Assistance Publique - Hôpitaux De Paris

This study tested whether a 14-day course of doxycycline pills works as well as the standard penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal is to offer a reliable oral option, especially when penicillin is in short supply…

This study tested a two-step vaccine approach in 70 adults who had their spleen removed. Participants received one shot of a conjugate vaccine followed by a second shot of a polysaccharide vaccine two months later. The goal was to see if this combination triggers a strong immune …

This study looked at how well the seasonal and H1N1 flu vaccine works in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or other immune-suppressing drugs. Researchers measured antibody levels three weeks after each shot to see if the v…

This study tested whether a short course of the steroid prednisone could improve sperm quality in men with infertility caused by inflammation. Researchers measured markers of oxidative stress and sperm health six months after treatment. The trial involved 200 men and compared pre…

This study tested whether rosuvastatin, a cholesterol-lowering drug, can reduce early signs of artery hardening and prevent heart attacks or strokes in people with ANCA-associated vasculitis. 121 adults in remission from vasculitis were randomly assigned to take rosuvastatin or a…

This study looked at whether placing a cervical dilator (Dilapan-S) before medication can shorten labor in second-trimester medical termination of pregnancy. 355 women participated. The main goal was to see if more women delivered within 12 hours with the dilator. Results could h…

This study tested whether sodium phenylbutyrate, a drug already used for other conditions, can reduce a marker of kidney injury in people with proteinuric kidney disease. 26 participants took the drug for 14 days. The goal was to see a 50% drop in a urine marker called Lcn2, whic…

This study tested a daily injection called teduglutide (Revestive) in 25 children aged 2 to 18 with short bowel syndrome who rely on IV nutrition at home. The goal was to see if the drug could help their intestines absorb more nutrients and fluids, reducing or eliminating the nee…

This study tested whether the drug rituximab can help people with a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA) achieve remission better than standard treatments. 107 adults with active EGPA were randomly assigned to receive either rituximab or conven…

This study tested whether using chemotherapy alone could delay or avoid radiotherapy in people with a specific genetic type of brain tumor (1p/19q codeleted anaplastic glioma). The goal was to see if skipping radiation helps preserve thinking and memory without shortening surviva…

This study tested a drug called alemtuzumab (Campath) as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if it could help children survive until they could receive a stem cell transplan…

This early-phase trial tested whether injecting special immune-building cells (HTLPs) could help children with severe combined immunodeficiency (SCID) rebuild their immune system faster after a partially matched stem cell transplant. Only 4 children took part. The goal was to see…

This phase 3 trial tested whether giving two anti-seizure drugs together (levetiracetam plus clonazepam) works better than clonazepam alone for stopping prolonged seizures in the ambulance or at home. 203 adults with generalized tonic-clonic status epilepticus took part. The main…

This study looked at whether giving rituximab for a longer period (46 months) is better than the usual 18-month treatment for preventing relapses of ANCA-associated vasculitis, a rare autoimmune disease. 97 patients who were already in remission after initial rituximab therapy we…

This study tested whether giving a higher dose of oxytocin (a drug that strengthens contractions) could lower the rate of C-sections in obese women having their first baby. Over 400 women took part, receiving either a standard or a higher dose during labour. The goal was to see i…

This study followed 852 cystic fibrosis patients aged 12 and older who started taking Orkambi outside of a clinical trial. Researchers tracked how many stopped treatment, why, and measured lung function and nutrition over one year. The goal was to see how the drug performs in rea…

This study tested whether a special type of dialysis (high-permeability hemodialysis) could help people in shock after a cardiac arrest. The treatment aims to remove inflammatory substances from the blood to improve blood pressure and reduce the need for medications. The trial in…

This study tested whether measuring a substance called procalcitonin in the blood can help doctors decide when to stop antibiotics in newborns with late-onset sepsis. Over 500 newborns were included, and the goal was to reduce antibiotic treatment duration by 30% without increasi…

This study tested whether rituximab, a targeted antibody therapy, is better than azathioprine, a standard immune-suppressing drug, at preventing relapses in people with ANCA-associated vasculitis. 117 patients who had achieved remission were randomly assigned to receive either ri…

This study tested whether HIV drugs (reverse transcriptase inhibitors) can lower abnormal immune activity in children with Aicardi-Goutières syndrome, a rare genetic disorder that affects the brain and immune system. Eleven children took the drugs to see if their interferon level…

This study looked at whether adding an advanced practice nurse (APN) to standard care helps people with high blood pressure get better control. 483 adults with essential hypertension were included. The nurse provided education, medication planning, and check-ups between doctor vi…

This study tested what happens when patients with rheumatoid arthritis, Crohn's disease, or eye inflammation switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Over 260 adults who had been on Remicade for at least 4 months were switched. The main goal …

This study tested whether rituximab (given as an infusion every 6 months) is better than azathioprine (daily pills) at keeping eosinophilic granulomatosis with polyangiitis (EGPA) in remission. 98 adults with newly diagnosed or relapsing EGPA who had already achieved remission to…

This Phase 2 trial tested a high dose (10 mg/kg/day) of the antifungal drug liposomal amphotericin B (Ambisome) in 40 people with zygomycosis, a rare but serious fungal infection. The goal was to see if the high dose could effectively control the infection after 4 weeks of treatm…

This study tested whether giving a stronger pneumococcal vaccine schedule (either two doses close together or a single larger dose) followed by a standard booster could improve immune protection in 96 adults with ANCA-associated vasculitis who are also receiving rituximab therapy…

This study tested a personalized way to dose the blood thinner enoxaparin in 50 children after kidney transplant. The goal was to prevent dangerous blood clots in the new kidney while avoiding excessive bleeding. Doctors used a computer model (Bayesian approach) to adjust doses b…

This study tested a new early dosing strategy for vancomycin in 100 children with MRSA infections. The goal was to reach effective drug levels faster while avoiding toxicity. The new approach used early blood monitoring and a computer model to adjust doses, compared to the usual …

This study tested whether giving special immune cells (T cells) that target CMV or adenovirus could help control these infections in people who had a stem cell transplant. Sixteen children and adults with signs of infection received the cells. The main goal was to see if the trea…

This study tested whether putting a heart-lung machine (ECMO) on a person right where they had a cardiac arrest, instead of waiting until they reach the hospital, could help more people survive with good brain function. About 65 adults with cardiac arrest that didn't respond to s…

This study looked at 62 children with juvenile idiopathic arthritis whose disease was inactive. Researchers tested whether slowly reducing and then stopping their biologic medication was as safe and effective as staying on the full dose for 24 weeks. The goal was to see if taperi…

This study tested whether adding rituximab to standard steroid treatment helps people with a mild form of microscopic polyangiitis (a rare disease that inflames small blood vessels) achieve remission and stay relapse-free longer. Eight adults with no poor prognosis markers took p…

This study tested a drug called bosentan in 16 adults with scleroderma who had a serious kidney complication called scleroderma renal crisis. The goal was to see if bosentan could help protect kidney function and improve survival over 6 months to a year. The drug works by blockin…

This study tested whether famotidine, a widely used heartburn medicine, can lower certain inflammatory markers in children with sickle cell disease. Thirty children aged 1 to 17 took the drug for 29 days, and researchers measured changes in blood markers linked to pain crises. Th…

This study reviewed medical records of 84 hospitalized adults with severe COVID-19 who received remdesivir. Researchers wanted to see how patients were doing 15 days after starting the drug. The goal was to understand factors that influenced recovery.

This study tested whether adding a strong immune-suppressing drug (cyclophosphamide) to standard steroid treatment (prednisone) could help stabilize or improve lung function in people with scleroderma-related lung scarring. Forty adults with worsening lung function took part. The…

This study tested whether topiramate, a drug usually used for seizures, can help severely obese children and teenagers lose weight. 18 participants aged 9 to 17 took either topiramate or a placebo for 9 months. The main goal was to see if the drug could lower their Body Mass Inde…

This study tested the drug ITACITINIB in 35 adults with a mild form of a rare immune disease called HLH. The goal was to see if the drug could control the disease by improving symptoms within 15 days. The trial is now complete, and results will show how well the drug works for th…

This study tested a new, less invasive surgery to repair spina bifida while the baby is still in the womb. Seven pregnant women took part. The surgery used small tools and a camera through tiny cuts in the uterus to close the opening in the baby's spine. The goal was to see if th…

This study tested whether the diabetes pill glyburide works as well as insulin shots for treating gestational diabetes in pregnant women. Over 900 women participated, and researchers looked at baby health issues like high birth weight, low blood sugar, and jaundice. The goal was …

This Phase 3 trial tested whether lanreotide, a drug given as a monthly injection, can slow the loss of kidney function in people with autosomal dominant polycystic kidney disease (ADPKD). The study included 159 adults with moderate kidney decline. Researchers measured changes in…

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were follo…

This study tested whether a serious computer game (DIVE) could help children aged 10-17 with newly diagnosed type 1 diabetes learn about their condition. 78 kids played the game twice a week for at least an hour, and researchers measured their knowledge with a 50-question test. T…

This study tested a surgical technique called osteodistraction to improve breathing in 14 children with faciocraniosynostosis, a condition where skull bones fuse too early. The surgery uses devices to gradually separate and reshape the skull and face. The main goal was to see if …

This trial compared two methods to treat tubo-ovarian abscess, a painful infection in the fallopian tubes or ovaries. 208 women were randomly assigned to either ultrasound-guided drainage through the vagina or laparoscopic surgery. Both groups also received antibiotics. The goal …

This study compared two antibiotics, cloxacillin and cefazolin, in 315 adults with a serious bloodstream infection caused by methicillin-susceptible Staphylococcus aureus (MSSA). The goal was to see if cefazolin works as well as cloxacillin, the standard treatment, while potentia…

This study tested a new way to treat low-risk prostate cancer using a microwave probe inserted through the rectum. The goal was to see if it could safely destroy the main tumor while avoiding more invasive treatments. Only 11 patients took part, and the main measure was whether t…

This study tested a device called NEMOST, which is implanted in the spine of children with progressive scoliosis. The goal was to see if the device, combined with physiotherapy, could keep the spine straight while allowing natural growth and avoiding the need for more surgeries. …

This trial tested a gene therapy for X-linked severe combined immunodeficiency (SCID-X1), a rare genetic disorder that leaves boys without a working immune system. Five boys received a single infusion of their own blood stem cells, modified with a corrected gene. The goal was to …

This study tested two different pneumococcal vaccination strategies in 47 adults with stable lupus. One group received a prime-boost approach with a conjugate vaccine followed by a polysaccharide vaccine six months later; the other got a placebo then the standard polysaccharide v…

This study tested the drug allopurinol in 8 children and adults with adenylosuccinate lyase deficiency (ADSL), a rare genetic disorder that can cause autism, seizures, and developmental delays. Researchers measured changes in thinking, daily skills, and seizure control over 12 mo…

This small pilot study looked at whether the drug pirfenidone is safe and effective for people with a specific type of lung scarring (pulmonary fibrosis) linked to MPO antibodies or vasculitis. Seven adults took the drug for a year, and researchers measured changes in lung functi…

This early-phase study tested whether low doses of a protein called interleukin-2 (IL-2) could increase regulatory T cells—immune cells that help the body accept a pregnancy—in 18 women who had at least five unexplained early miscarriages. The goal was to see if this approach cou…

This study tested whether miglustat, a drug that changes how cells process sugars, can improve chloride transport in adults with cystic fibrosis who have the F508del mutation. Sixteen participants received miglustat and a placebo in random order to compare effects. The goal was t…

This study tested a surgery done before birth to repair a type of spina bifida called myelomeningocele. The goal was to fix the spinal defect early, reduce fluid buildup in the brain, and improve the baby's movement after birth. The procedure involved 38 pregnant women and aimed …

This study tested whether a drug that blocks TNF-alpha, a protein involved in inflammation, can reduce pain from scar tissue that forms around spinal nerves after back surgery. The trial included 38 adults who had ongoing sciatica pain after a discectomy. Researchers measured pai…

This study tested whether giving small amounts of milk under the tongue (sublingual immunotherapy) could help children with cow milk allergy tolerate more milk over time. 51 children aged 5 and older with confirmed IgE-mediated milk allergy took part. The goal was to see if this …

This study looked at whether early surgery (vitrectomy) or waiting with ultrasound monitoring is better for people with sudden, dense bleeding inside the eye. The goal was to see if early surgery could lower the chance of the retina detaching. Only 8 adults with recent bleeding f…

This study looked at two different ways to manage blood sugar in pregnant women with MODY2 diabetes, a genetic condition that affects insulin release. The goal was to see if using ultrasound to guide insulin treatment could prevent the baby from growing too large. 46 women took p…

This study tested whether adding a probiotic (VSL#3) to standard treatment can improve disease activity and reduce flare-ups in children with juvenile idiopathic arthritis (JIA). 51 children aged 1 to 7 with specific types of JIA took part. The goal was to see if the probiotic co…

This study tested the drug baricitinib, given with steroids, in 16 children aged 3-18 with newly diagnosed juvenile dermatomyositis, a rare disease causing muscle weakness and skin rashes. The goal was to see if baricitinib works better than the standard treatment (methotrexate p…

This study looked at whether giving oxygen therapy at home can prevent serious sickle cell complications in pregnant women. The trial included 178 pregnant women with sickle cell disease. The goal was to see if oxygen could reduce painful episodes and other severe problems that r…

This study tested the drug adalimumab (Humira) in 34 children with juvenile arthritis who also had active eye inflammation (uveitis) that was not controlled by steroid eye drops and methotrexate. Half received adalimumab and half received a placebo for 2 months. The goal was to s…

This study tracked over 4,200 immunocompromised patients who received monoclonal antibodies to prevent or treat severe COVID-19. Researchers measured how many were hospitalized or died from the virus. The goal was to see if these antibody treatments help protect people whose immu…

This study tested whether turning off the labor drug oxytocin once a woman reaches 6 cm dilation (active labor) could lower the chance of newborn complications. Over 2,400 women with a single, full-term baby in head-down position took part. The goal was to see if this simple chan…

This study looked at men with advanced prostate cancer that was no longer controlled by standard hormone therapy. Researchers tested whether increasing the dose of the drug abiraterone could stop the cancer from growing. 94 men participated, and the goal was to see if the higher …

This early-phase study tested a gene therapy for sickle cell disease in 6 patients aged 12-20. Doctors took the patients' own blood stem cells, added a working gene to help produce healthy red blood cells, and infused them back after chemotherapy. The goal was to see if the treat…

This study tested a 5-week hospital program combining physical activity, nutrition advice, and education for 128 adults with Prader-Willi syndrome. The goal was to help patients stabilize or lose weight 6 months after leaving the hospital. The program focuses on changing daily ha…

This study compared two treatments for symptomatic uterine fibroids—surgery (myomectomy) and a minimally invasive procedure (uterine artery embolization)—to see which one better helps women get pregnant and have a live birth. It included 9 women aged 18 to 43 with fibroids larger…

This study tested a drug called ustekinumab in 16 adults with Behçet disease, a condition that causes painful mouth sores and eye swelling. The goal was to see if the drug could reduce the number of mouth ulcers and calm eye inflammation over 24 weeks. While not a cure, the treat…

This study tested whether giving methionine (an amino acid) by mouth or feeding tube is safe and tolerable for children with a severe, inherited lung disease called pulmonary alveolar proteinosis. The disease is caused by a faulty MARS gene that prevents cells from using methioni…

This study tested whether a medicine called isosorbide mononitrate, given to help soften the cervix, could reduce the need for C-sections in first-time mothers whose pregnancies went past 41 weeks. Over 1,400 women took part. The goal was to see if this outpatient treatment could…

This study tested the antiviral drug valacyclovir in 41 pregnant women whose unborn babies were infected with cytomegalovirus (CMV), a leading cause of birth defects. The goal was to see if treating the mother could lower the virus levels in the baby and reduce symptoms at birth.…

This study tested a new ovarian stimulation protocol using degarelix (a drug typically used for prostate cancer) to help breast cancer patients preserve their fertility before chemotherapy. The goal was to keep estrogen levels low while still collecting enough eggs for freezing. …

This study tested whether babies with a rare, permanent form of diabetes caused by specific gene changes could switch from daily insulin injections to an oral pill called glibenclamide. Nineteen infants took part. The goal was to see if the pill could control their blood sugar an…

This study tested whether the drug nintedanib can slow the loss of lung function in people who have had a lung transplant and developed a condition called bronchiolitis obliterans syndrome (BOS). 58 adults who were at least 6 months post-transplant and had early to moderate BOS t…

This study looked at 452 people with kidney cancer that had spread. It compared the standard approach of removing the kidney plus taking the drug sunitinib to just taking sunitinib alone. The main goal was to see which group lived longer. The results help doctors decide if surger…

This study tested whether a high dose of epoetin alfa, a drug that mimics a natural hormone, could improve brain recovery in people who remained unconscious after a cardiac arrest. 500 adults were randomly assigned to receive either the drug plus standard care or standard care al…

This study tested whether denosumab, a drug given as a shot every 6 months, can improve bone density in people with osteoporosis caused by systemic mastocytosis. 24 adults with the condition took part. The goal was to see if the drug strengthens bones and prevents fractures bette…

This study looked at two approaches for managing stage 1 twin-to-twin transfusion syndrome (TTTS), a serious condition where twins share a placenta unevenly. One approach was careful monitoring without immediate surgery, and the other was laser surgery to fix the blood vessel con…

This study tested three biologic drugs (adalimumab, anakinra, and tocilizumab) against each other in 112 people with non-infectious uveitis that did not improve with standard treatments. The goal was to see which drug best controls eye inflammation and reduces the need for steroi…

This study tested whether using technology for remote check-ins helps obese teenagers lose weight better than standard in-person visits. 91 teens aged 11-17 took part. The main goal was to see if their body mass index (BMI) improved after 15 months.

This study tested whether using a special antiseptic dressing on ECMO tubes can reduce serious infections in critically ill patients. About 270 adults on ECMO for heart or lung failure were randomly assigned to get either the special dressing or a standard one. The goal was to se…

This study tested a new way to treat children aged 6 to 18 who have a dead nerve in an immature tooth. The new method uses a material called MTA to help the tooth form a hard barrier, compared to the standard treatment with calcium hydroxide. The goal was to see which method work…

This study looked at whether adding azathioprine to standard corticosteroid treatment could help people with newly diagnosed microscopic polyangiitis, polyarteritis nodosa, or eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) who have no poor prognosis factor…

This study tested a special educational tool for parents of children aged 1 to 6 with type 1 diabetes. The goal was to see if the tool helps improve blood sugar control and prevent dangerous events like low blood sugar or ketosis. The study involved 24 children across French hosp…

This study tested whether triggering the sperm's acrosome reaction (a natural process that releases enzymes to help fertilize an egg) before doing ICSI (a type of IVF) could improve pregnancy outcomes. Researchers enrolled 111 couples undergoing their first ICSI cycle with at lea…

This early-stage study tested a new gene therapy in 2 HIV-positive people with high-risk lymphoma. The therapy involved taking their own stem cells and immune cells, adding a gene to block HIV, and giving them back after chemotherapy. The main goal was to see if the procedure was…

This study tested whether people with rheumatoid arthritis, psoriatic arthritis, or spine arthritis could safely switch from receiving infliximab through an IV infusion at a clinic to giving themselves a simple shot under the skin at home. 22 adults who were already stable on IV …

This study tested whether giving strong, early treatment to people with severe sepsis or septic shock right in the ambulance could lower the number of deaths. The treatment included early antibiotics and fluids to support blood pressure. The study involved 398 adults and measured…

This study looked at whether a high dose of vitamin D (100,000 IU) is better than a low dose (12,000 IU) for kidney transplant recipients. The goal was to see if it could prevent new diabetes, heart problems, cancer, or death. Over 500 adults who had a kidney transplant 1 to 4 ye…

This study tested a procedure called radiofrequency ablation (using heat) to treat Barrett's esophagus with low-grade dysplasia, a condition where cells in the food pipe look abnormal and may turn into cancer. 125 adults with this condition were randomly assigned to get the heat …

This study tested two ways of using liquid nutrition to prevent Crohn's disease from flaring up again in children aged 6 to 18. One group got all their calories from a special liquid diet for one week out of every four (cyclic), while the other group got 25% of their calories fro…

This study tested a special filter placed in a large vein to catch blood clots before they reach the lungs. It included 50 people who could not take blood thinners. The goal was to see how often the filter could be successfully placed and removed, and to track any problems.

This study looked at 126 children with juvenile idiopathic arthritis (JIA) to find the best individual dose of the drug etanercept. The goal was to control the disease effectively while minimizing side effects. Researchers measured drug levels in the blood and checked for remissi…

This study looked at whether gently pulling on the umbilical cord (controlled cord traction) after childbirth helps prevent heavy bleeding (postpartum hemorrhage). Over 4,300 women who had a vaginal birth took part. The goal was to see if this technique works better than waiting …

This study looked at how well the drug Ivacaftor works and how safe it is for people with cystic fibrosis who have a specific genetic change (G551D mutation) in everyday life, not just in a controlled trial. Researchers followed 57 French patients aged 6 and older for one year af…

This study tested whether sending supportive text messages to teenagers with poorly controlled type 1 diabetes could help lower their blood sugar levels. 92 teens aged 12-21 with high HbA1c levels participated. The approach used mobile phone reminders to encourage better diabetes…

This study tested whether the drug baclofen helps people with alcoholism reduce their drinking to safe levels or stop completely over one year. 323 adults who wanted to cut back or quit alcohol took either baclofen or a placebo pill. The goal was to see if more people on baclofen…

This study tested if the antibiotic temocillin works as well as a stronger antibiotic (carbapenem) for treating urinary tract infections caused by resistant bacteria. 29 hospitalized adults took part. The goal was to see if both treatments could clear the infection and symptoms. …

This study tested the drug Humira (adalimumab) in 11 people with Netherton Syndrome, a rare genetic skin condition that causes severe inflammation, itching, and pain. The goal was to see if Humira could reduce skin symptoms by at least 20% after 3 months of treatment, with a 3-mo…

This study looked at whether using a balloon device early, along with standard medication, can better control heavy bleeding after vaginal birth compared to waiting to use the balloon only if medication fails. About 405 women who had persistent bleeding after initial treatment we…

This study tested a new ovarian stimulation protocol for IVF that aims to keep estrogen levels more natural while still producing many eggs. 129 women with good IVF prognosis participated. The goal was to see if this approach leads to more live births compared to the standard met…

This study tested a new device (Smart-TO) that places a small balloon in the windpipe of unborn babies with congenital diaphragmatic hernia, a condition where the diaphragm has a hole and the lungs don't grow properly. The balloon is later removed using a special MRI technique. T…

This study tested an experimental enzyme therapy called METAZYM in one child with late infantile metachromatic leukodystrophy (MLD) who had already received a stem cell transplant. The goal was to see if the enzyme could slow nerve damage and improve function. The child received …

This study tested whether adding early steroids or SGLT2 inhibitors to standard blood pressure medication can better protect kidney function in people with IgA nephropathy who have severe kidney damage. 62 adults with active disease were randomly assigned to receive either the co…

This study tested whether a drug called bortezomib, given with steroids, plasma exchange, and immunoglobulins, can treat chronic antibody-mediated rejection in kidney transplant recipients. The trial included 60 adults who had a kidney transplant and developed donor-specific anti…

This study looked at 577 women under 45 who had an incomplete miscarriage and wanted to get pregnant again. It compared two surgical treatments—hysteroscopy and standard curettage—to see which one leads to more successful pregnancies later. The goal is to find the safest and most…

This study tested whether giving the drug rituximab only when certain blood markers (ANCA and CD19 cells) appear is as good as giving it on a fixed schedule for keeping ANCA vasculitis in remission. 166 adults with the disease who were already in remission took part. The goal was…

This study tested whether a noninvasive blood test (NIPT) is as good as the standard invasive test for detecting Down syndrome in over 2,000 pregnant women at higher risk. Women were randomly assigned to receive either the blood test or the usual invasive procedure. The goal was …

This study tested whether a special MRI technique called ASL-MRI can measure blood flow in the brains of children with autism. The goal was to see if this could be used as a non-invasive diagnostic tool, similar to PET scans but without radiation. Researchers studied 115 children…

This study tested a new MRI technique called Advanced ZTE to take pictures of children's lungs without using radiation or contrast dye. 72 children aged 6-16 who needed a chest CT scan also received this special MRI. The goal was to see if the MRI could produce clear images of th…

This study tested three new methods to diagnose bloodstream infections from central venous catheters in critically ill children, without removing the catheter. Researchers compared these methods to standard techniques in 148 children. The goal was to see if these tests could accu…

This study tested a new imaging technique called Full Field Optical Coherence Tomography (FFOCT) to see if it can detect prostate cancer in biopsy samples as well as standard microscope analysis. Researchers compared FFOCT results to the usual pathology exam in 91 men with elevat…

This study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…

This study looked at whether the Montreal Cognitive Assessment (MoCA), a short test, can accurately screen for thinking and memory problems in adults with sickle cell disease. Researchers compared MoCA results to a full set of standard cognitive tests in 65 adults. The goal is to…

This study looked at whether a simple blood test can help quickly identify stroke patients who need a procedure to remove a large blood clot. The goal is to get these patients to the right hospital faster, avoiding delays that can worsen outcomes. Over 3,800 adults with stroke sy…

This study tested a new rapid bedside device (qLabs®FIB) that measures a key blood clotting protein called fibrinogen in women with severe bleeding after childbirth. The goal was to see if the quick test gives results as accurate as the standard lab test, which takes longer. 70 w…

This study tested a new, non-invasive tool that measures skin conductance to detect small nerve fiber damage in children undergoing chemotherapy. Nerve damage is a common and serious side effect of cancer treatment, but current tests are often painful or not suitable for children…

This study tested whether special ultrasound scans can detect kidney damage in people who have received a kidney transplant. 141 transplant recipients had ultrasound imaging at 15 days, 3 months, and 12 months after surgery. The goal was to see if these scans could measure kidney…

This completed study tested a new way to find prostate cancer cells in blood samples, without needing a needle biopsy. Researchers used a special filtering technology to capture tumor cells from 127 patients. The goal was to see if this non-invasive method could accurately detect…

This study looked at CT scans from over 10,000 people to see if they can help diagnose COVID-19 more accurately. Researchers compared CT results with standard PCR tests and also used AI to predict which patients might need a ventilator. The goal is to make diagnosis faster and he…

This study tested a new blood test to diagnose Down syndrome (trisomy 21) in pregnant women without the risks of invasive procedures like amniocentesis. Researchers collected blood samples from 150 pregnant women at high risk and analyzed fetal cells. The goal is to provide a saf…

This study looked at how well a standard glucose tolerance test (drinking a sugary drink) can help diagnose acromegaly, a condition where the body makes too much growth hormone. Researchers tested 109 adults, some with acromegaly and some without, to see if the test results were …

This study looked at whether adding a CT scan of the legs and pelvis to the usual chest scan helps find more blood clots in women who may have a pulmonary embolism within six weeks after giving birth. 125 women took part. The goal was to see if the extra scan improves detection w…

This study looked at whether newborns who fail their hearing screening can be diagnosed with congenital CMV infection and have a full hearing test before they turn one month old. Researchers tested 235 babies to see how quickly they could get results. The goal is to improve early…

This study tested a new DNA test called the MycoGenie kit to see how well it can diagnose invasive aspergillosis, a serious fungal infection, in 350 blood cancer patients. The test looks for the fungus's DNA in blood samples and can also detect drug resistance. The goal is to fin…

This study tested a new blood test that looks at fetal DNA in the mother's blood to detect Down syndrome (trisomy 21) as early as 11 weeks into pregnancy. The goal was to see if this noninvasive test could accurately tell which babies have Down syndrome, potentially replacing ris…

This study tested whether using an MRI to guide prostate biopsies could detect cancer as well as the standard 12-sample systematic biopsy. Researchers enrolled 108 men aged 45-75 with elevated PSA levels and suspicious MRI findings. They compared the cancer detection rates of 3 t…

This study looked at whether a chest CT scan can accurately diagnose when a child has inhaled a foreign object, like a toy part or food. Researchers compared CT scan results with the standard method, a bronchoscopy (a tube with a camera). The goal was to see if the CT scan could …

This study looked at whether a blood test measuring tiny molecules called microRNAs can spot early signs of organ rejection in heart transplant patients. Researchers tested 461 people who had a heart transplant and compared the blood test results to the standard method, a heart b…

This study looked at whether testing saliva (spit) can find COVID-19 infections just as well as the standard nose swab test. Over 5,000 people of all ages provided both a nose swab and a saliva sample. The goal was to see if saliva testing could make screening easier and more com…

This study looked at whether a non-invasive breathing test called the lung clearance index (LCI) can find early signs of lung disease in young children with cystic fibrosis. 53 children aged 3 to 6 took the test along with standard lung scans and function tests. The goal was to s…

This study tested whether functional MRI can detect placental problems in pregnant women without invasive procedures. Researchers gave 101 pregnant women oxygen while scanning the placenta and fetus to see if the MRI signal changed. The goal was to tell the difference between hea…

This study looked at whether a blood test called the sFlt-1/PlGF ratio can help doctors make better decisions for pregnant women with suspected preeclampsia before 35 weeks. The goal was to see if using the test improves care for both mother and baby and lowers hospital costs. 84…

This study looked at whether measuring certain proteins (amyloid peptides) in the blood can help diagnose Alzheimer's disease or predict if someone with mild memory problems will develop Alzheimer's. Over 1,000 older adults with either mild cognitive impairment or Alzheimer's too…

This study tested a new rapid test that uses a vaginal swab to find germs and infection markers that can cause serious infections in newborns. Over 2,500 pregnant women took part. The goal was to see if this test could help doctors prevent infections in babies more effectively.

This study tested whether a noninvasive device called FibroScan can accurately measure liver scarring (fibrosis) in children, potentially replacing the need for a liver biopsy. Researchers compared FibroScan results with biopsy results in 264 children aged 6 months to 18 years wi…

This study looked at 339 emergency room patients with suspected pneumonia to see if a chest CT scan could improve diagnosis. The goal was to find out if the CT scan changed the doctor's initial diagnosis, and if it led to changes in antibiotic treatment or hospital admission deci…

This study tested whether lung ultrasound can accurately check if a breathing tube is in the right place in children. 79 children who were already intubated and on a ventilator received both an ultrasound and a chest X-ray. The goal was to see if ultrasound could reliably detect …

This study tested whether warming the fluids given through an IV during a scheduled C-section can prevent mothers from getting too cold and shivery afterward. 75 healthy pregnant women took part. The goal was to see if this simple method reduces hypothermia and discomfort after s…

This study tested whether somatostatin works better than octreotide at preventing pancreatic fistula, a common and serious leak after pancreatic surgery. Over 650 adults having their pancreas removed were randomly assigned to one of the two drugs. The goal was to see which drug r…

This completed study looked at whether giving antibiotics early to trauma patients on breathing machines can prevent ventilator-associated pneumonia (VAP). Researchers analyzed data from 2,143 adults admitted for severe trauma between 2021 and 2023. The goal was to see if this si…

This study tested whether high doses of erythropoietin, a hormone that boosts red blood cell production, can help prevent long-term brain damage in full-term newborns who suffered oxygen loss at birth. All 120 babies also received standard cooling therapy. The goal was to see if …

This study looked at whether an educational program for pregnant women who are overweight or obese could help prevent their babies from gaining weight too quickly in the first two years of life. The program focused on healthy eating and lifestyle habits. The goal was to reduce th…

This study looked at whether drinking toddler milk formula helps prevent iron deficiency in 2-year-old children in France. Iron deficiency can harm a child's brain development, thinking, and movement. Researchers studied 830 infants to see how formula use, along with diet and fam…

This study looked at whether testing people for COVID-19 just before a large indoor concert could keep the event from causing new infections. Over 6,600 healthy adults aged 18-45 either attended the concert after a negative test or stayed home. The goal was to see if the concert …

This study tested the H1N1 flu vaccine in 439 people with cystic fibrosis to see if it prevents the flu and is safe. Participants included adults, children, pregnant women, and lung transplant recipients. Researchers measured immune response and tracked flu symptoms, using antivi…

This study tested whether giving melatonin, a natural sleep hormone, could prevent delirium (sudden confusion) in elderly patients after surgery for a broken leg. About 357 people aged 70 and older took either melatonin or a placebo pill nightly from before surgery until five day…

This study tested whether nebivolol, a beta-blocker heart drug, could prevent heart failure in 51 boys aged 10-15 with Duchenne muscular dystrophy. Participants had normal heart function at the start and were randomly given either nebivolol or a placebo. The trial found that nebi…

This study tested whether hydroxychloroquine or azithromycin could prevent COVID-19 infection in hospital workers who were regularly exposed to the virus. 122 participants took one of the drugs or a placebo for 40 days. The study found no significant difference in infection rates…

This study tested whether having a therapy dog present during dental visits reduces anxiety in children with autism. Fifty children aged 6 to 17 took part. The dog was with them for the first two sessions, and the third session was without the dog. Researchers measured anxiety le…

This study tested whether a 7-day course of prednisone, started in the emergency department, can lower inflammation (measured by C-reactive protein) in patients with acute heart failure. Only 3 people took part, and the main goal was to see how CRP levels changed. The researchers…

This study tested whether a standardized osteopathic manipulation treatment works better than a placebo (light touch) for people with sub-acute or chronic non-specific low back pain. 400 adults were randomly assigned to one of the two groups and received six sessions over 12 week…

This study tested a special ureteral stent with a magnetic end in 67 children with urinary tract problems or kidney transplants. The goal was to see if the stent could be removed without general anesthesia, using a magnetic catheter instead. The approach aims to make the removal …

This study tested whether listening to music through headphones during cataract surgery could reduce anxiety and prevent high blood pressure. Over 300 patients took part, with some listening to music and others wearing silent headphones. The goal was to see if a simple, non-drug …

This study tested whether a personalized rehabilitation program could improve quality of life for people with systemic sclerosis, a disease that causes skin and joint stiffness. 220 adults with the condition were randomly assigned to either the rehab program or usual care. The pr…

This study looked at whether a therapeutic education program can improve quality of life for children aged 8 to 12 with IgE-mediated food allergies, as well as their families. 46 children and their families took part. The program focused on teaching them how to manage allergies a…

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids were randomly …

This study looked at whether adding relaxation sessions (sophrology) at home to usual pain treatments could help people with cystic fibrosis who have ongoing or frequent pain. Thirteen patients took part. The goal was to see if this combined approach could reduce pain intensity a…

This study tested whether a numbing cream (ropivacaine) can reduce severe pain during bath and dressing changes in children and young adults with epidermolysis bullosa, a rare genetic skin condition. Ten participants applied the cream before dressing changes and reported their pa…

This study tested whether a technique called ischemic preconditioning, which is used to protect organs during transplants, could reduce fat tissue damage after breast reconstruction surgery. 18 women who had breast reconstruction using their own belly fat were included. The appro…

This study tested a device called ANI that measures pain during surgery in children having scoliosis correction. The goal was to see if using this monitor to guide pain medicine during surgery would lower the amount of morphine needed in the first 24 hours after surgery. The stud…

This study tested whether adding art therapy to standard speech rehab could help people who recently had a stroke and lost some language ability (aphasia). Fifteen participants received 12 art therapy sessions alongside their usual care. Researchers used brain scans to see if art…

This study tested whether adding a sedative (midazolam, given under the tongue) to a standard painkiller (morphine, taken by mouth) helps children aged 5 to 16 with arm fractures feel less pain. Sixty children were split into two groups: one got morphine plus midazolam, the other…

This study tested whether a self-hypnosis smartphone app called Hypnotidoo could help reduce inattention and anxiety in children aged 7 to 12 with ADHD who are already taking medication. The app offers short, screenless audio sessions focused on relaxation and coping. Researchers…

This study tested a new liquid version of the drug glibenclamide in 10 children with neonatal diabetes caused by a potassium channel mutation. The goal was to see if the liquid form is easier to give and as safe and effective as the standard pills. Children took the pills for one…

This study tested a web-based program called Diapason for family caregivers of people with Alzheimer's disease. The program provides information, relaxation techniques, and a forum to connect with other caregivers. Researchers measured stress levels in 49 caregivers over 6 months…

This study tested whether 14 months of specialized medical care and monitoring of electromagnetic exposures could help people who report severe sensitivity to electromagnetic fields. Seventy-nine participants wore a dosimeter for a week and tracked their symptoms. The goal was to…

This study tested a 6-week personalized day-hospital program for people with persistent long COVID symptoms like fatigue, shortness of breath, and brain fog. The program included group education, exercise training, and cognitive behavioral therapy. Researchers compared the qualit…

This study tested whether using heat or cold packs during childbirth can lessen perineal pain after delivery. 115 women having their first vaginal birth took part. Researchers measured pain levels and healing. The goal was to find a simple, drug-free way to improve comfort after …

This study tested whether cannabidiol (CBD) can reduce severe itching in 10 children with hereditary epidermolysis bullosa, a rare genetic condition causing fragile skin and painful blisters. The children took oral CBD three times daily for one month. Researchers measured changes…

This study tested whether a jaw-widening surgery (surgically assisted maxillary expansion) could improve quality of life in 9 adults with obstructive sleep apnea. Participants completed sleep questionnaires before surgery and again 3 months and 1 year after. The goal was to see i…

This study looked at whether 6 weeks of osteopathic medicine (a type of hands-on therapy) can reduce pain in people with fibromyalgia. About 100 adults with long-term fibromyalgia took part. Researchers measured pain levels weekly and also checked quality of life and fatigue.

This study tested whether a safe, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) could reduce fatigue in people with multiple sclerosis (MS). Ten adults with MS-related fatigue used a home-based tDCS device. The goal was to see if i…

This study tested a short program of education and rehabilitation for people with subacute or chronic low back pain who are not severely disabled. The goal was to see if the program reduces activity limitations and changes risk factors. 100 participants took part in the program a…

This study tested whether a non-invasive brain stimulation technique called rTMS can reduce 'first rank symptoms' of schizophrenia, such as delusions and hallucinations. Researchers compared real rTMS to a sham treatment in 31 patients who still had symptoms despite medication. T…

This study tested whether hypnosis can lower pain and anxiety during an ultrasound-guided liver biopsy. 70 adults were randomly assigned to receive either hypnosis or standard care during the procedure. Researchers measured pain and anxiety levels to see if hypnosis made the expe…

This study tested a group program that provides training, information, and support for family caregivers whose parent has moved into a nursing home. The goal was to help reduce feelings of anxiety, guilt, and sadness that often come with this change. 73 caregivers took part, and …

This study tested whether a personalized home respiratory rehabilitation program is feasible for people with systemic sclerosis (scleroderma) who have early lung disease. Fifteen participants completed a 3-month program with one supervised session followed by home exercises. The …

This study tested whether a low dose of interleukin-2 (IL-2), a protein that helps regulate the immune system, could improve depressive symptoms in people with bipolar disorder. Fourteen participants already on mood stabilizers received the treatment. The goal was to see if it in…

This study tested whether applying a Xylocaine (numbing) compress before a trigger finger injection reduces pain during the procedure. 60 adults with trigger finger took part in a double-blind trial where neither they nor the doctor knew who got the numbing compress. The main goa…

This study tested whether injecting steroids directly into the spinal disc can reduce chronic lower back pain caused by inflammation seen on MRI. 137 adults with persistent pain for at least 3 months received the injection. The goal was to see if pain levels dropped below a certa…

This study tested whether using a PARO robot (a soft, interactive robot seal) could help prevent pain and distress in elderly people with moderate to severe dementia during daily nursing care. Ten participants living in nursing homes were given the robot before or during care to …

This study tested whether mangafodipir, an MRI contrast agent with antioxidant properties, could reduce nerve damage caused by oxaliplatin chemotherapy. Researchers enrolled 23 cancer patients who already had moderate nerve problems from oxaliplatin but needed to continue treatme…

This study tested whether a low dose of IL-2, a protein that helps calm the immune system, could reduce nasal symptoms in people with birch pollen allergy. Twenty-four adults with a history of seasonal hay fever received either the drug or a placebo and were then exposed to birch…

This study looked at 304 children aged 2 to 17 with broken arm or leg bones who came to the emergency room in severe pain. Researchers wanted to see if giving paracetamol (Tylenol) or ibuprofen (Advil) along with morphine worked better than morphine alone. They measured pain leve…

This study looked at whether letting cataract surgery patients eat and drink normally before their procedure could lower their anxiety. 126 adults having their first cataract surgery under numbing eye drops were included. The goal was to see if a non-fasting approach reduces worr…

This small pilot study tested whether therapeutic gardening (horticulture) could reduce pain-related brain activity in 16 adults with chronic low back pain. Participants tried both gardening and handiwork sessions, and researchers used MRI scans to measure changes in a brain regi…

This study tested whether using a small temporary screw (miniscrew) in the jawbone works better than using other teeth as anchors to close gaps after removing two upper premolars. 99 people aged 12 to 50 who needed braces and tooth removal took part. The main goal was to see how …

This study tested whether having a woman lie on one side (asymmetrical lateral decubitus) during labor can help turn a baby that is facing the wrong way (occipitoposterior position) into a better position for birth. The trial included 326 women in labor. The main goal was to see …

This study looked at whether taking oral corticosteroids for five days helps people with COPD who are having a flare-up. The goal was to see if it reduces the need for emergency doctor visits or hospital stays. The study involved 189 adults aged 40 and older who were treated in g…

This study tested whether adding a drug called droperidol to two standard anti-nausea medicines (ondansetron and dexamethasone) could better prevent vomiting after surgery in children at high risk. A total of 322 children aged 3 to 18 years took part. The main goal was to see if …

This study looked at whether a single antihistamine works as well as antihistamine plus steroids for treating sudden hives in the emergency department. 137 adults with acute hives (with or without mild swelling) took part. The goal was to see if adding steroids is necessary for s…

This study tested lithium as a treatment for social communication problems in children with autism spectrum disorder and Phelan-McDermid syndrome (a rare genetic condition). The goal was to see if lithium could reduce autism symptoms. The study included 22 children under 18. Rese…

This study aimed to find out which patients with severe frozen shoulder (adhesive capsulitis) respond best to a treatment that combines a special shoulder injection (arthrographic distension) with intensive physical therapy. Researchers enrolled 55 adults who had shoulder pain an…

This study tested whether resveratrol, a natural substance found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took either resveratrol or a placebo pill daily for three months. The main goal was to measure chang…

This study tested whether art and movement workshops could help 8 children and teens with unexplained chronic pain who had been bullied at school. The program combined martial-arts-inspired dance with creating a street-art mural to rebuild confidence and ease pain. Results focuse…

This study tested whether breathing high-flow oxygen can quickly stop dystonic (stiffening) and plegic (paralysis) attacks in children with alternating hemiplegia of childhood, a rare genetic condition. Twenty-four participants used oxygen or a placebo at the start of an attack. …

This study tested whether wearing a daily weighted brace on the unaffected ankle helps people who have had a stroke walk farther. 42 participants who had a stroke more than 3 months ago and could walk a little without help were split into two groups: one wore a weighted brace, th…

This study looked at whether injecting botulinum toxin A (like Botox) into a groin muscle can help athletes with long-lasting groin pain that hasn't gotten better with other treatments. Twenty adults with chronic athletic pubalgia received one injection, and researchers tracked t…

This study tested whether a single injection of botulinum toxin A (like Botox) into the thumb joint, along with wearing a splint, can reduce pain from base-of-thumb osteoarthritis. Sixty adults with moderate to severe thumb pain took part. The main goal was to see if pain decreas…

This study tested whether using virtual reality to guide children into a hypnotic state could reduce their pain and anxiety during a sickle cell crisis. Twelve children aged 6 and older participated. Researchers measured pain scores before and after a virtual reality session. The…

This study tested a short therapy program for mothers who developed PTSD after a traumatic pregnancy or childbirth. The therapy, called Interaction Guidance Therapy, uses video feedback to help mothers bond with their babies. Researchers measured whether it improved maternal sens…

This study tested a virtual reality device to see if it could reduce pain in adults with chronic low back pain that didn't respond to medication. 122 participants used the VR system, which creates a 3D environment with changing colors. The main goal was to measure pain levels aft…

This study tested whether inhaling tranexamic acid or terlipressin can quickly stop mild to severe coughing up blood (hemoptysis) without side effects. 315 adults were randomly assigned to receive one of the two drugs or a placebo. The goal was to see if these treatments could co…

This study tested a device that sends mild electrical pulses to the ear to stimulate the vagus nerve, aiming to reduce pain and inflammation in people with erosive hand osteoarthritis, a painful and hard-to-treat arthritis. 148 adults with this condition used either the active de…

This study tested whether a 1.5-day program combining education and exercise is feasible for people with low back pain that hasn't improved with first treatments. 23 adults with subacute or chronic low back pain took part. The program aimed to reduce pain and fear of movement, an…

This study tested whether using near-infrared light to make veins visible helps doctors successfully draw blood or start an IV on the first try in children with hard-to-see veins. 163 children in the hospital or emergency room took part. The goal was to see if the light reduces t…

This study tested whether rituximab, a drug used for certain cancers and autoimmune diseases, can reduce joint pain and swelling in people with scleroderma (systemic sclerosis) who have arthritis. 22 participants with active arthritis took the drug. The main goal was to see if it…

This study looked at whether a program of education and exercises before total knee replacement surgery helps people recover function more quickly. 262 adults with knee osteoarthritis took part. The program aimed to improve the ability to get out of bed, walk, and climb stairs sh…

This study looked at whether multi-family therapy (therapy with several families together) can help teenagers who refuse to go to school because of anxiety. 74 teens aged 12-18 who had been out of school for at least 2 weeks took part. The researchers measured anxiety and school …

This study tested a non-invasive brain stimulation technique called TMS in 20 young adults with autism. The goal was to see if stimulating a specific brain area could improve how they look at faces and interact socially. Participants received 10 daily sessions, and researchers me…

This study tested whether sitting cross-legged during epidural placement helps laboring women. It involved 457 women in France. The goal was to see if this position leads to successful placement on the first try without needing to adjust the needle.

This completed study looked at why some pregnant women choose not to join a clinical trial on early screening for pre-eclampsia, a serious pregnancy condition. Researchers surveyed 472 women to find factors linked to refusal and to understand their reasons for saying yes or no. T…

This study looked at whether smoking or using nicotine products changes the risk of catching COVID-19. Researchers sent surveys to over 600 healthcare workers who had been tested for the virus. The goal was to see if current or past tobacco and nicotine use was linked to testing …

This study looked at how the spine stiffens over time in children with neuromuscular scoliosis who had a special fusionless surgery. Researchers used ultrasound elastography to measure stiffness in the discs and muscles of the spine. The goal was to understand the natural stiffen…

This study looked at two important eye measurements, called angle kappa and angle alpha, in 70 healthy adults. Researchers used eye exams and photos to see how these angles relate to each other. The goal is to help eye surgeons better plan procedures like cataract or laser surger…

This study looked at whether patients can effectively preoxygenate themselves before surgery by holding their own oxygen mask, a concept called 'self-preoxygenation.' Researchers observed 110 adults undergoing scheduled surgery to see how many reached a safe oxygen level within 3…

This completed study looked at what factors contribute to the perceived workload of nurses in intensive care and pediatric continuous monitoring units. Researchers surveyed 484 nurses to measure mental demands, physical demands, time pressure, and frustration. The goal is to iden…

This study followed 150 people with nephronophthisis, a rare genetic kidney disease, to see how kidney and other organ damage progresses over time. Researchers looked at patients with specific gene mutations to better understand the disease's long-term effects. The goal was to im…

This completed study looked for gene changes that might make children more prone to severe tooth decay. Researchers compared 390 children with active cavities to cavity-free young adults. The goal was to find mutations that affect enamel and increase cavity risk, which could even…

This study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in young children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal wa…

This study looked at 166 people with unexplained bleeding to find out how common platelet dense granule defects are. Researchers measured the number, content, and release of these tiny granules inside platelets. The goal was to better understand what causes bleeding when standard…

This completed study surveyed 257 adults with sickle cell disease to understand how they use painkillers at home, including opioids and cannabis. Researchers wanted to find out how common opioid addiction is in this group. Patients answered a one-time questionnaire at three speci…

This study tested whether a diabetes self-management education program is possible for inmates at Paris' La Santé prison. Twenty-two men with type 1 or type 2 diabetes were offered workshops on diet, foot care, and medication. The main goal was to see how many attended at least t…

This study looked at how the heart medication amiodarone behaves in children aged 0 to 18 with heart rhythm disorders. Researchers took blood samples from 57 children to measure drug levels and understand how the body processes it. The goal is to find the right dose for kids, sin…

This study looked at 41 children with a rare gut condition called intestinal epithelial dysplasia (tufting enteropathy). Researchers collected blood and skin samples to find the genes involved. The goal was to better understand the disease, not to test a new treatment.

This study tested whether sending three text message reminders to adults over 50 who had a low-trauma fracture would encourage them to get a bone density test. The goal was to improve screening for osteoporosis, a condition that weakens bones. Researchers enrolled 97 patients fro…

This study looked at how often blood clots form soon after placing a central venous catheter (a special IV line) in children in the pediatric intensive care unit. Researchers used ultrasound to scan for clots 1 to 13 days after placement. The goal was to better understand the tim…

This completed study reviewed medical records of 203 adults hospitalized with Haemophilus influenzae pneumonia across 13 hospitals. Researchers aimed to find factors linked to early relapse (within 90 days) and severe outcomes like intensive care or death. By analyzing patient da…

This study looked at 130 children aged 2 to 10 with hearing loss who use hearing aids or cochlear implants. Researchers used a parent questionnaire called PEACH to measure how well the children hear in quiet and noisy situations. The goal was to understand their hearing quality o…

This completed study measured daily physical activity in 80 adults with cystic fibrosis using an armband monitor for 7 days. Researchers focused on non-lung factors such as nutrition, diabetes, bone health, anxiety, and heart function. The goal was to identify what influences act…

This completed study looked at how a specific layer of the eye (the pigment epithelium) works in people with neurofibromatosis type 1. Researchers used an electro-oculogram to measure electrical activity in the eye and compared it to infrared images of the back of the eye. The go…

This study collected blood samples from 236 pregnant women with and without preeclampsia. The goal was to test a new approach that filters out a protein called sFlt-1 from the blood, which may help restore normal blood vessel function. The research is a first step toward a possib…

This study used MRI scans to measure blood flow in the placenta of 135 women undergoing pregnancy termination for fetal reasons between 16 and 32 weeks. The goal was to create a set of normal reference ranges for placental perfusion, which could help doctors identify when the pla…

This completed study looked at 47 people with idiopathic CD4 lymphocytopenia (ICL), a rare condition where the body has too few CD4 immune cells, increasing infection risk. Researchers analyzed blood samples and genetics to better understand the disease. The goal was to improve d…

This study looked at 21 children, teens, and young adults who had surgery for Moyamoya disease, a rare brain vessel condition. Researchers used questionnaires and drawing tests to measure anxiety, depression, attachment, and quality of life in patients and their parents. The goal…

This study explored how adolescents aged 12 to 25 with anorexia nervosa feel about being prescribed antidepressants. Researchers interviewed 15 teens and asked them to answer written questions about their experiences. The goal was to understand their personal views, not to test w…

This study looked at 126 children and young adults (up to age 25) with serious, non-progressive brain conditions like cerebral palsy or traumatic brain injury. Researchers wanted to find the best time to introduce a pediatric palliative care team. They reviewed medical records fr…

This completed study reviewed medical records of 50 children on breathing machines to see if inhaled sedatives (halogenated gases) could reduce the need for other sedative drugs. The goal was to see if these gases help lower doses of medications like midazolam and morphine within…

This study looked at whether a breathing device called CPAP can reduce the work of breathing and improve heart function in 30 children with heart failure, aged 8 months to 17 years. Researchers measured breathing effort and heart performance during short periods of CPAP and norma…

This study tested whether a French translation of the SN-5 questionnaire, which measures quality of life in children with chronic rhinosinusitis, works as well as the original English version. Researchers asked 89 children (ages 2–12) and their parents to fill out the questionnai…

This study tested whether a rapid diagnostic test (Filmarray® Pneumonia Panel) combined with expert antibiotic advice improves care for hospital-acquired pneumonia. 116 adult patients were randomly assigned to get either standard care plus expert advice, or the rapid test plus ex…

This study reviewed medical records of 70 children under 18 who received clot-busting drugs or mechanical clot removal for a stroke. Researchers measured how quickly treatment was given and looked for side effects like bleeding. The goal is to better understand the safety and tim…

This study looked at how well a muscle relaxant called atracurium works for placing a breathing tube in 100 obese women undergoing gynecological surgery. Doctors waited exactly three minutes after giving the drug before attempting intubation. The goal was to see if this timing le…

This completed study tested whether washing children in the intensive care unit with a 2% chlorhexidine pad reduces skin bacteria more effectively than washing with mild soap. Researchers took skin samples from 34 children before and after each wash to measure bacterial levels. T…

This study checked whether HIV drugs called anti-integrases, taken during pregnancy, affect a newborn's immune system. Researchers compared 29 full-term babies exposed to these drugs in the womb with those exposed to other HIV drugs. A single blood sample at birth measured T-cell…

This study looked at whether a stool test for a protein called calprotectin can help predict severe gut inflammation in premature babies. Researchers collected stool samples from 122 preterm infants born at 33 weeks or earlier. The goal was to see if this test could help doctors …

This completed study collected blood, stomach, liver, intestine, and fat tissue samples from 360 severely obese adults undergoing bariatric surgery. The goal was to better understand how obesity and surgery affect the body, especially the digestive system. Researchers hope this k…

This study tested a simple technique called continuous anterior chest compression (CACC) in 20 adults with moderate to severe acute respiratory distress syndrome (ARDS). The idea is that pressing on the front of the chest might help air reach the back of the lungs, improving oxyg…

This study tested a French version of a questionnaire that helps evaluate dizziness in children aged 7 to 17. Researchers asked children with and without balance problems to fill out the questionnaire twice, two weeks apart. The goal was to see if the French version is reliable a…

This study looked at 70 patients who had a stem cell transplant for blood cancer. Researchers measured levels of complement proteins in the blood to see if they are linked to graft-versus-host disease, a common and serious side effect. The goal is to better understand how inflamm…

This study looked at how the lungs move chloride, sodium, and bicarbonate in 42 patients with idiopathic bronchiectasis (widened airways of unknown cause). Researchers measured electrical signals in the airway lining during bronchoscopy and took nasal and bronchial samples. The g…

This study analyzed data from 168 patients with a rare type of digestive neuroendocrine tumor (well-differentiated grade 3). Researchers compared survival and response rates in patients who received platinum-based chemotherapy versus those who received non-platinum chemotherapy. …

This study followed 60 heart transplant patients for one year to see if levels of a harmless virus called TTV in the blood are linked to infections or organ rejection. Researchers took monthly blood samples alongside routine care. The goal is to find a new way to monitor transpla…

This study tested whether calling patients a few days before surgery with a checklist could lower the number of last-minute cancellations. Over 4,000 adults and children scheduled for day surgery took part. The goal was to see if this simple step helps hospitals run more smoothly…

This study looked at why pregnant women in France refuse to take part in randomized clinical trials about pregnancy and childbirth. Researchers surveyed 526 women to understand factors like age, education, and personal reasons that influence their choice. The goal is to make futu…

This study looked at 76 healthy adults to see how eye dominance (which eye your brain prefers) relates to the angle lambda (a measurement of the eye's optical axis) and fixation disparity (how the eyes align when focusing). Researchers used eye exams and photos to gather data. Th…

This completed study looked at 204 adults with hemophagocytic syndrome, a rare immune condition. Researchers aimed to identify biological markers and refine diagnosis criteria, which are currently based on children's genetics. The goal is to better understand the disease's causes…

This completed study looked at 289 children to understand what factors are linked to serious complications from pharyngitis (sore throat). Researchers compared children hospitalized with complications like abscesses to those with simple pharyngitis. The goal was to identify expos…

This study used a special MRI technique called diffusion tensor imaging to look at the spinal cord in 40 people with cervical spondylosis, a type of arthritis in the neck. The goal was to see if changes in the spinal cord structure relate to symptoms like muscle weakness or numbn…

This study follows 25 women with MRKH syndrome, a condition where the uterus and upper vagina are underdeveloped, to see how their quality of life has changed 8 to 10 years after an initial assessment. Participants fill out questionnaires and take part in interviews about their s…

This study looked at 90 adults with Marfan syndrome to see how dural ectasia (a widening of the spinal sac) affects their symptoms and daily life. Researchers compared those with dural ectasia to those without, measuring back pain, headaches, and activity limits. The goal was to …

This study tested how well the flu vaccine works and if it's safe for people with inflammatory bowel disease (IBD). Researchers compared 228 adults with IBD who were either taking immunosuppressive drugs or not. The goal was to see if the vaccine triggers a strong immune response…

This study aimed to find genes that cause Chiari type I malformation, a condition where part of the brain extends into the spinal canal. Researchers took blood samples from 40 people with the condition and their family members to look for genetic mutations. The goal was to better…

This study looked at cells from the membranes that surround a baby during pregnancy (the 'water bag'). The goal was to find specific proteins these cells release that might signal when labor starts too early. 24 healthy pregnant women at full term provided samples to help identif…

This pilot study looked at how hemodialysis changes the electrical properties of skin and muscle in 18 adults on chronic dialysis. Researchers measured these changes to better understand fluid shifts during treatment. The goal was to gather knowledge, not to test a new treatment.

This study looked at 55 adults with severe breathing problems (acute respiratory failure) to understand how their lungs and diaphragm work. Researchers measured breathing difficulty, lung ventilation, and diaphragm movement using ultrasound and other tests. The goal was to find c…

This study looked at how families are told their child has craniosynostosis, a condition where skull bones fuse too early. Researchers interviewed and surveyed 574 parents and children to understand the emotional impact and improve the diagnosis process. The goal is to make the a…

This study looked at 57 people who had a stem cell transplant for blood cancer. Researchers wanted to see if certain immune cells (iNKT cells) could help predict the risk of graft-versus-host disease (GVHD), a serious side effect. They measured these cells in the blood and the tr…

This study used a non-invasive brain stimulation technique called rTMS to explore how a specific brain region (the superior temporal sulcus) affects social perception in people with autism. Researchers measured how participants looked at social scenes and recognized voices before…

This study looked at how cystinosis affects muscles and nerves in 20 patients aged 16 and older. Researchers measured motor function, breathing, swallowing, and sleep over time. The goal was to better understand the disease's impact, not to test a new treatment.

This study followed 50 children who received one or two cochlear implants for 3 years. Researchers compared brain activity recordings (auditory evoked potentials) with speech therapy results to see how well the implants help with hearing and language development. The goal is to i…

This study tested a personalized way to reduce steroid doses in 72 lupus patients. Doctors used blood tests and regular check-ups over 3 months to safely lower prednisone. The goal was to find the best tapering schedule for each person, minimizing side effects while controlling t…

This study looked at whether using frozen embryos instead of fresh ones in IVF leads to more live births. 237 women took part, and researchers compared pregnancy rates and baby health. The goal was to see if freezing embryos helps the womb lining work better.

This study examined how people with mild or no COVID-19 symptoms respond to the virus. Researchers measured immune markers in the blood of 57 adults who tested positive. The goal was to understand why some people clear the virus quickly while others develop severe illness.

This study looked at 629 adults with different types of pulmonary arterial hypertension (PAH), including those linked to HIV, heart defects, and connective tissue diseases. Researchers checked for specific antibodies that might help predict how the disease will progress. The goal…

This study looked at how certain immune cells (antigen-presenting cells) behave in people with sepsis, a severe response to infection. Researchers collected extra blood samples from 119 participants, including sepsis patients, other critically ill patients, and healthy volunteers…

This study looked at over 3,000 women in France whose labor was started artificially (induced). Researchers compared different methods like medication or a small balloon to see which worked best and were safest for mothers and babies. They also checked how well hospitals followed…

This study aimed to create new mathematical models to better predict which patients with severe liver disease are at highest risk of dying while waiting for a liver transplant. Researchers analyzed data from 501 adults on the French national transplant waiting list. The goal is t…

This study looked at whether an ultrasound measurement of the lower uterine segment thickness can help predict the risk of uterine rupture during labor in women who have had a previous C-section. Nearly 3,000 pregnant women with one prior C-section were enrolled. The goal was to …

This study looked at pregnant women at high risk for placenta accreta, a serious condition where the placenta grows too deeply into the womb. Researchers wanted to find out which factors, such as how the condition is diagnosed and managed, affect the mother's health. Over 600 wom…

This study followed 949 newborns and their mothers to understand how a specific, more dangerous type of Group B Strep (ST17) bacteria settles in babies' digestive tracts. Researchers compared it to other Group B Strep strains to see which ones persist longer. The goal was to lear…

This study looked at whether an exercise test can be used to monitor disease severity in people with acute rhabdomyolysis caused by inherited metabolic disorders. Researchers measured heart function and oxygen use during exercise in 27 participants. The goal was to find better wa…

This study compared two ways of giving information to young women (ages 18-40) with breast cancer who haven't started treatment yet. One group received standard face-to-face advice about preserving fertility, while the other used an online decision support tool before their appoi…

This study looked at 170 men from couples struggling with infertility to see if metabolic syndrome (a cluster of conditions like high blood pressure, high blood sugar, and unhealthy cholesterol) is linked to poor sperm health. Researchers measured sperm count and quality and comp…

This study looked at how well 105 adult patients with PICC lines (a type of central venous line) understood and followed a special education program. The program used webinars and a mobile app to teach patients how to care for their lines and reduce risks. The goal was to see if …

This study tested French versions of three hearing and quality-of-life questionnaires (PEACH, SSQ-C, SSQ-P) in 101 children and teens aged 1 to 17. The goal was to see if these tools are reliable and accurate for measuring hearing performance and quality of life in French-speakin…

This study aimed to create a standard way to measure how systemic sclerosis (a rare autoimmune disease) affects patients' daily lives. Researchers worked with 100 patients and experts to identify the most important areas to assess, like mobility, pain, and social participation. T…

This study looked at 575 adults in intensive care for a severe kidney infection (acute obstructive pyelonephritis). The goal was to find out which factors lead to worse outcomes, like death or lasting kidney damage. Researchers reviewed medical records to identify patterns that c…

This study looked at the emotional and psychological experiences of 12 children aged 10 to 16 who were born without one ear (ear aplasia) and chose to have reconstructive surgery. Researchers used interviews and tests to understand how the children think and feel, and how surgery…

This study looked at how often children with a rare adrenal gland problem (congenital adrenal insufficiency) experience dangerously low blood sugar. Even with standard treatment, these children may have low blood sugar without obvious symptoms. Researchers monitored 9 children ag…

This study looked at how often people with active lupus take their medication as prescribed. Researchers measured blood levels of hydroxychloroquine in 307 patients to find out who was skipping doses. The goal was to understand how common non-adherence is, especially in those wit…

This study looked at how blood clots in people with liver cirrhosis, a condition that can cause bleeding problems. Researchers used a special machine called T-TAS to measure clotting in blood samples from 60 patients. They also tested whether tiny particles that act like platelet…

This study looked at different non-invasive methods to measure liver scarring (fibrosis) in children with cystic fibrosis aged 6 to 18. The goal was to see how well these tests work compared to each other, to help doctors decide when to start treatment that may slow liver damage.…

This study looked at whether a simple urine test could predict scarring in kidney transplants, instead of using a needle biopsy. Researchers measured certain genetic markers in urine cells from 300 kidney transplant recipients over the first year after transplant. The goal was to…

This study looked at 127 pregnant women who received a steroid called betamethasone to help prevent lung problems in their premature babies. Researchers measured how much of the drug reached the baby and whether it reduced the risk or severity of hyaline membrane disease, a serio…

This study looked at how the HIV drug tenofovir passes from mother to baby through the placenta. Researchers used a lab model that mimics the third trimester of pregnancy. They studied 369 placentas from healthy pregnant women to understand what affects drug transfer. This was a …

This study looked at tumor samples from 15 children with rhabdoid tumors to understand why some parts of the tumor resist treatment. By analyzing individual cells, researchers aimed to identify different cell types within each tumor and find potential new targets for therapy. The…

This study aimed to find substances in vaginal fluid that could help doctors predict which pregnant women will go into labor early. Researchers studied 238 women, including those with signs of preterm labor and healthy pregnant women. The goal was to develop a simple test to impr…

This study looked at whether giving parents a simple information leaflet about fever before their child's emergency room visit improves their knowledge of how to handle fever at home. 220 parents of children with fever took part. The goal was to see if the leaflet helps parents f…

This study looked at scalp ringworm, a common fungal infection in children, across 11 French hospitals. Researchers collected samples from 701 patients to identify which fungus types were causing infections and whether they were resistant to common antifungal drugs. The goal was …

This completed study looked at how fourth-year medical students learn to build better relationships with patients. Over 400 students took part in training that included lectures, role play, simulated consultations, and Balint group discussions. Researchers interviewed students an…

This study looked at how often kidney hypodysplasia (a condition where one or both kidneys are small and underdeveloped) runs in families. Researchers collected DNA from 342 children aged 3 months to 18 years to try to find genes that may cause the condition. The goal was to bett…

This study looked at 146 children taking common steroids (prednisone, prednisolone, methylprednisolone, hydrocortisone) to understand why their bodies process these drugs so differently. By analyzing blood samples and genetic factors, researchers hope to find clues that could lea…

This study looked back at medical records of 91 children who had surgery for bone cancer in their leg between 1986 and 2017. It compared three different ways to rebuild the bone after removing the tumor: the induced membrane technique, a vascularized fibula graft, and a fibula gr…

This study looked at over 8,800 infants under 2 years old who came to the emergency room with a minor head injury. Researchers wanted to see if a special checklist (the PELICAN rule) could help doctors decide when a CT scan is truly needed. The goal is to avoid unnecessary radiat…

This study interviewed 62 healthcare workers—doctors, nurses, and physiotherapists—to learn how the COVID-19 epidemic affected their work and personal lives. Participants answered questions about their experiences and completed a short survey on how prepared they felt. The goal w…

This study followed 14 people who called a crisis hotline after terrorist attacks in Paris, London, Barcelona, and Strasbourg. Researchers asked them to rate how their symptoms of post-traumatic stress and depression changed over time. The goal was to understand what kind of help…

This completed study looked at 422 pregnant women who developed a fever during labor. The goal was to better understand whether the fever was caused by an infection or other factors like medication or labor itself. Researchers analyzed infection rates in mothers and newborns to i…

This study follows up on 52 children, now aged 7 to 13, who were born very prematurely and received either hydrocortisone or a placebo in the PREMILOC trial. Researchers are measuring their blood pressure, pulse wave velocity, and other heart-related markers to see if the steroid…

This study looked at why people with Lowe syndrome, a rare genetic disorder, may have unusual bleeding. Researchers took blood samples from 30 patients to test how well their platelets work. The goal was to confirm and understand any platelet problems that could cause bleeding ev…

Sacrococcygeal teratoma is a rare tumor near the tailbone in fetuses and newborns. This study reviewed 84 cases to find factors that predict complications, relapse, and long-term effects. The goal is to help doctors give clearer guidance to parents during pregnancy.

This study looked at how often brainstem problems occur in COVID-19 patients who are deeply sedated and on breathing machines in the ICU. Researchers used a simple reflex test (BRASS score) to check brainstem function while patients were sedated and again a few days after sedatio…

This study looked at protein patterns in tumor samples from 44 children with a rare cancer called rhabdoid tumor. Researchers used advanced techniques to see how tumors differ from each other. The goal was to find new targets for future treatments. The study is complete and did n…

This study measured how often teenagers develop chronic kidney disease after having heart surgery as young children. Researchers collected blood and urine samples from 120 teens aged 10 to 15 during their regular heart check-ups. The goal was to find out how common kidney damage …

This study looked at 60 patients who were resuscitated after a cardiac arrest but remained unconscious. Researchers took blood samples at the hospital and on days 1 and 3 to analyze the activity of all genes (the transcriptome). The goal was to see if these gene patterns could pr…

This study looked at 40 children who needed a life-support machine called ECMO. Researchers wanted to understand what brain problems can happen and how the children develop a year later. They used brain scans and developmental tests to track outcomes. The goal is to find ways to …

This study looked at whether showing patients a short video, in addition to the usual oral and written information, helps them better understand upcoming medical exams for infectious diseases. 97 adult patients participated. Researchers measured how well patients felt they unders…

This study tested a new evaluation plan for a training program that teaches parents how to care for children who need nutrition through a tube at home. Eleven parents participated after completing the training. The goal was to see if the evaluation session was useful for parents …

This study followed 355 teenagers who were born very small (under 3.3 pounds) to see how their lungs developed. Researchers measured breathing capacity and other lung functions at age 14-15. The goal was to understand long-term respiratory health in these children, without provid…

This study followed 179 children aged 4 to 16 who were born from twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS). Researchers checked their heart function, blood pressure, kidney health, and blood sugar control to see if the condition during pregnancy cau…

This study looked at how HIV medicines behave in children from birth to 18 years old. Researchers used blood test results from 65 children to create computer models that predict drug levels. The goal was to find the right dose for each child based on factors like weight and age, …

This study looked at how endometriosis affects egg development and quality. Researchers analyzed fluid and cells from the ovaries of 16 women with and without endometriosis. The goal was to find clues that might explain infertility and predict which eggs could lead to a live birt…

This study tested whether having a clinical pharmacist review medications for cancer patients before they start treatment could prevent drug-related problems. Researchers observed 440 adults with solid tumors who were about to receive chemotherapy, immunotherapy, or oral targeted…

This study looked at whether a special type of scan (PET scan) can help doctors decide how to treat a rare fungal infection in the liver and spleen. The infection happens in people with weakened immune systems, such as those with blood cancer or who had a stem cell transplant. Th…

This study looked at 57 people with CURRARINO syndrome, a rare condition that can include a tumor near the tailbone. Researchers checked genes and used yearly MRI scans to learn more about who is at risk. The goal was to better understand the link between genes and tumor developm…

This study looked at anxiety, depression, tiredness, and quality of life in 20 adults with Behçet's disease. Participants filled out questionnaires to measure these symptoms. The goal was to better understand the mental health challenges linked to this rare inflammatory condition…

This study looked at the experiences of family members who care for someone with systemic sclerosis (scleroderma), a rare and serious disease. Researchers surveyed 50 caregivers to understand their physical, mental, and social challenges. The goal is to use this information to cr…

This study looked at whether giving children a longer oral drug challenge test for penicillin-like antibiotics (to confirm an allergy) increases the chance of resistant bacteria growing in their gut. Fifty children aged 0-18 with mild, delayed allergic reactions were tested. The …

This study looked at 25 people with FOXP1 syndrome, a rare genetic condition that can cause developmental delays and behavioral issues. Researchers used interviews and questionnaires to measure symptoms like hyperactivity, anxiety, and psychosis. The goal was to better understand…

This study looked at 60 babies born with a heart defect called transposition of the great vessels. Researchers measured how often severe sensory integration problems occur one week after corrective heart surgery. The goal is to understand the impact of early heart surgery on a ba…

This study looked at how the steroid medication prednisone is processed by the body and what side effects it causes. Researchers followed 114 adults taking prednisone for at least 3 months. They measured drug levels in the blood and tracked side effects like bone loss and infecti…

This study looked at whether low vitamin D levels in the first trimester of pregnancy are linked to developing preeclampsia later on. Researchers measured vitamin D in over 3,000 pregnant women in France. The goal was to understand how common vitamin D deficiency is and if it rel…

This study looked at how a newborn's gut bacteria and immune system might help a dangerous type of Group B Strep (GBS) take hold. Researchers followed 151 pregnant women and their babies to understand why some newborns get severe infections. The goal was to gather information, no…

This study looked at whether a structured follow-up program, including regular screening for common health problems (like high blood pressure and diabetes) and nurse-led education on self-management, helps people with axial spondyloarthritis. Over 500 adults with stable disease t…

This study involved 160 elite French athletes from athletics, rugby 7, and bobsleigh. Researchers measured how each athlete runs and the properties of their muscles to create personalized training programs. The goal was to reduce lower-limb muscle injuries while maintaining top s…

This study looked at 22 deaf infants under 10 months old to find out which factors might increase their risk for neurodevelopmental disorders like autism. Researchers filmed special check-ups to see how the babies interacted and moved. They then compared this with medical history…

This study looked back at 46 women who had a procedure called uterine artery embolization to treat fibroids. The goal was to see how often women later had a baby and what pregnancy complications occurred. The researchers reviewed medical records from one hospital in France to gat…

This study analyzed data from 249 adults with blood cancers like lymphoma and leukemia who received immunotherapy. Researchers aimed to identify markers—such as patient history or lab results—that could predict whether the treatment would work or cause severe side effects. The go…

This pilot study tested whether a combination of two drugs (G-CSF and plerixafor) could safely collect enough blood stem cells from children with Fanconi anemia for future gene therapy. Only 4 children took part. The main goal was to see if the cell collection was possible, not t…

This study tested whether teaching emergency department staff about when IVs are truly needed could cut down on unnecessary placements. Over 500 patients took part, and researchers compared IV use before and after the training. The goal was to reduce complications, save time, and…

This study looked at how parents cope emotionally after their child is hospitalized in intensive care for a severe injury. Researchers checked for signs of anxiety, depression, and post-traumatic stress in 62 parents, 3 to 6 months after the child left the ICU. The goal was to un…

This study followed 19 teens and young adults with cystic fibrosis to see how starting the drug ORKAMBI changed their anxiety, depression, quality of life, and how well they stuck to their treatments. Researchers compared those taking ORKAMBI to a similar group not on the drug. T…

This study looked at 206 very premature babies (born before 32 weeks) to see how early nutrition affects their brain development. Researchers measured the amount of mother's milk, breastfeeding duration, and intake of healthy fats and iron during hospital stays. The goal was to f…

This study looked at how well supportive and palliative care works for infants under 1 year old with spinal muscular atrophy type 1, a severe muscle-weakening disease. Researchers measured oxygen use and breathing support, and also asked parents about their challenges and satisfa…

This study involved 39 adults and children with autoinflammatory diseases like FMF and Still's disease. Researchers conducted interviews to understand how these conditions affect quality of life. The goal was to create a tool that doctors can use to better assess and address pati…

This study looked at nearly 9,000 women giving birth to twins to figure out which delivery method is safest for both babies. Researchers tracked serious health problems in the second twin after birth. The goal is to help doctors choose the best way to deliver twins and reduce ris…

This study looked for simpler ways to measure how many insulin-making cells are left in people with type 1 diabetes. The current test is a long, 3-hour meal test that is not very sensitive. Researchers checked if immune cells in the blood could serve as a better marker. 156 child…

This study looked at whether listeria infection during pregnancy or in newborns leads to long-term brain problems. Researchers compared 53 children who had listeria with healthy children, testing their thinking, movement, and behavior. The goal was to understand how the infection…

This study looked at whether a visit with a nurse to check for other health problems (like heart disease, infections, or bone loss) and a program teaching patients to score their own arthritis activity could improve care. About 970 adults with stable rheumatoid arthritis took par…

This study looked at 98 women who had a blood patch to treat severe headaches caused by an accidental spinal fluid leak during labor. Researchers wanted to see if certain factors during the blood patch procedure were linked to headaches that last 1 to 6 months. The goal is to bet…

This study tested a simple bedside test—a 15-second pause in breathing—to see if it could predict whether infants in shock would benefit from more fluids. Ten infants under 2 years old on ventilators in intensive care were included. Researchers measured heart function before, dur…

This study tested an artificial intelligence system that helps doctors decide when to give fluids during high-risk abdominal surgery. The goal was to see if using this smart system could reduce serious complications like kidney injury, infections, or heart problems within 30 days…

This study looked at whether a 6-minute walk test can help predict survival and the need for a lung transplant in adults with cystic fibrosis. Researchers followed 291 patients to see how far they could walk and how their oxygen levels changed. The goal is to find a simple, non-i…

This study followed 349 people newly diagnosed with myelodysplastic syndromes (MDS), a group of blood disorders that can lead to leukemia. Researchers used advanced DNA testing to find gene mutations and see how they affected survival and treatment response. The goal was to bette…

This study looked at how well patients and their doctors understood each other after an emergency room visit. Researchers compared the answers from patients and doctors on a questionnaire to see if they agreed. Over 1,800 adults from 14 hospitals took part. The goal was to find g…

This study looked at 142 children aged 5-6 to see if their mothers' vitamin D levels during early pregnancy were linked to their lung function. Researchers measured airway resistance, a sign of breathing difficulty, in the children. The goal was to understand if low vitamin D in …

This study tested a new method called continuous anterior chest compression (CACC) to help people with severe lung injury (ARDS) breathe better. Twenty adults on ventilators were studied to see if pressing on the chest improved lung function compared to lying on the stomach. The …

This study examined healthy tissue near melanoma tumors in 226 people with early-stage skin cancer. Researchers looked for dormant (sleeping) cancer cells that might cause the cancer to come back. The goal was to see if these hidden cells are linked to survival and cancer return …

This study tested a technique called ischemic preconditioning (IPC) in 81 adults having major liver surgery. Before the main operation, surgeons briefly stopped blood flow to the liver to see if it would reduce liver injury. The goal was to lower liver enzyme levels after surgery…

This study looked back at medical records of 980 children who had surgery to fix a hole in their eardrum. The goal was to see how often the eardrum healed closed and how well hearing improved after the operation. Researchers checked results 9 to 18 months after surgery.

This study tested a social robot named ARI in a day hospital for elderly patients. The robot was designed to inform, guide, and entertain patients and their families, while also supporting nurses. Researchers measured how acceptable and easy to use the robot was for patients aged…

This study looks at how growth hormone treatment affects the quality of life of short children once they reach their final adult height. Researchers will ask 36 teens and young adults, along with their parents, to fill out questionnaires about physical, emotional, and social well…

This study looked at why girls with Rett syndrome often develop weak bones (osteoporosis) at a young age. Researchers checked 98 participants for bone density, fractures, and levels of certain proteins linked to bone health. The goal was to find risk factors and better understand…

This study looked at whether having a well-organized emergency system helps more people survive severe injuries. Researchers compared death rates within 28 days for patients treated in a structured system versus a non-structured one. Over 2,100 adults who had severe trauma and ar…

This study looked at different programs hospitals use to make sure antibiotics are prescribed correctly, aiming to fight antibiotic resistance. Researchers studied 27 French hospitals to see which strategies work best and are most cost-effective. They also checked how well doctor…

This study looked at two different methods of giving fluids to patients during major liver surgery. One method uses a fixed low amount of fluid, while the other tailors the fluid to each patient's needs using a special monitoring system. The goal was to see which approach leads t…

This study looked at whether specialized training for nurses on how to care for children with a rare, severe skin condition called epidermolysis bullosa (EB) can reduce their stress and anxiety. The study involved 19 nurses and nursing assistants at a hospital in France. Research…

This study looked at whether the measles vaccine virus can be found in the breast milk of new mothers who received the MMR vaccine shortly after giving birth. Fourteen breastfeeding women with no immunity to measles or rubella provided milk samples over two weeks. The goal was to…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This study looked back at 224 patients with tubulointerstitial nephritis (TIN), a common cause of kidney failure. Researchers reviewed kidney biopsies to better understand the causes, treatments, and long-term outcomes of the disease. The goal is to improve how doctors diagnose a…

This study talked to 52 adults with cystic fibrosis who are parents or raising children, along with their spouses, to learn about their hopes, challenges, and needs around parenthood. Through small group discussions and one-on-one interviews led by a psychologist, researchers ide…

This study looked at blood levels of certain immune markers (IgG4) in children with and without milk or egg allergies. Researchers compared these levels in allergic children, non-allergic children, and those who had outgrown their allergy. The goal was to better understand how to…

This study looked at the DNA of 73 children with a rare birth defect called isolated congenital diaphragmatic hernia (CDH), where a hole in the diaphragm allows organs to move into the chest. Researchers wanted to find new genetic changes that might cause the condition. They used…

This study looked at the types of fungi living on the head and neck skin of 30 adults with eczema (atopic dermatitis) compared to healthy volunteers. The goal was to understand if differences in the fungal community are linked to eczema in these areas. Researchers used advanced l…

This study looked at 400 couples to understand how diet, lifestyle habits like smoking and exercise, and genetics influence fertility. Researchers compared fertile and infertile couples to find nutritional factors that may help or hinder conception. No treatment was given; the go…

This study looked at blood clots from 380 people who had a heart attack or sudden cardiac death. Researchers wanted to see if the age and makeup of the clot could explain why some people die suddenly while others survive. They compared clots from sudden death victims, heart attac…

This study looked at 150 children with severe hearing loss to find how many have a specific genetic condition called DFNB9. The goal was to better understand this form of deafness by checking children's hearing and doing genetic tests. The results will help doctors know more abou…

This study tested whether a special MRI technique can measure lung scarring (fibrosis) in people with scleroderma. 24 adults with scleroderma had MRI scans of their lungs while breathing in and out. The goal was to see if MRI could provide a safe, radiation-free way to track lung…

This study looked at 72 adults with high blood pressure to see if how well the kidneys concentrate urine is related to artery stiffness. Researchers measured urine concentration and used a simple test to check artery health. The goal was to better understand the connections betwe…

This study looked at how the drug letermovir passes from a pregnant woman to her fetus during the second trimester. Seven women who were already scheduled to end their pregnancy for other reasons took part. The goal was to measure drug levels in fetal blood and amniotic fluid to …

This completed study looked at how neutrophils (a type of white blood cell) behave in people with granulomatosis with polyangiitis, a rare blood vessel inflammation disease. Researchers compared blood samples from 93 patients and healthy donors to find proteins that could help pr…

This study looked at whether teenagers with restrictive eating disorders (like anorexia or ARFID) have different sensory experiences compared to healthy teens. Researchers used a questionnaire to measure sensory over- or under-reactivity in 29 adolescents. The goal was to better …

This study aims to establish normal blood tryptase levels for children from birth to age 18. Researchers will use leftover blood samples from 402 children already having routine blood tests during surgery. Knowing these normal ranges could help doctors diagnose mast cell diseases…

This study followed over 1,400 pregnant women with endometriosis to see how the disease affects pregnancy outcomes like preterm birth and other complications. Researchers compared different types of endometriosis to better understand risks. The goal was to provide clearer informa…

This study followed 601 adults who survived a cardiac arrest outside the hospital. Researchers wanted to learn how many survive long-term and how their quality of life and daily functioning are affected. The goal is to better understand what helps people recover and live well aft…

This study examined 33 preterm babies born before 30 weeks to mothers with preeclampsia. Researchers measured certain proteins in the mother's blood, umbilical cord blood, and amniotic fluid to see if they were linked to a lung condition called bronchopulmonary dysplasia (BPD). T…

This study looked at 116 people who had a cardiac arrest outside the hospital and were treated with a special heart-lung machine (ECMO). The goal was to see how well their heart function recovered over time. Researchers measured the heart's pumping ability at 28 days and again at…

This study looked at nearly 1,000 children who had both a tumor and a developmental problem (like a birth defect or learning delay) before age 18. The goal was to find new genetic syndromes that make kids more likely to get cancer. Researchers collected information from across Fr…

This study looked at the gut bacteria and bile acids of 80 people—some with coronary artery disease and some healthy. Researchers wanted to see if differences in these gut-related substances might be linked to heart disease. The study was observational, meaning it only measured a…

This study looked at whether certain gene variations (ABCB1) make it harder for the brain to clear a protein called amyloid beta, which is linked to Alzheimer's disease. Researchers compared 510 people with and without Alzheimer's to see if these gene changes are more common in t…

This study looked at whether functional MRI (fMRI) can help doctors diagnose Auditory Processing Disorder (APD) in children aged 7 to 18. APD makes it hard for kids to understand sounds even though their ears work normally. Researchers compared brain scans of children with APD, c…

This study talked to 27 children (ages 6 and up) who have a parent with cystic fibrosis. Through interviews and small group discussions led by a psychologist, researchers aimed to understand their feelings, worries, and needs. The goal is to use this information to create better …

This study looked at how the antifungal medicine caspofungin is processed in the bodies of adults with serious burns. The goal was to find the best dose, since burns can change how drugs work. Only 2 people took part, so the results are very limited.

This study looked at how trouble controlling body temperature affects sleep in people with hypohidrotic ectodermal dysplasia (HED), a rare condition that limits sweating. Researchers compared sleep quality, body temperature, and melatonin levels in 22 HED patients and healthy vol…

This study followed 35 men with spinal cord injuries for 18 months to see how their sperm quality changes over time. Researchers looked at factors like bladder infections and inflammation that might harm sperm. The goal is to find ways to preserve fertility and reduce the need fo…

This study looked at tissue samples from 45 children under 8 who had surgery for a rare lung condition called CCAM. The goal was to find genetic and molecular changes that might cause the malformation. Researchers analyzed gene activity and protein patterns to better understand t…

This study looked at how epilepsy medicines behave in children aged 0 to 18. Researchers used data from 753 kids to build computer models that predict drug levels based on factors like age, weight, and genetics. The goal is to help doctors give the right dose to each child, reduc…

This study looked at 1,701 first-time mothers to see if a more relaxed approach to the pushing phase of labor is as safe as the usual intensive method. The researchers compared newborn health and delivery outcomes between the two approaches. The goal was to find out if a less int…

This study followed 530 working-age adults (18-70) who were hospitalized with COVID-19 to see how disability changes over time. Researchers measured physical and mental impairments, activity limits, and social participation using standard checklists at 12 and 36 months after leav…

This study looked at 225 adults with a rare, inherited form of kidney disease to find the genetic causes. Participants had chronic kidney failure and often had a family history of gout. Researchers tested for known gene mutations and searched for new ones in families without a cl…

This study followed 512 children born to parents with type 1 diabetes to see if early immune system changes and other factors could predict who might develop the disease. Researchers looked at blood markers, gut bacteria, and family environment. The goal was to better understand …

This study looked at 99 women with primary immune deficiency who had been or tried to become pregnant. Researchers tracked infections and pregnancy outcomes to better understand how to manage these patients. The goal was to gather information to help doctors provide better care, …

This study looked at how a specific type of spinal surgery (from the upper back down to the pelvis) changes the way children with scoliosis walk. Six children under 18 who could walk or stroll were followed for 6 months after surgery. Researchers measured walking quality, enduran…

This study looked at whether using physical restraints (like wrist straps) less often in the ICU could shorten the time patients on breathing machines experience delirium (confusion). Over 400 adults from six hospitals were randomly assigned to either routine restraint use or res…

This study looked at whether changing how prescriptions are written (like using words instead of numbers) helps people over 75 make fewer errors when organizing their daily pills. 64 hospitalized older adults with mild or no memory problems were asked to fill pillboxes using diff…

This study tracked 120 children with asthma to see how they used emergency inhalers at home during asthma attacks. Parents used a smart inhaler and a mobile app to report symptoms and treatments. The goal was to gather real-world data to create better, more practical asthma actio…

This study looked at how often heart iron buildup happens in people with thalassemia, sickle cell disease, or myelodysplasia who receive many blood transfusions. Researchers used MRI scans to measure iron in the heart and liver. The goal was to understand the problem better, not …

This study looked at whether a special training course on doctor-patient relationships can help 4th-year medical students keep or improve their empathy and emotional skills. Over 400 students took part, and the researchers measured changes using questionnaires and simulated patie…

This study looked at 240 people with ciliopathies—rare genetic disorders that often lead to kidney failure. Researchers analyzed genes and proteins from patient cells to find patterns that could predict how the disease will progress. The goal is to create a test that helps doctor…

This study asked 307 children with asthma, their parents, and their doctors to rank what they want most from daily asthma treatment—like preventing attacks or making medicine easier to take. The goal was to understand everyone's priorities so future computer programs can help man…

This study aimed to find risk factors for osteoporosis in people with cystic fibrosis. Researchers took blood samples to study monocytes, which can turn into osteoclasts—cells that break down bone. They also tested how CFTR modulators affect these bone cells. The study included 2…

This early-phase study tested whether a single injection of plerixafor could safely and effectively mobilize stem cells for collection in 3 adults with severe sickle cell disease who lacked a matched sibling donor. The goal was to see if enough stem cells could be gathered for a …

This study tested a new way to create 3D models of the head and neck area in young children (ages 1 to 5) who have tumors or birth defects. The models show where important nerves are located, which could help surgeons plan operations more carefully. Seven children participated, a…

This study looked at why children with hereditary epidermolysis bullosa (a rare condition causing fragile skin and painful blisters) often do not take prescribed opioid painkillers before baths and bandage changes. Researchers interviewed 10 children and their parents to understa…

This study tested whether 3D ultrasound can accurately measure kidney and tumor volumes compared to standard CT or MRI scans. 53 adults with chronic kidney disease or kidney tumors participated. Researchers compared 3D ultrasound measurements to those from contrast-enhanced CT or…

This study looked at 20 children with a rare lung condition called pulmonary alveolar proteinosis (PAP) caused by changes in the MARS gene. Researchers wanted to understand if the lung cleaning cells (macrophages) are not working properly. They grew these cells in a lab from bloo…

This study looked at how attention and daydreaming influence obsessive thoughts in people with Obsessive Compulsive Disorder (OCD). Researchers compared 80 participants—some with OCD and some without—to see if obsessions change depending on how much the mind wanders. The goal was…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This study examined the reasons why people with Parkinson's disease end up in the hospital after visiting the emergency room. Researchers looked at data from over 2,500 patients to understand what health problems lead to their hospitalization. The goal was to learn more about the…

This study looked at whether women with primary immunodeficiencies (weakened immune systems) face a higher risk of serious infections, like epidural abscess or meningitis, after receiving epidural or spinal anesthesia during childbirth. Researchers followed 30 women from a nation…

This study looked at how many children of hospital workers had antibodies against the virus that causes COVID-19. Researchers tested blood and saliva samples from 563 family members to see if a parent's infection status affected the child's risk. The goal was to better understand…

This study followed 85 adults who survived severe COVID-19 and needed a breathing machine in the ICU. Researchers tracked their thinking, movement, and emotional health as they moved from hospital to home. The goal was to better understand the challenges these patients face durin…

This study looked at whether a special type of scan (PET/CT) can help doctors see if treatment for a serious fungal lung infection is working earlier than usual. It involved 51 adults with blood cancer and invasive pulmonary aspergillosis. The goal was to see if the scan results …

This study looked at specific immune cells in the esophagus of children with eosinophilic esophagitis (EoE) compared to healthy children. Researchers counted these cells and also studied the microbiome. The goal was to better understand the disease, not to test a treatment. 35 ch…

This study tracked severe Group A Strep infections in 269 children admitted to a Paris hospital from 2018 to 2023. Researchers compared infection rates before, during, and after COVID-19 restrictions like mask-wearing and lockdowns. The goal was to understand how these measures i…

This study looked at how phenelzine, a monoamine oxidase inhibitor, affects immune cells in 51 adults with COVID-19. Researchers measured changes in T cells and monocytes to understand immune activation. The goal was to gather knowledge, not to treat or cure the disease.

This study observed 5000 cataract surgery patients to see if using a special handpiece (Active Sentry) makes the procedure safer. The handpiece helps control pressure inside the eye during surgery, which may reduce the amount of energy needed and lower the risk of complications. …

This study followed 46 obese men who had weight-loss surgery (gastric banding, bypass, or sleeve gastrectomy). Researchers checked their sperm quality and other health factors before and after surgery to see if losing weight improved fertility. The goal was to understand how bari…

This study looked at whether giving a small, fast fluid injection (mini-bolus) can help predict if a child with septic shock will benefit from more fluids. It included 11 children on breathing machines in intensive care. The goal was to find a simple way to guide fluid treatment …

This study looked at 54 children with severe asthma to better understand the different types of the disease. Researchers analyzed immune cells, lung tissue, and microbes from samples taken during a routine bronchoscopy. The goal was to identify patterns that could lead to more pe…

This study looked at 45 pregnant women having planned C-sections to see if a simple finger sensor (measuring perfusion index) could predict dangerous drops in blood pressure after spinal anesthesia. The goal was to find an easy, non-invasive way to identify high-risk patients so …

This study examined 20 children under 18 who were in intensive care with heart inflammation (myocarditis) and possible COVID-19. Researchers aimed to describe the symptoms and lab results, and to figure out whether the virus directly damages the heart or if the body's own immune …

This study looked at 45 people with patellofemoral pain syndrome (front knee pain) to see if different types of the condition have unique movement problems. Researchers used a non-invasive device to measure how the thigh and shin bones rotate during walking. The goal was to bette…

This study followed 80 people newly diagnosed with Cushing's disease to see how the condition affects the heart, bones, metabolism, and quality of life over three years. Researchers checked for complications before treatment and every year after, especially after pituitary surger…

This study looked at whether alendronate, a common osteoporosis medication, affects how well the jawbone heals after a tooth extraction in postmenopausal women. Researchers compared bone healing in 66 women who took the drug and those who did not. The goal was to see if the medic…

This study looked at 20 infants with severe bronchiolitis (a serious lung infection) to compare two types of breathing support: CPAP and NiPPV. The goal was to see which method reduces the effort of breathing more effectively. Researchers measured breathing effort using a special…

This study looked at how much taxi drivers are exposed to tiny air pollution particles (ultrafine particles and black carbon) inside their cabs during a workday. Researchers measured the air in the taxi and tested drivers' breathing before and after their shift. The goal was to s…

This study looked at whether measuring a hormone called pancreatic polypeptide can help doctors tell the difference between type 1 diabetes and type 3c diabetes (diabetes caused by pancreas damage). Thirty-six adults with either type 1 or type 3c diabetes had their pancreatic pol…

This study looked at how the lining of blood vessels (endothelium) might be involved in stroke-like episodes in people with Congenital Disorders of Glycosylation (CDG). Researchers measured how leaky the blood vessel lining was and checked proteins that help control blood clottin…

This study tested whether analyzing a patient's DNA and RNA can help doctors choose the right targeted therapy for hard-to-classify inflammatory diseases affecting multiple organs. 32 adults with such conditions were enrolled. The goal was to see if molecular mapping could predic…

This study measured levels of two related proteins, IGF-I and IGFBP-3, in the blood of 693 older adults. Researchers compared people with Alzheimer's disease, those with mild memory problems, and healthy older adults to see if these protein levels relate to thinking and memory. T…

This pilot study looked at 13 adults with shoulder pain (subacromial pain syndrome) to see if their arm movement speed changed after a 4-session rehab program. Researchers used a 3D motion tool to measure speed and smoothness during arm raises. They also checked if changes in spe…

This study looked at how patients with advanced cancer respond to being offered a conversation about their future care preferences. Researchers invited 71 patients to discuss their wishes and tracked who took part. The goal was to learn more about what helps patients feel ready t…

This study compared two types of imaging—ultra-low-dose CT and lung MRI—to see how well they show lung damage in adults with cystic fibrosis. 185 adults took part, and researchers checked if MRI could give similar results to the standard low-dose CT. The goal is to find a way to …

This study looked at whether giving healthy volunteers a small amount of their own stored blood (200 ml) causes detectable changes in blood cells and particles. Researchers analyzed blood samples before and after transfusion to find markers that could reveal this type of doping i…

This study looked at 50 adults having thyroid or parathyroid surgery to see if a muscle relaxant called rocuronium wears off quickly enough to allow nerve monitoring during the operation. Doctors used the drug to make intubation easier, then checked if the nerves recovered in tim…

This study looked at immune cells (T cells, NK cells, and macrophages) inside melanoma tumors from 217 patients. The goal was to understand how these cells affect the body's ability to fight the cancer and how chemotherapy might change them. It was an observational study, not a t…

This study followed 100 adults who had brain lesions from a serious heart infection (infectious endocarditis). Researchers used MRI scans and thinking tests to see how these brain spots changed over time and if they affected memory or daily life. The goal was to understand the lo…

This study looked at how blood clotting works in 57 people with congenital disorder of glycosylation (CDG), a rare genetic condition. Researchers used a special test to measure clotting balance, without giving any treatment. The goal was to better understand the clotting problems…

This study looked at 558 children and adults with congenital hypothyroidism (a thyroid condition present at birth) to find genetic causes. Researchers compared patients' genes with their medical and imaging results to better understand why the condition occurs and what other heal…

This study looked at how many infertile women have migraines and how those headaches change during IVF treatment. Researchers followed 137 women aged 18-40 at a fertility center. The goal was to understand the link between hormone changes from IVF and migraine attacks.

This study looked at 119 children who had platinum-based chemotherapy for certain cancers. Researchers wanted to find out if certain genes make some kids more likely to develop hearing loss from the treatment. By analyzing DNA from saliva samples, they hope to identify high-risk …

This study looked at whether explaining the potential harms of chemotherapy—including how it can worsen life-threatening conditions—helps patients with incurable stage IV lung cancer avoid unnecessary chemo near the end of life. 123 patients were randomly assigned to receive eith…

This study looked at 145 people who had an allergic or non-allergic reaction during surgery. Researchers wanted to find out which signs, like skin changes or heart rate, could tell the difference between a true allergy and a non-allergic reaction. The goal is to help doctors trea…

This study looked at whether heart rate patterns and pupil reactions can objectively measure anxiety in patients before day surgery. 71 adults scheduled for day-case surgery were monitored before and during a small procedure (cannulation). The goal was to see if these simple, non…

This study tested whether a special high-flow nose tube (HFNO) keeps oxygen levels better than a standard facemask during anesthesia in children under 11. It involved 44 kids having surgery that required a fast-acting anesthesia. The goal was to see which method prevents oxygen d…

This study tested a new ultrasound technique called ultrasound localization microscopy (ULM) to see very small arteries in the brain. Researchers used it on 24 people who had a stroke or Moya Moya disease. The goal was to see if ULM could find more tiny arteries than standard MRI…

This study looked at whether the seasonal flu vaccine works as well in people with sarcoidosis, an inflammatory disease, as it does in healthy people. Researchers enrolled 190 adults aged 18-65 with sarcoidosis and a control group of healthy volunteers. They measured immune respo…

This study looked at how physical therapy and rehabilitation departments function by interviewing 63 people, including doctors, nurses, and patients. The goal was to find ways to improve communication and patient care. No new treatments or drugs were tested—just gathering ideas t…

This study tested blood and urine samples from 100 adults who filed a police complaint for suspected chemical submission (being secretly given drugs). Researchers compared lab results with medical exams to find out how many cases were confirmed and which substances were used. The…

This study tested a simple method to see if giving extra fluids would help patients on breathing machines who are in shock. Doctors used a short increase in breathing machine pressure (PEEP test) to predict fluid needs. The goal was to avoid unnecessary fluids. The study involved…

This study looked at 15 people with severe haemophilia B who were taking a medicine called eftrenonacog-alfa (a recombinant factor IX). The goal was to see how well different lab tests measure the level of clotting factor in their blood. Researchers also checked how the medicine …

This study looked at how two different COVID-19 booster vaccines affect immune cells in the lymph nodes. Researchers used a needle to take samples from the lymph nodes of 12 adults who had already received at least three doses of an mRNA COVID-19 vaccine. The goal was to understa…

This study tested whether M-mode ultrasound can accurately confirm the placement of an epidural catheter in women in labor. Researchers enrolled 100 women receiving epidural pain relief during vaginal delivery. They used ultrasound to visualize the catheter and compared it to sta…

This study looked at the DNA of Staphylococcus epidermidis bacteria from 320 patients to find genetic markers that separate harmless strains from those that cause serious infections. The goal is to help doctors decide when antibiotics are truly needed. No new treatment was tested…

This study followed 72 children who were diagnosed before birth with a missing or abnormal corpus callosum, the bundle of nerves connecting the brain's two halves. Researchers tested their thinking, movement, and behavior at age 3 to understand how they develop. The goal was to g…

This study looked at blood neutrophils (a type of immune cell) in 47 adults with cystic fibrosis. Researchers wanted to see how these cells behave differently in people with chronic infections or on certain treatments. The goal was to learn more about the disease, not to test a n…

This study looked at 116 overweight or moderately obese adults who had a procedure called endoscopic sleeve gastroplasty to help them lose weight. The goal was to find out why some people lose more weight than others after the procedure. Researchers checked blood samples and medi…

This study looked at 82 pregnant women whose babies were growing slowly in the womb (intrauterine growth restriction). Researchers used a special brain MRI to see if differences in brain water movement could tell which babies would have serious problems after birth. The goal was …

This study looked at how a marker of inflammation called C-reactive protein (CRP) changes in the blood of 35 people having emergency angioplasty for a heart attack. Researchers took blood samples before the procedure and at several time points after, up to 30 days. The goal was t…

This study looked at 60 teens ages 12 to 18 to see if those with Avoidant and Restrictive Food Intake Disorder (ARFID) had more feeding problems before age 4 compared to healthy teens. Researchers used questionnaires to check early feeding history, growth, and sensory sensitiviti…

This study looked at whether two common pain relievers, ibuprofen and ketoprofen, enter breastmilk in significant amounts. Researchers measured drug levels in milk from 35 breastfeeding women who had been taking one of these medicines for more than 24 hours. The goal was to help …

This study tested a smartphone app called Predigraft that helps kidney transplant patients and their doctors monitor the health of the new kidney from home. The app predicts how long the kidney might last and lets patients send in test results and vital signs. The goal was to see…

This study looked at 51 adults with cardiac amyloidosis, a rare heart condition, to find out how many also have problems with smell and taste. Researchers used simple tests to measure these senses. The goal was to see if smell or taste loss could help doctors catch the disease ea…

This study looked at why people with myotonic dystrophy type 1 (DM1) have a much higher risk of dangerous blood clots in the legs or lungs. Researchers tested blood clotting in 130 participants, including people with DM1, those with a history of clots, and healthy volunteers. The…

This study looked at 175 premature babies to see if high iron levels in their blood during the first month of life are linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured iron-related markers and tracked which babies developed ROP. The …

This study followed 708 adults with early inflammatory back pain for up to 5 years. Researchers collected data to better understand how the disease progresses, what predicts joint damage, and how to improve diagnosis. The goal was to gather knowledge, not to test a new treatment.

This study looked at 27 children in intensive care who needed medicine to raise their blood pressure or treat shock. Researchers used ultrasound and light sensors to measure blood flow and oxygen levels in the brain during treatment. The goal was to understand how the brain respo…

This study tested whether artificial intelligence (AI) can help doctors better predict how diabetic retinopathy (an eye disease from diabetes) will progress. Over 3,000 adults with diabetes were followed for about 2 years. The goal was to create a smarter system that uses eye ima…

This study looked at how well the antibiotic ertapenem reaches prostate tissue after a single dose given before surgery. Twenty men with an enlarged prostate (BPH) who needed surgery took part. The goal was to see if enough antibiotic gets into the prostate to help prevent infect…

This study followed 912 men and women over 60 in France who were hospitalized for a severe bone fracture caused by a minor fall. Researchers tracked how many had another severe fracture or died within 2 and 5 years. The goal was to better understand the long-term risks after such…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study checks if men who had a treated urethritis infection still have signs of long-term inflammation and cell damage in their genital tract. Researchers measured a protein called elastase and markers of oxidative stress in semen 6 and 12 months after treatment. They compare…

This study looked at whether a passive leg raising test (lifting the legs while lying down) can predict low blood pressure after spinal anesthesia for planned C-sections. 64 women participated. The goal was to see if this simple test could help doctors know who might need extra m…

This study looked at 55 adults with diabetes to better understand insulin allergy, a rare but serious condition where the body reacts against insulin. The goal was to create a reliable way to diagnose the allergy and explore why it happens. Researchers tested skin reactions and s…

This study followed 574 adults hospitalized with end-stage liver disease to see if alcoholic patients face unfair barriers to getting on the national liver transplant waiting list. Researchers tracked who was registered for a transplant and compared it to their doctors' opinions.…

This study followed 436 pregnant women whose babies were found to have a lung malformation on ultrasound. The goal was to identify signs during pregnancy that could predict whether the baby would have breathing difficulties right after birth. By better understanding these rare co…

This study interviewed 25 health professionals who treat teens and young adults with long-lasting muscle or bone pain that is not caused by cancer. The goal was to learn how these experts figure out what is causing the pain, since there is no standard test. The results will help …

This study looked at how well telemedicine works for people with rheumatoid arthritis. Researchers tracked whether virtual visits led to in-person appointments, hospital stays, or changes in medication. The goal was to see if remote care can effectively manage the disease without…

This study tested a new self-administered questionnaire designed to measure shortness of breath and its impact on daily life in people with chronic respiratory diseases like COPD, pulmonary fibrosis, and cystic fibrosis. Researchers enrolled 199 adults to check if the tool is rel…

This study followed 133 people with PPNAD (a rare adrenal gland disorder) or Carney Complex (a related genetic condition) for three years. The goal was to better understand the symptoms and genetic causes of these diseases, not to test a new treatment. Participants had yearly che…

This study looked at whether offering counselling to family members right after a loved one's sudden death helps their mental health. Over 600 relatives were offered support by the emergency medical team. Researchers then checked for signs of depression, anxiety, and post-traumat…

This study used powerful MRI scans to track how a rare genetic disease called metachromatic leukodystrophy (MLD) damages the brain's white matter in young children. Researchers studied 29 children aged 1 to 6 years with MLD, along with a control group, to better understand how th…

This study looked at how often depression and anxiety occur in teenagers with cystic fibrosis (ages 14-17) and their parents. Researchers used simple screening questionnaires during regular clinic visits to measure mental health symptoms. The goal was to find out how common these…

This study looked at how closely 227 adults with precapillary pulmonary hypertension follow their prescribed diuretic (water pill) regimen. Researchers used questionnaires and pharmacy records to measure adherence and identify reasons for missed doses. The goal is to understand n…

This study looked at how the pressure used in mechanical ventilators affects the right side of the heart in people with acute respiratory distress syndrome (ARDS). Researchers measured lung pressure and heart function in 50 adults and children. The goal was to find out if high lu…

This study looked at how well 60 adults with type 2 diabetes could follow a Mediterranean diet for 12 months. Researchers wanted to see what makes it hard or easy to stick with this healthy eating plan. The goal is to find ways to help more people with diabetes adopt this diet.

This study looked at whether ultrasound can help doctors decide which children on breathing machines need extra fluids. Only about half of these children respond to fluids, and too much fluid can be harmful. The researchers tested ultrasound methods used in adults to see if they …

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study looked at over 2,100 people with listeriosis, a serious foodborne infection that can cause blood infections, brain infections, and pregnancy complications. Researchers collected data to find out which clinical, biological, and genetic factors make someone more likely t…

This study looked at a specific enzyme called IL4I1 in the blood and tissues of 127 people with cutaneous melanoma. Researchers wanted to see if this enzyme helps predict how fast the disease progresses and whether it plays a role in resistance to immunotherapy and targeted thera…

This study looked back at 72 children treated over 20 years for a rare kidney cancer (Wilms tumor) that had spread into the large vein carrying blood to the heart. The goal was to find the best surgical approaches to improve survival and reduce complications. No new treatments we…

This study tested a more accurate method to measure kidney function in 90 critically ill ICU patients whose kidneys were working overtime. The standard creatinine clearance test can be misleading in these patients, so researchers compared it with the iohexol plasma clearance tech…

This study looked at the overall health and sexual well-being of 138 women with Rokitansky syndrome, a condition where the vagina is underdeveloped. Participants had either surgery or used dilators to create a vagina. The goal was to see how these treatments affect quality of lif…

This study looked at whether a test using cells from the nose can predict if the drug Orkambi® will improve lung function in people with cystic fibrosis. Researchers collected nasal cells from 91 participants before they started Orkambi® and measured how well the drug fixed the c…

This study measured normal nasalance scores in 131 French-speaking children aged 8-10 using a non-invasive device called a nasometer. The goal was to create a reference for doctors to better diagnose velopharyngeal dysfunction, often seen in children with cleft palate. Participan…

This study tested over 1,000 children and their parents for COVID-19 antibodies to find out how many had been infected. Researchers also checked for active virus in nose, saliva, and stool samples. The goal was to better understand infection rates and immune responses in families…

This study looked at immune cells from 138 people with Wegener's granulomatosis, a rare disease causing inflammation of blood vessels. Researchers measured levels of a protein called DAP12 in different immune cells to understand how the disease works. No new treatment was tested;…

This study looked at 254 babies born with cytomegalovirus (CMV) infection to find early signs that predict hearing or brain problems at age 1. Researchers checked clinical exams, brain scans, and blood tests shortly after birth. The goal is to create a scoring system to identify …

This study followed 58 children with sickle cell disease from birth to find early warning signs of a life-threatening spleen problem called acute splenic sequestration. Researchers checked blood samples, cell properties, and genetic markers to identify which children are most at …

This study looked at how rare diseases impact oral health and quality of life. Researchers interviewed 28 patients aged 6 and older at Necker Hospital in Paris. The goal was to understand their experiences and identify barriers to dental care, not to test a treatment.

This study looked at nearly 6,000 ICU patients with severe kidney injury to see if a scoring tool called UNDERSCORE can predict when dialysis can be safely stopped. The goal was to avoid restarting dialysis or early death within 7 days. Researchers used existing hospital data to …

This study tested whether a special thermal camera could automatically detect breathing distress in patients on breathing machines. The camera measures heart rate, breathing rate, and facial expressions to spot signs of suffocation without needing a nurse to watch constantly. The…

This study looked at the extra costs that families of people with Duchenne muscular dystrophy (DMD) in France have to pay out of their own pockets. It included 28 patients of any age who had been diagnosed for at least six months. The researchers measured things like uninsured me…

This study created a registry to collect medical information from 868 people with Anti-Phospholipid Syndrome (APS) and/or Systemic Lupus Erythematosus (SLE). The goal was to gather data on these conditions, not to test a new treatment. Participants were adults diagnosed with APS …

This study looked for rare, single-gene causes of insulin-dependent diabetes in 127 participants. Researchers examined patients' genes, medical histories, and family members to identify new forms of diabetes. The goal was to better understand these genetic subtypes, not to test a…

This study reviewed medical records of 152 infants with rare solid tumors in the chest, belly, or pelvis. The goal was to see how well prenatal scans and exams matched the final diagnosis after birth. Researchers also looked at the range of conditions linked to these tumors. No n…