OSTEOPOROSIS

This study tests whether combining two osteoporosis drugs (romosozumab and denosumab) works better than either drug alone for postmenopausal women with weak bones. 90 women will receive one of three treatments for 6 months. The goal is to see if the combination improves bone dens…

This study tests whether a patient navigator who guides older adults to bone health care can reduce the chance of another broken bone after a fragility fracture. About 2,634 people aged 50 and older who recently broke a bone from a minor fall will be assigned to either the naviga…

This study tests two different ways of giving two osteoporosis drugs (romosozumab and denosumab) over two years. One group gets a repeating 6-month cycle of each drug, while the other gets 12 months of one drug followed by 12 months of the other. The goal is to see which schedule…

This study tests a program called OPTIONS that helps older adults recover after a broken hip or leg. The program provides exercise, diet advice, and bone-strengthening medication in nursing homes and after going home. About 1,500 people aged 65 and older will take part. The goal …

This study looks at a new way to stop taking the osteoporosis drug denosumab (Prolia) without losing bone density. When people stop denosumab after using it for years, their bones can weaken quickly. The standard approach of switching to another drug often doesn't fully prevent t…

This study tests whether two drugs used for osteoporosis—zoledronic acid and denosumab—can prevent bone loss in older adults who have been critically ill in the intensive care unit (ICU). The trial will include 450 women aged 50 or older and men aged 70 or older who spent more th…

This study tests whether a special screening and a tailored exercise program (RYMA) can reduce falls, fractures, and heart risks in people aged 65+ with type 1 or type 2 diabetes. About 490 participants will be assigned to either the exercise program or usual care and followed fo…

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women aged 65–92 who have already broken a hip due to osteoporosis. About 2,400 women will be randomly assigned to receive the procedure or standard care, and they will be follo…

This study tests whether Denosumab, a drug used for osteoporosis, can help preserve muscle strength and mobility in frail adults aged 65 and older. Researchers will measure changes in knee extension strength over time. The goal is to improve muscle health and function, not to cur…

This study tests whether a traditional Chinese medicine (TCM) formula can improve muscle strength and bone health in older adults who are starting to become frail. 90 people aged 65 and older who are pre-frail will be randomly assigned to take either the TCM formula or a nutritio…

This study is testing whether denosumab, a drug used for osteoporosis, can also improve muscle strength and insulin sensitivity in postmenopausal women with type 2 diabetes. About 40 women will receive either denosumab or a placebo for 12 months. The goal is to see if the drug of…

This study looks at whether drinking dairy milk, pea-based milk, or almond milk after resistance training (3 times a week for 12 months) helps improve bone strength in postmenopausal women and men aged 50 and older. The goal is to find which drink, combined with exercise, best su…

This study tests whether a special food containing probiotics and prebiotics can help slow or reverse bone loss in older women. About 220 women aged 60 and older will take either the active food or a placebo for 18 months. The main goal is to see if it improves spine bone density…

This study compares two FDA-approved medication regimens to see which works better for improving bone density in postmenopausal women with osteoporosis who are at high risk of fractures. About 50 women aged 45 and older will take one of the two drug combinations for 12 months. Th…

This study aims to help 200 adults aged 50 and older in a rural area who have had a hip or spine fracture or are taking osteoporosis medications. Participants receive education, regular check-ins every 4 months for 2 years, and support to take their medications correctly. The goa…

This study looks at whether donepezil, a medicine used for Alzheimer's, can also improve bone health and lower fracture risk in older adults with mild to moderate Alzheimer's. About 45 participants will take either donepezil or memantine daily for 12 months. Researchers will meas…

This study looks at whether a surgeon-initiated referral to a bone health specialist can reduce implant problems and fractures in people with osteoporosis who have hip or knee replacement surgery. About 2,000 participants aged 50 and older with confirmed osteoporosis will be foll…

This study aims to create an artificial intelligence (AI) system that can automatically diagnose and stage osteoporosis and osteoarthritis from medical images like X-rays and MRIs. Researchers will enroll 2,000 adults to test if the AI can provide more consistent and accurate res…

This study tests a smart wearable device called gaitQ that uses cues to help people with long-term movement conditions like Parkinson's disease, stroke, multiple sclerosis, and arthritis walk better. Researchers will measure walking speed, step length, and safety in 150 participa…

This study tests whether a virtual chiropractor program is practical for people over 50 who have had a spine fracture from osteoporosis. Participants will receive 12 online sessions over 8 weeks covering pain management, safe movement, exercise, and nutrition. The goal is to see …

This study tests a combined program of Baduanjin (a gentle Chinese mind-body exercise) and resistance training for elderly patients with osteoporosis and a herniated disc in the lower back. The goal is to reduce pain, improve muscle strength, and enhance quality of life. About 11…

This study looks at how often men over 50 have undetected spine fractures by using artificial intelligence to analyze CT scans done for other medical reasons. The goal is to find fractures linked to osteoporosis early, without extra tests or radiation. Researchers will enroll 250…

This study looks at whether a new ultrasound technology called REMS can safely measure bone density in children aged 5 to 18 who have conditions that weaken bones, like osteoporosis or growth hormone deficiency. Unlike the current standard (DXA), REMS uses no radiation. The goal …

This study investigates whether a protein called RANKL, which is known to regulate bone health, also plays a role in egg development and female fertility. Researchers will use mice, monkeys, and human ovarian tissue to see if blocking RANKL can improve egg maturation and potentia…

This study looks at how osteoporosis might change the way different parts of the brain communicate. Researchers will compare brain scans from 60 postmenopausal women—some with osteoporosis and fractures, some with osteoporosis but no fractures, and some healthy volunteers. Partic…

This study looks at whether a type of artificial intelligence (AI) can help doctors better identify complications in people with rheumatoid arthritis (RA). Researchers will use AI to suggest possible complications from patient records and see if doctors agree with and use those s…

This study is testing a new portable ultrasound device that measures bone density in the lower leg without using radiation. Researchers will compare its results to the standard X-ray method (DXA) in 350 healthy adults aged 21 to 55. The goal is to see if the ultrasound device can…

This study looks at how well older adults understand osteoporosis and their own health. Researchers will survey 190 people aged 65+ (women) or 70+ (men) to measure their health literacy and awareness of osteoporosis. The goal is to find out what factors affect knowledge so that b…

This study aims to see if a self-administered questionnaire can accurately capture family history of rare genetic bone diseases in adults with osteoporosis. Researchers will compare the questionnaire answers to detailed family trees (pedigrees) from 58 participants. The goal is t…

This study is testing a robotic system called Epione that helps doctors place needles or instruments into the bones of the pelvis and spine. The goal is to see if the robot makes these procedures more accurate and safer compared to doing them by hand. About 60 adults with bone tu…

This study looks at bone density in 100 pregnant women (ages 30-45) during their third trimester, comparing those carrying one baby versus twins. Researchers use a special bone scan and questionnaires to see if twin pregnancies lead to greater bone loss. The goal is to better und…

This study looks at how GLP-1 weight loss medications change muscle and bone in people with obesity. About 50 adults will take the drug and either follow a diet and exercise program or just standard advice. Researchers will measure muscle mass, bone health, and related blood mark…

This study aims to make sure lab tests, equipment, and procedures used in research on obesity, diabetes, heart disease, and bone disorders are accurate and give consistent results. It will involve up to 100 healthy volunteers and people with these conditions, aged 18 to 100. The …

This study looks at different ways to teach people over 50 with osteoporosis how to take better care of themselves. Participants will either get standard information, attend three in-person classes, or use an online program for a year. The goal is to see which method improves sel…

This study aims to better understand how bones break in people with osteoporosis by combining medical imaging with computer simulations. Researchers will analyze bone samples from 52 adults undergoing hip replacement surgery to see how tiny structural differences affect fracture …

This study looks at bone marrow from 24 adults aged 65 and older who are having hip surgery. Researchers will analyze the samples to see how metabolism and gene activity differ in stem cells with certain age-related mutations. The goal is to better understand clonal hematopoiesis…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biological markers that can predict how well a patient will respond to…

This study interviews 15 doctors in Alsace, France, who treat frail elderly patients with osteoporosis. The goal is to understand what makes them use (or not use) a practical guide on managing the condition. The findings could help improve how osteoporosis care is delivered to ol…

This study is testing whether a new scoring system helps doctors choose the best treatment for people with spine fractures caused by osteoporosis. About 648 adults over 50 will be followed for 3 months to see if following the score's advice leads to faster return to normal mobili…

This study looks at whether blood tests called Bone Turnover Markers (BTMs) can quickly show if osteoporosis medication is working in postmenopausal women. Currently, doctors use DEXA scans to check bone density, but these change slowly. BTMs might show results in just 3 to 6 mon…