TREATMENT RESISTANT DEPRESSION

This study tests a device that sends mild electrical pulses to the vagus nerve in the neck, aiming to reduce depression symptoms in people who haven't improved with standard treatments. About 6,800 adults with treatment-resistant depression will either receive active stimulation …

This study tests whether regular sessions of repetitive transcranial magnetic stimulation (rTMS) can help people with treatment-resistant depression maintain the benefits they got from an initial round of rTMS. 75 adults who previously responded to rTMS will receive either standa…

This study tests a brain implant called deep brain stimulation (DBS) for adults with severe depression that hasn't improved with multiple treatments. The device sends mild electrical pulses to a specific brain area to help regulate mood. Researchers will measure changes in depres…

This study tests whether a 6-week intensified drug treatment can help people with major depression who did not get better on their first antidepressant. About 418 adults aged 18-65 will either receive the stronger treatment or continue usual care. The goal is to see if this appro…

This study is tracking 500 people with treatment-resistant depression who receive a Vagus Nerve Stimulation (VNS) device, which sends mild electrical pulses to a nerve in the neck to help improve mood. The goal is to see how well the device works over 12 months, especially for th…

This early-stage study tests if deep brain stimulation (DBS) is safe and effective for people with depression that hasn't improved with other treatments. Twenty adults aged 18-65 with major depression or bipolar disorder will have a DBS device implanted. Their symptoms will be tr…

This study tests whether a 40 Hz flickering light therapy can help ease depression in people with major depressive disorder. Sixty adults will use a light device at home for one hour each day over six weeks. The goal is to see if this light therapy reduces depression symptoms bet…

This study tests an experimental nasal spray called BPL-003, given with psychological support, to see if it is safe and can help people with treatment resistant depression. About 64 adults who have not gotten better with at least two prior depression treatments will receive one o…

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training to improve brain function and reduce symptoms. The goal is to help 120 adults with treat…

This early study tests if a precise type of radiation (stereotactic radiotherapy) can safely reduce symptoms in people with severe depression that hasn't responded to standard treatments. Nine adults aged 18-50 will receive the treatment and be monitored for changes in mood and s…

This study tests whether using brain scans to guide repetitive transcranial magnetic stimulation (rTMS) can better treat depression that hasn't improved with medication. About 348 adults aged 22 to 65 with major depressive disorder will receive rTMS, with the stimulation targeted…

This study tests a new medicated film placed inside the cheek (VLS-01) for people whose depression hasn't improved with at least two other treatments. About 142 adults will receive either the film or a placebo to see if it safely eases depression symptoms. The goal is to find a f…

This study tests a new, quick brain stimulation treatment for people with depression that hasn't improved with standard medications. Over five days, 78 adults will receive 25 sessions of personalized magnetic pulses targeting specific brain areas. The goal is to see if this appro…

This study tests a non-invasive brain stimulation technique called accelerated theta burst stimulation (aTBS) to see if it can reduce suicidal thoughts in people with treatment-resistant depression. Researchers will compare two types of stimulation (bilateral vs. unilateral) in 7…

This study tests whether adding ketamine to an online therapy program can quickly reduce suicidal thoughts in people with depression that hasn't improved with other treatments. About 110 adults will receive weekly online therapy for 13 weeks, and half will also get six ketamine i…

This study tests a special talk therapy called schema therapy for people whose depression doesn't get better with usual treatments or medication. Researchers will compare schema therapy to standard psychotherapy in 129 adults across six psychiatric centers in Denmark. The goal is…

This study tests whether very small, repeated doses of psilocybin (the active ingredient in magic mushrooms) combined with short-term talk therapy can safely reduce depression in people who haven't gotten better with other treatments. Twenty adults aged 18-65 with treatment-resis…

This early-phase study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy is safe and tolerable for autistic adults with depression that hasn't responded to other treatments. Twenty participants will receive two doses (10mg and 25mg) al…

This study tests whether giving psilocybin (the active ingredient in magic mushrooms) followed by a type of brain stimulation called aiTBS is safe and can help people with depression that hasn't improved with other treatments. About 100 adults aged 22-65 with treatment-resistant …

This study tests if mild electrical stimulation on the brain's surface can help people with severe depression that hasn't improved with other treatments. About 15 participants will have a small device surgically placed under the scalp to deliver targeted pulses. The goal is to se…

This study follows 500 adults with depression, bipolar disorder, or suicide risk who are already receiving care. Researchers will use interviews, questionnaires, and optional tests like blood draws and brain scans to track how symptoms change over time. The goal is to find better…

This study aims to understand how deep brain stimulation (DBS) affects brain signals in people with severe depression that hasn't improved with other treatments. Ten participants will have a DBS device implanted that can both stimulate and record brain activity. Researchers will …

This study looks at 140 people with treatment-resistant depression to see how low-intensity focused ultrasound affects brain circuits linked to mood and thinking. The goal is not to treat depression directly, but to understand which brain connections cause symptoms like loss of p…

This study aims to understand how the brain processes social and emotional information in people with treatment-resistant depression or epilepsy. Researchers will use special electrodes placed inside the brain to record activity while participants perform mood-related tasks. The …

This study looks at how the brain handles negative beliefs in people with treatment-resistant depression. Researchers will use fMRI scans to see brain activity before and after a single dose of ketamine. The goal is to understand why some patients hold onto negative thoughts even…

This study follows 1,000 adults with hard-to-treat depression or OCD who receive advanced treatments like brain stimulation or ketamine. Researchers will collect data from brain scans, cognitive tests, and voice recordings to find markers that predict which treatment works best f…

This study aims to understand how electroconvulsive therapy (ECT) changes sleep patterns and brain communication in people with depression that hasn't improved with other treatments. Researchers will measure brain activity during sleep and wakefulness in 50 adults receiving ECT. …

This study aims to understand why some people with depression do not get better with standard medications. Researchers will use brain scans to compare dopamine receptors in three groups: people with treatment-resistant depression, those whose depression responds to treatment, and…