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Magic mushroom therapy shows promise for stubborn depression

NCT ID NCT06303739

First seen Apr 13, 2026 · Last updated May 22, 2026 · Updated 8 times

Summary

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can help people with depression that hasn't improved with standard treatments. Twenty adults with treatment-resistant depression will receive one or two psilocybin sessions and be followed for a year. Researchers will track symptom changes using depression questionnaires to see how well and how long the treatment works.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • UNC Chapel Hill Medical Center

    Chapel Hill, North Carolina, 27514, United States

Conditions

Explore the condition pages connected to this study.