AMYOTROPHIC LATERAL SCLEROSIS

This study is testing whether an inhaled mist called RNS60 can help people with ALS (amyotrophic lateral sclerosis, or Lou Gehrig's disease). It will involve 140 adults with early-stage ALS to see if the treatment can slow the decline in their physical abilities and breathing. Th…

This study is testing whether an oral preparation made from the Cordyceps cicadae fungus can slow the progression of ALS (amyotrophic lateral sclerosis) in patients who have specific elevated fat molecules in their blood. About 84 participants will be randomly assigned to receive…

This study is testing whether an oral drug called tazbentetol can slow the progression of ALS and help people maintain their ability to perform daily activities. About 430 adults with ALS will receive either the drug or a placebo for 36 weeks to see if it improves physical functi…

This study is testing a new drug called PLL001 for people recently diagnosed with ALS (Lou Gehrig's disease). The main goal is to see if daily injections can safely slow down the loss of physical function and improve survival. About 153 participants will receive either the real d…

This study is testing a custom-made drug designed for a single person with ALS caused by a specific genetic mutation. The goal is to see if the drug is safe and if it can help slow the progression of the disease over one year. The study will carefully track the participant's phys…

This study aims to improve a portable brain-computer interface (BCI) device that helps people with paralysis control computers and mobile devices using their thoughts. Two veterans with conditions like spinal cord injury or ALS will test the device at home to see if new software …

This study aims to understand how speech and breathing change over time in Spanish-speaking people with ALS (Lou Gehrig's disease). Researchers will use a smartphone app to collect recordings from about 35 participants, comparing those with ALS to healthy individuals. The goal is…

This study aims to validate a Polish-language version of a questionnaire that measures shortness of breath in people with ALS. Researchers will enroll 120 Polish-speaking ALS patients who experience breathing difficulty. The goal is to create a reliable tool for doctors to better…

This study aims to monitor the long-term safety of tofersen (Qalsody), a prescription drug for a specific genetic form of ALS. Researchers will follow about 125 people with SOD1-ALS for at least 7 years, collecting health data from their regular clinic visits. The main goal is to…

This is a small, early-stage study to check if a drug called terazosin is safe for people with ALS and if it can raise their cellular energy (ATP) levels. Researchers will measure energy in the blood and brain of about 20 participants over 12 weeks. The main goal is to gather inf…