AMYOTROPHIC LATERAL SCLEROSIS

This study tests an experimental drug called TP04HN106 in 60 people with ALS. Half get the drug, half get a placebo (salt water), and later everyone can receive the drug. The goal is to see if it slows down the disease and is safe. All participants also take standard riluzole tab…

This study tests whether darifenacin, a drug already used for other conditions, can help people with ALS. The drug aims to support nerve-muscle connections that break down in ALS. Thirty adults with ALS will take either darifenacin or a placebo daily for 24 weeks to check safety …

This early study tests a brain-computer interface (BCI) for safety in 2 people with severe paralysis from conditions like ALS or spinal cord injury. The device is designed to decode imagined speech and allow control of a computer, helping users communicate and connect. The goal i…

This study tracks the safety of tofersen (Qalsody) in 12 Chinese adults with a genetic form of ALS (SOD1 mutation). Participants receive 13 doses injected into the spine over one year. The main goal is to see how many people have side effects. This is a post-marketing study, mean…

This study is testing several experimental treatments at the same time to see if they can slow down ALS, a disease that weakens muscles over time. About 1,500 adults with early-stage ALS will take part. The main goal is to measure changes in daily function and survival.

This study tests whether the drug pridopidine can slow the progression of ALS, a serious nerve disease. About 500 adults with early-stage ALS will take either pridopidine or a placebo daily for 48 weeks, then all will receive pridopidine for another 48 weeks. Researchers will mea…

This Phase 3 trial tests whether adding masitinib to standard riluzole treatment can slow ALS progression better than riluzole alone. About 495 adults with ALS will receive either the combination or a placebo. The study measures changes in physical function, quality of life, and …

This study tests whether adding N-acetylcysteine (NAC) and EH-301 to standard riluzole treatment can slow down or improve symptoms in people with ALS. About 90 participants with early-stage ALS will receive either the active combination or a placebo for 6 months, followed by an o…

This early study tests the safety and function of a brain implant that helps people with severe paralysis control external devices like computers using their thoughts. The implant is placed in the brain by a special robot. The study involves 15 adults with paralysis from spinal c…

This study tests whether acetyl-L-carnitine (ALCAR), a natural substance, can slow the loss of function in people with ALS. About 246 adults with early-stage ALS will receive either a low or high dose of ALCAR or a placebo for 48 weeks, while continuing standard treatment. Resear…

This early-stage study is testing a new drug called VTx-002 in 12 people with ALS. The main goal is to see if the treatment is safe and tolerable at two different doses. Researchers will also check if it can slow down the disease, but this is a very early step and not a cure.

This study tests whether a new drug called dazucorilant can slow down ALS and improve muscle strength and breathing. About 279 adults with ALS will receive either the drug or a placebo for 24 weeks. The goal is to see if the drug is safe and helps people maintain their daily func…

This early-stage study tests a single injection of a gene therapy called INS1202 for people with ALS, a disease that weakens muscles over time. The main goal is to see if it is safe and to find the best dose. About 23 adults with certain genetic types of ALS will take part.

This study tests whether a very high-calorie, fatty diet can help people with ALS live longer and slow the disease. About 392 participants with early-stage ALS will either follow the special diet or a placebo. The main goal is to see if the diet improves survival and daily functi…

This early study tests a wireless brain implant from Neuralink that aims to let people with severe paralysis or ALS communicate just by thinking. The device is placed in the brain by a robot. The study will check if it is safe and works for 6 adults who cannot speak or use their …

This study is testing whether a quick, painless measurement of muscle activity can help doctors diagnose ALS earlier and more accurately. Researchers will compare this new test to current methods in 650 people with muscle symptoms. They will also track how the test changes over t…

This study aims to see if a device called SleepImage can accurately detect respiratory failure in people with ALS (amyotrophic lateral sclerosis). Researchers will compare SleepImage data with standard overnight sleep tests in 15 adults with ALS. The goal is to find a simpler way…

This study tests whether immersive virtual reality (VR) can reduce persistent shortness of breath in people with ALS who already use a breathing machine (non-invasive ventilation). About 35 adults with ALS and ongoing breathing discomfort will try VR sessions. The goal is to see …

This early-stage study tests whether a special helmet using sound waves can safely open a small part of the brain's protective barrier in people with ALS. This allows a powerful anti-inflammatory medicine (IVIg) to reach the motor cortex, the brain area controlling movement. The …

This study tests a non-drug treatment for people with ALS, especially veterans, who have hand weakness. The approach uses timed electrical pulses to the brain and spinal cord to strengthen nerve connections to hand muscles. Over 32 participants will receive a personalized two-wee…

This study tests whether a video-based home exercise program can improve trunk and limb control, daily activities, and quality of life in people with ALS. Twenty adults with a definite ALS diagnosis who can sit independently will follow the program 3 days a week for 8 weeks. The …

This study tests a drug called ranolazine to see if it safely reduces muscle cramps and improves quality of life in people with ALS. About 72 adults with ALS who have frequent cramps will receive either ranolazine or a placebo for 28 weeks. Researchers will track cramp frequency,…

This study tests whether a personalized physical therapy program, designed based on each person's specific muscle strengths and weaknesses, can help people with ALS maintain their ability to move and do daily activities better than standard physical therapy. About 38 adults with …

This study tests if a mechanical device that helps people cough can improve breathing in ALS patients. 36 adults with ALS who have trouble coughing will use the device for 4 weeks. Researchers will measure cough strength before and after treatment to see if it helps.

This study is testing whether whole-body electrical muscle stimulation (WB-EMS) can help adults with neuromuscular diseases like ALS, muscular dystrophy, and myasthenia gravis exercise safely. Because these conditions make normal exercise difficult, WB-EMS uses electrical pulses …

This study tests whether psilocybin (the active ingredient in magic mushrooms) can help ease depression and improve quality of life in people with ALS. About 24 adults with ALS and depressed mood will receive the therapy in a controlled setting. The goal is to see if this approac…

This study collects blood and spinal fluid samples from 100 people with ALS or similar neurodegenerative disorders. The samples are stored in a biorepository for future research to find biomarkers. Participants include patients and their spouses or partners. The study does not te…

This study aims to find the genetic causes of ALS in Norway. Researchers will look at the DNA of 1,200 people with ALS to identify disease-causing genes and risk factors. The goal is to better understand why some people develop ALS and to discover new genes linked to the disease.

This study looks at immune cells (macrophages) from people with ALS, people with other motor problems, and healthy volunteers. Researchers want to find differences in the cells' activity that could lead to new treatments or ways to diagnose ALS earlier. No treatment is given; it …

This study is testing a device called the mScan to see if it can track how ALS progresses over time. Researchers want to find a simple, objective way to measure the disease that can be used at home. About 80 people with ALS will use the device, and their results will be compared …

This study follows healthy people who have a family history and genetic risk for ALS, but no symptoms yet. Researchers want to learn what early changes happen before ALS begins and what factors increase risk. Participants will travel to Miami for regular check-ups over several ye…

This study follows 600 adults who have a family history of ALS and may carry genes that increase their risk. Over three years, researchers will collect blood samples, speech recordings, and health questionnaires to track early signs of the disease. The goal is to better understan…

This study aims to gather a wide range of samples, medical history, and measurements from 2,000 people with ALS and healthy volunteers over two years. Participants will provide blood samples every four months and complete monthly questionnaires and speech recordings. The collecte…

This study is looking for better ways to measure how ALS progresses over time. Researchers will use MRI scans of the brain and spine, along with blood tests, to track changes in 90 people with ALS and healthy volunteers over one year. The goal is to find reliable markers that can…

This early-stage study tests whether the experimental drug amisodin is safe and how it moves through the body in 48 healthy adults. Participants receive either the drug or a placebo, and researchers monitor for side effects. This is a necessary first step before testing the drug …

This study follows 140 adults with ALS over up to 3 years, collecting samples and health data to learn how the disease progresses. Researchers will measure proteins in spinal fluid and blood to find patterns linked to different symptoms. The goal is to improve diagnosis and patie…

This study aims to understand how amyotrophic lateral sclerosis (ALS) affects daily movement by having about 20 participants wear a small sensor called Actimyo for one month after each clinic visit. Over a year, researchers will measure walking speed and stride length during ever…

This study is building a large collection of health data and biological samples from 150 people with ALS and related conditions. The goal is to provide researchers worldwide with the information they need to better understand the disease and develop new treatments. Participants w…

This study aims to learn more about neurodegenerative disorders such as ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will screen up to 360 adults with these conditions using tests like memory exams, movement assessments, MRI scans, and genetic tes…

This study is creating a large collection of blood, spinal fluid, and urine samples from 800 people with ALS and 200 healthy volunteers. Researchers will also track symptoms and physical function over time. The goal is to provide this data to scientists worldwide to help them bet…

This early-stage study tests a brain-computer interface (BCI) in up to 2 people who have lost the ability to speak due to conditions like spinal cord injury or ALS. The device is implanted in the brain to record signals when the person tries to speak, aiming to translate those si…

This study looks at how physical abilities affect the quality of life in people with ALS, a disease that weakens muscles over time. Researchers will ask 30 participants to fill out questionnaires about their daily life and physical function during regular clinic visits for two ye…

This study tests a brain implant that may allow people with paralysis (from spinal cord injury, ALS, or similar conditions) to control a computer cursor or other devices using just their thoughts. The main goal is to check the device's safety and see if it works as a proof of con…

This study looks at how clearly people with ALS can speak during conversations compared to when they are just reading or talking alone. Researchers will record their speech and have listeners try to understand what was said. The goal is to learn how different speaking situations …

This early-stage study tests whether a brain implant can safely help people with severe paralysis (from ALS, spinal cord injury, or similar conditions) control a computer cursor or speech device just by thinking. Only 3 participants will be enrolled, and the main goal is to check…

This study is a gateway for people with ALS, their family members, and healthy volunteers to join various research projects. The goal is to gather information and samples to help scientists better understand ALS and related diseases. Participants must be at least 18 years old.

This study uses powerful MRI scans to find biological markers, or 'biomarkers,' for ALS and a related condition called PLS. Researchers will compare brain scans from 30 people—those with ALS, those with PLS, and healthy volunteers—to spot differences that could lead to better tre…

This study surveys 208 ALS patients who carry the C9orf72 mutation and their caregivers. The goal is to learn about their care, home support, and quality of life so that better help can be offered. No new treatment is tested; instead, the study gathers information to guide future…

This study aims to understand amyotrophic lateral sclerosis (ALS) by taking small skin samples from people with and without the disease. Researchers will grow these skin cells in the lab to see how they change under stress, which may help explain how ALS damages nerves. The study…

This study aims to find biological markers (biomarkers) in the blood of people with ALS that can show whether a potential new treatment is working. Researchers will collect tiny particles shed by neurons from blood samples of 30 ALS patients and 30 healthy volunteers. By comparin…

This study looks at the long-term safety of the drug tofersen (Qalsody) in people with a rare, inherited form of ALS called SOD1-ALS. Researchers will collect health information from about 125 participants in Europe and the U.S. over at least 7 years, without changing their medic…

This study collects information from the medical records of 1,200 people with ALS and related conditions. The goal is to learn more about these diseases and improve future research. Participants must receive care at a clinic that uses Epic electronic health records and speak Engl…

This study follows 100 people with ALS to see how their autonomic and sensory nerves change over time. Researchers will use skin biopsies and other tests to look for signs of nerve damage. The goal is to find markers that could help predict disease progression and be used in futu…

This study collects spinal cord and brain tissues, along with MRI scans, from 40 adults with ALS after they pass away. The goal is to find biological markers that show how the disease progresses. By linking imaging data with genetic and tissue changes, researchers hope to better …

This study is creating a large national registry of people with ALS in the United States. Researchers will collect information from up to 30,000 participants to better understand how many people have the disease, who is affected, and what environmental or occupational factors mig…