Assistance Publique - Hôpitaux De Paris

This trial tested a gene therapy to treat X-linked severe combined immunodeficiency (SCID-X1), a rare genetic disorder that leaves boys without a working immune system. Five boys received a corrected copy of their faulty gene using a self-inactivating retroviral vector. The goal …

This study tested whether giving a stronger or extra dose of the pneumonia vaccine could improve protection for people with ANCA vasculitis who take rituximab. 96 adults received either the standard vaccine schedule or a boosted version. The goal was to see if the stronger approa…

This study looked at how well the seasonal and H1N1 flu vaccine works and how safe it is for people with autoimmune diseases like lupus or vasculitis. Researchers measured antibody levels three weeks after each shot. The goal was to see if the vaccine provides protection even in …

This study tested the drug itacitinib in 35 adults with non-severe hemophagocytic lymphohistiocytosis (HLH), a rare immune condition. The goal was to see if itacitinib can control the disease by reducing symptoms within 15 days. Participants took the drug for at least 7 days, and…

This study tested whether giving strong, early treatment to people with severe sepsis or septic shock before they reach the hospital could lower the number of deaths. The treatment included antibiotics, fluids, and medicines to support blood pressure. The study involved 398 adult…

This study tested whether using a special antiseptic dressing on the tubes that connect patients to an ECMO machine (a heart-lung bypass) can reduce serious infections. The trial involved 270 critically ill adults with heart or lung failure. Patients were randomly assigned to rec…

This study tested a new way to stimulate the ovaries for IVF that aims to get more eggs while keeping hormone levels more natural. 129 women with good IVF prospects took part. The main goal was to see if this method leads to more live births compared to the standard approach.

This study tested whether a special blood-filtering treatment (high-permeability hemodialysis) could help people in shock after their heart restarts from a cardiac arrest. The treatment aims to remove harmful inflammatory substances from the blood to improve blood pressure and re…

This study tested whether the pill glyburide works as well as insulin shots for managing gestational diabetes in pregnant women. Over 900 women participated, and researchers looked at baby health issues like high birth weight, low blood sugar, and jaundice. The goal was to see if…

This study tested the drug topiramate in 18 severely obese children and teens aged 9 to 17. The goal was to see if it could lower their Body Mass Index (BMI) more than a placebo over 9 months. Success was defined as a BMI reduction greater than 2.5%. The study also tracked side e…

This study tested whether a drug called denosumab can improve bone density in adults with osteoporosis caused by systemic mastocytosis, a rare disease where too many mast cells weaken bones. Twenty-four participants received either denosumab or a placebo every 6 months for 3 year…

This study looked at 62 children with juvenile idiopathic arthritis (JIA) whose disease was inactive. Researchers tested whether slowly reducing and stopping their biologic medication was as safe and effective as staying on the full dose for 24 weeks. The goal was to see if kids …

This study looked at two different care plans for pregnant women with a rare type of diabetes called MODY2. The goal was to find the best way to use insulin to help the baby grow normally without causing low birth weight or other problems. 46 women took part, and researchers comp…

This study tested whether a less common antibiotic, temocillin, works as well as the standard treatment (carbapenem) for urinary tract infections caused by resistant bacteria. 29 hospitalized adults with complicated UTIs took part. The goal was to see if temocillin could clear th…

This study looked at whether a specific method of delivering the placenta—called controlled cord traction—can lower the chance of severe bleeding after a vaginal birth. Over 4,300 women took part, and researchers compared this technique to waiting for the placenta to come out on …

This study looked at whether taking aspirin twice a day (100 mg each time) works better than once a day to prevent another heart attack, stroke, or urgent heart procedure in people with diabetes who have had a recent heart attack or unstable chest pain. About 2,500 participants w…

This study tested whether rituximab, a targeted immune therapy, is better than azathioprine (a standard drug) at preventing major relapses in people with ANCA-associated vasculitis, a rare autoimmune disease that inflames blood vessels. 117 adults who were already in remission we…

This study tested whether giving rituximab based on blood markers (ANCA and CD19) works as well as giving it on a fixed schedule to prevent relapses in people with ANCA-associated vasculitis. 166 adults in remission were randomly assigned to one of two rituximab plans and followe…

This study tested a new, less invasive way to repair spina bifida before birth. Instead of open surgery, doctors used a tiny camera and small tools through two small cuts in the uterus. Seven pregnant women took part. The goal was to see if this approach could successfully cover …

This study tested whether medicines usually used for HIV could help children with Aicardi-Goutières syndrome (AGS), a rare genetic disease that causes severe brain inflammation. Eleven children took reverse transcriptase inhibitors to see if the drugs could lower their interferon…

This early-phase study tested whether low-dose interleukin-2 (IL-2) can safely increase regulatory T cells in the blood of women who have had at least five unexplained early miscarriages. The goal was to see if this immune approach might help prevent the body from rejecting a pre…

This study tested whether giving the antiviral drug valacyclovir to pregnant women with CMV infection could reduce harm to their unborn babies. CMV is a common virus that can cause brain damage and other problems in newborns. The trial enrolled 41 pregnant women whose babies were…

This study tested whether rosuvastatin, a common cholesterol-lowering drug, could reduce early signs of artery hardening and prevent heart problems in 121 adults with ANCA-associated vasculitis, a rare inflammatory blood vessel disease. Participants were in remission and received…

This study tested three biologic drugs (adalimumab, anakinra, and tocilizumab) in 112 people with a severe eye condition called non-infectious uveitis that did not improve with standard treatments. The goal was to see which drug best controls inflammation and reduces the need for…

This study tested whether miglustat, a drug used for other conditions, can help restore the function of a faulty protein in adults with cystic fibrosis who have the F508del mutation. Sixteen participants received miglustat and a placebo in a crossover design to measure changes in…

This study tested a 5-week program combining adapted physical activity, nutrition guidance, and therapeutic education for 128 adults with Prader-Willi syndrome. The goal was to help patients stabilize or reduce their body mass index (BMI) for 6 months after leaving the hospital. …

This study tested a surgery performed on the fetus before birth to repair a type of spina bifida called myelomeningocele. The goal was to see if fixing the spinal opening early could reduce brain problems and limit nerve damage. The study included 38 pregnant women carrying a bab…

This study followed 852 cystic fibrosis patients aged 12 and older who were taking the drug combination ivacaftor+lumacaftor (Orkambi) for one year. Researchers wanted to see how many people stopped treatment, why, and how the drug affected lung function, nutrition, and flare-ups…

This study tested a procedure called radiofrequency ablation, which uses heat to remove abnormal cells, in 125 people with Barrett's esophagus and low-grade dysplasia (a precancerous condition). The goal was to see if this treatment could control or eliminate the abnormal cells b…

This study tested whether adding azathioprine to standard corticosteroids helps people with newly diagnosed microscopic polyangiitis, polyarteritis nodosa, or eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) who have no poor prognosis factors. The goal was t…

This study tested whether giving small amounts of milk under the tongue (sublingual immunotherapy) could help children with cow milk allergy tolerate more milk over time. 51 children aged 5 and older with confirmed IgE-mediated cow milk allergy participated. The goal was to safel…

This study tested a high dose (10 mg/kg/day) of the antifungal drug Ambisome in 40 people with zygomycosis, a rare but serious fungal infection. The goal was to see if the treatment could control the infection, measured by complete or partial response after 4 weeks. Researchers a…

This study tested the drug Humira (adalimumab) in 11 people with Netherton syndrome, a rare genetic skin condition that causes severe redness, itching, and pain. The goal was to see if Humira could reduce skin inflammation and improve quality of life after 3 months of treatment, …

This study tested a new method to stimulate the ovaries for egg freezing in women with breast cancer who need chemotherapy. The goal was to keep estrogen levels low during the process, which is safer for hormone-sensitive cancers. Eight women participated, and the approach used a…

This study tested whether the drug baclofen helps people with alcoholism reduce their drinking to safe levels or stop completely. Over 300 adults who wanted to cut back took either baclofen or a placebo for a year. The main goal was to see if more people in the baclofen group ach…

This study tested a gene therapy for people with severe sickle cell disease. Doctors took stem cells from the patient's own blood, added a working gene to help produce healthy red blood cells, and put them back. The goal was to see if this approach is safe and can reduce painful …

This study tested whether a drug called isosorbide mononitrate, given to help prepare the cervix, could lower the chance of needing a C-section in women whose pregnancies go past 41 weeks. Over 1,400 first-time mothers took part. The goal was to see if this simple outpatient trea…

This study looked at whether anti-inflammatory medication can improve sperm health in men with infertility caused by inflammation. About 200 men with signs of inflammation in their semen took either the drug or a placebo for 6 months. The goal was to reduce oxidative stress damag…

This study looked at whether a high dose of vitamin D (100,000 IU) is better than a low dose (12,000 IU) for kidney transplant recipients. The goal was to see if it could lower the risk of new diabetes, heart problems, cancer, or death. Over 500 adults who had a kidney transplant…

This study compared two methods to treat tubo-ovarian abscess (a pocket of infection in the female reproductive organs): draining it through the vagina using ultrasound guidance, or removing it with keyhole surgery (laparoscopy). Both groups also received antibiotics. The goal wa…

This study looked at two approaches for managing stage 1 twin-to-twin transfusion syndrome (TTTS), a serious pregnancy condition where blood flow is uneven between twins. Researchers compared immediate laser surgery with careful monitoring (watchful waiting) in 179 pregnant women…

This study looked at 94 men with advanced prostate cancer that had stopped responding to standard treatment. Researchers tested whether increasing the dose of the drug abiraterone could help stabilize the disease. The goal was to see if a higher dose could slow or stop cancer gro…

This study tested whether a technique called ischemic preconditioning, which is used in organ transplants, could help reduce fat tissue damage after breast reconstruction surgery in women who had a mastectomy for breast cancer. The approach involves short cycles of blood flow int…

This study tested whether a drug called sodium phenylbutyrate could reduce a specific protein (Lcn2) in the urine of people with chronic kidney disease and proteinuria. 26 participants took the drug to see if it lowered their protein levels. The goal was to find a new way to mana…

This study tested whether adding early steroid treatment to standard blood pressure or diabetes medications can better control IgA nephropathy, a kidney disease. 62 adults with severe kidney damage on biopsy were randomly assigned to get either the combination or standard care al…

This study tested whether adding bortezomib to standard treatments (steroids, plasma exchange, and immunoglobulins) can help control chronic antibody-mediated rejection in kidney transplant recipients. 60 adults who had a kidney transplant and developed donor-specific antibodies …

This study tested whether allopurinol, a medicine usually used for gout, can help people with a rare genetic condition called ADSL deficiency. The condition causes autism, seizures, and developmental delays. Eight children and adults took allopurinol for 12 months, and researcher…

This study tested whether a drug called rituximab works better than standard treatments to bring a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA) under control. EGPA causes inflammation of small blood vessels, leading to organ damage. The trial involved …

This small pilot study looked at whether the drug pirfenidone is safe and effective for people with a specific type of lung scarring (pulmonary fibrosis) linked to certain antibodies or a related blood vessel condition. Seven adults took the drug for a year, and researchers measu…

This early-phase study tested whether giving methionine (an amino acid) by mouth or feeding tube is safe for children with a rare, severe lung disease caused by a specific gene mutation. The disease leads to breathing problems and has no cure. Only 3 children took part. The main …

This study collected CT scans from over 10,000 adults to find better ways to diagnose COVID-19 and predict how sick a person might become. Researchers used the images to develop and test both visual scoring and artificial intelligence (AI) methods. The goal was to improve accurac…

This study looked at whether adding a CT scan of the legs and pelvis to the standard chest scan helps find more blood clots in women who may have a pulmonary embolism (a clot in the lung) within six weeks after giving birth. Researchers enrolled 125 women and compared detection r…

This study looked at whether whole body MRI can correctly identify inflammatory muscle diseases like myositis, polymyositis, and dermatomyositis. Researchers compared MRI results to muscle biopsy in 139 people suspected of having these conditions. The goal was to see if MRI could…

This study tested whether using a blood test called the sFlt-1/PlGF ratio helps doctors make better decisions for pregnant women with suspected preeclampsia before 35 weeks. The goal was to see if the test could reduce unnecessary hospital stays and improve care for both mother a…

This study looked at three new methods to diagnose whether a central line (a special IV) is causing a bloodstream infection in seriously ill children. The goal is to avoid removing the line if it's not infected. Researchers tested 148 children and compared the new methods to stan…

This study tested a new MRI technique (called Advanced ZTE) to take clear pictures of children's lungs without using radiation or injecting contrast dye. 72 children aged 6-16 who already needed a chest CT scan took part. The goal was to see if the new MRI could match the quality…

This study tested a new DNA test (MycoGenie kit) to see how well it can detect a serious fungal infection called invasive aspergillosis in blood cancer patients. The test looks for the fungus's DNA in blood samples and can also check if the fungus is resistant to common medicines…

This study tested whether using saliva samples can detect the COVID-19 virus as accurately as the standard method (a swab inserted into the nose). Over 5,000 adults and children provided both a nose swab and a saliva sample. The goal was to see if a simpler, less invasive spit te…

This study tested a new, non-invasive method to find and count prostate cancer cells from blood or urine samples. Researchers enrolled 127 men with suspected prostate cancer to see if this approach could detect tumor cells before a standard biopsy. The goal is to make diagnosis e…

This study tested a new, non-invasive blood test to diagnose Down syndrome (trisomy 21) during pregnancy. Current screening methods have high false-positive rates, and the only way to confirm a diagnosis is through invasive procedures like amniocentesis, which carry a 1-3% risk o…

This study looked at whether a stool test (fecal calprotectin) can help predict serious gut inflammation in premature babies. Researchers followed 122 infants born before 33 weeks, collecting stool samples weekly. The goal was to create a scoring system that combines this test wi…

This study tested a new imaging technique called Full Field Optical Coherence Tomography (FFOCT) to see if it can accurately detect prostate cancer in biopsy samples. Researchers compared FFOCT results with standard lab analysis in 91 men with elevated PSA levels. The goal was to…

This study involved over 2,100 pregnant women at higher risk for Down syndrome. Researchers compared a simple blood test (NIPT) with the standard invasive test to see which was safer and more accurate. The goal was to reduce miscarriages caused by invasive procedures while still …

This study looked at whether measuring certain proteins (amyloid peptides) in the blood can help diagnose Alzheimer's disease or predict how fast it will progress. Researchers followed over 1,000 older adults, some with mild cognitive impairment and some with Alzheimer's, to see …

This study tested whether a special type of MRI scan could be used to measure lung scarring (fibrosis) in people with scleroderma. Researchers wanted to see if this method, which doesn't use radiation, could be a better and more reproducible way to track the disease compared to c…

This study looked at different non-invasive methods to measure liver scarring (fibrosis) in 56 children with cystic fibrosis aged 6-18. The goal was to see which tests work best to detect early liver damage, so doctors can start treatment sooner. The methods compared include bloo…

This study tested whether a noninvasive ultrasound device called FibroScan can accurately measure liver scarring (fibrosis) in children. Currently, the only reliable method is a liver biopsy, which involves inserting a needle into the liver. The study included 264 children aged 6…

This study tested two ways to give pneumococcal vaccines to 47 adults with stable lupus. One group got a prime-boost approach (conjugate vaccine first, then standard vaccine 6 months later), while the other got only the standard vaccine. The goal was to see which strategy produce…

This study tested whether high doses of erythropoietin, a drug that boosts red blood cell production, could help prevent long-term brain damage in full-term newborns who suffered oxygen loss at birth. All 120 babies also received standard cooling therapy. The main goal was to see…

This study tested whether giving pregnant women with sickle cell disease oxygen at home every night could prevent serious complications like severe pain, lung problems, or stroke. 178 women took part. The goal was to see if this simple approach could reduce hospital stays and pro…

This study tested whether somatostatin is better than octreotide at preventing pancreatic fistula—a serious leak of digestive fluids—after pancreatic surgery. 655 adults having their pancreas removed were randomly assigned to one of the two drugs. The goal was to see which drug m…

This study aimed to see if the drugs azithromycin and hydroxychloroquine could prevent hospital workers from catching COVID-19. About 122 workers who tested negative for the virus were given either one of the drugs or a placebo for 40 days. The main goal was to see if fewer peopl…

This study looked at whether giving antibiotics early to trauma patients on breathing machines can prevent ventilator-associated pneumonia (VAP). Researchers analyzed data from 2,143 adults admitted for severe trauma who needed a ventilator. The goal was to see if this approach r…

This study tested whether applying heat or cold therapy during childbirth can lessen perineal pain after delivery. 115 women with no prior vaginal birth took part. Researchers measured pain levels and healing to see if thermotherapy helps.

This study looked at whether a numbing cream called ropivacaine can ease the severe pain children and young adults with epidermolysis bullosa feel during bath and dressing changes. Ten participants applied the cream before their usual care. The goal was to see if pain scores drop…

This study involved 55 adults with severe frozen shoulder (pain and stiffness for at least 3 months) who had not improved with standard treatments. Researchers used MRI and clinical exams to find factors that predict a better response to a shoulder injection (arthrographic disten…

This study tested a new liquid version of the diabetes drug glibenclamide in 10 children with neonatal diabetes caused by a genetic mutation. The goal was to see if the liquid form is easier for children to take and works as well as the standard pill. The study measured how accep…

This study tested whether wearing a weighted brace on the unaffected ankle helps people who have had a stroke walk better after returning home. 42 participants who had a stroke more than 3 months ago were assigned to either a weighted brace or a placebo brace. The main goal was t…

This study tested whether a self-hypnosis smartphone app could reduce attention problems and anxiety in 49 children aged 7-12 with ADHD who were already taking medication. Children used the app alongside their usual treatment. The goal was to see if the app could provide extra re…

This study looked at whether giving a sedative (midazolam) along with morphine can better reduce pain in children with broken arm bones. Sixty children aged 5 to 16 took part. One group got morphine plus the sedative, the other got morphine plus a placebo. The main goal was to se…

This small pilot study tested whether gardening (therapeutic horticulture) could reduce brain activity related to pain in 16 adults with chronic low back pain. Participants tried both gardening and handiwork sessions, and researchers used MRI scans to measure changes in a brain a…

This study looked at whether special education sessions could help children aged 8 to 12 with food allergies feel better day-to-day. 46 children and their families took part. The goal was to see if learning more about managing allergies could improve their quality of life.

This study tested whether breathing high-flow oxygen can quickly stop dystonic and plegic attacks in children with alternating hemiplegia of childhood (AHC), a rare genetic disorder causing temporary paralysis and muscle spasms. Twenty-four participants used oxygen or a placebo d…

This study tested a psycho-educational program for family caregivers whose parent has moved into a nursing home. The program aimed to reduce feelings of anxiety, guilt, and sadness by providing information and group support. 73 caregivers participated, and the main goal was to se…

This study tested a short program that combines education and physical rehabilitation for people with subacute or chronic low back pain. The goal was to see if it could reduce activity limitations and help patients avoid severe disability. 100 adults with mild to moderate back pa…

This study tested whether a 6-week personalized, multidisciplinary day-hospital program could improve quality of life for people with persistent long COVID symptoms like fatigue, shortness of breath, and brain fog. 80 adults with ongoing symptoms after a confirmed COVID-19 infect…

This study tested whether a virtual reality device could reduce pain in adults with chronic low back pain that did not respond to medication. 122 participants used a VR system that immersed them in a 3D environment with soothing colors. The main goal was to measure pain intensity…

This study looked at whether taking oral corticosteroids for five days helps people with COPD who are having a flare-up. The goal was to see if it reduces the need for emergency visits or hospital stays. The study involved 189 adults aged 40 and older who were treated in general …

This study looked at whether having a therapy dog present during dental visits can lower anxiety in children with autism. Fifty children aged 6 to 17 who were very anxious or uncooperative at the dentist took part. They had two sessions with a dog, then a third session without th…

This study tested a special educational tool for parents of children under 6 with type 1 diabetes. The goal was to see if the tool helps improve blood sugar control and prevent serious events like low blood sugar (hypoglycemia) and ketosis. The study involved 24 children across F…

This study tested whether art and movement workshops could help 8 children and teens who have unexplained chronic pain linked to school bullying. The program combined martial-arts-inspired dance with creating a street-art mural to rebuild confidence and ease pain. Results focused…

This study looked at whether 14 months of specialized medical follow-up and individual care can help people who say they are sensitive to electromagnetic fields (electrosensitivity). Researchers measured changes in symptom severity, frequency, and quality of life in 79 participan…

This study tested whether cannabidiol (CBD) can reduce severe itching in 10 children with hereditary epidermolysis bullosa, a rare genetic condition causing fragile skin and blisters. The children took oral CBD three times daily for one month. Researchers measured changes in itch…

This study tested whether art therapy can help people who have trouble speaking after a stroke. Fifteen participants with recent stroke and language difficulties took part. The goal was to see if making art could activate parts of the brain that support language recovery. The stu…

This study tested whether resveratrol, a natural substance found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took either resveratrol or a placebo pill daily for three months. Researchers measured changes in kn…

This study looked at 304 children aged 2 to 17 who came to the emergency room with a broken arm or leg bone. Researchers wanted to see if giving paracetamol (Tylenol) and/or ibuprofen (Advil) along with morphine would relieve pain better than morphine alone. The goal was to find …

This study looked at how well supportive and palliative care works for infants under 1 year old with spinal muscular atrophy type 1, a severe muscle-weakening disease. Researchers measured oxygen use and breathing support, and asked parents about their challenges and satisfaction…

This study tested whether a single injection of botulinum toxin A (like Botox) into the thumb joint, along with a splint, can reduce pain from base-of-thumb osteoarthritis. Sixty adults with moderate to severe pain took part. The main goal was to see if pain decreased three month…

This study looked at whether injecting botulinum toxin A into a groin muscle could reduce pain and improve daily activities in 20 adults with long-term athletic pubalgia (sports-related groin pain). Participants had already tried other medical or surgical treatments without succe…

This study tested whether using near-infrared light to see veins helps doctors draw blood or place an IV on the first try in children with hard-to-find veins. It included 163 newborns and children up to age 18 in the hospital or emergency room. The goal was to reduce pokes and ma…

This study tested a device that sends mild electrical pulses to a nerve in the ear to see if it can reduce pain and inflammation in people with a severe type of hand osteoarthritis. 148 adults with painful, swollen finger joints used either the active device or a sham (fake) devi…

This study tested a special stent with a magnetic end in 67 children with urinary tract problems or kidney transplants. The goal was to see if doctors could remove the stent without general anesthesia, using a magnetic tool instead. The approach aims to make the procedure easier …

This study tested whether a single antihistamine works as well as an antihistamine plus a corticosteroid for treating acute hives in the emergency department. 137 adults with hives (with or without mild swelling) took part. The main goal was to see if symptoms improved over 7 day…

This study tested whether a special pain monitor (called ANI) used during scoliosis surgery in children could help doctors give just the right amount of pain medicine, reducing the need for morphine after surgery. About 260 children took part. The goal was to see if using the mon…

This study looked at whether listening to music during cataract surgery can reduce anxiety and prevent spikes in blood pressure. Over 300 adults having the procedure under numbing eye drops took part. Researchers measured blood pressure and asked patients about their anxiety befo…

This study tested whether having a woman lie on one side (asymmetrical lateral decubitus) during labor can help turn a baby that is facing the wrong way (occipitoposterior position) into the correct position. The trial involved 326 women in labor. The goal was to see if this simp…

This study looked at whether using cervical dilators (tools to open the cervix) before starting labor medication can shorten the time to delivery in second-trimester pregnancy terminations. 355 women participated. The main goal was to see if more women delivered within 12 hours w…

This study looked at how phenelzine, a drug used for depression, affects immune cells in people with COVID-19. Researchers measured changes in T cells and monocytes from blood samples of 51 patients. The goal was to understand if phenelzine could reduce harmful immune activation,…

This study looked at teenagers who were born very low birthweight (under 3.3 pounds) to see how their lungs and breathing developed. Researchers measured lung function and asked about breathing problems in 355 teens from the French EPIPAGE study. The goal was to understand the lo…

This study looked at the gut bacteria and bile acids of 80 people with and without coronary artery disease. Researchers wanted to see if differences in these gut-related substances could be linked to heart health. The study was observational, meaning it only measured and compared…

This study looked at whether melanoma cells that are dormant or can start new tumors are present in healthy tissue near the original tumor. Researchers followed 226 people with early-stage melanoma for 5 years to see if the presence of these cells was linked to survival or cancer…

This study looked at whether using frozen embryos instead of fresh ones improves the chance of having a baby in women doing IVF. 237 women took part. The goal was to see if freezing embryos first leads to more live births and healthier pregnancies.

This study looked at how adults with sickle cell disease use painkillers and cannabis at home. Researchers surveyed 257 patients from three hospitals to find out how many have an opioid use disorder. The goal is to gather data to improve care and support for these patients.

This study looked at whether a simple 6-minute walk test can help predict how cystic fibrosis will progress in adults. Researchers followed 291 patients to see if the distance walked or oxygen levels during the test were linked to survival without needing a lung transplant. The g…

This study looked at whether it is possible to run diabetes education workshops for inmates at the Paris jail "La Santé". 22 male prisoners with type 1 or type 2 diabetes were invited to take part. The main goal was to see how many attended at least two workshops, and to measure …

This study looked at 558 children and adults with congenital hypothyroidism (an underactive thyroid from birth) to find genetic causes. Researchers compared patients' genes with their medical and imaging results to better understand why the condition happens and why some have oth…

This study looked at 204 adults with hemophagocytic syndrome, a rare condition where the immune system becomes overactive. Researchers aimed to find better ways to diagnose it and understand its causes, including possible genetic defects. No new treatments were tested; the goal w…

This study looked at 99 women with primary immune deficiency to understand how pregnancy affects their health. Researchers tracked infections and pregnancy outcomes like miscarriages and live births. The goal was to gather information to help guide future care, not to test a new …

This study looked at nearly 1,000 children who had both a childhood cancer and a developmental abnormality (like a birth defect, learning delay, or growth problem). The goal was to create a national database to help scientists discover new genetic syndromes that make children mor…

This study looked back at 91 children who had surgery to remove a malignant bone tumor from their leg and then had the bone rebuilt using one of three techniques: the induced membrane method, a vascularized fibula graft, or a fibula graft combined with a donor bone. The goal was …

This study aims to find the genetic causes of a rare, inherited kidney disease called HTIN. Researchers will study 225 adults with the condition and their families to look for specific gene mutations. The goal is to better understand the disease, not to test a new treatment.

This study collected blood samples from 236 pregnant women with and without preeclampsia. The goal was to test a new treatment that filters out a harmful protein (sFlt-1) from the blood to help restore normal pregnancy function. The research focused on measuring protein levels to…

This study looked at how a marker of inflammation called C-reactive protein (CRP) changes in the blood of 35 people having emergency angioplasty for a heart attack. Researchers took blood samples before the procedure and at several time points up to 30 days after. The goal was to…

This study examined 29 newborns to see if exposure to a class of HIV drugs called anti-integrases in the womb changes their immune system at birth. Researchers compared babies whose mothers took anti-integrase drugs with those whose mothers took other HIV medications. The goal wa…

This study tested a new way to create 3D models of the head and neck area in children aged 1 to 5 years. The models show where important nerves are located near tumors or birth defects. The goal was to help surgeons plan operations more carefully and avoid damaging nerves. Seven …

This study looked at whether a serious game (a video game designed to teach) can help children aged 10-17 with newly diagnosed type 1 diabetes learn more about their condition. 78 kids were split into two groups: one got standard education, the other also played the game. The goa…

This study looked at 45 people with patellofemoral pain syndrome (pain around the kneecap) to see if different types of the condition have different movement problems. Researchers used a special device to measure how the thigh and shin bones rotate during walking. The goal was to…

This study followed 80 people newly diagnosed with Cushing's disease to see how the condition affects the heart, bones, metabolism, and quality of life. Researchers checked these complications before treatment and every year for three years after. The goal was to better understan…

This study followed 179 children aged 4 to 16 who were born from twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS). The goal was to check their heart, kidney, and metabolic health, as well as puberty development, to see if the condition during pregnancy has…

This study looks at how quality of life changes over 8 to 10 years in 25 women with MRKH syndrome, a condition where the uterus and vagina are underdeveloped. Researchers used questionnaires and interviews to understand social and work life impacts. The goal is to learn more abou…

This study looked at 28 healthy male volunteers to see if a small transfusion of their own blood (200 ml) causes detectable changes in blood cells and particles. The goal is to find markers that could identify athletes who use blood doping. No treatment or cure is involved—just o…

This study tested French versions of three hearing and quality-of-life questionnaires (PEACH, SSQ-C, SSQ-P) in 101 children aged 1 to 17 with deafness and a control group. The goal was to see if these tools are reliable and accurate for use in clinics and research. The study did …

This study looked at 25 people with FOXP1 syndrome, a rare genetic condition, to better understand their psychiatric symptoms. Researchers measured hyperactivity, attention issues, psychotic symptoms, autism traits, anxiety, sleep problems, and behavior. The goal was to describe …

This study looked at how children born with a missing outer ear (ear aplasia) feel and think before and after reconstructive surgery. Researchers used psychological tests and questionnaires to understand their emotional state, body image, and quality of life. The goal was to lear…

This study looked at how certain immune cells (antigen-presenting cells) behave in people with sepsis, a life-threatening response to infection. Researchers collected extra blood samples from 119 ICU patients and healthy volunteers to analyze these cells at a molecular level. The…

This study looked at 5,000 people having cataract surgery to see if a new tool called the Active Sentry handpiece makes the procedure safer. The tool helps control pressure inside the eye during surgery, which may reduce the energy needed and lower the risk of complications. The …

This study looked at 90 adults having major liver surgery to compare two fluid management approaches: a restrictive method that limits fluids, and an individualized method tailored to each patient. The goal was to see which approach leads to better outcomes, such as less blood lo…

This study looked at 472 pregnant women to understand why some refused to join a clinical trial on first-trimester screening for pre-eclampsia, a serious pregnancy condition. Researchers analyzed factors like age and background, and asked women who accepted or declined to share t…

This study followed 100 people who had a serious heart infection (infectious endocarditis) to see how brain lesions found during the infection changed over time. Researchers used MRI scans and thinking tests to compare results from the acute phase and later follow-up. The goal wa…

This study looked at how trouble controlling body temperature affects sleep in people with hypohidrotic ectodermal dysplasia (HED), a rare genetic condition that limits sweating. Researchers compared sleep quality, body temperature, and melatonin levels between 22 HED patients an…

This study looked at how the way prescriptions are written affects whether older adults (over 75) can correctly fill their pillboxes. Researchers tested different writing styles, like using abbreviations or writing numbers as words, to see which caused fewer errors. The goal is t…

This study tested a simple technique—pressing on the front of the chest—in 20 adults with severe lung injury (ARDS). The goal was to see if this pressure could improve how air and blood flow in the lungs, and whether it affects heart function. Researchers used special imaging to …

This completed study collected blood, stomach, liver, intestine, and fat tissue samples from 360 severely obese adults undergoing bariatric surgery. The goal was to better understand how obesity and weight-loss surgery affect the body, especially the digestive system. Researchers…

This study followed 530 working-age adults (18-70) who were hospitalized with COVID-19 to see how the disease affected their daily lives over 3 years. Researchers measured disability from both doctor and patient perspectives using standard checklists. The goal was to understand t…

This study looked at two specific eye measurements, called angle kappa and angle alpha, in 70 healthy adults. The goal was to better understand these natural eye features so that eye surgeries like cataract or strabismus correction can be more precise. Participants had their eyes…

This study looked at 20 children under 18 who were in the intensive care unit with heart inflammation (myocarditis) and fever, possibly linked to COVID-19. The goal was to describe their symptoms and test results, and to figure out whether the virus directly damages the heart or …

This study looked at how many infertile women have migraines and how those migraines change during IVF treatment. Researchers tracked 137 women aged 18-40 at a fertility center. The goal was to understand the link between hormone changes from IVF and migraine headaches.

This study looked at 100 women having gynecological surgery to see if waiting exactly three minutes after giving a muscle relaxant called atracurium helps doctors place the breathing tube more easily. The researchers checked how good the conditions were for putting in the tube. T…

This study aimed to find out how common platelet dense granule defects are in people with unexplained bleeding. Researchers measured the number, content, and release of these granules in 166 patients. The goal was to link specific granule problems to bleeding severity and type, h…

This study looked at 22 deaf infants under 10 months old to find out which factors might be linked to early signs of neurodevelopmental disorders, like autism. Researchers filmed special check-ups to see how the babies interacted and moved. They also reviewed medical records to c…

This study looked at whether a well-organized emergency system helps more people survive severe injuries. Researchers compared death rates within 28 days for over 2,000 patients treated in either a structured or non-structured system. The goal was to see if having a coordinated t…

This study followed 601 adults who survived a cardiac arrest outside the hospital. Researchers tracked their survival, brain function, and quality of life over time to understand long-term outcomes. The goal was to learn which treatments help people live better after such a serio…

This study looked at a rare lung condition called pulmonary alveolar proteinosis (PAP) caused by changes in the MARS gene. Researchers wanted to understand why the lungs' cleaning cells (macrophages) don't work properly. They studied cells from 20 children with and without the MA…

This study looked at how often people with active lupus take their medication as prescribed. Researchers measured the amount of hydroxychloroquine in the blood of 307 patients to find out who was not taking their medicine. The goal was to understand how common non-adherence is, e…

This study aimed to find risk factors for osteoporosis in people with cystic fibrosis. Researchers took blood samples from 25 patients and grew bone-degrading cells in the lab to understand their potential to weaken bones. They also tested how CFTR modulators affect these bone ce…

This study looked at whether certain immune system markers (autoantibodies) can help predict the course of pulmonary arterial hypertension (PAH), a serious lung condition. Researchers examined blood samples from 629 adults with different types of PAH, including those linked to HI…

This study aimed to find normal nasalance scores for French-speaking children aged 8 to 10. Nasalance measures how much sound comes through the nose during speech, which can help diagnose resonance disorders like those caused by cleft palate. Researchers used a non-invasive devic…

This study tested a social robot named ARI in a day hospital for elderly patients. The robot was designed to inform, guide, and entertain patients and their families, while also supporting healthcare workers. Researchers measured how acceptable and easy to use the robot was for p…

This study interviewed 62 doctors, nurses, and physiotherapists to understand how the COVID-19 epidemic impacted their work and personal life. Researchers identified common themes about the difficulties these healthcare workers faced while caring for patients. The goal was to lea…

This study looked at how closely 227 adults with precapillary pulmonary hypertension follow their prescribed diuretic (water pill) regimen. Researchers used questionnaires and pharmacy records to measure adherence and identify factors that lead to missed doses. The goal was to un…

This study looked at 150 children with severe hearing loss from birth to find out how many have a specific genetic condition called DFNB9. The children had hearing tests and genetic analysis. The goal was to better understand this type of deafness, not to provide a treatment.

This study looked at 575 adults admitted to intensive care for a severe kidney infection (acute obstructive pyelonephritis). Researchers wanted to find out which factors are linked to worse outcomes, such as death, severe kidney injury, or failure to recover kidney function. The …

This study looked at whether two common pain relievers, ibuprofen and ketoprofen, enter mature breastmilk. Researchers measured drug levels in milk from 35 breastfeeding women who had been taking either medication for more than 24 hours. The goal was to see if these drugs stay lo…

This study reviewed the medical records of 980 children who had surgery to repair a hole in their eardrum. The goal was to see how often the eardrum healed properly and how well hearing improved after the operation. Researchers looked at results from hearing tests and ear exams d…

This study looked at how fourth-year medical students learn to communicate with patients during a required training course. The training included role play, simulated doctor visits, Balint groups, and lectures. Researchers interviewed students and teachers and reviewed written wo…

This study looked at how antiretroviral drugs behave in children's bodies. Researchers used data from 65 kids to create models that predict drug levels based on factors like weight and age. The goal was to help doctors give the right dose to each child, improving treatment and re…

This study used a special MRI technique to look at spinal cord structure in 40 adults with cervical spondylosis (neck arthritis). Researchers compared the imaging results with standard clinical tests like muscle strength and reflexes. The goal was to better understand how the dis…

This study looked at how well the antibiotic ertapenem reaches prostate tissue after a single dose given before surgery. Twenty men with benign prostatic hyperplasia (BPH) scheduled for prostate surgery received the antibiotic, and researchers measured its concentration in the re…

This study looked at whether an ultrasound measurement of the lower part of the womb can predict the risk of uterine rupture during labor in women who have had a previous C-section. About 3,000 pregnant women with one prior C-section were enrolled. The goal was to see if using th…

This study looked at whether giving parents a simple information leaflet about fever before their child's emergency room visit improves their knowledge on how to handle fever at home. 220 parents of children with fever took part. The goal was to see if the leaflet helps parents f…

This study looked at whether measuring a marker called procalcitonin in the blood can help doctors decide when to stop antibiotics in newborns with late-onset sepsis. Over 500 babies were included. The goal was to reduce antibiotic use by 30% without raising the risk of infection…

This study looked at how often depression and anxiety occur in teenagers with cystic fibrosis and their parents. Researchers asked 108 participants to complete screening questionnaires during a routine clinic visit. The goal was to understand how mental health symptoms relate to …

This study looked at whether the measles vaccine virus can be found in the breast milk of women who received the MMR vaccine shortly after giving birth. Fourteen breastfeeding mothers with no immunity to measles or rubella were vaccinated, and their milk was tested over two weeks…

This study looked at how often kidney hypodysplasia (underdeveloped kidneys) runs in families. Researchers collected DNA from 342 children aged 3 months to 18 years with the condition. The goal was to find genes that might cause it, but this study did not test any treatment.

This study looked at blood clots from 380 people who had a sudden cardiac arrest or a heart attack. Researchers wanted to see if the age and makeup of the clot could explain why some people die suddenly while others survive. They found that fresh, fast-forming clots were more com…

This study explored whether certain genes make children more likely to develop severe cavities. Researchers compared 390 young patients with many cavities to cavity-free young adults, looking for mutations in genes that affect tooth enamel. The goal was to find genetic factors th…

This study tested a simple breathing test (PEEP test) to see if it can predict whether patients on ventilators need extra fluids. 66 adults on mechanical ventilation were included. The goal was to avoid giving unnecessary fluids, which can cause harm. The test was compared to sta…

This study talked to 27 children (ages 6 and up) who have a parent with cystic fibrosis, a serious lung disease. Researchers held interviews and small group chats led by a psychologist to learn about the children's feelings, worries, and needs. The goal is to use this information…

This study looked at how the heart medication amiodarone behaves in children aged 0 to 18 with heart rhythm disorders. Researchers measured drug levels in the blood to understand dosing, effectiveness, and safety. The goal is to help doctors use this medicine more precisely in yo…

This study looked at whether giving stage IV lung cancer patients clear information about chemotherapy's risks—including that it can sometimes worsen life-threatening conditions—helps them avoid aggressive treatment at the end of life. 123 patients were randomly assigned to recei…

This study looked at how well the drug letermovir passes from a pregnant woman to her fetus in the second trimester. It involved 7 women who were already scheduled to end their pregnancy for other reasons. The goal was to measure drug levels in fetal blood and amniotic fluid to s…

This study aimed to understand why people with Lowe syndrome experience unusual bleeding. Researchers tested the blood platelets of 30 patients to see if they work properly. The goal was to confirm and describe any platelet problems, which could help explain the bleeding events.

This study tested a new method to predict whether children with severe sepsis or septic shock would benefit from additional fluids. Doctors gave a very small amount of fluid quickly (a mini-bolus) and measured changes in heart function. The goal was to find a simple, reliable way…

This study followed 58 children with sickle cell disease from infancy to look for clues that might predict a life-threatening complication called acute splenic sequestration. Researchers collected blood samples and genetic information to identify early warning signs. The goal was…

This study looked at 36 children with short stature who were treated with growth hormone. Researchers wanted to see if their quality of life improved by the time they reached their final adult height. They used questionnaires to measure emotional, social, and physical well-being.…

This study looked at 119 children who had platinum-based chemotherapy for certain childhood cancers. Researchers collected saliva samples to find genetic differences that might explain why some children develop severe hearing loss while others do not. The goal is to identify high…

This completed study looked at 127 pregnant women who received betamethasone (Celesten) to prevent lung problems in their premature babies. Researchers measured how much of the drug crossed the placenta and checked if it reduced the risk or severity of hyaline membrane disease, a…

This study looked at the different types of cells inside rhabdoid tumors in 15 children. The goal was to understand how this cell diversity might make tumors resistant to treatment. Researchers used advanced single-cell techniques to identify cell clusters and potential targets f…

This study followed 85 adults who survived severe COVID-19 and needed a breathing machine in the ICU. Researchers checked their thinking, mood, and walking abilities as they moved from hospital to home. They compared these survivors to healthy people of similar age to understand …

This study involved 70 people with rheumatoid arthritis to see how well telemedicine (virtual doctor visits) works for managing their condition. Researchers tracked how often patients needed in-person visits, hospital stays, or changes in medication after a virtual consultation. …

This study looked at whether a special type of PET/CT scan can help doctors see how well treatment is working for a serious fungal lung infection (invasive pulmonary aspergillosis) in people with blood cancer. 51 patients were enrolled. The goal was to see if the scan could detec…

This study looked at 71 adults having day surgery to see if heart rate patterns and pupil reflexes can objectively measure anxiety before an operation. Researchers compared these physical signs with patients' own reports of anxiety. The goal was to find a simple, non-invasive way…

This study looked at 146 children taking common steroids (prednisone, prednisolone, methylprednisolone, hydrocortisone) to understand why each child processes the drug differently. Researchers measured drug levels in the blood and checked for genetic and other factors that might …

This study looked at whether a special PET scan can help doctors decide the best treatment for a rare fungal infection of the liver and spleen. The infection happens in some people with blood cancer or those who had a stem cell transplant. The goal was to see if the scan could tr…

This study looked at how teenagers with anorexia nervosa feel about being prescribed antidepressants. Researchers interviewed 15 adolescents aged 12 to 25 who had taken or were taking a type of antidepressant called SSRIs. The goal was to understand their personal experiences, no…

This study looked at the types of fungi living on the skin of adults with eczema (atopic dermatitis) that affects the head and neck. Researchers compared 30 participants with eczema to healthy controls to see if an imbalance in skin fungi plays a role. The goal was to better unde…

This study looked at how the antifungal medicine caspofungin is processed in the bodies of adults with serious burns. The goal was to find the best dose for this group. Only 2 people took part, and the study is now complete.

This study looked at how spinal surgery with pelvic fixation changes walking ability in children with scoliosis. Six children under 18 who could walk were observed before and 6 months after surgery. Researchers measured walking quality, endurance, and daily function to see if sur…

This study looked at whether offering counselling to family members right after a loved one's sudden death can reduce depression, anxiety, and post-traumatic stress. Over 600 relatives of sudden death victims were involved. The goal was to see if early support from medical teams …

This study looked for simpler ways to measure how many insulin-making cells are left in people with type 1 diabetes. Currently, doctors use a long, 3-hour meal test, which is not very sensitive. Researchers checked if immune cells in the blood or urine tests could give the same i…

This study measured the hearing quality of life of 130 children aged 2 to 10 with hearing aids or cochlear implants. Researchers used the PEACH questionnaire to understand how well children hear in quiet and noisy situations. The goal was to compare different types of hearing dev…

This study looked at children with neuromuscular scoliosis (a curved spine caused by brain, spinal cord, or muscle disorders) who had a special surgery that doesn't fuse the spine. The goal was to measure how the spine stiffens over time using ultrasound. 36 children participated…

This study measured how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) received the HPV vaccine, compared to those without chronic illness. Researchers reviewed medical records at a French hospital to find out vaccination rates…

This study looked at why some 2-year-olds in France have low iron levels, which can harm brain development. Researchers checked if drinking toddler milk formula helps protect against iron deficiency. They studied 830 children and their eating habits, along with family background,…

This study used a non-invasive brain stimulation technique called rTMS to learn how a specific brain area (the superior temporal sulcus) affects social perception in people with autism. Researchers measured how participants looked at social scenes and recognized human voices befo…

This study looked at 422 pregnant women who had a fever during labor to understand how often it leads to infections in mothers and babies. Fever in labor can have many causes, including infection, medication side effects, or labor itself. The goal was to better predict and manage…

This study looked at 51 adults with cardiac amyloidosis, a rare heart condition, to find out how many also have problems with smell or taste. Researchers used simple tests to measure these senses. The goal is to see if smell or taste loss could be an early warning sign of the dis…

This study looked at medical records from 168 patients with a rare type of digestive neuroendocrine tumor (grade 3). The goal was to compare how well different chemotherapy treatments work and how long patients live. The study did not test a new treatment but instead gathered inf…

This study looked at what factors affect how heavy the workload feels for nurses in intensive care and pediatric units. Researchers surveyed 484 nurses to measure mental demands, physical effort, time pressure, and frustration. The goal was to identify service, staff, and patient…

This study examined severe Group A Streptococcus (strep) infections in children in Paris from 2018 to 2023. Researchers looked at how COVID-19 lockdowns and mask rules changed infection rates over time. The study included 269 children under 18 and found a rise in infections after…

This study aimed to find genes that cause Chiari type 1 malformation, a condition where part of the brain pushes into the spinal canal. Researchers took blood samples from 40 people with the condition and their family members to analyze their DNA. The goal was to identify genetic…

This study tested whether a special thermal camera could automatically detect signs of breathing distress in patients on mechanical ventilators. Researchers monitored 85 adults during a breathing trial, measuring heart rate, breathing rate, and facial expressions. The goal was to…

This study looked at how many children of hospital workers had antibodies against COVID-19, and whether that was linked to their parents' infection status. Over 500 family members provided blood and saliva samples to check for past infection. The goal was to better understand how…

This study tested whether a 15-second pause in breathing (end-expiratory occlusion) can predict if giving fluids will improve blood flow in infants under 2 years old who are in shock and on a breathing machine. Ten infants in intensive care were monitored with ultrasound before a…

This study followed 512 children born to parents with type 1 diabetes to find early signs that might predict the disease. Researchers looked at immune cells, gut bacteria, and lifestyle factors. The goal was to understand how type 1 diabetes develops, not to test a treatment.

This study looked at 50 adults having thyroid or parathyroid surgery to see if a muscle relaxant called rocuronium wears off quickly enough to allow nerve monitoring during the operation. The goal was to find out if using this drug for breathing tube placement is safe and effecti…

This study looked at 55 adults with diabetes to better understand insulin allergy, a rare but serious condition where the body reacts to insulin. Researchers tested skin tests to diagnose the allergy and studied patients' immune systems to find out why it happens. The goal is to …

This study looked at how well patients and doctors understand each other in the emergency room. Over 1,800 adults from 14 hospitals answered questions after their visit to see if their understanding matched the doctor's. The goal was to find where communication breaks down, not t…

This study looked at why children with a rare, painful skin condition called epidermolysis bullosa often do not take their prescribed opioid pain medicine before baths and bandage changes. Researchers interviewed 10 children and their parents to understand the barriers. The goal …

This study tested whether having a pharmacist review medications before cancer treatment starts can prevent drug-related problems. Researchers tracked 440 adults with solid tumors who were about to begin chemotherapy, immunotherapy, or oral targeted therapy. The goal was to see h…

This study looked back at 46 women who had a procedure called uterine artery embolization to treat fibroids or other uterine issues. The goal was to see how often women later had a baby and what pregnancy complications occurred. The research aims to provide clearer information fo…

This early-phase study tested whether a single injection of plerixafor could safely and effectively collect stem cells from the blood of adults with severe sickle cell disease who do not have a matched sibling donor. Only 3 people took part, and the main goal was to see if the pr…

This study looked at why people with myotonic dystrophy type 1 (DM1) have a much higher risk of dangerous blood clots in the legs or lungs. Researchers tested blood clotting in 130 participants, including people with DM1, people with a history of clots, and healthy volunteers. Th…

This study tested whether a special ultrasound technique (M-mode) can help doctors confirm that an epidural catheter is correctly placed in women during labor. About 100 women having vaginal delivery with epidural pain relief took part. The goal was to see if ultrasound could red…

This study tested a French version of a questionnaire that measures how chronic sinusitis affects children's quality of life. It involved 89 children aged 2 to 12, some with sinusitis and some without. The goal was to make sure the translated questionnaire works as well as the or…

This pilot study tested whether a combination of two drugs (G-CSF and plerixafor) could safely collect enough stem cells from the blood of children with Fanconi anemia for future gene therapy. Four patients aged 2 to 17 took part. The main goal was to see if the stem cell collect…

This study looked at the experiences of 50 family caregivers of people with systemic sclerosis, a rare chronic disease. Researchers used questionnaires to understand caregivers' quality of life, health, and relationship with the patient. The goal is to learn how to better support…

This study looked at 116 people who had a cardiac arrest outside the hospital and were treated with a special heart-lung machine called ECMO. The goal was to see how well their heart pumped blood 28 days and 90 days later. Researchers measured the heart's pumping strength using u…

This study looked at whether the activity of genes in the blood (the transcriptome) can help predict how well the brain will recover in people who are resuscitated after a cardiac arrest outside the hospital. Researchers collected blood samples from 60 adults shortly after they a…

This study interviewed 25 health professionals to learn how they diagnose and manage chronic (non-cancer) muscle and bone pain in teenagers and young adults. The goal is to use their insights to create a new tool that helps doctors better identify and treat this complex condition…

This study looked at how the lining of blood vessels (the endothelium) might be involved in stroke-like episodes in people with Congenital Disorders of Glycosylation (CDG). Researchers measured how leaky the blood vessel barrier was and tested the protein C system, which helps co…

This study analyzed data from 249 adults with blood cancers like lymphoma and leukemia who received immunotherapy. The goal was to find markers—such as patient history or lab results—that could predict whether the treatment would work or cause severe side effects. By identifying …

This study tested a smartphone app called Predigraft that helps doctors monitor kidney transplant patients remotely. The app predicts how long the new kidney might last and lets patients send health data like blood pressure and lab results from home. Researchers wanted to see how…

This study involved 39 adults and children with autoinflammatory diseases like FMF and Still's disease. Researchers conducted interviews to understand how these conditions affect quality of life. The goal was to create a tool that doctors can use to better assess and address pati…

This study looked at how blood clots in people with liver cirrhosis, a condition that can cause dangerous bleeding. Researchers used a special machine to test blood flow and also checked if tiny artificial platelets could help improve clotting. The study included 60 adults with a…

This study looked at why some newborns get severe infections from Group B Streptococcus (GBS) bacteria. Researchers examined how the baby's gut bacteria and immune system might help the dangerous GBS strain grow. 151 pregnant women took part to help understand these risks.

This study looked at nearly 9,000 twin births to figure out the best way to deliver twins safely. Researchers compared different delivery methods and tracked serious health problems in the babies, like breathing issues or infections. The goal was to help doctors choose the safest…

This study tested a method called continuous anterior chest compression (CACC) in 20 patients with severe breathing failure (ARDS). Researchers compared CACC to the standard prone (face-down) position to see if it improved lung function. The goal was to gather information, not to…

This study looked at how families experience being told their child has craniosynostosis, a condition where skull bones fuse too early. Researchers surveyed and interviewed 574 parents and older children to understand the emotional impact and care journey. The goal is to improve …

This study looked at 400 couples, both fertile and infertile, to see how diet, lifestyle, and genetics affect the chance of getting pregnant. Researchers checked food habits, body measurements, and blood tests. The goal was to understand which nutritional factors might help or hu…

This study looked at whether measuring a hormone called pancreatic polypeptide can help doctors tell the difference between type 1 diabetes and type 3c diabetes (diabetes caused by pancreas damage). Thirty-six adults with diabetes took part. The goal was to improve how diabetes i…

This study looked at 436 pregnant women whose babies were found to have a lung malformation before birth. The goal was to find early signs that could predict if the baby would have trouble breathing right after delivery. By identifying these signs, doctors hope to give families b…

This study followed 50 children who received one or two cochlear implants for 3 years. Researchers compared automated brain responses (cortical auditory evoked potentials) with speech therapy results to see how well the implants help with hearing and language development. The goa…

This study aimed to find molecules made by cells from the water bag (the sac around the baby) that might signal when labor starts too early. Researchers collected samples from 24 healthy pregnant women after 37 weeks. The goal was to better understand the biology of preterm labor…

This study looked at 145 patients who had allergic or non-allergic reactions during surgery. The goal was to find specific signs, like skin changes or heart rate, that could tell doctors whether a reaction is truly allergic and life-threatening or not. By better understanding the…

This study followed 72 children whose prenatal ultrasound showed their corpus callosum (the bridge connecting the brain's two halves) was missing or abnormal. Researchers tested their thinking, movement, and behavior at age 3 to understand how these children develop. The goal was…

This study created a registry to collect medical information from 868 patients with Anti-Phospholipid Syndrome (APS) and/or Systemic Lupus Erythematosus (SLE). The goal was to better understand these autoimmune diseases by gathering data from affected individuals. No treatments w…

This study tested a simple checklist to help doctors decide if a baby under 2 with a minor head injury needs a CT scan. The goal was to safely reduce the number of scans, which expose children to radiation. Researchers checked the rule in over 8,800 children to see if it could sp…

This study looked at how endometriosis might affect egg development and quality. Researchers analyzed fluid and cells from the ovaries of 16 women undergoing fertility treatment. The goal was to find clues that could help predict which eggs lead to a live birth.

This study followed 60 heart transplant patients for one year to see if the level of a harmless virus called TTV in their blood could predict when they might get an infection or reject the new heart. Researchers measured TTV levels monthly and compared them to actual infections a…

This study used powerful MRI scans to track how a rare brain disease called metachromatic leukodystrophy (MLD) damages white matter in children aged 1 to 6. Researchers studied 29 children recently diagnosed with MLD to better understand the disease's progression. The goal was to…

This study looked at whether functional MRI (fMRI) can help diagnose Auditory Processing Disorder (APD), a condition that makes it hard for children to understand sounds despite normal hearing. Researchers compared brain scans of 45 children aged 7 to 18—some with APD, some suspe…

This study looked at how rare diseases affect oral health and quality of life. Researchers interviewed 28 patients (ages 6 and up) at Necker Hospital in Paris. The goal was to understand their experiences and challenges with dental care, not to test a new treatment.

This study examined 33 preterm babies born before 30 weeks to mothers with preeclampsia, a pregnancy complication. Researchers measured certain proteins in the mother's blood, umbilical cord blood, and amniotic fluid to see if they were linked to a lung condition called bronchopu…

This study tested whether 3D ultrasound can measure kidney and tumor volumes as accurately as CT or MRI scans. Researchers enrolled 53 adults with chronic kidney disease or kidney tumors. The goal is to see if a safer, radiation-free method can be used for monitoring.

This study reviewed medical records of 70 children under 18 who had a stroke and received clot-busting treatments (medication or a procedure to remove the clot). Researchers measured how quickly treatment was given and whether any bleeding complications occurred. The goal was to …

This study looked at blood neutrophils (a type of immune cell) in 47 adults with cystic fibrosis to see how chronic infection and certain treatments affect these cells. Researchers compared cells from patients with those from healthy blood donors. The goal was to learn more about…

This study looked at how two different COVID-19 booster vaccines affect immune cells in the lymph nodes of 12 adults who had already received at least three doses of an mRNA COVID-19 vaccine. Researchers used a needle to take a small sample from lymph nodes a few weeks after the …

This study looked at 20 adults with Behçet's disease to understand how the condition affects mental health and thinking. Researchers used questionnaires to measure anxiety, depression, fatigue, and quality of life. The goal was to gather information, not to test a treatment.

This study looked at whether a test using cells from the nose can predict how well the drug Orkambi works for people with cystic fibrosis. Researchers collected nasal cells from 91 participants before treatment and measured how the drug improved cell function. They then compared …

This study looked at how the pressure used to help patients with Acute Respiratory Distress Syndrome (ARDS) breathe affects the right side of the heart. Researchers measured lung and heart pressures in 50 adults and children to see if high pressure leads to heart failure. The goa…

This completed study looked at how certain immune cells called neutrophils behave in people with granulomatosis with polyangiitis (GPA), a rare disease that causes blood vessel inflammation. Researchers compared blood samples from 93 participants—including GPA patients, patients …

This study looked at blood levels of a specific immune marker (IgG4) for cow's milk and egg in 135 children, both with and without allergies. The goal was to understand how these levels change with age and whether they can show if a child has outgrown their allergy. Researchers a…

This study looked at 21 children and young adults (ages 7-25) who had surgery for Moyamoya disease, a rare brain vessel condition. Researchers used questionnaires and interviews to measure anxiety, depression, and family relationships, aiming to understand why some patients still…

This study tested a personalized method for safely lowering steroid doses in people with lupus. Researchers monitored 72 patients over three months to see how their bodies processed the medication. The goal was to find the best way to reduce steroids while keeping the disease und…

This study examined blood samples from 57 people who received stem cell transplants for blood cancers. Researchers looked at specific immune cells to see if they could predict a serious complication called graft-versus-host disease, where donor cells attack the patient's body. Th…

This study looked at 20 infants with severe bronchiolitis (a serious lung infection) to compare two types of breathing support: CPAP and NiPPV. The goal was to see which one reduces the effort of breathing more effectively. Researchers measured breathing effort using a special tu…

This study checked if men who had a treated urethritis infection develop long-term inflammation in their genital tract. Researchers measured a marker called elastase in semen 6 and 12 months after treatment, and also looked for signs of oxidative stress. They compared 113 men who…

This study looked at 674 pregnant women at high risk for placenta accreta (a condition where the placenta grows too deeply into the womb). Researchers wanted to find out which factors—like how the condition was diagnosed or the type of care received—affect the mother's health. Th…

This study followed over 1,400 pregnant women with endometriosis to see how the disease affects pregnancy. Researchers looked at risks like early birth, pregnancy loss, and other complications based on the type of endometriosis. The goal is to help doctors better monitor and care…

This study looked at 142 children aged 5 to 6 to see if their mothers' vitamin D levels during early pregnancy affected their breathing. Researchers measured airway resistance, a sign of lung health, and compared children whose mothers had low vitamin D to those with higher level…

This study aimed to better understand a rare bowel disease called intestinal epithelial dysplasia (tufting enteropathy) by looking at the genes and physical traits of affected children. Researchers studied 41 children aged 0 to 15 who were being evaluated for an intestinal transp…

This study tested whether using a checklist could lower the number of same-day or day-before cancellations for planned outpatient surgeries. Over 4,000 adults and children took part. The goal was to see if better organization could help surgeries happen as scheduled.

This study looked at whether an exercise test can be used to monitor treatment in people with a rare inherited disease that causes sudden muscle breakdown (rhabdomyolysis). Researchers measured heart function and oxygen use during exercise in 27 patients. The goal was to find bet…

This study followed 912 men and women over 60 in France who were hospitalized for a severe bone fracture caused by a minor fall. Researchers tracked how many had another severe fracture or died within 2 and 5 years. The goal was to better understand long-term outcomes, not to tes…