Radboud University Medical Center

This early-stage trial tests whether it is safe and possible to give people with advanced thyroid cancer a personalized combination of existing drugs based on their tumor's genetic profile. The study includes 10 patients who have run out of standard treatment options. The goal is…

This study tests a new way to give radiation therapy to women with endometrial cancer after surgery. The approach uses MRI scans during each treatment to aim the radiation more precisely at the tumor area, which may reduce side effects. About 61 participants will receive five rad…

This study tests whether giving insulin through a nasal spray can prevent delirium (sudden confusion) in older adults after heart surgery. About 30 people aged 65 and older will take part. The goal is to see if the spray is practical, safe, and possibly effective.

This early-stage trial tests a custom-made vaccine for people with Lynch syndrome, a genetic condition that raises cancer risk. The vaccine uses the patient's own immune cells to target unique cancer markers. The goal is to see if it's safe and can train the body to fight off tum…

This study will test whether 3D-printed or milled dental splints are more comfortable and stable for healthy adults. Twenty-four participants will try both types and report how they feel. Dentists will also check the fit and stability. The goal is to find which method works best …

This study tests whether adding hydroxychloroquine to the standard antibiotic doxycycline can reduce long-term physical complaints in adults with Lyme disease. Fifty participants will take either the combination or a placebo for 28 days and be followed for a year. The goal is to …

This study tests whether modafinil, a drug used to promote wakefulness, can reduce severe fatigue in adults with inactive inflammatory bowel disease (IBD). Sixty participants will take either modafinil or a placebo for 8 weeks, and researchers will measure changes in fatigue leve…

This study will follow 700 men with high-risk or metastatic prostate cancer to collect detailed information on how they are treated in everyday practice and how treatments affect their quality of life. Researchers will also gather blood and tissue samples to help discover new bio…

This study looks at how well tirzepatide, a newer weight-loss medication, works when used in regular doctor visits—not just in strict research settings. Researchers will track weight loss and dosing patterns in 1700 adults with obesity across multiple Dutch clinics over six month…

This study looks at whether a hybrid care model—using digital tools like telemonitoring and online consultations—can help manage type 2 diabetes and chronic heart failure during health emergencies. About 180 patients will be observed and interviewed over a year to see how this ap…

This study looks at how well an inhaled antifungal drug (liposomal amphotericin B) reaches the lungs in people with chronic pulmonary aspergillosis, a long-term lung infection. About 18 adults will receive two different doses on separate days, then have special scans to see where…