New study aims to find best Non-Invasive liver test for cystic fibrosis kids
NCT ID NCT02342964
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compared four non-invasive methods—FibroTest, Fibroscan, ShearWave Elastography, and Magnetic Resonance Elastography—to measure liver fibrosis in 56 children with cystic fibrosis aged 6-18. The goal was to see which test best detects early liver damage, helping doctors decide when to start treatment with ursodeoxycholic acid to prevent cirrhosis. The study is complete, but results are not yet widely available.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help doctors choose the best non-invasive test to detect liver fibrosis early in cystic fibrosis, potentially slowing disease progression with timely treatment.
- What could go wrong
- This is a small, completed study with only 56 participants, so results may not apply to all patients. The tests are compared to each other, not to a gold standard, so accuracy remains uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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56 people
The number who actually took part.
- Started
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Jan 2015
- Finished
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Jan 2019
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 to 18 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Children with cystic fibrosis aged 6-18 years. The diagnosis of cystic fibrosis will be based on testing the abnormal sweat (\> 60 mEq / L of chloride sweat) and / or on the presence of two pathogen mutations of CFTR. * Written consent of parents or holders of parental rights. * Affiliated or benefiting from a national social insurance Exclusion Criteria: * Presence of another disease associated with cystic fibrosis that may be responsible for a chronic hepatic disease such as deficiency of alpha-1antitrypsine ZZ genotype or chronic infection by virus B or C. * Child grafted * Actual febrile pulmonary infection that can change the value of Fibrotest * Important peri-hepatic ascites preventing the elasticity measurements by Fibroscan® * Severe respiratory insufficient preventing attainment of Magnetic Resonance Imagery
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hôpital Necker
Paris, 75015, France
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Other studies related to the condition(s) this trial covers.
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