Radboud University Medical Center

This early-stage study tested a new COVID-19 vaccine called ABNCoV2 in 45 healthy adults who had never had COVID-19. The goal was to check the vaccine's safety and see how well it triggers an immune response. Researchers gave two doses, with or without an immune booster (adjuvant…

This study tested a combination of two immunotherapy drugs (ipilimumab and nivolumab) in 69 men with a specific type of advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if the treatment could shrink tumors or stop the cancer from growing fo…

This study tested a new antibody called TB31F in 167 adults and children in Mali who are often exposed to malaria. The goal was to see if it is safe and can reduce the spread of the malaria parasite to mosquitoes. Participants received either the antibody or a placebo, and resear…

This study tested whether psoriasis patients with well-controlled disease can safely reduce their dose of IL17 or IL23 inhibitor biologics without causing flare-ups. 244 adults with stable psoriasis (clear or almost clear skin for at least 6 months) were randomly assigned to eith…

This study tested a new type of radiation therapy (177Lu-PSMA) in 58 men with prostate cancer that had spread to a few spots in the bones or lymph nodes but was still hormone-sensitive. The treatment targets cancer cells specifically, aiming to delay disease progression compared …

This study tested a support program for people with dementia living at home. The program trained nurses to focus on what the person can still do and involved family caregivers in conversations about daily choices. 12 people with dementia, 14 caregivers, and 33 nurses took part. W…

This study tested whether personalized strategies to reduce anxiety and stress can help people with Parkinson's disease who experience freezing of gait—a sudden inability to move while walking. 41 participants with daily freezing linked to anxiety were enrolled. Researchers measu…

This study looked at whether doing bone-anchored hearing implant surgery in a single step is as safe as the usual two-step approach in children aged 4 to 9. The main goal was to see how many implants were lost. The research involved 70 children and aimed to simplify treatment by …

This study tested whether giving a lower dose of radiation to the neck area in people with head and neck cancer could reduce side effects and improve quality of life after treatment. About 300 patients with certain throat or voice box cancers took part. The goal was to see if thi…

This study looked at whether adding extra protein to the diet helps older adults recover from muscle damage caused by exercise. 199 active adults aged 60 and older who could walk 30-50 km per day took part. They used different protein supplements or a carbohydrate drink for 5 wee…

This study tested a special wrist brace called the STIL Orthosis to see if it can reduce shaking (tremor) in people with Parkinson's disease. 25 participants had their tremor measured with the brace, with a fake brace, and with no brace. The goal was to find out if the device hel…

This study tested a computer model that helps doctors give the right dose of anti-rejection drugs to children who have had a kidney transplant. The model uses drug levels measured in the blood to predict future exposure and guide dosing. 29 children participated, and the goal was…

This study looked at how much HIV medication passes from mother to baby through breastmilk. Sixteen HIV-positive mothers who chose to breastfeed provided blood and breastmilk samples at 1, 3, and 6 months after giving birth. Researchers measured drug levels to calculate how much …

This study looked at how five common HIV drugs enter breastmilk. Twenty healthy women at the end of breastfeeding took a single dose of one of the drugs. Researchers measured drug levels in blood and milk to see if concentrations could be harmful to infants or lead to drug resist…

This study checked how well a specific bone-anchored hearing implant (BIA300) held up over 10 years. Researchers measured implant stability and looked for any skin problems in 51 adults who had received the implant. The goal was to understand the long-term safety and reliability …

This study looked at how immune cells from people with thyroid or colon cancer might be 'trained' to fight tumors. Researchers collected blood samples from 33 newly diagnosed patients before they started treatment. They tested whether certain agents could reprogram immune cells t…

This study tested a new laser-based measuring tool (AccuMeasure) to see if it can measure colon polyps more accurately than the usual visual estimate. Accurate polyp size is key for deciding how often patients need follow-up colonoscopies to catch cancer early. The study involved…

This study tested two devices that measure pain in children aged 1 to 12 during surgery. The goal was to see how well they detect pain signals. Fifty children took part, and the results help doctors choose better pain monitors for young patients.

This study tested a tool called KomPas+ that helps physical therapists and patients with intermittent claudication (leg pain from blocked arteries) make shared decisions about treatment. Over 2,200 participants used the tool to see if it improved walking distance and quality of l…