements of the diaphragm can estimate how hard a patient is trying to breathe. The standard test (P0.1) works well in intubated patients but not in those on non-invasive ventilation or high-flow oxygen. Researchers will compare ultrasound…

This study looks at children with ulcerative colitis (UC) to see if changes in bile acids in the gut make them more likely to get a serious C. difficile infection. Researchers will compare bile acid and gut bacteria patterns in 80 children: those with active UC (with or without C…

This study looks at whether doing a special X-ray (arteriography) before surgery to find a key spinal cord artery can prevent nerve damage in children with certain chest tumors. Researchers will review records of 150 children treated in France between 2005 and 2024. The goal is t…

This study tests whether a smartphone app can help people with rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis learn how to use their anti-rheumatic drugs more safely. About 144 adults will either use the app or receive standard care with a website. The goal is to…

This study aims to find biological markers and understand what goes wrong in the body of people with Congenital Central Hypoventilation Syndrome (CCHS), a rare condition that affects breathing. Researchers will compare blood and urine samples from 40 adults with CCHS and healthy …

This study looks at how personal traits like anxiety, self-esteem, and perfectionism affect the ability to adapt to uncertainty in people with alcohol use disorder. About 30 adults receiving care at Paul Brousse Hospital will complete a computer task and questionnaires in one 45-…

This study follows 412 patients who survived severe acute kidney injury in the intensive care unit. Researchers want to see if two blood markers (galectin-3 and CD146) can predict future heart attacks, strokes, heart failure, chronic dialysis, or death. The goal is to better iden…

This study looks at the blood immune cells of 10 adults with a rare inherited skin condition called NIPAL4 ichthyosis. Researchers want to understand why three patients with this skin disease also developed a very rare lymphoma (Sezary syndrome). By describing the normal immune c…

This study tests whether a computer can decode what a person is saying by recording brain activity during awake brain tumor surgery. Twenty adults with brain tumors near language areas will have a special graphene electrode grid placed on their brain surface for up to 2 hours whi…

This study interviews 15 people who have donated a kidney to understand their feelings about receiving a symbolic token of gratitude, like a commemorative medal. Researchers want to know if such recognition could improve donors' experience and encourage more donations. The study …

This study looks at how cytomegalovirus (CMV) infection changes the immune system's ability to fight other infections in kidney transplant patients. Researchers will take blood samples from 60 participants, both before and after CMV infection, to measure immune cell responses. Th…

This study will test whether a mobile app called Resilience PRO can help monitor symptoms and quality of life in 80 adults with IDH-mutated glioma who are starting a new systemic treatment. Participants will use the app to report side effects and complete questionnaires every two…

This study aims to create a new lab model of human diaphragm muscle cells using tissue from women undergoing surgery for diaphragmatic endometriosis. Researchers will compare these cells to arm muscle cells to understand what makes the diaphragm unique. The goal is to provide a t…

This study will look at medical records of 350 children with sickle cell disease in France who had serious bacterial infections between 2020 and 2025. The goal is to find out which bacteria are causing these infections today, especially with new vaccines available. The results co…

This study follows 30 women aged 18-80 who are getting an artificial urinary sphincter to treat severe urine leakage. Researchers want to see if the surgery changes their sexual quality of life. Participants will fill out questionnaires 6 and 12 months after the procedure.

This study tests whether a personalized computer model, called a digital twin, can predict which patients with high blood pressure will respond to a procedure called renal denervation. About 60 adults with different types of high blood pressure will join. If successful, this appr…

This study looks for early signs of ADHD in children aged 3 to 5, before the official diagnosis age of 6. Researchers will use eye-tracking and balance tests to find differences between 30 children with ADHD symptoms and 30 healthy children. The goal is to create better tools for…

This study looks at whether giving doctors antibiotic sensitivity results in 4 to 6 hours (instead of the usual 18 to 24 hours) helps them choose a better antibiotic for ICU patients with Gram-negative bloodstream infections. About 200 adults will take part. The goal is to see if…

This study will collect blood samples and medical information from 600 adults with rare diseases affecting blood vessels in the brain and eye, such as CADASIL and cavernous angioma. The goal is to create a long-term biobank that researchers can use to find biomarkers and better u…

This study will review heart MRI scans from 5,000 adults diagnosed with acute myocarditis, a heart muscle inflammation that can be deadly in young adults. Researchers aim to identify patterns that predict serious outcomes like death, heart failure, or dangerous heart rhythms. The…

This study gathers information from 5,000 adults with hypertrophic cardiomyopathy, a condition where the heart muscle is too thick. Researchers will use heart MRI scans to look for scarring and build a better way to predict who is at risk of dying from the disease. The goal is to…

This study aims to understand why some women repeatedly fail to get pregnant or experience multiple miscarriages, even with fertility treatments. Researchers will compare uterine tissue and blood samples from 100 women with and without these conditions to look for differences in …

This study will follow 5,000 adults with immune system problems to see if certain blood cell mutations (called clonal hematopoiesis) are linked to their condition. Researchers will track new cases of immune-related diseases over time. No treatments or drugs are tested—this is pur…

This study compares children with Denys-Drash syndrome who received a kidney transplant to other young kidney transplant patients. The goal is to see if the syndrome increases the risk of a type of cancer called post-transplant lymphoproliferative disorder. Researchers will revie…

This study looks at whether nerve ultrasound can help doctors tell the difference between inherited and acquired forms of a rare nerve condition called sensory neuronopathy. Researchers will review medical records and ultrasound images from about 50 adults. The goal is to see if …

This study will follow 473 women with polycystic ovary syndrome (PCOS) and a control group to understand what affects their ability to get pregnant. Researchers will look at medical history, hormone levels, and lifestyle factors to see which ones help or hinder natural or assiste…

This study looks at how sepsis changes the RNA in white blood cells over time. Researchers will follow 200 sepsis patients, 50 other critically ill patients, and 40 healthy people to map these changes. The goal is to understand why some people have long-term immune problems after…

This study looks at stored samples from 2500 adults newly diagnosed with hepatitis C in France to map the different virus types (genotypes and subtypes) circulating in the country. Researchers will also examine why some treatments fail by checking for drug resistance. The goal is…

This study follows 300 adults with a genetic condition that causes very high cholesterol (familial hypercholesterolemia) to see how their heart arteries change over 5 years. Participants will get a special CT scan to measure plaque buildup and blockages. The goal is to learn more…

This study will test whether new lab techniques can help doctors diagnose hard-to-identify bone and joint diseases. Researchers will collect joint fluid and tissue from 50 adults undergoing joint aspiration or replacement. They will use both standard and advanced methods to find …

This study looks at 1,500 couples undergoing IVF to see if a computer can predict which embryos will successfully implant in the womb. Researchers will use time-lapse videos of embryo development and patient health data to train a machine learning algorithm. The goal is to make e…

This study looks back at data from 562 people who received a liver transplant for liver cancer (hepatocellular carcinoma) to develop a better way to decide who will truly benefit. Current methods mainly consider tumor size and blood tests, but this research will also include fact…

This study looks at whether objective measurements, like the stapedius reflex, can help doctors program cochlear implants more precisely. Currently, tuning relies on patients describing what they hear, which can be subjective. Researchers will test 60 adults with severe hearing l…

This study looks at the healthcare path of 36 young people aged 12 to 25 who have somatic symptom disorder—physical symptoms like pain or fatigue that doctors can't explain with a standard medical condition. Researchers will interview participants and their parents to map every d…

This study follows 1,000 patients with rare, life-threatening skin and soft tissue infections who are treated through a special care network in the greater Paris area. Researchers will track survival rates, long-term complications, and quality of life to understand what factors a…

This study looks at whether sending a neonatal transport team to be present before birth (antenatal) versus after birth (postnatal) improves survival and brain development in extremely premature babies (23-28 weeks) born at hospitals without a specialized intensive care unit. Res…

This study looks at whether certain natural chemicals in vaginal fluid can predict if labor induction will work in first-time mothers. Researchers will measure these chemicals in 190 women with full-term pregnancies who are scheduled for induction. The goal is to find a way to be…

This study watches for thinking and memory issues in 90 adults with early-stage, operable lung cancer. Researchers will track complaints like forgetfulness or trouble focusing before, during, and after treatment using simple questionnaires. The goal is to understand when these pr…

This study checks if a new French questionnaire accurately measures how the look of your smile affects your daily life. Researchers will ask 120 adult dental patients to fill out the survey twice to see if the results are consistent. The goal is to give dentists a reliable way to…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just observation and data collection over time.

This study looks at people with Enamel Renal Syndrome, a rare genetic condition that causes calcium deposits in the body, leading to kidney and blood vessel problems. Researchers will measure kidney function and test how the body handles calcium, phosphate, water, and acid. The g…

This study aims to create a 3D model of the bile ducts using MRI and CT scans, along with an AI tool to help doctors guide a camera during a procedure called ERCP. The goal is to improve safety and accuracy. The study will use existing medical images from 100 adult patients who h…

This study aims to develop blood tests that can predict if a person with early-stage liver disease will develop serious complications like liver failure or liver cancer. Researchers will analyze tiny particles in the blood called extracellular vesicles, along with other markers, …

This study will follow 200 adults with pulmonary arterial hypertension who experience a sudden worsening of right heart failure. Researchers will collect medical data to see how many survive or need a lung transplant within 3 and 12 months. The goal is to identify better ways to …

This study will analyze blood and tissue samples from 500 adults with rare inflammatory disorders called systemic histiocytoses. The goal is to find new biological markers that can help doctors better diagnose, classify, and monitor these diseases without invasive procedures. Res…

This study looks at how a new type of heart ablation (pulsed-field ablation) changes the heart's structure in people with atrial fibrillation. Researchers will use MRI scans before and 4 months after the procedure to measure scarring and function. About 39 adults with persistent …

This study watches brain activity (EEG) in 330 people during routine anesthesia or sedation—including children with autism, adults over 70, and patients having digestive endoscopy. Researchers aim to link brain wave patterns to drug levels and patient responses, without changing …

This study looks at whether a common, non-invasive jaundice test (using a light meter on the skin) is accurate for newborns with different skin colors. Darker skin may interfere with the device. Researchers will compare the skin test results with blood tests in 510 babies to see …

This study looks at how safe surgery is for a rare condition called functional popliteal artery entrapment, which causes leg pain in young athletes during exercise. Researchers will track 138 adults who have the surgery to see how many need to return to the hospital within 30 day…

This study looks at whether a newer, gentler heart procedure called pulse-field ablation (PFA) can reverse harmful changes in the heart's upper chambers caused by atrial fibrillation. Researchers will compare CT scans taken before and 3 months after the procedure in 200 adults. T…

This study looks at 43 adults in intensive care with septic shock who already have a special heart catheter (Swan-Ganz IQ). It compares a new continuous method that analyzes heart pressure waves to the standard method (thermodilution) for measuring how well the heart pumps blood.…

This study will compare the costs and benefits of a new, non-invasive blood test that screens for many genetic disorders in unborn babies, versus current methods that often require invasive procedures like amniocentesis. Researchers will enroll 300 couples in France who are alrea…

This study will follow 400 people receiving a stem cell transplant to learn why some develop serious heart issues like heart attacks, irregular heartbeat, or heart failure. Researchers will use heart scans, blood tests, and other monitoring to find early warning signs. The goal i…

This study will follow 1,500 people with lupus or other autoimmune diseases to see if advanced heart scans can predict heart attacks, strokes, or other heart problems. Participants will have one of three types of heart imaging. The goal is to learn if these scans can help doctors…

This study will use artificial intelligence to analyze sleep recordings from 1,500 adults with chronic insomnia and/or epilepsy. The goal is to see if AI can accurately identify sleep stages and patterns, which could help doctors diagnose these conditions more easily. No new trea…

This study looks at how male hormones (androgens) might influence the immune system around glioblastoma, an aggressive brain cancer that is more common and deadly in men. Researchers will analyze tumor and blood samples from 40 newly diagnosed patients aged 18 to 55. The goal is …

This study looks at whether certain gut bacteria help the remaining intestine absorb nutrients better after surgery for short bowel syndrome. Researchers will follow 15 adults who are having surgery to reconnect their small intestine and colon. They will measure how well the inte…

This study looks at how the antibiotic cefazolin spreads in the chest of children after heart surgery. Ten children under 6 years old will have a tiny probe placed in their chest to measure antibiotic levels. The goal is to learn how to give the right dose to prevent infections.

This study looks at how a person's genes affect their response to the heart drug mavacamten for obstructive hypertrophic cardiomyopathy. Researchers will collect DNA samples from 300 patients to see which genetic types respond best. The goal is to improve dosing safety and effect…

This study will combine medical and genetic information from 2000 children with acute myeloid leukemia (AML) into one large database. The goal is to find hidden patterns that can predict which children are at high risk of relapse. No new treatments are tested; instead, researcher…

This study looks at a new way to program cochlear implants in children aged 0 to 7 years. Normally, programming relies on the child's response, which can be hard to get. The study will test if measuring a reflex in the ear (eSRT) is a reliable and practical method. If successful,…

This study aims to understand how a less invasive stomach procedure called endoscopic sleeve gastroplasty changes digestion, hormones, and gut bacteria compared to traditional weight-loss surgery. Researchers will follow 40 adults with obesity to measure stomach emptying and othe…

This study aims to understand the biological causes of autism by creating mini-organs (organoids) from cells of people with autism. Researchers will compare these organoids to those from siblings without autism to find differences in brain cell development. The goal is to discove…

This study looks at how air moves in the lungs of brain-injured patients when doctors are removing their breathing tube. Using a special imaging belt (electrical impedance tomography), researchers will track changes in lung ventilation patterns. The goal is to find patterns that …

This study will gather information from 100 people in France with SITRAME syndrome, a rare disease that causes repeated episodes of skin rash and fever. Researchers will look at patient characteristics, treatments, and outcomes to better understand the disease. The goal is to cre…

This study watches how the lungs work during surgery in 34 adults under general anesthesia. It uses special monitors to measure lung pressure and air distribution during a routine breathing technique called alveolar recruitment. The goal is to see if these monitors can help docto…