Radboud University Medical Center

Researchers are following 100 people newly diagnosed with Mycobacterium avium complex pulmonary disease (MAC-PD) who need standard three-drug antibiotic treatment. The study measures how many patients clear the infection after six months, how their bacterial load changes, and how…

This study explores whether adding high-intensity interval training (HIIT) to standard immunotherapy (nivolumab plus ipilimumab) helps patients with advanced kidney cancer. Thirty participants are randomly assigned to either a supervised exercise program or usual care. Researcher…

This trial tests a person-centered care program for adult ICU patients who are or may become agitated. The program combines non-drug calming strategies with light sedation using dexmedetomidine when needed, aiming to reduce the use of physical restraints. Researchers will compare…

This trial investigates whether a five-week vegetarian diet can dampen the inflammatory response of the immune system in people who recently had a heart attack, as well as in healthy volunteers. Participants will follow a vegetarian diet for five weeks, then return to their usual…

This trial investigates whether giving standard combination immunotherapy (ipilimumab and nivolumab) in the early morning (before 10 AM) versus the afternoon (after 1 PM) improves tumor response in people with advanced melanoma. About 170 participants with metastatic or inoperabl…

This study tests whether taking daily protein supplements and doing resistance exercises (like lifting weights) can prevent too much muscle loss after bariatric surgery. About 400 patients will be randomly assigned to either standard care or standard care plus the protein and exe…

This trial tests whether methylphenidate, a standard ADHD medication, can reduce attention and hyperactivity problems in children and adolescents with KBG syndrome, a rare genetic condition often accompanied by ADHD-like symptoms. Participants receive alternating blocks of the dr…

This trial investigates whether adding dried chicory root fiber to standard immunotherapy helps people with advanced melanoma. The fiber is meant to increase beneficial gut bacteria, which may in turn improve immune cell activity and the body's response to treatment. About 70 par…

This study tests whether a higher dose of the antibiotic rifampicin (1800 mg daily) is safe and works better than the standard dose for adults with pulmonary tuberculosis. About 164 participants will be randomly assigned to either the optimized or standard dose. Researchers will …

This study tests whether levosimendan, a drug that strengthens heart and breathing muscles, can help critically ill patients get off a ventilator faster. About 250 adults who have been on a breathing machine for over 48 hours and failed a breathing test will receive either the dr…

This study tests a drug called obinutuzumab in 20 adults with a high-risk form of membranous nephropathy, a kidney disease caused by antibodies attacking the kidneys. The goal is to see how quickly the drug lowers those harmful antibodies and whether it leads to remission. Partic…

This phase 3 trial tests whether using a sentinel lymph node biopsy to guide radiation can safely reduce the amount of neck radiation in people with certain head and neck cancers. The goal is to lower long-term side effects like severe dry mouth while still controlling the cancer…

This early-phase trial tests a personalized vaccine made from a patient's own immune cells and tumor material in 10 women with advanced ovarian cancer. The goal is to see if the vaccine can safely boost the immune system to recognize and attack cancer cells after chemotherapy. Th…

This early-phase study tests a new imaging agent (TGW211) in 19 adults with HER2-positive solid tumors. The goal is to see if a special 'trigger' can help clear the imaging tracer from healthy tissues faster, making tumor scans clearer. The study focuses on safety and image quali…

This study compares a new diagnostic approach—using an MRI plus a same-day biopsy—against the standard procedure (TURBT) for diagnosing muscle-invasive bladder cancer. Researchers will enroll 360 adults suspected of having this aggressive cancer. The goal is to see if the new met…

This trial tests whether a smartphone app can help people with REM sleep behavior disorder, a condition that often precedes Parkinson's, become more physically active over two years. Participants receive personalized activity goals through the app and track their steps and exerci…

This trial tests whether a smartphone app can help 600 people with Parkinson's-related gene mutations increase their daily physical activity over two years. Participants set their own exercise goals and get feedback through the app. Researchers will measure changes in step counts…

Researchers are testing whether inhaling a concentrated saltwater mist, added to standard supportive care, can improve quality of life and help clear Mycobacterium avium complex (MAC) bacteria from the lungs. The trial enrolls 30 adults with nodular-bronchiectatic MAC lung diseas…

This study tests whether modafinil, a drug used for sleep disorders, can reduce severe fatigue in adults with inactive inflammatory bowel disease (IBD). Sixty participants will take either modafinil or a placebo for 8 weeks, starting at 100 mg daily with possible dose increases. …

This study tests whether atomoxetine, a medication that affects noradrenaline, can reduce freezing of gait in people with Parkinson's disease. About 60 participants will take either atomoxetine or a placebo and perform walking tests, MRI scans, and questionnaires. The goal is to …

This study tests whether a smartphone app that provides personalized lifestyle advice can help reduce depression symptoms in adults visiting their general practitioner. 216 participants will either use the app alongside their usual care or receive usual care alone. The app helps …

This study will follow 700 men with high-risk localized or metastatic prostate cancer to collect detailed information on how they are treated in everyday practice. Researchers will track treatments, side effects, quality of life, and disease progression over time. The goal is to …

This study follows 185 adults in the Netherlands who are hospitalized with serious trauma injuries. Researchers will ask them to fill out short questionnaires about their quality of life, pain, fatigue, and daily functioning at several points over a year. The goal is to see wheth…

This study is investigating why some patients develop pancreatitis after an ERCP, a procedure used to diagnose and treat issues in the bile and pancreatic ducts. The researchers are collecting blood samples from 700 adults undergoing ERCP to look for genetic variations that affec…

This study looks at how the immune system reacts during and after sepsis in 400 intensive care patients. Researchers will analyze blood samples to identify different immune response types, called immunotypes. The goal is to understand which immune patterns lead to better or worse…

This pilot study tests whether it's possible to run a larger trial comparing plant-based and animal-based oral nutritional supplements (ONS) in hospital patients at risk of malnutrition. Sixty patients from two Dutch hospitals will be randomly assigned to receive either a soy-bas…

This study is testing a computer model called ENDORISK that helps doctors predict whether endometrial cancer has spread to lymph nodes. About 735 patients with early-stage endometrial cancer will use the model to guide decisions about lymph node surgery. The goal is to see if the…

This study looks at whether a special blood test can find tiny bits of tumor DNA left after prostate cancer surgery. The goal is to see if this test can better predict if the cancer will come back early in high-risk patients. About 50 men with high-risk prostate cancer will give …

This study looks at 1000 people with heart artery disease who already need a special camera (OCT) inside their arteries during a routine procedure. Researchers will use those detailed images and artificial intelligence to find patterns that might predict future heart problems, li…

This study looks at how changing the pressure in a breathing machine (ventilator) affects the effort and drive to breathe in 20 ICU patients with severe lung failure. Researchers will test six different pressure levels and measure breathing muscles, lung activity, and oxygen leve…