15-Second breath test may guide fluid therapy in sick infants
NCT ID NCT04932590
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a simple bedside test—a 15-second pause in breathing—to see if it could predict whether infants in shock would benefit from more fluids. Ten infants under 2 years old on ventilators in intensive care were included. Researchers measured heart function before, during, and after the pause to see if it could guide treatment decisions.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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10 people
The number who actually took part.
- Started
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Dec 2021
- Finished
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Sep 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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0 to 2 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Newborn and infant \<2 years. * Born at or near term (\> 36 weeks of amenorrhea). * Hospitalized in pediatric and neonatal intensive care. * Requiring the use of invasive mechanical ventilation. * In a state of shock defined by a cardio-circulatory dysfunction associating arterial hypotension, an alteration in organ perfusion, one or more organ dysfunctions or vasopressor's requirement. Clinical signs retained: heart rate ≥ 90th percentile associated with at least one sign of peripheral hypoperfusion represented by a a capillary refill time ≥ 3sec, or the presence of mottling or coldness of the extremities or urine output ≤ 0.5ml / kg / h or disturbance of consciousness. * The practitioner in charge of the patient has decided to perform volume expansion. * Non-opposition expressed by the holders of parental authority. Exclusion Criteria: * Any serious and urgent clinical hemodynamic situation, the management of which would be delayed by inclusion in the protocol. * Patient with unoperated congenital heart disease. * Patient in spontaneous or non-invasive ventilation or with spontaneous ventilatory cycles in invasive ventilation. * Patient in prolonged cardiac arrest (\> 5min) or refractory. * Patient under venous-arterial extracorporeal membrane oxygenation. * Refusal of the holders of parental authority to exploit the collected data.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Armand Trousseau
Paris, 75012, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could less food help critically ill patients recover faster?
- Ultrasound could reveal when ICU tube feeding fails
- A new device aims to track the heart's pumping power in the ICU — without invasive tubes
- New pressure test may help doctors give right fluids in shock
- Non-invasive heart monitor tested against standard method in shock patients