New trial tests CPAP combo to save lives in breathing crisis
NCT ID NCT06213168
First seen Apr 26, 2026 · Last updated Jun 22, 2026 · Updated 11 times
Summary
This study compares two oxygen therapy strategies for adults in the ICU with severe breathing failure. One group gets high-flow oxygen alone, the other gets high-flow oxygen plus CPAP sessions. The goal is to see if adding CPAP reduces the need for a breathing tube and lowers the risk of death within 90 days. About 1,084 participants will be enrolled.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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APHP - hôpital Pitié-Salpêtrière
RECRUITINGParis, 75013, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Amiens-Picardie
NOT_YET_RECRUITINGAmiens, 80054, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU Angers
NOT_YET_RECRUITINGAngers, 49933, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Nantes
NOT_YET_RECRUITINGNantes, 44000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Sud Francilien
NOT_YET_RECRUITINGCorbeil-Essonnes, 91100, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier Victor Dupouy
NOT_YET_RECRUITINGArgenteuil, 95107, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier de Bourg-en-Bresse - Site de Fleyriat
RECRUITINGBourg-en-Bresse, 01012, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier de Dieppe - Site Pasteur
RECRUITINGDieppe, 76200, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centre Hospitalier du Mans
RECRUITINGLe Mans, 72037, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital André Mignot
RECRUITINGLe Chesnay, 78157, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Avicenne
NOT_YET_RECRUITINGBobigny, 93000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Bicêtre
NOT_YET_RECRUITINGLe Kremlin-Bicêtre, 94270, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Charles-Nicolle
RECRUITINGRouen, 76000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital François Mitterrand
RECRUITINGDijon, 21000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Henri-Mondor
RECRUITINGCréteil, 94010, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Lapeyronie
RECRUITINGMontpellier, 34090, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Louis-Mourier
NOT_YET_RECRUITINGColombes, 92700, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Lyon Sud - Hospices Civils de Lyon
NOT_YET_RECRUITINGLyon, 69495, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Pasteur
ACTIVE_NOT_RECRUITINGNice, 06000, France
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Hôpital Pontchaillou
NOT_YET_RECRUITINGRennes, 35000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Saint-Antoine
RECRUITINGParis, 75012, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Saint-Joseph Saint-Luc
NOT_YET_RECRUITINGLyon, 69007, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Salengro
RECRUITINGLille, 59037, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Tenon
RECRUITINGParis, 75020, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital de l'Archet
RECRUITINGNice, 06200, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital de la Croix-Rousse - Hospices Civils de Lyon
RECRUITINGLyon, 69004, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital la Milétrie
NOT_YET_RECRUITINGPoitiers, 86000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Édouard Herriot - Hospices Civils de Lyon
RECRUITINGLyon, 69003, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nouvel hôpital civil
RECRUITINGStrasbourg, 67000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Continuous positive airway pressure (CPAP) and high-flow nasal cannula oxygen therapy
What this could lead to
If it works, this could show that adding CPAP to high-flow oxygen helps more people survive severe breathing failure without needing a breathing tube.
What could go wrong
This is a large trial, but earlier studies on CPAP for this condition have had mixed results. The treatment may not lower death rates and could cause discomfort or delays in needed intubation.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.