Radboud University Medical Center

This early-stage trial is testing a personalized vaccine for advanced ovarian cancer. Doctors create the vaccine using a patient's own tumor cells and specialized immune cells called dendritic cells. The goal is to see if this vaccine, given alongside standard chemotherapy and su…

This study is testing if a much higher daily dose of the antibiotic rifampicin is safe and works better for treating lung tuberculosis than the standard dose. Researchers will compare the two doses in 164 adult patients to see if the higher dose causes more liver problems or side…

This study is testing if adding daily protein supplements and a weekly supervised strength training session to standard care helps people keep more muscle after bariatric surgery. About 400 patients scheduled for surgery will be randomly assigned to receive either standard care a…

This study is testing a more personalized way to deliver radiation for head and neck cancer. Researchers want to see if using a small biopsy to check lymph nodes can safely allow doctors to skip or reduce radiation to healthy parts of the neck. The goal is to control the cancer j…

This study is testing a drug called obinutuzumab to see how quickly it can lower harmful antibodies in adults with a serious autoimmune kidney disease called membranous nephropathy. It will involve 20 patients who still have high protein in their urine despite standard care. The …

This study is testing a new computer model called ENDORISK in real-world clinics. It helps doctors and patients with early-stage endometrial cancer better understand the risk of the cancer spreading to lymph nodes before surgery. The goal is to see if using this tool improves dec…

This study is testing a new approach to diagnosing invasive bladder cancer. It compares the standard surgical biopsy method against a new method that uses a detailed MRI scan first, followed by a smaller biopsy on the same day. The goal is to see if the MRI method helps patients …

This study is testing a new blood test to find tiny amounts of leftover cancer cells in men who have had prostate removal surgery for high-risk prostate cancer. Researchers want to see if this test can predict which patients are most likely to have their cancer return within a ye…

This study is testing if the drug atomoxetine can help reduce 'freezing of gait'—a sudden, temporary inability to move the feet—in people with Parkinson's disease. Researchers will compare atomoxetine to a placebo (inactive pill) in 60 participants to see if it decreases how ofte…

This study is testing whether a drug called levosimendan can help critically ill patients who are struggling to breathe on their own after being on a ventilator. The drug is designed to strengthen the diaphragm muscle to help with breathing. Researchers will compare the drug to a…

This study is testing whether a smartphone app that helps people make healthy lifestyle changes can reduce symptoms of depression. Researchers will compare adults who use the app alongside their regular doctor visits to those who only receive regular care. The app guides users to…

This study aims to understand if detailed images of heart arteries (called OCT scans) can predict future heart problems. Researchers will follow 1,000 patients for up to 10 years, tracking their health outcomes. They will also use artificial intelligence to help doctors analyze t…

This study aims to understand how the immune system responds during and after sepsis, a life-threatening reaction to infection. Researchers will follow 400 intensive care patients with sepsis, collecting blood samples and health information over one year to identify different imm…

This study aims to understand how adjusting a key setting on a mechanical ventilator (called PEEP) affects a patient's own breathing effort and muscle function. It will observe 20 adult ICU patients with severe lung failure who are already on a breathing machine. Researchers will…

This study is a small pilot to see if a larger trial comparing plant-based and animal-based nutrition drinks is practical. It will enroll 60 hospital patients at risk of malnutrition to test if they can stick to the drink plan and complete the study tests. The main goal is to che…

This early-phase study is testing a new imaging technique for cancers that have a protein called HER2, like some breast and stomach cancers. Researchers are using a special radioactive tracer attached to an antibody (trastuzumab) that targets HER2. After the tracer reaches the tu…