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Brain wave battle: deeper suppression may halt post-arrest seizures

NCT ID NCT05851391

Disease control Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

After a cardiac arrest, some patients develop seizures that do not respond to standard treatment. This trial tests whether putting the brain into a deeper state of electrical silence — called burst suppression — can stop those seizures better than the usual approach of only suppressing seizure activity. Thirty adults in intensive care will be randomly assigned to one of two EEG-guided anesthesia targets, and researchers will track how quickly seizures return.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intravenous anesthesia titrated to burst suppression or seizure suppression on EEG
What this could lead to
If successful, this could establish a better way to stop dangerous seizures after cardiac arrest, potentially improving survival and brain recovery.
What could go wrong
This is a small, early-phase trial with only 30 participants, so results may not apply broadly. Deep anesthesia carries risks like low blood pressure and longer sedation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2023

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years old 2. Non-traumatic, out-of-hospital cardiac arrest 3. Comatose on admission - defined as not following commands 4. Return of spontaneous circulation (ROSC) within less than 45 minutes 5. Admission to the intensive care unit 6. Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous EEG monitoring within 7 days from ROSC Exclusion Criteria: 1. Acute cerebral hemorrhage or infarction 2. Pregnancy 3. Prisoners

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest new-onset refractory status epilepticus perinatal asphyxia Status Epilepticus visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anoxia-ischemia, cerebral Anoxic-ischemic encephalopathy Heart arrest Hypoxia-ischemia, brain Refractory status epilepticus Seizures Status epilepticus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    1 site. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Zuckerberg San Francisco General Hospital

    RECRUITING

    San Francisco, California, 94110, United States

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