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Scientists hunt for hidden antibodies in severe seizure disorders

NCT ID NCT04421846

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study collects blood, spinal fluid, and brain tissue from 400 people with severe seizures (status epilepticus) or epilepsy linked to brain inflammation (dysimmune encephalitis), plus control patients. Researchers aim to find antibodies and markers of nerve cell death that could improve diagnosis and understanding of these serious conditions. Participants must be 2 years or older and enrolled in French social security.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2020

Expected to finish

Jun 2033

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Group 1: * Patients aged 2 years or above, with status epilepticus. * Affiliation to a French social security system excluding "Aide Médicale" Etat (AME). * Patients or relatives have been informed and given free informed and written consent to participate * Patients under legal protection (guardianship, curatorship) or not Group 2: * Patients aged 2 years or above, with clinical signs of epilepsy associated to dysimmune encephalitis. * Affiliation to a French social security system excluding "Aide Médicale" Etat (AME). * Patients or relatives have been informed and given free informed and written consent to participate * Patients under legal protection (guardianship, curatorship) or not Group 3: * Patients aged 18 years or above, without status epilepticus and/or dysimmune encephalitis. * Affiliation to a French social security system excluding "Aide Médicale" Etat (AME). * Patients or relatives have been informed and given free informed and written consent to participate * Patients under legal protection (guardianship, curatorship) or not Exclusion Criteria: Group 1: * Women with known or clinically detected pregnancy. * Patient deprived of liberty * Patients with known neurodegenerative disease. Group 2: * Women with known or clinically detected pregnancy. * Patient deprived of liberty * Patients have been already treated by corticoids or IgIV. Group 3: * Women with known or clinically detected pregnancy. * Patient deprived of liberty. * Patients with status epilepticus. * Patients with known neurodegenerative disease, brain tumor, severe head trauma, meningitis, subarachnoid hemorrhages, stroke.

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Conditions

The condition(s) this trial relates to.

autoimmune disease autoimmune encephalitis epilepsy Status Epilepticus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dysimmune encephalopathy Status epilepticus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hôpital de la Pitié Salpêtrière

    RECRUITING

    Paris, 75013, France

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