Assistance Publique - Hôpitaux De Paris

This study tests whether extra nursing care, both in the hospital and at home, can help tuberculosis patients stick with their treatment. About 40 adults with active or latent TB will receive education and support to improve medication adherence. The goal is to increase the numbe…

This study looks at people with two types of vasculitis (GPA and MPA) who are in remission on maintenance rituximab. When a blood test shows the disease marker (ANCA) has returned, half will get early rituximab treatment and half will just be monitored. The goal is to see if earl…

This study tests a drug called secukinumab in 52 people with active, severe Takayasu arteritis, a rare disease that causes inflammation and narrowing of major blood vessels. The goal is to see if the drug can stop disease activity and allow patients to stop taking steroids. Parti…

This study tests whether giving the drug etoposide early, when organ failure first starts, works better than waiting in people with severe hemophagocytic lymphohistiocytosis (HLH) in the intensive care unit. HLH is a rare condition where the immune system overreacts, causing dang…

This study tests whether transplanting healthy donor stool into the gut can improve liver function in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD). About 72 adults with stable IBD and elevated liver enzymes will receive either real fecal t…

This study tests whether a combination of three drugs (prednisone, azithromycin, and hydroxychloroquine) can slow lung function decline in adults with interstitial lung disease caused by specific gene variants. About 30 participants will receive either the triple therapy or stand…

This study looks at people newly diagnosed with pulmonary arterial hypertension (PAH) who also have at least two heart-related conditions. It compares starting treatment with two oral medications (tadalafil and ambrisentan) versus just one. The goal is to see if the combination h…

This study tests a special day hospital program for people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. The program combines blood tests, doctor visits, education, and support in a single session. Researchers want to see if this approach help…

This study tests whether the drug brentuximab vedotin, given right after a stem cell transplant, can help prevent the lymphoma from coming back in people with advanced cutaneous T-cell lymphoma (CTCL). About 84 adults aged 18-70 with CD30-positive mycosis fungoides who have alrea…

This study tests a new 6-month treatment called BPaLM for people with multidrug-resistant tuberculosis (MDR-TB) in France. It aims to see if this shorter regimen works as well as the standard long treatment that can last over a year. About 55 adults with confirmed MDR-TB will rec…

This study tests whether adding the drug sildenafil to standard cooling treatment can help prevent brain damage in full-term newborns who suffered oxygen loss at birth. About 24 babies will receive IV sildenafil while being cooled, and researchers will measure how the drug behave…

This early-stage study tests a new gene therapy for GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff diseases. Researchers will take blood cells from 6 patients, modify them in the lab, and see if they can help fix nerve cells grown from patient stem cells. The goal is t…

This study tests whether a lower dose of a chemotherapy drug (cyclophosphamide) given after a half-matched stem cell transplant can help people with blood cancers live longer without severe complications. About 180 adults will be randomly assigned to receive either the standard d…

This early-phase trial tests a new antibody drug, DT-7012, in 30 adults with advanced cutaneous T-cell lymphoma (CTCL) that has not responded to at least two prior treatments. The drug aims to kill cancer cells by targeting a protein called CCR8 found on tumor cells. The main goa…

This study tests a smartphone app that automatically measures capillary refill time—how quickly blood returns after pressing a finger—from a short video. Sixty adult ICU patients will have their finger compressed and recorded with a professional Android phone. The app's measureme…

This study tests whether a special PET scan using 82-Rb can accurately tell how aggressive a kidney tumor is. About 50 adults with suspected or confirmed kidney cancer will get the scan before surgery. The goal is to see if the scan can separate low-grade from high-grade tumors, …

This study tests whether a non-invasive liver scan (Fibroscan) can quickly and accurately diagnose acute heart failure in 100 emergency room patients with shortness of breath. Current diagnostic methods can be slow or unclear, and this device may offer a faster, bedside alternati…

This study will collect photos of mouth lesions from 5,000 patients to train an artificial intelligence (AI) system to detect oral cancer and precancerous conditions. The goal is to help doctors identify dangerous lesions earlier and more accurately. Participants are adults seen …

This study evaluates a new rapid test that can detect Candida auris, a drug-resistant fungus that causes severe infections in hospitals, in about 15 minutes. Researchers will compare the test's accuracy to standard lab methods using samples from 554 patients. No extra samples are…

This study aims to improve how doctors diagnose and manage hyperandrogenism, a hormone condition causing excess male-pattern hair growth, acne, and infertility in women. Researchers will use machine learning and metabolomics (detailed analysis of body chemicals) to better disting…

This study tests a new way to help transgender sex workers and their clients get HIV and STI prevention services through a digital teleconsultation program called E-PrevenT. The goal is to make it easier for these often-hidden groups to access sexual health care. Researchers will…

This study looks at whether a functional restoration program (a type of rehab) is worth the cost for people with long-term low back pain who are unable to work. Researchers will compare the program's effects on quality of life, healthcare use, and return to work over 24 months. T…

This study tests if methoxyflurane, an inhaled painkiller patients can give themselves, works as well as morphine for severe chest pain during a heart attack. About 700 adults with a specific type of heart attack (STEMI) will be enrolled in pre-hospital settings. The goal is to f…

This study tests a therapeutic education program designed to improve self-image in adults with chronic inflammatory rheumatic diseases like rheumatoid arthritis. Researchers will enroll 60 participants to see if workshops focused on body image can help patients feel better about …

This study reviews a surgical technique for functional popliteal artery entrapment syndrome, a rare condition where leg muscles compress an artery during exercise, causing pain. Researchers will look back at 70 patients who had surgery between 2015 and 2025 to see if the procedur…

This study tests whether awake prone positioning (lying on the stomach while awake) can improve breathing in 15 adults with sickle cell disease who are in the ICU for severe acute chest syndrome. The approach aims to improve oxygen levels and reduce breathing effort. It is a smal…

This study tests whether restoring airflow to the nose can reduce breathlessness in patients who have a tracheostomy and are on a breathing machine. Researchers will compare three simple, non-drug methods: continuous nasal airflow, nasal sprays, and facial airflow. The goal is to…

This study tests whether adding movement sonification—turning body movements into sounds—to standard talk therapy can help people with acute stress disorder (ASD). ASD can cause feelings of disconnection from your own body after a traumatic event. The study will include 30 adults…

This study tests a portable device called ActiTENS mini that uses mild electrical pulses to relieve chronic pelvic pain in women with endometriosis. About 208 women will use the device daily for 30 minutes over three 3-month periods, comparing different stimulation strengths. The…

This study looks at the blood immune cells of 10 adults with a rare genetic skin condition called NIPAL4-related ichthyosis. Researchers want to understand why three people with this condition also developed a very rare skin lymphoma. By describing the immune cell types in patien…

This study looks at how gut bacteria change and help the remaining intestine work better after surgery in adults with short bowel syndrome. Researchers will follow 15 people for a year after they have a surgery to reconnect their intestine. The goal is to see if certain bacteria …

This study will collect information from 1,500 people with autoimmune diseases like lupus who have already had advanced heart scans (CT or MRI). Researchers want to see if these scans can help predict serious heart problems such as heart attacks or strokes. The goal is to improve…

This study will observe 34 adults undergoing long surgeries (over 2 hours) who are at higher risk for lung complications, such as obese patients or those in certain positions. Researchers will use advanced monitors to measure lung pressures and air distribution during routine bre…

This study looks at why glioblastoma, an aggressive brain cancer, is more common and deadly in men. Researchers will analyze tumor and blood samples from 40 patients to see how male hormones (androgens) influence immune cells around the tumor. The goal is to understand the role o…

This study looks at people with rare genetic conditions called imprinting disorders, which can affect growth and development. Researchers want to find out how often extra DNA changes (called MLID) occur in these patients. They will test a new method to detect these changes in up …

This study looks at whether objective measurements like eSRT, eABR, and eCAP can help doctors program cochlear implants more accurately. Currently, adjustments rely on patients describing what they hear, which can be subjective. The study will enroll 60 adults with severe to prof…

This study tests whether a blood test that looks for tiny bits of tumor DNA can be used instead of a bone marrow biopsy to monitor how well treatment is working in children with acute lymphoblastic leukemia (ALL). About 205 children and teens with newly diagnosed ALL will give bl…

This study aims to understand why some cancer patients develop neurological issues after receiving immunotherapy drugs called immune checkpoint inhibitors. Researchers will analyze spinal fluid and blood from 160 participants to identify immune cells and antibodies that may mista…

This study looks at how a common virus called CMV changes the immune system in people who have had a kidney transplant. Researchers will compare immune responses in 60 patients, some with and some without CMV infection. The goal is to understand which immune pathways are affected…

This study looks at whether a new, non-invasive blood test using next-generation sequencing can replace current invasive methods (like amniocentesis) for detecting severe genetic diseases in unborn babies. Researchers will compare the costs and benefits of this new test with stan…

This study looks for early signs of ADHD in children aged 3 to 5, before the usual diagnosis age of 6. Researchers will use eye-tracking and balance tests to find differences between 30 children with ADHD and 30 healthy children. The goal is to create better tools for early detec…

This study collects dental pulp (nerve) tissue from 1,200 adults during routine dental procedures to analyze inflammation at the molecular level. The goal is to better understand how inflammation progresses and to see if current diagnostic methods match the actual biological stat…

This study follows 450 adults with diabetes who were part of an earlier study. Researchers want to see if levels of a nutrient called glutamine in the blood are linked to future heart problems. No new treatments are given—just tracking health over time to better understand the co…

This study will collect and analyze heart MRI data from 5,000 adults who have had acute myocarditis (heart muscle inflammation). The goal is to better understand which patients are at higher risk for serious problems like death, heart failure, or dangerous heart rhythms. No new t…

This study will follow 200 adults with pulmonary arterial hypertension who experience a sudden worsening of right heart failure. Researchers across Europe will collect medical data to see how many patients survive or need a lung transplant within 3 and 12 months. The goal is to i…

This study looks at how different speech therapy methods affect language skills in children with severe hearing loss who get cochlear implants before age 2. Researchers will compare two therapy styles and track language growth over time. The goal is to find which approach works b…

This study looks at tiny particles called extracellular vesicles in the blood to see if they can help predict who will get worse from liver disease or develop liver cancer. Researchers will study 845 people with and without liver disease. The goal is to create simple tests that d…

This study looks at whether giving doctors rapid (4-6 hours) antibiotic sensitivity results, instead of the usual 18-24 hours, helps them choose better antibiotics for ICU patients with Gram-negative bloodstream infections. About 200 adults will take part. The goal is to see if f…

This study tests a mobile app called EPIDAY that uses daily symptom reports and machine learning to predict the risk of an epileptic seizure the next day. Researchers will enroll 50 adults with focal epilepsy to use the app in real life and check how accurate its predictions are.…

This study will test whether a smartphone app called Resilience PRO can help doctors keep track of symptoms and quality of life in 80 people with IDH-mutated glioma (a type of brain tumor) who are starting a new treatment. Participants will answer weekly questionnaires about how …

This study will test a new, simpler motion capture system that uses only four cameras to analyze how children walk. Current systems require special labs and many cameras, limiting their use. The goal is to see if this easier method can be used for routine check-ups in children wi…

This pilot study is testing whether a personalized computer model, called a 'digital twin,' can predict which patients with high blood pressure will respond to a procedure called renal denervation (RDN), which calms overactive kidney nerves. The study will enroll 60 adults, inclu…

This study will collect data from 5,000 adults with hypertrophic cardiomyopathy, a condition where the heart muscle is abnormally thick. Researchers will use cardiac MRI scans to look for scarring in the heart muscle and see if it helps predict who is at higher risk of death. The…

This study will follow 400 people receiving stem cell transplants for blood cancers to better understand why some develop serious heart problems like heart attacks, irregular heartbeats, or heart failure. Researchers will use heart scans, blood tests, and other monitoring to find…

This study looks at whether a simple ultrasound can help doctors tell the difference between inherited and acquired forms of a rare nerve disease called sensory neuronopathy. Researchers will review medical records and ultrasound images from 50 adults to compare nerve size in bot…

This study will test 173 adults with major depression to see how well light therapy works for them. Researchers will measure depression scores before and after 5 weeks of light therapy. The goal is to find biological markers that predict who will have a good response, helping doc…

This study aims to find new biological markers (biomarkers) in adults with rare inflammatory diseases called systemic histiocytoses. Researchers will analyze blood samples from 500 participants to identify proteins and genes linked to inflammation and disease progression. The goa…

This study looks at how women with Polycystic Ovary Syndrome (PCOS) get pregnant—whether naturally or with medical help. Researchers will track 473 women over time to find out which factors, like hormones or lifestyle, affect their fertility. The goal is to better predict and per…

This study looks at the different types and subtypes of the hepatitis C virus in 2500 newly diagnosed patients in France. By analyzing virus samples collected during routine care, researchers aim to identify which types are most common and why some treatments fail. The goal is to…

This study explores whether a computer can decode what a person is saying by analyzing brain signals recorded during awake brain tumor surgery. Twenty adults with brain tumors near language areas will name pictures while electrodes on their brain surface capture neural activity. …

This study looks at children with ulcerative colitis (UC) to see if changes in bile acids and gut bacteria make them more likely to get a C. difficile infection. Researchers will compare bile acid profiles in 80 children: those with active UC and C. diff, those with active UC alo…

This study looks at 200 women with primary immune deficiency to see if using IUDs, tampons, or menstrual cups leads to more infections. Participants will answer a questionnaire about their birth control and period products. The goal is to provide safety data so doctors and patien…

This study looks at how a person's genes influence their response to the heart drug mavacamten, used for obstructive hypertrophic cardiomyopathy. Researchers will collect DNA samples from 300 patients to see why some respond better than others. The goal is to make treatment safer…

This study watches for memory, attention, and concentration problems in 90 adults with early-stage, operable lung cancer. Researchers will track when these issues start, how bad they get, and how long they last. They will also look at how mood, fatigue, and social factors might p…

This study will test new lab methods to better diagnose inflammatory and non-inflammatory bone and joint diseases. Researchers will collect joint fluid and tissue from 50 adults who need joint aspiration or replacement. They will use both standard and advanced techniques to find …

This study will gather information from 100 people in France with SITRAME syndrome, a rare autoinflammatory disease that causes repeated skin rashes and fever. Researchers will track patients' symptoms, treatments, and health outcomes over time. The goal is to better understand t…

This study aims to grow diaphragm muscle cells in the lab from tissue removed during surgery for endometriosis. Researchers will compare these cells to arm muscle cells to find unique features of the diaphragm. This tool may help develop new therapies for severe neuromuscular dis…