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Blood test clues: could two proteins predict heart failure after a heart attack?
NCT ID NCT00762333
First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time
Summary
This study looks at whether two proteins released when heart muscle is damaged can be detected in the blood during a heart attack. Researchers want to see if higher levels of these proteins are linked to a greater chance of developing heart failure afterward. The study includes adults who have had a heart attack, with or without heart failure, and a control group for comparison. By measuring these proteins, the study aims to uncover potential markers that might one day help guide patient care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If these proteins prove to be reliable markers, they could help identify heart attack patients at higher risk of developing heart failure, guiding earlier or more intensive treatment.
- What could go wrong
- This is an observational study, so it cannot prove cause and effect. The proteins may not consistently predict heart failure, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 550 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2007
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
There are two arms to this study: The investigators hope to enroll 350 healthy individuals, as defined by having no prior diagnosis of heart disease to determine baseline levels and diurnal variations of the markers. Participants being evaluated for an acute Myocardial Infarction as determined by positive CK MB/troponin levels, will be asked to enroll.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * men and women, 18 years of age and over with acute myocardial infarction (determined by positive cardiac markers -CKMB/ troponin) with or without heart failure (dyspnea, rales, edema, elevated jugular venous pressure, ascites). * Heart failure can be diagnosed using imaging evidence such as dilated heart, poor contractile function or echocardiographic Doppler evidence of diastolic dysfunction or elevated right- or left-sided filling pressures * A control group of male subjects age 60 and older without history of MI or heart disease Exclusion Criteria: * Subjects unable to give consent * Subjects who have undergone cardiac or non-cardiac surgery in the 3 months prior to enrollment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Connecticut Health Center
RECRUITINGFarmington, Connecticut, 06030, United States
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