Assistance Publique - Hôpitaux De Paris

This early-stage trial is testing a one-time gene therapy for babies with a rare and severe form of immune deficiency called Artemis SCID. Doctors take a patient's own blood stem cells, use a virus to insert a corrected gene in the lab, and then transplant the cells back. The goa…

This study aims to find out if people with sarcoidosis who are in remission can safely stop their infliximab treatment. It will compare two groups: one that stops the drug and one that continues it, to see which strategy is better at keeping the disease from coming back. The goal…

This study is testing whether adding cannabidiol (CBD) to standard care helps people with severe alcohol use disorder stay alcohol-free after they leave a detox program. 210 participants will be randomly assigned to receive either a placebo or one of two CBD doses for 11 days dur…

This early-stage study is testing a new vaccine designed to help the body's immune system fight glioblastoma, a serious type of brain cancer. The vaccine targets specific proteins found on the tumor. Participants will receive the vaccine after completing their standard surgery an…

This study is testing whether adding a new drug, letermovir, to the standard treatment (valganciclovir) works better against a common viral infection called CMV in people who have received a kidney transplant. The goal is to clear the virus from the blood faster and reduce the ch…

This study is testing if adding a protein solution called albumin to standard IV fluids during a major cancer surgery leads to fewer complications. It will involve 140 adults undergoing surgery for cancer that has spread to the abdominal lining. Researchers will compare the compl…

This study is testing if adding a specific diet, called the Crohn's Disease Exclusion Diet (CDED), to a child's regular medication helps them stay in remission longer and have fewer disease flare-ups. It will involve about 120 children and teenagers (ages 6-17) in France who have…

This study is testing if a cochlear implant can help children who are deaf or have very poor hearing in one ear. It will compare the implant to standard hearing aids to see if it improves the child's ability to understand speech in noisy places and figure out where sounds are com…

This large study aims to improve treatment for adults with acute lymphoblastic leukemia (ALL) by testing new targeted immunotherapy drugs. It will enroll 1,200 newly diagnosed patients to see if these drugs can control the cancer so well that a risky stem cell transplant is no lo…

This study compares two treatment approaches for children aged 8-13 with severe anorexia nervosa. One group receives traditional longer hospital stays, while the other gets shorter hospital stays followed by weekly day treatment. Researchers want to see if the shorter hospital ap…

This study is for people with colorectal cancer that has spread to the liver. After successful surgery to remove the liver tumors, researchers want to know if restarting the same chemotherapy patients had before surgery helps keep the cancer from coming back. They are comparing p…

This study aims to find the best way to prevent another stroke in people aged 60 to 80 who have had an unexplained stroke and a small, common heart hole called a PFO. Researchers will compare three approaches: closing the hole with a device plus aspirin, taking stronger blood-thi…

This study is testing whether a short course of the drug baricitinib can shrink large, inflammatory benign liver tumors in young women. The goal is to see if this treatment can reduce tumor size enough to avoid the need for liver surgery, which carries risks and scarring. Researc…

This study aims to find the best way to give antibiotics to critically ill sepsis patients in the ICU. It will compare giving antibiotics continuously versus in separate doses, and using one drug versus a combination of two drugs. The main goal is to see which approach leads to b…

This study is testing whether the drug itacitinib is safe and effective for treating adults with systemic sclerosis, a rare autoimmune disease that causes skin thickening and can damage internal organs. About 74 participants with active, diffuse forms of the disease will be enrol…

This study compares two different energy sources used during a heart procedure called catheter ablation for people with paroxysmal atrial fibrillation (a type of irregular heartbeat). Researchers want to see if a newer method called pulse field ablation causes less scarring and b…

This study is testing a new gene therapy called DREAM01 for people with severe sickle cell disease who don't have a matched sibling donor for a bone marrow transplant. Doctors take a patient's own blood stem cells, genetically modify them in a lab to produce healthy hemoglobin, a…

This study is testing whether aggressively lowering blood pressure can slow the progression of white matter lesions (brain damage seen on MRI) in older adults who have memory complaints. It will enroll 820 participants aged 60-88 with high blood pressure and moderate brain change…

This early-stage study is testing a new cell injection called HTLP. The goal is to see if it can safely help the immune system rebuild itself faster in adults with blood cancers who receive a cord blood transplant. Faster immune recovery could lower the risk of serious infections…

This study aims to find out which treatment works better for long blockages in the main leg artery that cause painful cramping when walking (claudication). Researchers will compare traditional bypass surgery to a less invasive procedure that uses catheters to open the artery. The…

This study is testing whether a drug called levosimendan can prevent dangerous complications after a severe brain bleed caused by a ruptured aneurysm. The trial will involve 30 adult patients in intensive care, who will receive either the drug or a placebo. The main goal is to se…

This early-stage study is testing the safety of a small, implanted ultrasound device in children with hard-to-treat brain tumors that have come back. The device is designed to temporarily open a natural protective barrier in the brain, which may allow more chemotherapy to reach t…

This study is testing whether a three-month course of strong chemotherapy before surgery works as well as the current standard approach of chemotherapy followed by radiation for locally advanced rectal cancer. It will involve 540 patients across France who have rectal cancer that…

This study is checking how well a heart procedure works over five years to prevent strokes in people with atrial fibrillation (AFib) who cannot take long-term blood thinners. Doctors close off a small pouch in the heart where clots often form. The research will follow 250 patient…

This study aims to find out if heart failure medication alone is just as good as medication plus an implanted defibrillator for preventing sudden cardiac death in people aged 70 and older. It will enroll 730 patients in France and follow them for four years to compare survival ra…

This study is testing whether a new medical device called the Endorotor PED® can remove dead tissue from the pancreas more effectively than current standard techniques. It involves 64 adults hospitalized with severe pancreatitis who have already had a drainage procedure. Research…

This study is testing whether a drug called fampridine can improve movement control and vision problems in people with a specific genetic brain condition called SCA27B. It will involve 70 adults who have this condition. For 3 months, half will receive the real drug and half a pla…

This study aims to find the best way to treat new irregular heartbeats that develop in critically ill patients with septic shock. Researchers will compare three common approaches: controlling heart rate with medication, trying to restore normal rhythm with medication or electrica…

This study is testing whether a dietary supplement made from omega-3 fatty acids can help reduce harmful inflammation in blood vessels. It will involve 50 adults in France who have both obesity and high blood pressure, conditions that increase heart disease risk. Researchers want…

This study is testing whether metformin, a medication commonly used for diabetes, can improve muscle function and control symptoms in adults with myotonic dystrophy type 1 (Steinert's disease). Researchers will compare metformin against a placebo in 142 participants over 12 month…

This study is testing if a drug called ruxolitinib can help control inclusion body myositis (IBM), a rare and progressive muscle-wasting disease. It will involve 80 adults with IBM who can walk for at least 6 minutes. For one year, half will receive the drug and half will receive…

This large study aims to determine which intensive care unit (ICU) patients with sepsis might benefit from a 7-day course of steroid medications (hydrocortisone and fludrocortisone) compared to a placebo. It will enroll 1800 adults to see if specific biological markers can identi…

This trial is testing if adding the anti-inflammatory drug colchicine to standard care can reduce heart scarring and prevent serious complications in people with acute myocarditis, a sudden inflammation of the heart muscle often caused by viruses. It will involve 300 hospitalized…

This major Phase 3 trial is testing if a new drug combination can effectively treat lupus nephritis (a serious kidney complication of lupus) without needing high doses of oral steroids. The study will compare the standard steroid-based treatment against a new regimen using a drug…

This study is looking at whether starting an automated insulin delivery system very soon after a child is diagnosed with type 1 diabetes can help protect their brain development and thinking skills. Researchers will compare brain scans and thinking tests in 60 children, aged 5 to…

This study is testing if dapagliflozin, a medication originally for diabetes, can help prevent heart failure in people who have just had a serious heart attack and have weakened heart function. About 450 participants will take either the drug or a placebo pill daily for six month…

This study is following children born very early (before 32 weeks) to see if their brain development at age 5 is just as good when their mothers received a half-dose of a common steroid (betamethasone) before birth, compared to the standard full dose. The steroid is given to moth…

This study is testing a precise form of radiation therapy (SBRT) to control liver cancer in patients waiting for a liver transplant. It is for people who cannot receive the standard bridge treatments like ablation or chemoembolization. The goal is to see if this radiation can saf…

This study is testing whether a simple blood test can help doctors monitor kidney transplant patients with fewer invasive biopsies. It will involve 500 new transplant patients in France. Half will get standard care with scheduled biopsies, while the other half will have their car…

This study is testing whether an oral medication called TECFIDERA® (dimethyl fumarate), already used for multiple sclerosis, can slow the progression of geographic atrophy. Geographic atrophy is a form of 'dry' age-related macular degeneration that causes gradual, irreversible vi…

This study tests if a drug called dapagliflozin can protect the heart and kidneys of patients after they leave the intensive care unit (ICU). About 600 patients who were on life support in the ICU will take either the drug or a placebo pill daily for one year. Researchers will tr…

This study is testing whether a 48-hour medication to relax the uterus can help babies when a pregnant person's water breaks too early (between 22 and 34 weeks). The goal is to delay birth just long enough to give steroids time to work, which can dramatically improve a baby's cha…

This study is following patients with severe, medication-resistant Tourette syndrome for five years after they receive a surgical treatment called deep brain stimulation. Doctors implant small electrodes in a specific brain area to send electrical pulses, aiming to reduce tic sev…

This large Phase 3 trial is testing whether adding two common medications to standard care can prevent future strokes, heart attacks, and other major vascular problems in high-risk patients who have recently had a stroke. It will compare a low-dose anti-inflammatory drug (colchic…

This study is testing if keeping patients with severe Acute Respiratory Distress Syndrome (ARDS) lying on their stomachs for longer periods (40 hours) saves more lives than the standard shorter sessions (16 hours). It will involve 800 critically ill patients who are on breathing …

This study is testing if intensive treatment for severe gum disease can reduce dangerous inflammation in the arteries of people who have recently had a heart attack. It will involve 210 participants in France. Half will receive specialized gum treatment from a periodontist, while…

This study is testing whether a new AI-based computer system can help doctors better manage the fluids given to patients during major abdominal surgery. The system suggests when to give fluid and checks the patient's response, aiming to follow a proven care plan more consistently…

This study aims to find out which approach works better for people newly diagnosed with Alzheimer's disease: taking the medication donepezil or receiving a specialized non-drug therapy program. It will involve 240 participants in France who will be randomly assigned to one of the…

This study is testing whether a special health program improves the well-being of young children placed in protective care. The program provides regular, thorough checkups to catch and address health and development issues early. Researchers will compare 400 children who receive …

This study is testing if a drug called interferon gamma can help critically ill patients in intensive care. These patients often have a weakened immune system after a severe illness or injury, which makes them vulnerable to new infections. The trial will see if boosting their imm…

This study is testing whether an intensive, early treatment program in a day hospital setting works better than standard outpatient care for teenagers newly diagnosed with anorexia nervosa. It will follow 164 teens and their families for up to 5 years to see if the program reduce…

This study is testing if a newer, simpler version of gastric bypass surgery works as well as the current standard surgery for severe obesity. It will enroll 368 people to see if the newer procedure leads to similar weight loss and has the same risk of nutritional problems over tw…

This study is testing whether a simple home sleep monitor can help doctors check if a nighttime breathing machine is working properly for adults with muscle-weakening diseases. Researchers want to see if the monitor provides clear data that can be used to adjust the machine's set…

This study is testing whether a gentle, non-invasive brain stimulation technique can help people who want to quit smoking. Researchers will use a device that delivers a very mild electrical current to the scalp to see if it reduces cravings for tobacco. The treatment will be give…

This study aims to find out how long it takes for urate crystals, which cause painful gout flare-ups, to completely dissolve in the joints. Researchers will enroll 250 adults with newly diagnosed gout and use medication to aggressively lower their uric acid levels. They will trac…

This study is testing whether using a smart scale can help people maintain their weight loss after obesity surgery. It will involve 182 adults who had surgery about a year ago. Half will use a connected scale weekly, which sends data to their care team and triggers alerts if weig…

This study is testing whether a promising two-drug cancer treatment is safe for people whose liver cancer returned after a transplant. It will enroll 50 liver transplant patients to see if the treatment can control their advanced cancer without causing their body to reject the tr…

This study is testing a personalized approach for people with severe, hard-to-classify inflammatory diseases that affect multiple organs and have not responded to standard treatments. Researchers will analyze each patient's unique molecular pathways to select a targeted therapy f…

This study is testing if a drug called Ravicti can help control symptoms of a rare genetic disorder called pyruvate dehydrogenase deficiency (PDH). It will involve about 15 children and young adults (ages 2-25) with specific genetic forms of PDH. The main goal is to see if taking…

This study aims to find a safer long-term treatment for people who have had a heart attack and are at high risk of bleeding. Researchers are testing if using a quick genetic test to guide the choice of a milder blood-thinning drug can reduce serious bleeding events just as effect…

This study is testing if the drug tadalafil can help people with COPD who also have severe high blood pressure in their lungs. About 200 participants will be randomly assigned to take either tadalafil or a placebo pill for 16 weeks. The main goal is to see if the drug improves ho…

This study is testing if giving a low dose of a natural hormone called arginine-vasopressin (AVP) during liver transplant surgery can better protect patients' kidneys afterward. It will compare AVP against the standard medication (norepinephrine) in 304 adults getting a liver tra…

This study is testing a new surgical technique to prevent dangerous bleeding after a major pancreas surgery called pancreaticoduodenectomy. In high-risk patients, surgeons will wrap the exposed arteries near the pancreas with a flap of fatty tissue from the abdomen. Researchers w…

This study is testing whether following a strict high-fat, low-carbohydrate ketogenic diet for one year is practical and helpful for people with early Alzheimer's disease. Researchers will enroll 70 participants to see if this diet changes how the brain uses energy and whether it…

This study is testing if a shorter, 3-day course of intravenous (IV) antibiotics is just as effective as the standard 10-day treatment for kidney infections in children aged 1 month to 3 years. It aims to see if the shorter course can cure the infection and prevent future ones wh…

This study is testing whether a smart scale that patients use at home can help doctors remotely monitor adults with lymphoma or myeloma who are getting chemotherapy. For about 7 weeks, 30 patients will weigh themselves daily. The scale sends data to the medical team, who can get …

This study aims to determine if heart failure patients whose heart pumping function has returned to normal can safely stop taking beta-blocker medications. Researchers will compare 1,300 patients who either continue their current medications or gradually stop beta-blockers while …

This study is testing if a pill called glibenclamide can safely control high blood sugar in very premature, low-birth-weight babies. It aims to offer an easier alternative to the current standard treatment, which involves tricky-to-manage insulin injections that carry a risk of d…

This study is testing whether following up with patients using a smartphone app is as good as or better than traditional in-person visits after a gynecological emergency. It involves 200 women who have conditions like ectopic pregnancy, miscarriage, or severe vomiting. The goal i…

This study is testing a new, quick cognitive test—a block-building task—to see if it can reliably screen for minimal hepatic encephalopathy (MHE), a subtle form of brain fog caused by liver problems. Researchers will compare this simple test against more complex standard assessme…

This study is testing whether adding MRI scans to standard pregnancy ultrasounds can help doctors better detect and understand potential health problems in unborn babies. It will involve 1,500 pregnant participants who will receive a short, safe MRI scan. The goal is to see if MR…

This study is testing a new, portable scanning device to improve the diagnosis of sarcopenia, the age-related loss of muscle mass and strength. Researchers will use the device on 846 hospitalized patients aged 75 and older who are suspected of having this condition. The goal is t…

This study is testing whether a simple measurement from an ear sensor can help emergency room doctors quickly tell if a patient's sudden breathlessness is caused by heart failure (congestive) or something else like asthma or pneumonia (non-congestive). Researchers will place a sm…

This study aims to see if a non-invasive finger cuff is as accurate as the standard invasive arterial catheter for monitoring blood pressure during carotid artery surgery. It will involve 40 adults undergoing this specific surgery. The research is observational, meaning patient c…

This study is testing a new computer tool called PRECOM that analyzes brain signals to predict whether comatose patients will wake up after a cardiac arrest. It aims to provide doctors with a clearer, more accurate early prognosis during the first week in the intensive care unit.…

This study is testing if a new, portable ultrasound device can help doctors diagnose patients more quickly. It will be used by doctors in a hospital clinic, local medical practices, and a mobile health bus. The main goal is to see if using this tool reduces the time it takes to f…

This study is looking back at past medical records to see how effective a tiny, swallowable camera (capsule endoscopy) is at finding early signs of cancer in the small intestine of people with Lynch syndrome. Lynch syndrome is a genetic condition that increases a person's risk fo…

This study aims to create and validate a new tool to diagnose communication problems in people who have had a right-side stroke. Researchers will test 150 stroke patients and healthy volunteers using a computer-based listening task that analyzes how people interpret tone of voice…

This study aims to develop artificial intelligence tools to help doctors analyze capsule endoscopy videos. Capsule endoscopy involves swallowing a tiny camera that takes thousands of pictures of the digestive tract. The AI is designed to spot potential problems faster and more ac…

This study compares two methods for diagnosing bone infections in diabetic foot ulcers: a simpler bedside procedure versus the standard surgical or radiological biopsy. Researchers aim to see if the bedside method works as well as the conventional approach for identifying the spe…

This study is testing whether adding a quick, 10-minute MRI scan to the standard 6-month ultrasound check can help find liver cancer at its earliest, most treatable stage in people with cirrhosis who are at high risk. Researchers will compare the two approaches in about 944 patie…

This study is testing a new computer software tool called MyCMV, designed to help doctors and midwives interpret blood test results for a common virus called cytomegalovirus (CMV) during pregnancy. The goal is to see if the software can identify CMV infections in the first trimes…

This study is testing a short, 8-item questionnaire called the AMSE to see if it can accurately identify autism in adults before they undergo a full, lengthy specialist evaluation. The goal is to help reduce long wait times at expert centers by allowing non-specialist doctors to …

This study is testing a new checklist, called the EPIC Assessment, to help doctors decide when it's safe to take a patient off a ventilator (breathing machine). Specially trained physiotherapists will perform the assessment on 330 ICU patients who are ready to try breathing on th…

This study aims to validate French versions of two short mental health screening questionnaires. Researchers will test these tools with 90 French-speaking adults to see if they accurately identify anxiety, depression, and post-traumatic stress disorder (PTSD). The goal is to give…

This study aims to see if patients with a staph bloodstream infection and a low risk score can safely skip a heart ultrasound (echocardiogram). It will compare outcomes for 700 patients who either get the scan or don't. The goal is to avoid unnecessary tests for low-risk patients…

This study is evaluating a new, non-invasive blood test to diagnose serious inherited genetic disorders in unborn babies. The test analyzes tiny bits of the baby's DNA found in the mother's blood, aiming to provide a safe and accurate diagnosis as early as 9 weeks into pregnancy.…

This study is testing a new blood test to monitor kidney transplants. Researchers want to see if they can detect early signs of transplant problems by measuring tiny bits of kidney DNA in the blood. If successful, this could help doctors catch issues sooner and reduce the need fo…

This study is testing a new way to measure movement in infants with a severe genetic muscle disease called spinal muscular atrophy (SMA). Researchers will use special sensors on babies' limbs during a bath to see if water, which removes the effect of gravity, reveals more movemen…

This study is testing a new type of MRI scan to see if it can measure blood flow in the brain more accurately than the current standard scan in children with cerebral arteriopathy. The new scan, called eASL, takes about 4 minutes and doesn't require an injection. Researchers will…

This study is evaluating a genomic test called EndoPredict that helps predict the 10-year risk of breast cancer returning. It aims to see if the test can reliably identify patients with a low risk of recurrence, so they can safely avoid chemotherapy and receive hormone therapy al…

This study is testing a new, faster bedside blood test (qLabs®FIB) to see if it works as well as the standard lab test for measuring a key blood-clotting protein (fibrinogen) in mothers experiencing severe bleeding after delivery. The goal is to help doctors get critical results …

This study is testing new laboratory methods to better identify the bacteria or fungi causing serious eye infections like endophthalmitis and corneal ulcers. Researchers will compare newer genetic testing techniques to standard lab cultures in 153 adult patients with these infect…

This study aims to see if using a rapid test that checks for common viruses like flu, COVID-19, and RSV during a doctor's visit can help reduce unnecessary antibiotic prescriptions. Doctors will treat patients as usual for a period, then use the test for another period to compare…

This study is testing a new medical device called PrediMAP that aims to predict whether a woman in preterm labor will deliver within 7 days. The device combines vaginal fluid biomarkers with ultrasound and clinical information to create a personalized prediction. Researchers are …

This study is testing a special monitor to see if it can accurately predict which critically ill children will benefit from receiving extra IV fluids. The research involves up to 100 children, aged 0-10, who are in intensive care after major surgery or severe trauma. Doctors will…

This study is testing a new type of camera called a Mueller polarimetric colposcope to see if it can predict when a pregnant person will give birth. Researchers want to see if images of the cervix can create a 'score' that accurately forecasts delivery date and identifies risk of…

This large study aims to find out if giving a single dose of antibiotics right before burn skin graft surgery helps prevent serious infections afterward. It will compare antibiotics to a placebo (inactive substance) in over 500 adult burn patients. The goal is to provide clear ev…

This study is testing if a short course of radiation given before a major pancreas surgery can prevent a dangerous complication called a pancreatic fistula, which is a leak of digestive fluid. The trial will enroll 50 patients in France who are scheduled for this specific surgery…

This large study aims to find out if screening pregnant women early for preeclampsia (a serious blood pressure condition) improves health for mothers and babies. About 14,500 women will be randomly assigned to either receive the early screening test or receive standard care. If t…

This study aims to find the best way to protect adults without a spleen from a severe bacterial infection called meningococcus B. It will compare the safety and immune response of three different vaccination schedules using two approved vaccines. The goal is to provide clear guid…

This study is testing whether having your regular family doctor recommend annual low-dose CT scans can get more high-risk smokers to participate in lung cancer screening. It aims to see if this doctor-led approach helps detect lung cancer at its earliest, most treatable stages, p…

This study aims to see if support group workshops can improve the quality of life for people who have had their larynx (voice box) removed due to cancer. The research will involve 50 participants who have had this surgery in the last four years. Half will attend four group sessio…

This study is testing which of two common sedation drugs helps very premature babies who need breathing machines come off the ventilator faster. Researchers will compare dexmedetomidine to midazolam in 380 infants to see which leads to quicker removal of the breathing tube and po…

This study is testing which setting on a new hearing system helps children with hearing loss understand speech best in noisy environments. Researchers will compare three different programming modes on the 'Sky' hearing system for 20 children aged 6-16. The goal is to find the bes…

This study is testing if adding the drug ketamine to a standard antidepressant (venlafaxine) helps hospitalized patients with severe depression feel better more quickly. It will involve 60 adults with major depression to see if the combination reduces symptoms faster, lowers suic…

This study aims to find a better way to quickly relieve pain for children with broken arms or legs in the emergency room. Researchers are comparing two nasal spray painkillers (fentanyl and ketamine) against the standard liquid morphine to see which works best within 30 minutes. …

This study is testing whether a personalized home exercise program is practical and acceptable for people with scleroderma (systemic sclerosis) who have early lung disease. Fifteen participants will attend one supervised session and then follow a 3-month program of breathing and …

This study is testing whether yoga therapy works as well as or better than standard physiotherapy for adults with moderate axial spondyloarthritis, a type of chronic inflammatory arthritis that mainly affects the spine and pelvis. Researchers will compare the two approaches to se…

This study is testing whether a non-invasive brain stimulation technique can help improve social perception in young adults with autism. Researchers will use magnetic pulses on a specific brain area involved in social processing to see if it increases eye contact during social sc…

This study aims to help people with severe movement disabilities communicate more easily by testing different layouts for on-screen keyboards. Researchers will work with 12 participants who use scanning keyboards to see which layout helps them type text faster and with less fatig…

This study is testing if using a connected exercise bike at home, along with usual care, can help people with lumbar spinal stenosis move better and with less pain. It will compare this approach to standard care alone in 302 participants over 50 years old. The main goal is to see…

This study is testing a new 3D calendar tool designed to help people with mild to moderate Alzheimer's or dementia who get confused about the time, date, or season. Researchers will observe 20 hospitalized patients to see if using the tool daily helps them stay oriented. The main…

This study is testing whether a specific type of Japanese massage called Shiatsu can help ease symptoms and improve quality of life for people with severe cardiac amyloidosis. Researchers will compare a version of Shiatsu targeted at specific symptoms to a general 'comfort' versi…

This study is testing if adding yoga to standard care can improve the quality of life for people with stable chronic heart failure. It will enroll 66 patients, who will be randomly assigned to either attend yoga classes or social activity workshops for three months. Researchers w…

This study is testing if using walking sticks can help people with a forward-leaning spinal imbalance walk farther and more safely. Researchers will measure how far 35 adults can walk with and without sticks over 3 months. They will also check if the sticks reduce pain, improve b…

This study is testing if immersive virtual reality (VR) can help reduce the feeling of shortness of breath in people with ALS (Lou Gehrig's disease). It will involve 35 ALS patients who already use a non-invasive breathing machine but still experience discomfort. Researchers will…

This study aims to understand how often heart rhythm problems occur in critically ill patients who need a life support machine called VA ECMO. Researchers will track 600 adult patients on this machine to see if they develop irregular heart rhythms, particularly atrial fibrillatio…

This study aims to understand how children with Angelman syndrome view social situations by tracking their eye movements. Researchers will compare the eye-tracking patterns of 40 children with Angelman syndrome to 20 typically developing children. The goal is to see if this techn…

This study aims to find out if removing surgical dressings just one day after abdominal surgery is as safe as keeping them for about six days. Researchers will compare infection rates in 1,288 patients who have elective abdominal procedures. The goal is to gather strong evidence …

This study aims to understand which type of support program works better to help young adults with childhood-onset rheumatic diseases successfully transition from pediatric to adult healthcare. Researchers will compare two approaches: one that includes an educational workshop plu…

This study aims to improve predictions about how patients with severe alcohol-related liver disease (acute alcoholic hepatitis) will fare. Researchers will analyze past medical records of 1,400 patients to find patterns that better forecast survival and complications. The goal is…

This study aims to understand why infections happen after surgery for esophageal cancer and how they affect recovery. Researchers will look back at the medical records of 350 patients who had this surgery in France between 2017 and 2024. The goal is to identify risk factors for i…

This study aims to understand if the location of the emergency department affects the health outcomes of cancer patients. Researchers will compare patients who visit a specialized emergency department at their cancer hospital against those who visit a general emergency department…

This study aims to see if a simple blood test can better predict which children with Hodgkin lymphoma are at high risk of their cancer returning. Researchers will test blood samples from 400 children and young adults under 25 to look for tiny pieces of tumor DNA. The goal is to s…

This study aims to understand the quality of life and care experiences of pregnant women living with HIV. It will follow 100 women in France from early pregnancy until one year after they give birth. Researchers will use questionnaires and medical records to learn how care affect…

This study follows advanced practice nurses in France to understand how they establish their roles in the healthcare system. Researchers will track 1600 nurses and nursing students over several years using surveys and interviews. The goal is to identify what helps or hinders thes…

This study is testing whether blowing humidified air through the nose can improve brain activity and lung function in sedated ICU patients who are on a breathing machine. Researchers will measure brain waves, oxygen levels, and lung performance while patients receive different ra…

This study is checking on the health and development of 6-year-old children whose mothers had their water break very early in pregnancy. The mothers were part of an earlier trial where they received either nifedipine (a medication to relax the uterus) or a placebo. Researchers wa…

This study aims to better understand the body's immune and inflammatory response that causes bone and tissue damage in serious gum disease (periodontitis) and infections around dental implants (peri-implantitis). Researchers will collect saliva, gum fluid, and tissue samples from…

This study aims to better understand how the brain works in people with autism. Researchers will use MRI brain scans and eye-tracking technology to measure brain activity and social perception in 160 children and young adults with and without autism. The goal is to identify brain…

This study is testing a lab method to see if a new cell therapy could work for a rare and aggressive skin cancer called Merkel cell carcinoma. Researchers will take immune cells from 15 patients and test their cancer-fighting ability in a dish. The goal is to validate the lab pro…

This study aims to find better ways to predict which pregnant women with high blood pressure will develop pre-eclampsia, a serious condition that can harm both mother and baby. Researchers will measure tiny particles and other markers in the urine and blood of 110 pregnant women …

This study aims to better understand vasculitis, a group of diseases involving inflamed blood vessels, by observing 670 patients over time. Researchers will collect health information to describe how the disease presents, what treatments patients receive, and how they fare. The g…

This study aims to understand if children with multiple sclerosis (MS) have a greater natural ability to repair the protective coating (myelin) around their brain's nerve cells than adults do. Researchers will use a special type of brain scan on 40 children and teens with MS to m…

This study aims to understand why people with certain weakened immune systems often develop chronic liver and digestive problems. Researchers will follow 120 patients with different types of immune deficiencies to see if long-term infections from common gut viruses are the cause.…

This study aims to measure how hard children with conditions affecting their breathing muscles or lungs have to work to breathe. Researchers will insert a thin tube through the nose to measure pressures in the chest and stomach. The goal is to better understand these breathing pr…

This study aims to understand why some women experience multiple miscarriages when no clear cause can be found. Researchers will follow 700 women who have had three or more early miscarriages or failed embryo implantations to identify patterns and potential causes. By collecting …

This study aims to find out how common feeding and eating problems are in young children (ages 1-7) who have rare inherited metabolic diseases and require special dietary treatments. Researchers will use a standard questionnaire to assess the children's feeding behaviors and iden…

This study aims to understand how common erectile dysfunction is in men with severe liver disease (cirrhosis) both before and one year after they receive a liver transplant. Researchers will also test the effectiveness of a common medication (PDE-5 inhibitors like tadalafil) for …

This study follows young people who were hospitalized for anorexia between 2016 and 2021 to understand their long-term recovery. Researchers will check in with 140 former patients 4-9 years after their hospital stay to see how they're doing physically and mentally. The study does…

This study aims to better understand how women with a genetic hormone condition called congenital adrenal hyperplasia (CAH) plan for and experience pregnancy. Researchers will follow 200 women with CAH to learn about their pregnancy journeys, complications, and outcomes. The goal…

This study aims to understand the connection between gut bacteria and mental health symptoms in people with severe anorexia nervosa. Researchers will compare the gut bacteria of hospitalized patients with very low body weight to healthy volunteers. They want to see if changes in …

This study aims to discover biological markers in blood and joint fluid that can predict how knee osteoarthritis will progress and which patients might eventually need joint replacement. Researchers will follow 300 patients with knee arthritis for up to 10 years, collecting sampl…

This study aims to establish normal score ranges for French-language tests used to diagnose spatial neglect, a common attention disorder after a stroke. Researchers will recruit 210 healthy volunteers, grouped by age and gender, to complete a series of paper-and-pencil tests. The…

This study aims to understand how specific immune cells (monocytes and macrophages) behave in sarcoidosis, a disease that causes inflammation and lumps called granulomas. Researchers will compare blood and tissue samples from 100 people with sarcoidosis to those with tuberculosis…

This study aims to better understand how psychotherapy helps teenagers with Post-Traumatic Stress Disorder (PTSD). Researchers will interview 65 teens, aged 12-18, and their parents before and after therapy to learn about their personal experiences. The goal is to identify the ke…

This study aims to understand how a person's daily sleep-wake cycle (circadian rhythm) and other lifestyle factors might be linked to different types and stages of dementia. Researchers will observe 1,200 patients from memory clinics in Paris, collecting data on sleep, activity, …

This study aims to better understand the eye and body symptoms experienced by people with congenital aniridia, a rare genetic condition that affects eye development. Researchers will give a one-time survey to 100 patients (or their parents) to learn about their symptoms and asses…

This study aims to learn how the immune system responds to severe mold infections. Researchers will monitor 20 adult patients with these infections over time, taking blood samples to measure specific immune cells. The goal is to gather information that could help identify which p…

This study aims to gather detailed information from 700 patients with infective endocarditis, a serious heart valve infection, to better understand the disease and its complications like strokes. Participants will be followed for up to 10 years so researchers can track long-term …

This study aims to understand why lung cancer sometimes becomes resistant to immunotherapy treatments. Researchers will collect tumor tissue samples from 50 patients whose cancer has progressed despite receiving immunotherapy. By analyzing these samples, they hope to identify bio…

This study aims to understand how often a common pain-blocking injection for knee surgery spreads to affect two other major nerves in the leg. Researchers will observe 70 adults having knee surgery to measure this spread using simple sensation and movement tests. The goal is to g…

This study aims to understand and develop new ways to test the function of the choroid plexus, a critical brain barrier. Researchers will study 65 participants, including people with a rare condition called LHIPFOLD, other neurological patients, and healthy volunteers. They will …

This study aims to understand if robotic surgery is safe, effective, and worth the cost compared to traditional surgery. It will enroll 16,000 children and adults needing various operations to track complications, recovery, and expenses. The goal is to gather real-world evidence …

This study is creating a large collection of leftover blood, urine, and other samples from hospitalized patients. The goal is to use these samples to develop and test faster diagnostic tools for new infectious diseases and potential biothreats. No extra tests or procedures are ne…

This study aims to better understand how the spleen works to filter abnormal blood cells, which is important for diseases like malaria. Researchers will study spleens donated by 100 adult patients who are having them surgically removed for medical reasons. They will test how the …

This study aims to find out if certain proteins in the blood can predict how severe a child's juvenile arthritis will become. Researchers will measure these markers in about 300 patients and see if they match up with joint damage seen on X-rays or the need for stronger treatments…

This study aims to find the best antibiotic doses for hospitalized patients by using mathematical models. Researchers will analyze data from 60 patients receiving antibiotics to understand how factors like age, weight, and illness severity affect how the body processes these drug…

This study aims to find out if measuring a specific protein in the blood (called GPC-3) can help doctors predict which patients with advanced liver cancer will respond best to a standard immunotherapy drug combination. Researchers will track 240 patients receiving the drugs atezo…

This study aims to understand the personal experiences of teenagers with anorexia nervosa, their parents, and their healthcare providers regarding psychiatric medications. Researchers will conduct interviews with 90 participants to learn about their perceptions, feelings, and the…

This study aims to see if using a standardized checklist called AnesList when one anesthesia doctor hands off care to another during surgery improves patient safety. It will involve about 1,120 adults undergoing major surgery. The main goal is to check if this better communicatio…

This study aims to discover genetic markers that could predict which cancer patients are at risk of developing severe heart inflammation (myocarditis) from immunotherapy drugs. Researchers will compare the DNA of 500 cancer patients, looking for differences between those who deve…

This study looks back at medical records of 150 patients who died in intensive care units between 2018 and 2022 with serious joint infections around artificial hips, knees, or shoulders. Researchers will analyze patient information, treatments received, and outcomes to better und…

This study aims to find new blood markers that can predict how quickly Alzheimer's disease will progress in a person. Researchers will follow 244 patients with early Alzheimer's for three years, taking blood samples to measure 'resilience'—the brain's ability to resist damage. Th…

This study aims to find out why some people lose more weight than others after a specific, less invasive stomach-reduction procedure. Researchers will follow 205 adults with moderate obesity who had the surgery between 2017 and 2023. They will analyze blood, stool, and saliva sam…

This study aims to better understand how blood pressure changes affect blood flow to the brain in sedated intensive care unit (ICU) patients. Researchers will observe 92 adult ICU patients using non-invasive monitors on the head to measure brain blood flow, oxygen levels, and bra…

This study aims to find a better way to predict if unconscious patients will wake up. Researchers will measure brain activity in 114 patients while they listen to recordings, including their own name spoken by a familiar voice versus an unfamiliar voice. The goal is to see if the…

This study aims to better understand liver cirrhosis and improve care for patients, including those who receive transplants. Researchers will follow 3000 patients over time, collecting health data and biological samples to identify what factors lead to complications and affect su…

This study aims to understand if severe hearing loss is linked to early memory or thinking problems in adults aged 45-64. Researchers will compare thinking skills in 90 adults with significant hearing loss to 90 adults with normal hearing. The goal is to gather knowledge about th…

This study aims to find biological signs of aging that can help doctors better predict how older adults with lung cancer will respond to treatment. It will follow 385 patients aged 70+ to see if certain markers in their blood and tissues are linked to outcomes like unplanned hosp…

This study aims to understand how the immune system goes wrong in children recently diagnosed with type 1 diabetes. Researchers will compare blood samples from 80 children, half with diabetes and half without, focusing on specific immune cells. The goal is to gather knowledge tha…

This study aims to understand the long-term effects of choosing surgery versus regular monitoring for children born with congenital lung malformations. It follows 434 children and their families to see how the decision impacts parent anxiety, the child's respiratory health, and o…

This study aims to see if advanced brain imaging can predict long-term disability progression in people with multiple sclerosis (MS). Researchers will analyze detailed brain scans from 80 participants who were in previous studies to see if certain patterns can forecast worsening …

This study is testing a new virtual reality game to see how children with chronic inner ear (vestibular) problems that affect their balance and coordination perform compared to children without these issues. Researchers want to create a reliable and fun VR tool to better understa…

This study aims to understand the experiences of brothers and sisters when a sibling is hospitalized in a pediatric intensive care unit (PICU). Researchers will conduct two interviews with 20 siblings, aged 9 to 18, to learn about their feelings, needs, and how the situation impa…

This study aims to understand how changes in bladder sensation during filling relate to overactive bladder severity in people with multiple sclerosis (MS). Researchers will observe 113 MS patients with bladder symptoms during standard urodynamic testing. The goal is to gather kno…

This study aims to understand if reminding patients about the clicking noise a mechanical heart valve makes before their surgery affects their quality of life after the operation. Researchers will survey about 180 patients who have had this type of valve implanted. The goal is to…

This study aims to understand why people with advanced liver disease (cirrhosis) are at risk for dangerous blood clots in a major abdominal vein. Researchers will enroll 45 patients who are already scheduled for a standard procedure to relieve liver pressure. During that procedur…

This study aims to find a reliable way to measure a specific lung pressure in children with severe breathing failure who are on breathing machines. Researchers will test two different measurement methods on 50 children in intensive care. The goal is to gather knowledge that could…

This study aims to find better blood markers to tell if a child has outgrown a milk or egg allergy. It will involve 500 children, including those with allergies, those who have outgrown them, and non-allergic kids. Researchers will analyze blood samples to see if certain proteins…

This study aims to understand how endometriosis and adenomyosis change over time, including pain levels, bleeding, and infertility. It will follow 5,300 women to see if the diseases get worse and to look for biological clues in blood and tissue samples. The goal is to find better…

This study aims to understand if a specific enzyme is less active in people with Lewy body dementia, a type of dementia. Researchers will compare blood samples from 118 patients and 118 healthy volunteers. The goal is to identify a group of patients who might be eligible for futu…

This study aims to understand how group therapy sessions that bring together multiple families help teenagers with anorexia nervosa. Researchers will interview teens and their family members who have already completed a 10-session therapy program. The goal is to learn what parts …

This study aims to understand how the immune system weakens in critically ill patients, which can lead to dangerous infections. Researchers will track a key immune signal (INF-γ) in 200 adults admitted to intensive care after severe trauma, major surgery, or respiratory distress.…

This study aims to understand how fetal cells, which remain in a mother's body after pregnancy, might help heal chronic skin ulcers. Researchers will analyze blood samples from postpartum women with and without ulcers to identify specific signals that attract these cells to wound…

This study aims to understand if and how Osteogenesis Imperfecta (OI), a rare genetic condition causing brittle bones, is linked to problems with hearing and balance. Researchers will perform hearing and balance tests on 44 young people (ages 12-20) with OI. The goal is to see if…

This study aims to understand the long-term health of people who have survived a rare and life-threatening blood clotting disorder called immune thrombotic thrombocytopenic purpura (iTTP). Researchers will look back at the medical records of over 1,200 patients in France to learn…

This study aims to understand if a new 3D ultrasound technique can detect heart muscle scarring as well as an MRI scan. Researchers will compare measurements from both tests in 40 patients with a leaky mitral valve heart condition. The goal is to see if ultrasound could eventuall…

This study aims to understand how a patient's immune system responds during a critical illness requiring intensive care. Researchers will collect small blood samples from 540 ICU patients to measure immune cells and inflammation markers. The goal is to find patterns that might he…

This study aims to find better ways to predict which patients with advanced neuroendocrine tumors will benefit from a targeted radiation therapy. Researchers will use a special combined PET-MRI scan and artificial intelligence (AI) to analyze images from 80 patients before, durin…

This study aims to better understand birdshot chorioretinopathy, a rare inflammatory eye disease. Researchers will follow 600 patients over time, using eye scans and vision tests to map the different ways the disease appears and changes. A key goal is to search for new genetic fa…

This study aims to find new blood markers to better monitor Activated PI3K Delta Syndrome (APDS), a rare and serious immune disorder. Researchers will collect blood samples from about 14 patients aged 12 and older who are taking a specific medication for APDS. By analyzing these …

This study aims to understand why people with low platelet counts (thrombocytopenia) often experience severe fatigue. Researchers will compare blood samples from 280 patients and healthy volunteers to see if specific brain-related proteins from platelets are linked to tiredness. …

This study aims to better understand a type of kidney inflammation called tubulointerstitial nephritis (TIN). Researchers will look back at medical records and kidney tissue samples from 200 adult patients who already had a biopsy for this condition. The goal is to learn more abo…

This study aims to see how reliable automated computer tools are at measuring the amount of scarring in the lungs from CT scans. Researchers will test this by having 150 patients with interstitial lung disease get two CT scans on the same day and using different software to analy…

This study aims to understand the unique DNA patterns in fetuses with rare genetic diseases and birth defects. Researchers will analyze DNA samples from 63 participants, including fetuses and children, to see if these patterns differ from those found after birth. The goal is to g…

This study aims to better understand how Dravet syndrome, a severe genetic epilepsy, affects development over time. Researchers will follow 50 children and young adults (ages 6 months to 21 years) for four years, tracking their motor skills, thinking abilities, and daily living s…

This study aims to understand how losing all your teeth and wearing dentures affects your sense of taste, mouth sensations, and food preferences. Researchers will compare 40 people—20 who wear dentures and 20 with natural teeth—using taste tests and questionnaires. The goal is to…

This study aims to understand how well patients, mostly children and young adults, follow their prescribed medication plans for inherited metabolic diseases. Researchers will survey 200 patients and their parents at Necker Hospital to measure adherence and knowledge. The goal is …

This study aims to understand why some people's immune systems attack and reject a transplanted kidney. Researchers will collect and analyze immune cells from kidney biopsies of transplant patients with suspected rejection. By studying these cells, they hope to learn what trigger…

This study aims to understand which breathing machine setting works better during chest physical therapy for ICU patients on ventilators. Researchers will compare two common ventilator modes while patients receive standard chest compression therapy to help clear mucus from their …

This study aims to better understand the psychiatric and developmental profiles of children who have survived a serious suicide attempt. Researchers will assess 200 children aged 9-15 who were hospitalized after serious attempts, comparing them to children with less severe attemp…

This study aims to understand why less invasive lung cancer surgeries lead to fewer complications and better quality of life than traditional open surgery. Researchers will measure posture and breathing coordination in 50 patients before and after their operations. They are compa…

This study aims to understand how antibiotics move through and work in the bodies of critically ill children. Researchers will measure drug levels in the blood of 3,000 children to see how well the doses fight infections. The goal is to gather information that will help doctors p…

This study aims to find easier, noninvasive ways to monitor eosinophilic esophagitis (EoE), a chronic allergic/immune condition that causes swallowing problems in children. Currently, tracking the disease requires repeated endoscopies under anesthesia. Researchers will check if s…

This study aims to understand if serotonin, a chemical known for its role in the brain and mood, is connected to the symptoms of albinism. Researchers will compare blood samples from 160 children with albinism to children without it, looking at serotonin levels, iron, and blood h…

This study aims to track the long-term health of cardiac arrest survivors for five years after they received an experimental treatment. The treatment involved rapidly cooling the body to protect the brain and heart from damage after the heart was restarted. Researchers will follo…

This study aims to improve how doctors program cochlear implants for children with profound hearing loss. It will compare a new, more objective method of setting comfortable sound levels to the current method, which relies on the child's subjective feedback. Researchers will enro…

This study aims to understand how two different surgical techniques for closing a neck artery affect blood flow to the brain in children who have been on ECMO life support. Researchers will use advanced brain scans and computer modeling to compare blood flow patterns in about 30 …

This study aims to understand why a small percentage of cancer patients experience unexpectedly severe side effects from radiation therapy. Researchers will compare blood samples from 40 patients who had severe reactions with those who did not. The goal is to find immune system m…

This study aims to test new questionnaires that can better describe breathing difficulties in children. Researchers want to understand not just how severe the breathing problems are, but also how they feel emotionally and physically to the child. The study will involve 400 childr…

This study is testing a new video game-like assessment tool called REALSoCog to see if it can better detect problems with social skills and behavior in people with Alzheimer's disease, Lewy body dementia, or frontotemporal dementia. Researchers will give the test to 120 patients …

This study aims to better understand rare childhood epilepsies by following 1000 children and adolescents in real-world settings. Researchers will track how different treatments affect seizure frequency and how thinking skills and mental health change over time. The goal is to ga…

This study is testing whether 3D computer models of tumors help surgeons and families better understand and plan surgery compared to standard 2D scans. It involves 60 children with tumors in the abdomen or pelvis. Surgeons and families will view both types of images and answer qu…

This study aims to understand how major weight loss after bariatric surgery affects the spine and back pain in obese patients. Researchers will follow 80 patients for over a year, using questionnaires, X-rays, and MRI scans to measure changes in pain, spinal alignment, and fat de…

This study aims to understand how medications travel from mother to baby across the placenta. Researchers will examine donated placentas after delivery to measure how different drugs transfer between mother and fetus. The goal is to gather crucial safety information about medicat…

This study aims to understand how standard emergency treatments affect blood flow in the smallest vessels of patients in intensive care with life-threatening circulatory failure. Researchers will observe 180 patients, measuring skin blood flow and a simple bedside test before and…

This study aims to understand how the community of bacteria in a patient's lungs influences their recovery from pneumonia. Researchers will observe 300 adults with different types of pneumonia, tracking their lung bacteria over time to see if specific patterns can predict when st…

This study aims to better understand sleep problems in people with Parkinson's disease and those with a related sleep disorder called REM sleep behavior disorder. Researchers will compare sleep patterns in 457 participants across three groups: people with Parkinson's, people with…

This study aims to understand if giving albumin (a blood protein) during the first day of treatment helps severely burned patients survive and avoid organ failure. Researchers will follow 200 adults with major burns across multiple hospitals for 90 days, collecting data on their …

This study aims to better understand ongoing brain inflammation in people with multiple sclerosis (MS). Researchers will use a special type of PET-MRI scan on 18 MS patients and 23 healthy volunteers to create detailed maps of inflammation. The goal is to see if this hidden infla…

This study is creating a long-term registry to track adults with hypophosphatasia, a rare genetic bone disease. Researchers will follow 130 patients to better understand their symptoms, how long it takes to get diagnosed, and how they respond to treatments. The goal is to improve…

This study aims to find out how many women who are freezing their eggs for non-medical reasons have endometriosis or adenomyosis, conditions that can cause pain and infertility. Researchers will use an ultrasound and questionnaires to check for these conditions and see if they ar…

This study aims to better understand psychosis in children and adolescents by observing them over time. Researchers will collect detailed information on symptoms, development, brain scans, and genetics from about 200 young people in France. The main goal is to see if different pa…

This study aims to understand if women with early menopause (Premature Ovarian Insufficiency) have a higher risk of a dangerous heart rhythm problem. Researchers will compare the heart rhythms of 120 women with early menopause to healthy women, and see if standard hormone replace…

This study aims to measure how well a specialized Paris emergency team's advanced resuscitation technique works in real life. It will follow 840 adults who suffered a cardiac arrest outside the hospital and did not respond to standard CPR, receiving instead a machine called ECMO …

This study aims to better understand rare, hard-to-classify autoinflammatory diseases and a serious complication called AA amyloidosis, which can damage the kidneys. Researchers will study blood and tissue samples from about 200 patients to investigate unclear genetic test result…

This study aims to understand how the body's immune cells, specifically macrophages, might influence the progression of several rare inherited brain diseases. Researchers will collect a single blood sample from 100 participants, including patients with conditions like adrenoleuko…

This study aims to understand how the community of bacteria in our gut (the microbiota) influences the energy levels of our immune cells, particularly in people with inflammatory bowel diseases (IBD) like Crohn's disease and ulcerative colitis. Researchers will compare 45 healthy…

This study aims to understand why blood vessels become leaky during a severe body-wide inflammatory response (SIRS), a dangerous condition common in ICU patients. Researchers will measure specific proteins in the blood and lung fluid of 180 patients with SIRS to see if these prot…

This study is creating a registry to better understand adult tic disorders. It will observe 450 adults to see if tic severity affects quality of life differently for men and women. The goal is to gather knowledge to help improve future care, not to test a new treatment.

This study aims to understand if a dangerous drop in blood pressure after heart surgery is linked to poor function of the adrenal glands, which produce stress hormones. Researchers will enroll 200 patients undergoing heart surgery and use a detailed blood test to map their hormon…

This study aims to find substances in the blood (biomarkers) that can act as early warning signs for a severe condition called acute mesenteric ischemia, where the intestines lose blood flow. Researchers will analyze blood samples from 556 adults with sudden severe abdominal pain…

This study aims to understand why many lung cancer patients do not respond to immunotherapy. Researchers will take blood samples from 100 patients and healthy volunteers to analyze specific types of white blood cells called neutrophils. The goal is to learn if certain cells can p…

This study aims to see if giving parents specific feedback can help them create a better language-learning environment for their young deaf child who has received a cochlear implant. Researchers will use a small recording device worn by the child at home to measure how much adult…

This study aims to understand how painful nerve damage affects daily life and healthcare expenses for people with Sjögren's syndrome. Researchers will compare 100 patients with and without this nerve condition using questionnaires about pain, fatigue, and quality of life. The goa…

This study aims to understand if CAR-T cell therapy, a powerful new cancer treatment, might affect heart function in the first few days after patients receive it. Researchers will follow 60 patients with blood cancers, performing heart ultrasounds before and shortly after their C…

This study aims to better understand sleep-disordered breathing (SDB) in children and young adults. Researchers want to see if problems with thinking, memory, or behavior are linked to what doctors see on a standard sleep test. They will enroll about 1,200 participants aged 1 to …

This study aims to understand what happens to benign thyroid nodules three years after they are treated with a heat-based procedure called radiofrequency ablation. Researchers will perform ultrasounds and biopsies on 180 previously treated nodules to create a detailed picture of …

This study aims to understand how different forms of growth hormone treatment affect children's body weight and composition. Researchers will follow 100 children with growth hormone deficiency for three years, measuring their body fat, muscle, and bone. The study compares newer l…

This study aims to better understand a specific behavioral problem linked to crack-cocaine addiction. Researchers will observe 20 people with severe crack addiction by having them wear a wrist-worn activity tracker for three weeks to see how their movement and sleep change around…

This study aims to see if having France's national health insurance pay for vaccines given during hospital outpatient visits increases how many people get vaccinated. It focuses on whooping cough shots for pregnant women and pneumonia shots for eligible patients in the Paris regi…

This study aims to better understand hereditary pancreatitis, a rare genetic condition caused by mutations in the PRSS1 gene. Researchers will follow 800 patients in France over time to learn about the disease's natural course, track the risk of developing pancreatic cancer, and …