TREATMENT RESISTANT DEPRESSION

This study tests whether breathing nitrous oxide (laughing gas) can reduce depression symptoms in people whose depression hasn't improved with at least two medications. 120 adults aged 18-65 with moderate to severe depression will be randomly assigned to receive either the gas or…

This study tests a new, intensive brain stimulation technique for people aged 65 and older who have depression that hasn't improved with medication and also have memory or thinking problems. The treatment uses personalized magnetic pulses to target a specific brain area. The goal…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy is safe and can reduce depression and substance use in veterans and first responders who haven't responded to standard treatments. Fifty participants will re…

This study tests whether adding the drug NRX-101 to transcranial magnetic stimulation (TMS) helps people with treatment-resistant depression more than TMS alone. About 120 adults will receive either NRX-101 or a placebo alongside TMS, and researchers will measure changes in depre…

This study looks at whether having a monitor present during psilocybin (magic mushroom) therapy helps adults whose depression hasn't improved with other treatments. About 40 people will take part to see if this approach is practical and safe. The goal is to ease depression sympto…

This study tests whether adding virtual reality (VR) to standard ketamine treatment helps adults with treatment-resistant depression feel better faster. All 31 participants will get ketamine, and half will also use a VR headset during treatment. The main goal is to see if a large…

This study looks at how implanted vagus nerve stimulation (VNS) changes brain and heart activity in people with treatment-resistant depression. Researchers will measure brain waves and heart signals in 12 adults to understand how VNS works. The goal is to learn more, not to test …

This study looks at whether special cells in the eye can help predict who will respond to a brain stimulation treatment called TMS for severe depression. Researchers will measure eye responses in 44 people before and after TMS, and check if those measurements match improvements i…

This study tests whether a brain stimulation treatment called iTBS can be improved by customizing it for each person with treatment-resistant depression. Researchers will use brain wave measurements (EEG) to find the best stimulation settings for each participant. The goal is to …

This study will enroll 2000 adults with major depressive disorder or bipolar depression to understand why some people respond to treatment and others do not. Researchers will analyze clinical symptoms, genetics, metabolism, and immune markers. Participants may also be contacted f…