AMYOTROPHIC LATERAL SCLEROSIS

This study tests a new drug called PLL001 in 153 adults with ALS (Lou Gehrig's disease). The goal is to see if it is safe and can slow the disease, improve daily function, and extend survival. Participants will receive daily injections of PLL001 or a placebo for up to 48 weeks, w…

This study looks at the long-term safety of a drug called LY4256984 for people with ALS, a progressive nerve disease. It is an extension of an earlier study and will follow 32 participants for about 96 weeks. The main goal is to see if the drug causes any serious side effects ove…

This study tests whether the experimental drug tazbentetol can slow the decline in physical function for people with ALS. About 430 adults aged 18-80 with ALS will receive either the drug or a placebo. The main goal is to see if tazbentetol helps maintain daily living abilities o…

This study tests an oral traditional Chinese medicine made from the fungus C. cicadae in people with ALS who have high levels of certain fats (sphingolipids) in their blood. About 84 participants will receive either the medicine or a placebo for 6 months, with 9 months of follow-…

This study tests a personalized medicine designed for one person with ALS caused by a specific CHCHD10 gene mutation. The drug is an antisense oligonucleotide (ASO) that aims to slow disease progression. The single participant will be monitored for changes in muscle strength, bre…

This early-stage study tests whether repeatedly opening the blood-brain barrier with ultrasound is safe and might slow disease progression in people with ALS (Lou Gehrig's disease). 23 adults with ALS will receive 9 ultrasound sessions over 24 weeks. The goal is to check safety a…

This pilot study tests whether terazosin, a drug already used for other conditions, can safely increase energy production in people with ALS. Twenty participants will receive either terazosin or a placebo for 12 weeks. The main goal is to measure changes in ATP, a key energy mole…

This study will test if a smartphone app can reliably measure speech and breathing changes in Spanish-speaking people with ALS. Researchers will compare 35 ALS patients to healthy volunteers over time. The goal is to develop digital biomarkers that help track disease progression …

This study aims to improve a mobile brain-computer interface (BCI) that lets people with paralysis control computers and touchscreen devices using only their thoughts. Researchers will test the system's accuracy and ease of use in 2 participants who are already part of a larger B…

This study looks at the long-term safety of different treatments for amyotrophic lateral sclerosis (ALS). It is for people who have already completed a related earlier study. The goal is to monitor side effects and tolerability over at least 96 weeks. About 32 participants will t…

This study looks at whether a robot named Alter-Ego can safely help healthcare workers care for people with ALS. The robot can do tasks like help with remote doctor visits, deliver items, give reminders, and check for pain or distress. About 40 patients and their care teams will …

This study aims to validate a Polish-language version of a questionnaire that measures shortness of breath (dyspnea) in people with ALS, a fatal nerve disease. About 120 adults with ALS who experience breathing difficulty will fill out the questionnaire and other breathing tests.…