TREATMENT RESISTANT DEPRESSION

This study is testing whether a surgically implanted brain stimulation device can help adults with severe, long-term depression that hasn't improved with at least four different antidepressant treatments. For 12 months, half the participants will receive active stimulation while …

This study is testing a new way to personalize a non-drug treatment for depression that hasn't responded to medication. Researchers will use a special brain scan to try to match each person to the most effective type of magnetic brain stimulation. About 348 adults with treatment-…

This study is testing whether electrical stimulation of the front part of the brain can help people with severe depression that hasn't improved with other treatments. Participants will have a small device surgically implanted, similar to a pacemaker, which delivers mild electrica…

This study is testing whether combining psilocybin (a psychedelic compound) therapy with a rapid form of non-invasive brain stimulation is safe and more effective for treating severe depression that hasn't responded to other treatments. One hundred adults will receive either a hi…

This study tests whether magnetic stimulation applied to both sides of the brain works better than stimulation on just the left side for reducing suicidal thoughts in people with treatment-resistant depression. Researchers will enroll 76 adults who still have suicidal thoughts de…

This early-stage study is testing whether a surgically implanted brain stimulation device can help people with severe depression that hasn't responded to other treatments. Researchers will implant a device in 20 participants and track their symptoms over 5 years, periodically tur…

This study is testing if a combination of intravenous ketamine and online cognitive behavioral therapy (i-CBT) can quickly and effectively reduce suicidal thoughts and behaviors in people with treatment-resistant depression. Over 13 weeks, 110 participants will all receive weekly…

This study is for adults with major depression whose first antidepressant didn't work well enough. It compares two next steps: switching to a different standard pill (usual care) versus quickly adding a stronger treatment, esketamine (a nasal spray or IV infusion), to a pill. The…

This study is testing whether nitrous oxide (commonly known as laughing gas) can help reduce symptoms of depression. Researchers will give 172 adults with major depressive disorder weekly one-hour breathing sessions of either nitrous oxide or a placebo air mixture for four weeks.…

This study is testing whether taking very small, non-hallucinogenic doses of psilocybin (the active compound in 'magic mushrooms') alongside therapy can help people with depression that hasn't improved with standard medications or therapy. It will involve 20 adults who will take …

This study is testing a new, faster version of magnetic brain stimulation for people with depression that hasn't improved with standard medications. It aims to see if delivering five short magnetic stimulation sessions per day for five days can reduce depression symptoms. The tre…

This study is testing a specialized form of talk therapy called schema therapy for people whose depression is long-lasting and hasn't responded well to medication. It will compare 30 weekly sessions of schema therapy against the usual therapy offered in Denmark. The goal is to se…

This study is testing whether a small, implanted device that gently stimulates a nerve in the neck can help people with severe depression that hasn't improved with standard treatments. About 6,800 participants will be randomly assigned to have the device turned on or left off for…

This study aims to see how well an implanted device called Vagus Nerve Stimulation (VNS) Therapy works over several years for people with depression that hasn't improved with standard treatments. It will follow 500 patients who receive the device for up to 5 years, tracking their…

This is a small, early-stage study to see if psilocybin (a psychedelic compound) combined with therapy is safe and tolerable for autistic adults with depression that hasn't responded to other treatments. Twenty participants will receive two doses of psilocybin alongside therapy s…

This study is testing a new medication film placed inside the cheek (VLS-01) for people with depression that hasn't improved with standard antidepressants. About 142 participants will receive either the active film or a placebo film to see if it helps reduce depression symptoms a…

This study is testing a brain implant called deep brain stimulation (DBS) for people with severe depression that hasn't improved with other treatments. The implant delivers small electrical pulses to a specific brain area. Researchers will also use the device to record brain sign…

This study is testing an experimental nasal spray called BPL-003, given with psychological support, for people with treatment-resistant depression. It aims to see if the spray is safe and how it affects the brain in 64 participants whose depression hasn't improved with at least t…

This study is testing whether daily exposure to a special 40 Hz flickering light can help reduce depression symptoms. Researchers will enroll 60 adults with major depression who will use a light device at home for one hour daily for six weeks. The goal is to see if this non-invas…

This study aims to understand why some people with major depression don't get better with standard antidepressant medications. Researchers will use MRI and PET brain scans to compare brain chemistry in three groups: people with treatment-resistant depression, people whose depress…

This study aims to understand how the brain processes social and emotional information in people with severe, treatment-resistant depression or epilepsy. Researchers will use electrodes temporarily implanted in the brain for clinical care to record and gently stimulate brain acti…

This study aims to understand how people with depression or bipolar disorder respond to their regular treatments. Researchers will follow 500 adults already receiving clinical care for up to 12 weeks, conducting interviews and optional tests like blood draws and sleep studies. Th…

This study aims to understand how electroconvulsive therapy (ECT) helps people with severe depression that hasn't responded to medications. Researchers will measure how ECT affects brain network connections and sleep patterns in 50 participants receiving treatment. The goal is to…

This study aims to identify biological markers that predict how well different brain stimulation and medication treatments work for severe depression and obsessive-compulsive disorder (OCD). Researchers will collect data from 1,000 patients receiving treatments like electroconvul…

This study aims to understand how specific brain circuits are involved in the persistent symptoms of treatment-resistant depression. Researchers will use a non-invasive, focused ultrasound device on 120 participants to temporarily and safely alter activity in deep brain pathways.…

This study aims to learn more about how a type of talk therapy called schema therapy might help people with depression that hasn't improved with standard treatments. It will closely follow three patients as they receive about 30 therapy sessions over a year. The goal is to unders…