Could one radiologist be enough for lung cancer screening in women?

NCT ID NCT05195385

Diagnosis Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether a single trained radiologist can read low-dose CT scans for lung cancer screening as accurately as two experts. It will enroll 2,635 women aged 50 to 74 who are at risk due to heavy smoking. The goal is to see if this simpler approach can work well in practice.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: low-dose computed tomography (CT) scan
What this could lead to: If successful, this could make lung cancer screening more accessible and efficient for at-risk women by relying on a single trained radiologist instead of two experts.
What could go wrong: This is an implementation study, not a treatment trial. It may show that single reading is less accurate than double reading, and results may not apply to other populations or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 2,635 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2022

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 74 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged from 50 to 74 years * who had smoked at least 20 pack years and quit less than 15 years ago * Had given their consent and accepted the need for a 2-year follow-up * Affiliated to the social security system Exclusion Criteria * Presence of clinical symptoms suggesting malignancy (weight loss, hemoptysis) or ongoing infection (cough with fever) * Evolving cancer * History of lung cancer * A 2-year follow-up not possible * Chest CT scan performed within 2 years prior to inclusion

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Conditions

The condition(s) this trial relates to.

lung neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung cancer screening

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Could one radiologist be enough for lung cancer screening in women?

What the study statuses mean