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Heart scan study aims to predict artery disease in High-Risk patients

NCT ID NCT07427472

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 300 adults aged 30–60 with genetically confirmed familial hypercholesterolemia, a condition causing very high cholesterol. Researchers use CT scans to see how coronary artery plaques change over 5 years. The goal is to better understand disease progression and identify those at highest risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Coronary computed tomography angiography (CCTA) with contrast dye
What this could lead to
If successful, this could help doctors better predict and monitor heart disease in people with familial hypercholesterolemia, leading to earlier interventions.
What could go wrong
This is an observational imaging study, not a treatment trial. It will not directly improve health, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 300 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2026

Expected to finish

Jun 2036

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with heterozygous familial hypercholesterolemia 2. Aged 30 to 60 years. 3. Patients who underwent a CAC score and a coronary CT angiogram at least 5 years ago, exclusively at the same imaging center (ICT de la Pitié Salpetrière). 4. Patient asymptomatic for exertional chest pain at the time of CCTA 5. Clinical examination performed 6. Beneficiary of a social protection scheme or entitled person (excluding AME) 7. Patient informed and consent form signed Exclusion Criteria: 1. Patient under guardianship, or unable to give consent 2. Pregnancy, breast-feeding 3. Technical contraindication: weight \> 250 kg 4. Simultaneous participation in other interventional research involving the human body, or period of exclusion following previous research involving the human body still in progress. 5. Adults subject to a legal protection order 6. Contraindication to esmolol and/or atenolol 7. Only for patients who need to undergo a CT angiogram and a thoraco-abdominal-pelvic CT scan: * Renal insufficiency (LC\<60) * Unbalanced diabetes when acquiring a previous coronary angioscanner * Personal history of cardiovascular disease and myocardial infarction at the time of CCTA * Contraindication to iodinated contrast media * Patient having already had an adverse event (AE) during the acquisition of a prior coronary angioscanner

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Conditions

The condition(s) this trial relates to.

atherosclerosis coronary artery disorder familial hypercholesterolemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heterozygous familial hypercholesterolemia (HEFH)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • APHP- Hospital Saint-Antoine

    NOT_YET_RECRUITING

    Paris, Île-de-France Region, 75013, France

  • APHP-Sorbonne, Pitié Salpêtrière Hospital

    RECRUITING

    Paris, Île-de-France Region, 75013, France

  • Plateau d'investigation clinique (PIC) IHU-ICAN

    NOT_YET_RECRUITING

    Paris, 75013, France

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