Radboud University Medical Center

This study tests a personalized vaccine made from a patient's own tumor cells and immune cells. The goal is to see if the vaccine can train the immune system to fight ovarian cancer more effectively. Ten women with advanced ovarian cancer will receive the vaccine alongside standa…

This study tests whether taking extra protein every day and doing supervised strength training once a week can help people who have had weight-loss surgery keep their muscle. About 400 adults scheduled for bariatric surgery will be randomly assigned to either standard care or sta…

This study tests if levosimendan, a drug that strengthens the heart and breathing muscles, can help critically ill patients get off a ventilator faster. About 250 adults who have struggled to breathe on their own will receive either the drug or a placebo. The goal is to see if th…

This study tests whether a higher dose (1800 mg) of the TB drug rifampicin is safe and works better than the standard dose in 164 adults with pulmonary tuberculosis. Researchers will compare side effects, especially liver problems, and how well patients recover. The goal is to se…

This phase 3 trial tests whether using a sentinel lymph node biopsy can help doctors decide which side of the neck needs radiation, instead of treating both sides in all patients. About 242 adults with certain head and neck cancers will be randomly assigned to standard bilateral …

This study tests whether the drug obinutuzumab can quickly lower harmful antibodies that attack the kidneys in people with a type of kidney disease called membranous nephropathy. Twenty adults with high-risk disease will receive two infusions two weeks apart, and possibly two mor…

This study tests whether a special MRI scan, followed by a same-day biopsy, can diagnose muscle-invasive bladder cancer faster and more accurately than the usual surgery (TURBT). About 360 adults with suspected aggressive bladder cancer will be randomly assigned to one of the two…

This early-phase study tests a new imaging agent called TGW211 for people with HER2-positive solid tumors. The goal is to see if a special "trigger" can help clear the imaging tracer from healthy organs quickly, making tumors easier to see on scans. About 19 adults will take part…

This study tests if atomoxetine, a medication that boosts noradrenaline, can reduce freezing of gait in people with Parkinson's disease. About 60 participants will take either atomoxetine or a placebo and perform walking tests, MRI scans, and questionnaires. The goal is to see if…

This study tests whether a smartphone app that gives personalized lifestyle advice can help reduce depression symptoms in adults visiting their general practitioner. Participants set goals in areas like sleep, diet, and exercise, and track their mood. The app is used alongside re…

This study is testing a new blood test that looks for tiny bits of cancer DNA in the blood after prostate removal surgery. The goal is to see if this test can better predict if the cancer will come back early in men with high-risk prostate cancer. About 50 men will participate, a…

This study looks at how changing the pressure on a breathing machine affects the effort and drive to breathe in 20 ICU patients with severe lung failure. Researchers will test six different pressure levels and measure diaphragm function, breathing effort, and lung activity. The g…

This study tests whether it's possible to run a larger trial comparing plant-based and animal-based nutritional drinks for hospital patients at risk of malnutrition. About 60 adults from two Dutch hospitals will be randomly assigned to drink either a soy-based or milk-based suppl…

This study looks at how the immune system reacts during and after sepsis in 400 intensive care patients. Researchers will analyze blood samples to identify different immune response patterns, called immunotypes. The goal is to understand which patterns lead to better or worse out…

This study looks at 1000 people who already had a special type of heart artery scan (OCT) during a routine procedure. Researchers want to see if details in those scans can predict future heart problems. They will also use the scans to train an AI to automatically spot important f…

This study is testing a new computer model called ENDORISK that helps doctors predict whether early-stage endometrial cancer has spread to lymph nodes. About 735 patients will use the tool to guide treatment decisions, and researchers will compare results to standard care. The go…