New hope for depression? accelerated brain zaps show promise
NCT ID NCT03680781
First seen Apr 25, 2026 · Last updated Jun 21, 2026 · Updated 4 times
Summary
This study tested an accelerated schedule of theta-burst stimulation, a type of brain stimulation, in 40 people with treatment-resistant depression. Participants received multiple sessions per day targeting the left or both sides of the brain. Researchers measured changes in depression scores to see if the faster schedule could improve mood.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine
Palo Alto, California, 94305, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Intermittent theta-burst stimulation (iTBS) delivered via a TMS device
What this could lead to
If successful, this could offer a faster and more effective treatment option for people with depression that hasn't responded to other therapies.
What could go wrong
This was a small, open-label study with no placebo group, so results may be biased. The treatment is still experimental and may not work for everyone.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.