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Gum treatment may cool artery inflammation after heart attack

NCT ID NCT04046237

Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether treating severe gum disease can reduce inflammation in the arteries of people who have recently had a heart attack. 210 participants will be randomly assigned to receive either intensive periodontal treatment or standard dental care. The main goal is to see if the treatment lowers inflammation in the carotid arteries, measured by PET scans at the start and after 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Periodontal treatment (deep cleaning, root scaling, antiseptic irrigation)
What this could lead to
If it works, this could show that treating gum disease lowers artery inflammation, potentially reducing the risk of future heart attacks.
What could go wrong
This is an early-stage study focused on a biomarker (inflammation on PET scans), not on actual heart attack rates. The treatment is intensive and may not be practical for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 210 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2019

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients hospitalized for an acute myocardial infarction and included in the Frenchie registry * Score ≥ 5 on the screening questionnaire for periodontitis * Six teeth at least (excluding wisdom teeth) * Consent signature * Affiliation to a French medical insurance (Sécurité Sociale) Exclusion Criteria: * Patients with diseases,other than cardiovascular and diabetes, known to change the periodontal state such as AIDS, rheumatoid arthritis, Chediak-Higashi syndrome, Papillon-Lefèvre * Systemic antibiotic therapy\> 48 hours in the 3 months prior to inclusion * Acute heart failure * Uncontrolled ventricular rhythm disorders * Impossibility for the patient to attend follow-up visits * Impossibility to maintain the extended position for 20 minutes * Immunosuppressive therapy\> 1 month in the 6 months prior to inclusion * Pregnancy, breastfeeding * Known hypersensitivity to chlorhexidine, povidone, 18-fluoro-deoxyglucose

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction atherosclerosis carotid artery disorder carotid stenosis chronic periodontitis periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute myocardial infarction Carotid atherosclerosis Severe periodontitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hôpital Bichat, AP-HP

    RECRUITING

    Paris, France

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