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Brain scans reveal why some depressed patients Can't shake negative thoughts

NCT ID NCT05577247

First seen Apr 14, 2026 · Last updated Jun 17, 2026 · Updated 8 times

Summary

This study looks at how the brain handles negative beliefs in people with treatment-resistant depression. Researchers will use brain scans to see how these beliefs change after a single dose of ketamine. The goal is to understand why some depressed patients hold onto negative thoughts even when faced with positive evidence, and how treatment might help.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • GH Pitié Salpêtrière

    RECRUITING

    Paris, France

    Contact

Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.