TREATMENT RESISTANT DEPRESSION

This study tests whether a combination of two drugs, dasatinib and quercetin, can safely slow down accelerated aging in older adults with treatment-resistant depression or schizophrenia. The drugs are known to remove aging cells from the body. The study involves 40 participants a…

This small pilot study tested a treatment for people with severe depression that did not improve with standard therapies. The approach involved surgically placing a thin wire on the surface of the brain's frontal area to deliver mild electrical pulses. The goal was to see if this…

This study tests a brain pacemaker (deep brain stimulation) for people with severe depression that hasn't improved with other treatments. About 16 adults aged 22-70 will have electrodes placed in a brain area linked to mood. The goal is to see if this reduces depression symptoms …

This study tests a new approach for people with depression that hasn't improved with standard treatments. It combines a type of brain stimulation called iTBS with digital mindfulness training. The goal is to improve attention and reduce depression symptoms. About 70 adults with m…

This study tests a drug called COMP360, made from a psychedelic compound, in people with depression that hasn't improved with other treatments. About 572 adults will receive either a low or higher dose to see if it safely reduces depression symptoms and improves daily functioning…

This study aimed to see if a single 45-minute dose of inhaled nitrous oxide (laughing gas) could quickly reduce suicidal thoughts and depression in adults visiting the emergency department. Participants would have had major depressive disorder and be at immediate risk. The trial …

This study tests a new treatment called low-intensity focused ultrasound (LIFUP) for people with depression that hasn't improved with standard treatments. The ultrasound targets a small area deep in the brain linked to mood. The goal is to see if it is safe and can reduce depress…

This study tests a single dose of COMP360, a psilocybin-based drug, in 255 adults with treatment-resistant depression. Participants receive either the drug or a placebo, and researchers measure changes in depression severity and daily functioning over time. The goal is to see if …

This study looks at whether a non-invasive brain stimulation technique called tDCS is practical and well-liked by hospitalized adults with depression that hasn't improved with standard treatments. Ten participants will receive 10 sessions of tDCS alongside their usual care. Resea…

This study tests a new version of electroconvulsive therapy (ECT) for people with treatment-resistant depression. The goal is to reduce memory loss, a common side effect, by placing electrodes on one side of the head to better target the brain's prefrontal cortex. About 20 adults…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with depression that hasn't improved with standard treatments. Twenty adults with treatment-resistant depression will receive one or two psilocybin sessions a…

This study aimed to see if breathing nitrous oxide (laughing gas) could help people with major depression, especially those who hadn't improved with other treatments. It planned to compare four weekly sessions of nitrous oxide to a placebo. However, the study was withdrawn before…

This study tests a faster way to treat depression that hasn't improved with standard treatments. Instead of 6 weeks of daily brain stimulation, participants receive 10 sessions per day for 5 days. The goal is to quickly reduce depressive symptoms in 40 adults aged 18-70 with trea…

This study tests a new way to treat depression that hasn't improved with standard treatments. It uses a personalized brain scan to guide high-dose magnetic pulses to specific areas. Sixty adults aged 18-65 will receive either real or fake (sham) treatment to see if it safely redu…

This study aims to find clues that show which patients with treatment-resistant depression will respond best to a single dose of IV ketamine. Researchers will study 40 adults with depression or bipolar disorder who haven't improved with other treatments. Participants will receive…

This study looks at whether certain brain wave patterns (called gamma oscillations) can predict how well ketamine therapy works for people with treatment-resistant depression. Researchers will measure brain activity before and during ketamine treatment in 100 adults. The goal is …

This study looks at 10 people with severe depression that hasn't improved with other treatments. They will get a special brain implant that can both stimulate a key area and record electrical signals. The goal is to find patterns in these signals that show when the treatment is w…

This study looks at how electroconvulsive therapy (ECT) affects brain wave patterns in 31 adults with treatment-resistant depression. Researchers measure depression symptoms and brain activity during and after ECT sessions to find links. The goal is to better understand why ECT w…