New hope for rare bone disease: drug may strengthen fragile bones
NCT ID NCT03401060
First seen Apr 11, 2026 · Last updated Apr 30, 2026 · Updated 3 times
Summary
This study tested whether a drug called denosumab can improve bone density in adults with osteoporosis caused by systemic mastocytosis, a rare disease where too many mast cells weaken bones. Twenty-four participants received either denosumab or a placebo every 6 months for 3 years. The main goal was to measure changes in spine bone density using X-rays.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Caen Hospital, Clinical haematology department
Caen, 14033, France
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Cochin Hospital, Rheumatology department
Paris, 75014, France
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Estaing Hospital, Cellular therapy and clinical haematology department
Clermont-Ferrand, 63100, France
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Jean Minjoz Hospital, Dermatology department
Besançon, 25030, France
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La Pitié-Salpêtrière Hospital, Internal medicine and clinical immunology department
Paris, 75013, France
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La Timone Hospital, Dermatology and cutaneous oncology department
Marseille, 13385, France
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Lapeyronie Hospital, Rheumatology and Immunology department
Montpellier, 34295, France
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Lille CHRU Hospital, Internal medicine and clinical immunology department
Lille, 59037, France
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Necker Hospital, Adult haematology department
Paris, 75015, France
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Strasbourg Hospital, Rheumatology department
Strasbourg, 67098, France
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Toulouse Hospital, Dermatology department
Toulouse, 31060, France
Conditions
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