TREATMENT RESISTANT DEPRESSION

This study tested a brain implant that sends electrical pulses to a specific area in the brain to help people with severe depression that hasn't improved with other treatments. 46 adults with treatment-resistant depression took part. Half got the active stimulation and half got a…

This study tested an experimental drug called NV-5138 in 250 adults whose depression did not improve with standard treatments. The goal was to see if the drug could reduce depression symptoms better than a placebo over 4 weeks. The study is complete, and results will show if this…

This study tested an accelerated schedule of theta-burst stimulation, a type of brain stimulation, in 48 adults with treatment-resistant depression. Half received the real treatment and half received a sham (fake) treatment. The goal was to see if the treatment changes brain conn…

This study tested whether low-dose ketamine can quickly reduce depression in teenagers (ages 13-19) whose depression did not improve with at least two standard antidepressants. The trial was small, with 12 participants, and compared ketamine to a placebo. The goal was to see if k…

This early-stage study tested a new medicine called ALA-3000 in 37 adults whose depression did not get better with standard treatments. The main goal was to see if the drug is safe and how the body processes it. Researchers also looked for early signs that it might help lift depr…

This study tested a single 25mg dose of psilocybin (the active ingredient in magic mushrooms) in 20 adults with depression that didn't respond to standard treatments and who also had ongoing suicidal thoughts. The goal was to see if the drug is safe and tolerable when given in a …

This study looked at whether omega-3 fatty acids can reduce inflammation and improve depression in people whose depression hasn't improved with standard antidepressants. 14 adults with treatment-resistant depression were randomly given either omega-3 or a placebo for 12 weeks. Re…

This study tested a technique called real-time fMRI neurofeedback in 60 adults with treatment-resistant depression. Participants learned to increase activity in the amygdala, a brain area linked to emotion, by recalling positive memories while watching their own brain activity on…

This study tested a very intense, 5-day course of brain stimulation (called accelerated theta burst stimulation) in 130 adults with depression that hadn't improved with other treatments. Half received the real stimulation and half received a fake (sham) procedure. The goal was to…

This study tested whether adding the antibiotic minocycline to usual treatment can reduce depressive symptoms in adults with treatment-resistant depression. About 76 participants took either minocycline or a placebo for 12 weeks. The goal was to see if the drug, which reduces bra…

This study tested a personalized brain stimulation technique called accelerated intermittent theta burst stimulation (aiTBS) in 79 adults with treatment-resistant depression. The goal was to see if it could ease symptoms like loss of interest or pleasure. Participants received th…

This small study tested whether combining ketamine with a type of talk therapy called RO DBT is safe and helpful for adults with treatment-resistant depression. Sixteen people took part. The goal was to see if this combination could reduce depression symptoms and understand how i…

This small pilot study tested whether psilocybin, the active ingredient in magic mushrooms, combined with psychological support could help people with treatment-resistant depression who have lost the ability to feel pleasure (anhedonia). Twenty adults with major depressive disord…

This small pilot study tested an accelerated version of theta-burst stimulation (a type of transcranial magnetic stimulation) in 7 adults with bipolar depression that hadn't improved with other treatments. All participants received the active treatment, and researchers measured c…

This study looked at whether taking aspirin and ketamine by mouth at the same time can help people with depression that hasn't improved with other treatments. Fifteen adults with treatment-resistant depression received the combination alongside their usual antidepressant. The mai…

This study tested magnetic seizure therapy (MST) as a gentler alternative to electroconvulsive therapy (ECT) for people with depression that hasn't improved with medication. About 239 adults with treatment-resistant depression received either MST or ECT to see if MST could ease d…

This early-phase study tested whether a carefully controlled dose of propofol, a drug used for sedation, could safely improve brain wave patterns linked to deep sleep in 16 older adults with treatment-resistant depression. Participants received two propofol infusions days apart w…

This study tested a new way of using mild electrical currents on the scalp (tDCS) to treat depression that hasn't responded to other treatments. Only 3 people took part, and the main goal was to see if the approach was safe and doable. The treatment involved stronger and more fre…

This study tested a new virtual navigation system to help doctors deliver TMS (a brain stimulation treatment) more precisely for people with treatment-resistant depression. 22 adults with depression that didn't improve with standard treatments took part. The goal was to see if th…

This study tested whether a faster version of brain stimulation, called accelerated theta burst, could help people with depression that hasn't improved with other treatments. 40 adults who had already tried this type of therapy received a retreatment. The goal was to see if it co…

This study tested a new computer system that uses MRI scans to guide a brain-stimulation technique called TMS. Twenty healthy volunteers had an MRI and then a TMS session to help researchers build and test the navigation software. The goal is to make TMS more precise for treating…

This study looked at how the brain reacts to nitrous oxide (laughing gas) in people with treatment-resistant depression. Researchers used brain scans and ultrasound to measure changes in blood flow and connectivity before, during, and after a one-hour exposure. The goal was to fi…

This study looked at whether schema therapy, a type of talk therapy, can help people with depression that hasn't gotten better with standard treatments. Two patients received 30 therapy sessions over about a year. The goal was to see if this approach is practical and to learn how…

This study looked at whether psilocybin (the active ingredient in magic mushrooms) needs to cause psychedelic effects to help with depression. 41 adults with treatment-resistant depression were given either psilocybin alone, psilocybin plus risperidone (a drug that blocks the psy…