Radboud University Medical Center

This study tracks adults with squamous cell carcinoma of the nasal vestibule who receive brachytherapy, a type of radiation placed directly into the tumor. Researchers will record treatment techniques, radiation doses, and outcomes like tumor control, side effects, and patient sa…

This trial investigates whether a new technique called pulsed field ablation (PFA) can more effectively treat atrial fibrillation, a common heart rhythm problem. The procedure uses short electrical pulses to create precise lesions in the heart tissue, aiming to block faulty signa…

This trial tests whether a 9-month program called STEP COACH can help people with coronary artery disease stay physically active after completing cardiac rehab. Participants use their own smartwatch or smartphone to track steps and receive coaching on increasing both step volume …

This study tests a new way to deliver radiotherapy for endometrial cancer after surgery. Using real-time MRI guidance, doctors can target radiation more accurately and reduce damage to nearby organs like the bowel and bladder. About 61 women will receive five high-dose sessions o…

This early-phase trial tests a personalized vaccine made from a person's own immune cells (dendritic cells) loaded with cancer-specific markers. The goal is to train the immune system to recognize and destroy precancerous cells in people with Lynch syndrome, who have a high risk …

This phase III trial tests whether a vaccine made from a person's own immune cells can prevent cancer in 372 adults with Lynch syndrome, a genetic condition that raises cancer risk. Participants receive either the vaccine or a placebo and are monitored for tumor development. The …

This study tests whether adding hydroxychloroquine (a malaria drug) to standard doxycycline treatment can reduce long-term complaints in adults with Lyme disease. Fifty participants will take either hydroxychloroquine or a placebo twice daily for 28 days, with follow-up visits ov…

Researchers at Radboud University Medical Center are studying whether the diaphragm, the main breathing muscle, enters a hibernation-like state in ICU patients who need a breathing machine. The study follows 112 adults on invasive mechanical ventilation for at least three days. S…

Researchers at Radboud University Medical Center are asking what adults with serious trauma injuries and financial concerns need from physical therapy. The study includes 17 people in the Netherlands who were injured between three months and two years earlier. Through interviews,…

This study looks at how well an inhaled antifungal drug (liposomal amphotericin B) reaches the lungs in people with chronic pulmonary aspergillosis, a long-term lung infection. About 18 adults will inhale two different doses on separate days and then have special scans to see whe…

This study tests whether occlusal splints (night guards) made using a fully digital workflow are as comfortable and effective as those made with a traditional wax bite registration. Healthy volunteers aged 18 to 45 will wear both types of splints overnight for three weeks each. T…

This study will look at medical records of 1700 adults with obesity who took tirzepatide along with lifestyle coaching at several Dutch clinics. Researchers want to see how much weight people actually lose after six months and how doctors prescribe the medication in daily practic…

This study looks at whether a hybrid care model—using telemonitoring, teleconsultations, and online tools—can help patients with type 2 diabetes or chronic heart failure get regular care during health emergencies like pandemics. Researchers will follow 180 patients for one year, …