AMYOTROPHIC LATERAL SCLEROSIS

This study tests an experimental drug called NX210c in 80 adults with ALS, a progressive nerve disease. Participants receive multiple intravenous infusions of the drug or a placebo to see if it can slow the disease by measuring nerve damage markers in blood and spinal fluid. The …

This study tests if using a mechanical insufflation device (BiWaze Cough) twice daily for 6 months can slow the loss of cough strength in people with early ALS. Twenty adults with ALS will use the device at home with a caregiver's help. Researchers will measure changes in peak co…

This program gives adults with ALS access to an investigational drug called trehalose (SLS-005) if they cannot join other clinical trials. The goal is to provide treatment while gathering more safety and effectiveness information. Participants receive the drug through an IV infus…

This study tested a drug called ARGX-119 in 60 adults with ALS to see if it was safe and could slow the disease. The trial was stopped early because early results showed it was unlikely to help patients. The decision was not due to safety concerns, and follow-up visits are still …

This study aimed to test whether a mist-inhaled drug called RNS60 could help people with ALS, a progressive nerve disease. It planned to enroll adults with early-stage ALS and measure changes in function, breathing, and survival. However, the trial was withdrawn before any partic…

This study tests whether the drug ibudilast (MN-166) can slow the progression of amyotrophic lateral sclerosis (ALS), a severe nerve disease that weakens muscles over time. About 234 adults with early-stage ALS will receive either ibudilast or a placebo for 12 months, followed by…

This early-stage study tests the safety of an experimental drug called QRL-201 in 69 people with ALS (Lou Gehrig's disease). Participants receive either the drug or a placebo to check for side effects and how the drug moves through the body. The goal is to find safe doses for fut…

This study is for people with early-stage ALS who finished a previous trial of the experimental drug CNM-Au8. It aims to check the long-term safety of the treatment, not to cure the disease. About 40 participants will receive the drug openly, and researchers will monitor side eff…

This early-stage study tests the safety of a treatment made from stem cells found in baby teeth (SHED-CM) for people with ALS, a nerve disease that weakens muscles. Ten adults with definite or probable ALS will receive the treatment through an IV. Researchers will track side effe…

This study tests a new treatment for ALS, a disease that weakens muscles over time. Researchers take stem cells from a patient's own belly fat, grow them, and inject them into the fluid around the spine every 3 months for a year. The goal is to see if this is safe and can slow do…

This program offers early access to an experimental drug called CNM-Au8 for people with amyotrophic lateral sclerosis (ALS), a serious nerve disease. Participants must be 18 or older and have a confirmed ALS diagnosis. The goal is to provide treatment while more research is done,…

This trial provides early access to an experimental stem cell therapy called RAPA-501 for people with amyotrophic lateral sclerosis (ALS). The treatment uses a patient's own immune cells to potentially slow disease progression. It is available to adults 18 and older with a confir…

This early-stage study tests whether a new drug, prosetin, is safe for people with ALS and healthy volunteers. Researchers will give different doses to find the safest amount and see how the body processes the drug. The study involves about 72 people and is a first step before la…

This program gave up to 300 people with amyotrophic lateral sclerosis (ALS) access to an experimental drug called CNM-Au8. The main goal was to provide treatment, not to test if it works. Researchers also tracked safety by monitoring side effects. The program is no longer availab…

This study tests a gene therapy called AMT-162 in 20 adults with a specific genetic form of ALS (SOD1-ALS). The treatment is given as a single injection into the spinal fluid. The main goal is to check safety and tolerability, while also looking for early signs that it might slow…

This study tests whether a combination of two natural supplements (nicotinamide riboside and pterostilbene) can slow the progression of ALS, a fast-moving nerve disease. About 380 adults with ALS will receive either the supplement or a placebo. The goal is to see if the treatment…

This study tested a stem cell treatment for one person with ALS, a progressive nerve disease. The treatment used the patient's own fat-derived stem cells to try to control the disease. The study is no longer available for new participants.

This early-stage study tests a drug called acamprosate in 30 adults with ALS who have a specific gene mutation (C9orf72). The main goal is to see if the drug is safe. Researchers will also check if it helps slow the disease by measuring changes in muscle function and daily living…

This study tests an experimental drug called ION363 in people with a rare, inherited form of ALS caused by FUS gene mutations. The goal is to see if the drug can slow the disease and help people live longer. About 89 participants will receive the drug via spinal injection, and re…

This study aimed to test an experimental drug called IC14 in 50 people with rapidly progressing ALS. Participants would have received either the drug or a placebo intravenously twice a week for 12 weeks. The goal was to measure changes in disease markers and track safety. However…

This study is testing whether a simple saliva sample can help diagnose Amyotrophic Lateral Sclerosis (ALS). Researchers are analyzing RNA in the saliva of 653 people, including ALS patients and healthy caregivers. The goal is to find a unique RNA signature that can identify ALS, …

This study tests whether people with ALS can start using a breathing machine (non-invasive ventilation) at home instead of being admitted to the hospital. 46 adults with ALS who need breathing support will be randomly assigned to start at home with remote monitoring or in the hos…

This study aims to create a simple test to determine the risk of falling for people with neuromuscular disorders like muscular dystrophy, ALS, and myasthenia gravis. Researchers will evaluate how well a series of physical tasks (like standing up, walking, and balancing) can predi…

This study is collecting samples and data from 610 people with ALS and related disorders, as well as healthy volunteers. The goal is to track natural changes in biological markers over time, which will help researchers design better future clinical trials. Participants do not rec…

This study is testing a new, comfortable headset that reads brain signals to help people with ALS type on a virtual keyboard. The goal is to see if the headset is easy to set up and use in daily life. Five people with ALS will try the device, and researchers will measure setup ti…

This study aims to learn more about ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers will look at participants' symptoms, genetic information, and biological markers to find connections. The goal is to better understand these co…

This study looks at people with early ALS who still have some body areas unaffected. Researchers want to find the very first signs of the disease spreading. About 100 adults with ALS and healthy controls will be followed over time. No treatment is tested; the goal is to better un…

This study explores whether advanced MRI scans can detect changes in the brain caused by ALS, a disease that affects nerve cells. Researchers will scan 119 people (ALS patients and healthy volunteers) three times over 8 months to see if these scans can track the disease's progres…

This study was designed for people with rapidly progressing ALS. It aimed to see if the drug IC14 could change brain inflammation measured by special PET scans. The study was withdrawn before any participants were enrolled, so no results are available.

This study looks at 80 people with ALS to see if electrical tests of breathing muscles and ultrasound of the diaphragm and nerves can predict when breathing problems will start. The goal is to help doctors decide the best time to start breathing support (noninvasive ventilation).…

This study involves 170 people with ALS who will use a smartphone app at home to record their speech and swallowing sounds. The goal is to see if this remote method can accurately track changes in these functions over time. Researchers hope this approach could make monitoring eas…