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Which strategy wins for heart attack patients with multiple blocked arteries?

NCT ID NCT03298659

Disease control Sponsor: Radboud University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial investigates the best way to treat people who have a heart attack and also have other narrowed arteries. It compares doing an immediate procedure to open those other arteries, guided by a pressure wire, versus waiting and using a heart scan to decide later. The goal is to see which approach better prevents future heart problems, like another heart attack or heart failure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Two diagnostic tests: iFR (pressure wire) and stress perfusion CMR (imaging)
What this could lead to
If successful, this could establish the best way to treat additional blocked arteries in heart attack patients, potentially reducing the risk of future heart events and improving survival.
What could go wrong
The trial is large but results may not apply to all patients. Both strategies carry risks, including procedure-related complications, and the optimal approach may depend on individual patient factors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1,146 people

The number who actually took part.

Started

Dec 2017

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 years and older * Clinical presentation of STEMI and successful primary PCI within 12 hours from onset of symptoms * One or more other, noninfarct coronary artery lesions of \>50% stenosis and feasible to be revascularized (i.e., minimal diameter 2mm) Exclusion Criteria: * History of ST-elevation myocardial infarction or coronary artery bypass graft * Hemodynamic instability, respiratory failure, Kilips class ≥III * Known GFR\<30 ml/min * Known contra-indications for stress CMR (e.g.: severe claustrophobia, metal implants, severe renal failure, severe astma) * Refusal or inability to provide informed consent * Life expectancy due to noncardiovascular co-morbidity of less than 12 months * Chronic total occlusion * Left main stem stenosis (\>50%) * Residual noninfarct lesion in infarct coronary artery * Complex noninfarct target lesions * Pregnancy

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction coronary artery disorder ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute myocardial infarction Multi vessel coronary artery disease

Contacts and locations

Locations

  • Radboudumc

    Nijmegen, Netherlands

More trials for these conditions

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