Could this study unlock the secrets of ALS before symptoms start?
NCT ID NCT06581861
First seen Nov 01, 2025 · Last updated Jun 21, 2026 · Updated 40 times
Summary
This study follows 600 adults who are genetically at risk for ALS due to family history. Over three years, researchers collect blood samples, speech recordings, and health data to track early signs of the disease. The goal is to build a rich database that scientists can use to better understand ALS and potentially find ways to prevent or delay it.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Barrow Neurological Institute
RECRUITINGPhoenix, Arizona, 85013, United States
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CHALS-CCT, University of Puerto Rico, Medical Sciences Campus
RECRUITINGSan Juan, Puerto Rico, 00935, Puerto Rico
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Columbia University
RECRUITINGNew York, New York, 10032, United States
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Dartmouth Hitchcock Medical Center
RECRUITINGLebanon, New Hampshire, 03756, United States
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Duke University
RECRUITINGDurham, North Carolina, 27705, United States
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Georgetown University
RECRUITINGWashington D.C., District of Columbia, 200007, United States
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Henry Ford Health
RECRUITINGDetroit, Michigan, 48202, United States
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Hospital for Special Care
RECRUITINGNew Britain, Connecticut, 06053, United States
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
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John Hopkins University
RECRUITINGBaltimore, Maryland, 21205, United States
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Massachusetts General Brigham
RECRUITINGBoston, Massachusetts, 02145, United States
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Mayo Clinic
RECRUITINGJacksonville, Florida, 32224, United States
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Nih/Ninds
RECRUITINGBethesda, Maryland, 20892, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Ohio State University
RECRUITINGColumbus, Ohio, 43221, United States
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Penn State Health
RECRUITINGHershey, Pennsylvania, 17033, United States
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Providence ALS Center
RECRUITINGPortland, Oregon, 97213, United States
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Saint Alphonsus Regional Medical Center
RECRUITINGBoise, Idaho, 83704, United States
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Temple University
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
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Texas Neurology
RECRUITINGDallas, Texas, 75206, United States
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University of Alabama Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
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University of California Irvine
RECRUITINGOrange, California, 92868, United States
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University of California San Diego
RECRUITINGLa Jolla, California, 92037, United States
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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University of Colorado Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55455, United States
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University of Nebraska Medical Center
RECRUITINGOmaha, Nebraska, 68198, United States
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University of Utah
RECRUITINGSalt Lake City, Utah, 84132, United States
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University of Washington
RECRUITINGSeattle, Washington, 98195, United States
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23298, United States
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Washington University
RECRUITINGSt Louis, Missouri, 63110, United States
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help researchers understand early signs of ALS and develop ways to detect or delay the disease in at-risk individuals.
What could go wrong
This is an observational study, not a treatment trial. It may not directly benefit participants, and results may take years to translate into clinical advances.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.