Sound waves against ALS: can opening the Brain's barrier slow the disease?
NCT ID NCT07571486
First seen May 15, 2026 · Last updated Jun 23, 2026 · Updated 4 times
Summary
This early study tests whether repeatedly opening the blood-brain barrier with ultrasound is safe and might slow ALS. Twenty-three adults with ALS will receive 9 ultrasound sessions over 24 weeks. The first part checks safety; the second looks for signs of slowing the disease.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hôpital Pitié-Salpêtrière
Paris, 75013, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SonoCloud-4 ultrasound device
What this could lead to
If successful, this could point toward a new way to treat ALS by temporarily opening the blood-brain barrier, potentially slowing disease progression.
What could go wrong
This is a very early, small study (23 people) testing safety first. It may not show any benefit, and the procedure carries risks like brain swelling or bleeding.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.