Could a simple oxygen mask halt rare childhood paralysis attacks?
NCT ID NCT06248645
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether breathing high-flow oxygen for 15 minutes can stop dystonic or plegic attacks in children with Alternating Hemiplegia of Childhood (AHC), a rare genetic disorder causing temporary paralysis and muscle spasms. 24 participants used oxygen or a placebo (medical air) during attacks over 5 weeks. The goal was to see if attacks stopped within 30 minutes, offering a potential new acute treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- high-flow oxygen
- What this could lead to
- If it works, this could provide a quick, safe way to stop disabling motor attacks in children with Alternating Hemiplegia of Childhood.
- What could go wrong
- This is a small, early-phase trial with only 24 participants. The effect may not be strong or lasting, and oxygen therapy may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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24 people
The number who actually took part.
- Started
-
Sep 2024
- Finished
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Mar 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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1 year and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age \> 1 year old 2. Patients able to administrate high-flow oxygen through a non rebreathing facial mask, either alone or with assistance 3. Patients with a diagnosis of AHC caused by ATP1A3 mutations presenting at least one dystonic or plegic attack per week lasting more than 30 minutes 4. Absence of long-term treatment or long-term treatment stable over the last month and during the duration of the trial 5. Patients able to give written informed consent 6. Affiliation to social insurance Exclusion Criteria: 1. Inability for the patients and/or caregivers to follow the protocol (inability to read or understand the instructions, no access to smartphone or computer to fill the informatics patient's form) 2. Patients with severe or uncontrolled obstructive or restrictive chronic respiratory disease (asthma, COPD, obesity, neuromuscular disease), acute systemic aggression (acute coronary syndrome, stroke, sepsis, head trauma) or congenital cardiopathy with a risk of hypercapnia following oxygen administration 3. Women that are pregnant (a negative pregnancy test is required for inclusion) or breath feeding 4. Patients involved in an other clinical trial
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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HCL LYON
Lyon, France
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Hôpital Pitié Salpêtrière
Paris, 75013, France
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