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New risk model could spare endometrial cancer patients unnecessary surgery

NCT ID NCT07200466

Knowledge-focused Sponsor: Radboud University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This study is testing a computer model called ENDORISK that helps doctors predict whether endometrial cancer has spread to lymph nodes. About 735 patients with early-stage endometrial cancer will use the model to guide decisions about lymph node surgery. The goal is to see if the model improves accuracy, reduces unnecessary procedures, and supports shared decision-making between patients and doctors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 735 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Oct 2032

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with early stage (FIGO stage I-II) endometrial carcinoma (every grade permitted) * Eligible for primary surgical treatment (neo-adjuvant therapy is permitted) Exclusion Criteria: * Unable to give informed consent * No understanding of Dutch or English language * Rare types of endometrial cancer, such as endometrial stroma cell sarcoma

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Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

endometrial cancer endometrial carcinoma endometrium neoplasm Lymphatic Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometrial cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    14 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Amphia

    RECRUITING

    Breda, North Brabant, Netherlands

  • Bernhoven Hospital

    RECRUITING

    Uden, North Brabant, Netherlands

  • Canisius Wilhelmina Ziekenhuis (CWZ)

    NOT_YET_RECRUITING

    Nijmegen, Gelderland, Netherlands

  • Catharina Hospital

    RECRUITING

    Eindhoven, North Brabant, Netherlands

  • Elisabeth-Tweesteden Hospital

    RECRUITING

    Tilburg, North Brabant, Netherlands

  • Elkerliek Hospital

    RECRUITING

    Helmond, North Brabant, Netherlands

  • Gelderse Vallei

    RECRUITING

    Ede, Gelderland, Netherlands

  • Jeroen Bosch Hospital

    RECRUITING

    's-Hertogenbosch, North Brabant, Netherlands

  • Maxima Medical Center

    RECRUITING

    Veldhoven, North Brabant, Netherlands

  • Radboudumc

    RECRUITING

    Nijmegen, Gelderland, 6525GA, Netherlands

  • Rijnstate

    RECRUITING

    Arnhem, Gelderland, Netherlands

  • Slingeland Hospital

    NOT_YET_RECRUITING

    Doetinchem, Gelderland, Netherlands

  • St. Anna Hospital

    RECRUITING

    Geldrop, North Brabant, Netherlands

  • Streekziekenhuis Koningin Beatrix

    NOT_YET_RECRUITING

    Winterswijk, Gelderland, Netherlands

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