Earlier hormone therapy: a lifeline for transgender teens?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adolescents aged 13.5 years +/- 6 months, * Having initiated puberty: tanner score ≥2 for transgender boys; tanner score ≥2 for ; (clinic and/or testosterone \>0.3 ng/mL) for transgender girls * Presenting the criteria for gender dysphoria according to the DSM5 assessed by at least two child psychiatric interviews at least six months apart where the diagnosis of gender dysphoria was clinically established and that of associated autism spectrum disorder refuted and/or associated cognitive impairment, confirmed by specific scales (Gender Identity / Gender Dysphoria Questionnaire for Adults and Adolescents (GIDYQ-AA) and Utrecht Gender Dysphoria Scale (UGDS)) * Whose indication for hormonal transition has been validated in a multidisciplinary consultation meeting after at least one consultation with the pediatric endocrinologist with clinical examination, blood pressure measurement, and information on hormonal treatments in the context of gender dysphoria. Exclusion Criteria: * Contraindication to hormonal treatment (see paragraph 1.5) * Hormonal treatment needs to be adjusted (transgender boys patients treated with anti-coagulants or with thrombophilia). * Patients with risk of aggravation of certain diseases under oestrogen treatment (transgender girls patients with uncontrolled diabetes with HBA1C \> 8%, patients with cholelithiasis, biliary lithiasis, systemic lupus erythematosus, severe asthma, severe arterial hypertension, severe migraines, otosclerosis, epilepsy not controlled by treatment). * Patients with cancer with a risk of hypercalcemia (and associated hypercalciuria), linked to bone metastases. * Severe cardiac, hepatic or renal failure or ischemic heart disease, due to the risk of severe complications characterized by edema, with or without congestive heart failure. * Uncontrolled high blood pressure. * Patients with epilepsy and migraine. * Patients with current or history of thromboembolic events. * Severe untreated chronic depression clinically assessed and documented using the Beck Depression Inventory (BDI). * Diagnosed schizophrenia that is unstable or progressive * Diagnosed bipolar disorder that is unstable or progressive * Suicidal ideation identified through the MINI with a Columbia C-SSRS score \> 4, until the clinical condition has stabilized * Current anticoagulant treatment * Severe autism Spectrum Disorder (clinical screening, confirmed in cases of doubt by the Social Responsiveness Scale (SRS) Raw-score \> 76, carried out as part of usual care in cases of clinical evidence, * Cognitive deficit (clinical screening, confirmed by an QI \< 80 on the Weschler scale (WISC V), carried out as part of the usual treatment in the event of clinical evidence. * Refusal to participate in the study on the part of the adolescent or one of the holders of parental authority (both holders and the adolescent must sign a written consent after receiving appropriate information). * No social security cover * Participation in other intervention research * Pregnancy in progress * Insufficient knowledge of French