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Blood genes may reveal brain recovery after cardiac arrest

NCT ID NCT03895736

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 60 patients who were resuscitated after a cardiac arrest but remained unconscious. Researchers took blood samples at the hospital and on days 1 and 3 to analyze the activity of all genes (the transcriptome). The goal was to see if these gene patterns could predict how well the brain would recover 60 days later. No treatment was given; this was purely an observation to find potential early markers of neurological outcome.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a blood test that helps doctors predict neurological recovery early after cardiac arrest.
What could go wrong
This is a small, completed observational study, not a treatment trial. The findings may not lead to a reliable test or change patient care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Feb 2020

Finished

Feb 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 80 years * Delay between patients collapse and resumption of spontaneous circulation (ROSC) \< 60 minutes * Comatose patients ROSC with Glasgow score \< 7 * Patient already registered in the social security system * Consent of a family member, if able to understand in the emergency context, or attestation of emergency situation with a follow-up information notice Exclusion Criteria: * Cardiac arrest supposed to be provoked by trauma or sepsis

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Conditions

The condition(s) this trial relates to.

cardiac arrest post-cardiac arrest syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Out-of-hospital cardiac arrest after initial successful resuscitation

Contacts and locations

Locations

  • Hôpital Cochin, Assistance Publique Hôpitaux de Paris

    Paris, 75005, France

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