AMYOTROPHIC LATERAL SCLEROSIS

This study is testing a brain implant system to help people who have lost the ability to speak due to conditions like ALS, spinal cord injury, or stroke. The implant reads brain signals related to speech, aiming to let participants control a computer to communicate with their tho…

This study aims to find out if a drug called pridopidine can slow the progression of ALS (amyotrophic lateral sclerosis, also known as Lou Gehrig's disease). It will involve about 500 adults with early and rapidly progressing ALS. For the first 48 weeks, some participants will ta…

This study is testing whether darifenacin, a medication usually used for overactive bladder, can help slow the progression of ALS (Lou Gehrig's disease). Researchers believe it might protect the connections between nerves and muscles. The trial will involve 30 people with ALS who…

This large, late-stage trial is testing whether adding an oral drug called masitinib to the standard ALS medication riluzole can better slow the progression of the disease. The study will involve 495 adults with ALS who are already taking riluzole. Researchers aim to see if the c…

This early study is testing the safety and basic function of a new brain implant system designed for people with severe paralysis. A small, wireless device is surgically placed in the brain to read neural signals. The goal is to see if participants can use their thoughts to contr…

This study is testing a tiny brain implant that could help people who have lost the ability to speak due to conditions like ALS, stroke, or spinal cord injury. The device reads brain signals when a person tries to talk and translates them into computer-generated speech. Researche…

This study is testing whether adding two substances, EH-301 and N-acetylcysteine (NAC), to the standard ALS drug riluzole can slow down the disease. It will involve 90 people with early-stage ALS who can still walk. Participants will be randomly assigned to get either the real co…

This study monitors the long-term safety of tofersen (Qalsody®) in Chinese adults with a specific genetic form of ALS. Researchers will track side effects and how the drug moves through the body in 12 participants over one year. The drug is already approved in China, so this stud…

This is an early, small study to find a safe dose of an experimental gene therapy called INS1202 for people with ALS. It will test a single injection into the spinal fluid of about 23 adults with ALS, including some with a specific genetic mutation (SOD1) and some without. The ma…

This is an early-stage study to check the safety of a new, one-time gene therapy called VTx-002 for people with ALS. It will involve 12 participants who will receive a single injection and be closely monitored for up to 5 years. The main goal is to see if the treatment is safe an…

This large, ongoing trial is testing several experimental drugs at the same time to find treatments that can slow the progression of ALS (Lou Gehrig's disease) and help people live longer. The study will enroll 1,500 adults recently diagnosed with ALS who can still swallow pills.…

This study is testing a brain implant system called BrainGate2 to see if it's safe and if it works. People with paralysis from conditions like spinal cord injury or ALS have a small sensor placed in their brain. The main goal is to see if they can use their thoughts to control a …

This early-stage trial is testing whether a special ultrasound helmet can safely and temporarily open the brain's protective barrier. The goal is to help deliver an immune therapy (IVIg) directly to the brain areas affected by ALS. Six participants will receive the therapy, with …

This study is testing whether an investigational drug called dazucorilant is safe and can help slow the progression of ALS (amyotrophic lateral sclerosis). It will involve about 279 adults with ALS across North America and Europe. The main goal is to see if the drug can help pati…

This trial is testing whether a supplement called acetyl-L-carnitine can slow the progression of ALS (Lou Gehrig's disease). Researchers will enroll 246 people with early-stage ALS to receive either the supplement or a placebo for 48 weeks, in addition to their standard medicatio…

This study is testing whether a simple, painless measurement of muscle activity can help doctors diagnose ALS (amyotrophic lateral sclerosis) earlier and more accurately. Researchers will use surface electrodes on the skin to measure how two muscles work together during a simple …

This early study is testing Neuralink's brain implant system to help people who have lost the ability to speak due to conditions like ALS, spinal cord injury, or stroke. A small group of participants will have a wireless device implanted in their brain by a surgical robot, which …

This study is testing whether using a special breathing device can help slow the decline of cough strength in people with early-stage ALS. Twenty participants will use the device twice daily for six months to perform deep breathing exercises. Researchers will compare their cough …

This study is testing a new approach to help improve hand strength and function in people with ALS (Lou Gehrig's disease). Researchers will use a combination of non-invasive magnetic brain stimulation and electrical spinal cord stimulation, tailored to each person, over a two-wee…

This study is testing a special type of exercise for people with neuromuscular diseases (like ALS or muscular dystrophy) who often can't do regular workouts. It uses a suit that sends mild electrical signals to make muscles contract, aiming to improve strength, walking, balance, …

This early study is testing the safety of a new brain implant designed to help people who have lost the ability to speak or move. The device, called Connexus, aims to translate a person's thoughts into speech or computer commands. It is being tested in a small group of people wit…

This study is testing if immersive virtual reality (VR) can help reduce the feeling of shortness of breath in people with ALS (Lou Gehrig's disease). It will involve 35 ALS patients who already use a non-invasive breathing machine but still experience discomfort. Researchers will…

This study is testing whether a special home exercise program, guided by videos, can help people with ALS (amyotrophic lateral sclerosis or Lou Gehrig's disease). Researchers want to see if these exercises improve trunk and limb control, daily activities, and quality of life. The…

This study is testing whether a personalized physical therapy program, designed based on a detailed assessment of each patient's specific movement problems, works better than standard physical therapy for people with ALS. The goal is to help patients maintain their physical funct…

This early-stage study is exploring whether psilocybin, the active compound in 'magic mushrooms,' can help treat depression in people with ALS (Lou Gehrig's disease). Researchers at Johns Hopkins will give up to 24 participants with ALS and depression two guided psilocybin sessio…

This study is testing whether a drug called ranolazine is safe and can help reduce painful muscle cramps in people with ALS (amyotrophic lateral sclerosis). About 72 adults with ALS who experience frequent cramps will take either ranolazine or a placebo pill twice daily for 28 we…

This research aims to understand how well listeners can understand speech from people with ALS compared to typical speakers. About 1,300 online participants will listen to recorded speech samples and indicate what they heard. The study compares understanding during interactive co…

This study aims to find measurable signs (biomarkers) of ALS and Primary Lateral Sclerosis (PLS) using advanced MRI brain scans. Researchers will compare scans from 30 people with ALS or PLS to scans from healthy individuals. The goal is to better understand these diseases, which…

This study is a survey designed to understand the specific challenges and needs of people living with a particular, often more aggressive, form of ALS (C9orf72 mutation) and the people who care for them. Researchers will ask patients and caregivers about their care, support, and …

This study aims to understand how ALS develops by closely monitoring 600 adults who have a family history of the disease but don't yet show symptoms. Participants will be followed for 3 years with regular check-ins, blood tests, and symptom tracking to identify early warning sign…

This study aims to better understand Amyotrophic Lateral Sclerosis (ALS) by collecting detailed information from patients. Researchers will gather medical data during life and, with consent, perform rapid autopsies after death to bank tissue. The goal is to identify reliable mark…

This study follows healthy people who have family members with ALS and carry genetic risk factors, but don't yet have symptoms. Researchers will track participants over 10+ years to understand what happens in the body before ALS develops and identify early warning signs. Particip…

This study aims to gather a large group of people to help researchers learn more about ALS. It will recruit 10,000 participants, including people with ALS, their family members, and healthy volunteers. The goal is to understand the disease better by tracking its course and identi…

This study aims to build a large collection of blood, spinal fluid, and health information from people with ALS and healthy volunteers. Researchers will follow 800 ALS patients and 200 healthy controls for up to 5 years, collecting samples and tracking symptoms. The goal is to cr…

This study aims to collect detailed information from 2000 people, including those with ALS and healthy volunteers, over two years. Researchers will track symptoms, collect blood samples, and gather voice recordings to create a large database for scientists. The goal is to better …

This study aims to understand how ALS affects daily movement by having patients wear a sensor device for one month after each clinic visit. Researchers will track walking speed, stride length, and arm function in about 20 ALS patients over a year. The goal is to gather detailed i…

This French study aims to understand how immune cells called macrophages behave differently in people with ALS compared to healthy individuals and people with other movement disorders. Researchers will analyze blood samples from 180 participants to identify potential new drug tar…

This study aims to better understand related brain diseases like ALS (Lou Gehrig's disease) and frontotemporal dementia. Researchers are recruiting 360 adults who have been diagnosed with these conditions or carry a genetic risk. Participants undergo detailed testing, including b…

This study aims to collect blood and spinal fluid samples from people with ALS and their family members to build a research library. Researchers will use these samples in future studies to look for biological markers that could help diagnose ALS earlier or track how the disease p…

This study aims to better understand why ALS progresses differently in each person by tracking 140 patients for up to 3 years. Researchers will regularly collect blood and spinal fluid samples to measure biological markers while recording symptoms and disease progression. The goa…

This study aims to learn more about ALS and related diseases by collecting health information from patients' medical records. It will enroll up to 1,200 people with ALS, PLS, or PMA who receive care at specific clinics. The goal is to build a detailed picture of how these disease…

This study aims to find biological markers in the blood that could indicate the presence of ALS. Researchers will compare blood samples from 30 people with ALS and 30 healthy volunteers, looking for differences in tiny particles released by nerve cells. The goal is to find tools …

This is the first study in people to test the safety of a new oral drug called Amisodin, which is being developed for ALS (Lou Gehrig's disease). Researchers will give the drug to 48 healthy adults to see how their bodies process it and to check for side effects. The study will t…